List of certificates issued by the EDQM Official Announcement - Rapid Implementation on 01/01/2000 Magnesium stearate Isopropyl alcohol Products with risk of transmitting agents of animal spongiform encephalopathies Minimising the risk of transmitting animal spongiform encephalopathy agents via medicinal products (5.2.8) Replacement Production statements for monographs on TSE-risk products Aprotinin Aprotinin concentrated solution Calcium stearate Cholesterol Chymotrypsin Decyl oleate Diethylene glycol monopalmitostearate Erythromycin stearate Ethyl oleate Ethylene glycol monopalmitostearate Glycerol distearate Glycerol mono-oleates Glycerol monostearate 40-55 Hyaluronidase Insulin Macrogol stearate Macrogol stearyl ether Magnesium stearate Parnaparin sodium Propylene glycol monopalmitostearate Stearic acid Stearoyl macrogolglycerides Trypsin Vaccines for human use International Conferences Mycoplasma Testing the Potentialities & Roles of PCR Tests - 13-14 March 2000, Paris, France The Future Face of the European Pharmacopoeia Current Concerns in Pharmaceutical Analysis 9-10 October 2000, Lisbon, Portugal Tetanus Vaccines for Human Use 22-23 June 2000, Strasbourg, France

January 2000 General Information CD-ROM 2000 of the European Pharmacopoeia Press release: Conference in Berlin Conditions of sale of CRS List of CRS adopted in November 1999 Prepublication brochure (June 1999) List of texts published in the June 1999 prepublication brochure List of texts adopted in November 1999 Draft monographs for comment Arnica tincture Assay of human coagulation factor II (2.7...) Assay of human coagulation factor X (2.7...) Azaperone Bovine viral diarrhoea vaccine (inactivated) Canine adenovirus vaccine (live) Caraway oil Carbon dioxide Cetyl palmitate Dihydroergocristine mesilate Diphtheria, tetanus and pertussis (acellular, component) vaccine (adsorbed) Diphtheria, tetanus, pertussis (acellular, component) and haemophilus type b conjugate vaccine (adsorbed) 95 Diphtheria, tetanus, pertussis (acellular, component) and hepatitis B (rDNA) vaccine (adsorbed) Diphtheria, tetanus, pertussis (acellular, component) and poliomyelitis (inactivated) vaccine (adsorbed) Framycetin sulphate Gemfibrozil Greater celandine Heptaminol hydrochloride Human coagulation factor VII, freeze-dried Human plasma (pooled and treated for virus inactivation) Human prothrombin complex, freeze-dried Hymecromone Ibuprofen Iodinated (125I) human albumin injection Ioxaglic acid Java tea Levamisole Levamisole hydrochloride Lobeline hydrochloride Marsh mallow leaf Mesterolone Mint oil, dementholised Neomycin sulphate Netilmicin sulphate Nitrous oxide Oak bark Orphenadrine citrate Orphenadrine hydrochloride Phytosterol Pipemidic acid trihydrate Poloxamers Pravastatin sodium Rosemary oil Sage leaf (salvia officinalis) Semi-solid preparations for cutaneous application Sodium perborate trihydrate Star anise Thyme Wild pansy (flowering aerial parts) Zinc stearate © PHARMEUROPA Vol.

The previous edition contained translations in sixteen European languages : Croatian, Danish, Dutch, English, Finnish, French, German, Greek, Italian, Norwegian, Portuguese, Slovak, Slovenian, Spanish, Swedish and Turkish).

Information and orders: Council of Europe European Department for the Quality of Medicines (EDQM) BP 907 - F67029 Strasbourg Cedex 1 tel.

Readers of Pharmeuropa are asked to inform EDQM of their opinion on the need for a test and limit in the light of their experience with mesilate salts.

Potential applications for the design of novel materials with predictable structural features and properties can be found in almost every commercial and academic area concerned with macroscopic structure-property considerations, e.g. non- t Permanent address: University of Sussex, School of Chemistry and Molecular Sciences, Falmer, Brighton, UK BN 1 9QJ.

However, since the existing graph-set language is not always adequate for examining multi-dimensional aggregates with a high hydrogen-bond density (a consequence of the inherent difficulties with translating 3D information into scalar quanti- ties), an additional descriptor,$ based upon the terminology of Etter et al., has been utilized as a means of specifically representing 2D hydrogen-bonded networks.

Most patterns in organic molecular solids can be adequately described in terms of four principal motifs; chains (C), dimers (D), rings ( R ) and intramol- ecular hydrogen bonds (S).V Although this notation may not $ The 2D descriptor utilized in this paper is employed as a means of facilitating a comparison and analysis of specific aggregate-types.

Although it is impossible to predict, a priori, the exact arrangement of the cations within this salt, their spatial freedom' has been severely restricted by the presence and geometry of the anionic sheets, thereby locking them into the structural framework in the anticipated fashion.

The relevant crystallographic data were the transferred to a Macintosh IIfx and a Silicon Graphics Workstation where software from CAChe Tektronix, Molecular Simulation Inc. (Cerius 3.2 and Quanta 3.3) and Biosym (Insight/Discover 2.10) was employed in the analysis of the patterns generated by the hydrogen bonds within these structures.