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IPR2019-01095, No. 1009-9 Exhibit - Osborne, DW, Diethylene glycol monoethyl ether an emerging solvent in topical dermatology products, J Cosmetic Derm 10324 329 2011 Osborne I (P.T.A.B...
Parting Thought Diethylene glycol monoethyl ether: an emerging solvent in topical dermatology products David W Osborne, PhD TOLMAR Inc., Fort Collins, CO, USA Summary Background The solvent diethylene glycol monoethyl ether (DEGEE) is currently used in over 500 cosmetic products and has enabled the formulation of a topical 5% dapsone gel for the treatment of acne.
In this study, the 5% dapsone topical gel vehicle containing 25% DEGEE demonstrated tumor growth essentially identical to untreated control animals when both groups received 600 RBU ⁄ week.
The Scientific Committee on Consumer Products issued opinion on DEGEE4 provided a detailed synopsis of three well-conducted in vitro studies on percutaneous Ó 2011 Wiley Periodicals, Inc. • Journal of Cosmetic Dermatology, 10, 324–329 Mylan (IPR2019-01095) MYLAN1009, p. 002
Additionally, when an anti-inflam- matory agent is used to treat acne, it is important to increase the level of drug that will cross the intact stratum corneum lining the upper third of the piloseba- ceous unit.
In vitro infinite dose animal skin studies tend to bias high the enhancement factors for any solvent that can extract the lipids from the stratum corneum.
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IPR2019-01095, No. 1009-9 Exhibit - Osborne, DW, Diethylene glycol monoethyl ether an emerging solvent in topical dermatology products, J Cosmetic Derm 10324 329 2011 Osborne I (P.T.A.B. Jun. 7, 2019)
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IPR2019-01095, No. 1006-6 Exhibit - Certification for Translation of WO 2010072958 (P.T.A.B. Jun. 7, 2019)
1 AMN1006 Mylan (IPR2019-01095) MYLAN1006, p. 001
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IPR2019-01095, No. 1014-14 Exhibit - Rowe, RC et al Eds, Handbook of Pharmaceutical Excipients, 6th Ed, Pharmaceutical Press London, UK 2009 (P.T.A.B. Jun. 7, 2019)
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IPR2019-01095, No. 1029-27 Exhibit - Kim, J Y, et al, Rheological properties and microstructures of Carbopol gel network system, Colloid Polym Sci 281614 6232003 Kim (P.T.A.B. Jun. 7, 2019)
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IPR2019-01095, No. 1029-27 Exhibit - Kim, J Y, et al, Rheological properties and microstructures of Carbopol gel network system, Colloid Polym Sci 281614 6232003 Kim (P.T.A.B. Jun. 7, 2019)
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