) - None.

Substitute for Form PTO-875 Application or Docket Number 18/043,562 Column 2 Zz—>

$310 ($155 for small entity) for each additional (37 CFR 1.16(s)) 50 sheetsor fraction thereof.

* If the entry in column 1 * If the "Highest Number Previously Paid For" IN THIS SPACE is less than 20, enter "20".

* If the "Highest Number Previously Paid For" IN THIS SPACEis less than 3, enter "3".

he "Highest Number Previo Paid For" (Tots on independent)

United States Patent and Trademark Office Address: COMMISSIONER FOR PATENTS Alexandria, Virginia 22313-1450 ov www.uspto.gi 18/043,562 Shivani SRIVASTAVA 3338.2240002 115018 Sterne, Kessler, Goldstein & Fox P.L.L.C. BMS/Scripps 1101 K Steet, NW 10th Floor Washington, DC 20005 Date Mailed: 05/30/2024

The applicant is hereby advised that the United States Patent and TrademarkOffice, in its capacity as a Designated / Elected Office (37 CFR 1.495), has ACCEPTED the aboveidentified international application for national patentability examination in the United States Patent and TrademarkOffice.

A Filing Receipt will be issued for the present application in due course.

Basic National Feesfiled on 02/28/2023 FORM PCT/DO/EO/903 (371 Acceptance Notice)

Applicant is reminded that any communications to the United States Patent and Trademark Office must be mailed to the address given in the heading and include the U.S. application no. shown above (37 CFR 1.5)

Claims 1-176 are sought to be canceled without prejudice to or disclaimer of the subject matter therein.

These changes introduce no new matter, and their entry is respectfully requested.

dated August 16, 2023 Bristol-Myers Squibb Company Application No. 18/043,562 Conclusion Prompt and favorable consideration of the Preliminary Amendmentis respectfully requested.

If the Examiner believes, for any reason, that personal communication will expedite prosecution of this application, the Examineris invited to telephone the undersigned at the numberprovided.

/Scott A. Schaller/ Scott A. Schaller, Ph.D. Attorney for Applicant Registration No. 60,167 Date: August 16, 2023 1100 New York Avenue, N.W.

Inventors: SRIVASTAVAef al.

Confirmation No.: 2437 Applicant: Bristol-Myers Squibb Company Art Unit: 1647 Application No.: 18/043,562 Filing Date: February 28, 2023 Examiner: 7o Be Assigned Atty.

If any additional fees are due other than those included with this response, the Office is authorized to charge such fees to Deposit Account No. 19-0036.

Amendments to the Claims begin on page 2 of this paper.

Remarksbegin on page8 ofthis paper.

Art Unit Examiner To Be Assigned 1647 This is a request under the provisions of 37 CFR 1.136(a) to extend the period for filing a reply in the above-identified application.

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