Their high hydrophilic nature, favouring wettability probably as a result of the polar ionised groups being exposed on the crystal surfaces, leads to water vapour sorption (hygroscopicity) which on occasions, may be excessive.
Furthermore, “[w]hen there is a design need or market pressure to solve a problem and there are a finite number of identified, predictable solutions,” a POSA “has good reason to pursue the known options within his or her technical grasp.
Secondary considerations, including long-felt need, failure of others, unexpected results, commercial success, copying, licensing, and industry praise, may provide “powerful tools for courts faced with the difficult task of avoiding subconscious reliance on hindsight.” Mintz v. Dietz & Watson, Inc., 679 F.3d 1372, 1378 (Fed. Cir. 2012).
Here, Pfizer admitted before the PTO and in its Canadian patent application that written description support for the varenicline species and its salts, and methods for making them, are found in the substantively identical specifications of Coe and US ‘550.
Since the only “secondary consideration” Pfizer put before the examiner was the entirely expected hygroscopicity point, and as noted below (Section XIII) denying institution based on any other hypothetical secondary considerations would be premature at this stage, Galderma applies here to render claim 1 obvious.