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2318 Exhibit: Biogen Exhibit 2318

Document IPR2015-01993, No. 2318 Exhibit - Biogen Exhibit 2318 (P.T.A.B. Jun. 22, 2016)

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2291 Exhibit: Biogen Exhibit 2291

Document IPR2015-01993, No. 2291 Exhibit - Biogen Exhibit 2291 (P.T.A.B. Jun. 22, 2016)

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2047 Exhibit: Biogen Exhibit 2047

Document IPR2015-01993, No. 2047 Exhibit - Biogen Exhibit 2047 (P.T.A.B. Jun. 22, 2016)

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1041 Exhibit: History of Changes and the ClinicalTrialsgov Archive

Document IPR2015-01993, No. 1041 Exhibit - History of Changes and the ClinicalTrialsgov Archive (P.T.A.B. Sep. 28, 2015)

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2069 Exhibit: Biogen Exhibit 2069

Document IPR2015-01993, No. 2069 Exhibit - Biogen Exhibit 2069 (P.T.A.B. Jun. 22, 2016)

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1062 Exhibit: Petitioners Exhibit 1062

Document IPR2015-01993, No. 1062-17 Exhibit - Petitioners Exhibit 1062 (P.T.A.B. Sep. 28, 2016)

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2073 Exhibit: Biogen Exhibit 2073

Document IPR2015-01993, No. 2073 Exhibit - Biogen Exhibit 2073 (P.T.A.B. Jun. 22, 2016)

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2092 Exhibit: Biogen Exhibit 2092

Document IPR2015-01993, No. 2092 Exhibit - Biogen Exhibit 2092 (P.T.A.B. Jun. 22, 2016)

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2255 Exhibit: Biogen Exhibit 2255

Document IPR2015-01993, No. 2255 Exhibit - Biogen Exhibit 2255 (P.T.A.B. Jun. 22, 2016)

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1004 Exhibit: ICH Guideline E4

Document IPR2015-01993, No. 1004 Exhibit - ICH Guideline E4 (P.T.A.B. Sep. 28, 2015)

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1005 Exhibit: Declaration of Dr Steven E Linberg

Document IPR2015-01993, No. 1005 Exhibit - Declaration of Dr Steven E Linberg (P.T.A.B. Sep. 28, 2015)

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2385 Exhibit: Biogen Exhibit 2385

Document IPR2015-01993, No. 2385-35 Exhibit - Biogen Exhibit 2385 (P.T.A.B. Oct. 21, 2016)

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2368 Exhibit: Biogen Exhibit 2368

Document IPR2015-01993, No. 2368 Exhibit - Biogen Exhibit 2368 (P.T.A.B. Jun. 22, 2016)

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2130 Exhibit: Biogen Exhibit 2130

Document IPR2015-01993, No. 2130 Exhibit - Biogen Exhibit 2130 (P.T.A.B. Jun. 22, 2016)

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2214 Exhibit: Biogen Exhibit 2214

Document IPR2015-01993, No. 2214 Exhibit - Biogen Exhibit 2214 (P.T.A.B. Jun. 22, 2016)

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