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2023 Exhibit: Exhibit 2023 Kircik 2011a

Document IPR2019-00207, No. 2023-54 Exhibit - Exhibit 2023 Kircik 2011a (P.T.A.B. Aug. 9, 2019)
Microsphere technology eliminates the rapid delivery of high concentrations of active dmg to the application site and instead facilitates controlled release of potentially initating drugs.
The macroporous beads, which typically measure 10 to 25µm in diameter, release active ingredient over time or in response to certain stimuli, such as change in pH, temperature, or physical manipulation when mbbed into the skin.
18 In addition to enhanced tolerability, microsphere fo1mulations provide the benefit of improved drng stability.20.21 Tretinoin has been shown to degrade significantly upon exposure to ultraviolet (UV) radiation as well as when combined with BPO.
1n a study comparing BPO microsphere 5.5% wash to a gentle nonmedicated cleanser once daily in patients age 12 or older, tolerability as rated by investigators and subjects was very good for both products.
Del Rosso JQ, Kircik L. Comparison of the tolerability of benzoyl peroxide microsphere cream wash versus gentle cleansei· when used in combination with clindamycin and tI-etinoin gel: a multicenter, investigator-blind, randomized study.
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2011 Exhibit: Exhibit 2011 Cordain et al 2002

Document IPR2019-00207, No. 2011-42 Exhibit - Exhibit 2011 Cordain et al 2002 (P.T.A.B. Aug. 9, 2019)
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2001 Exhibit: Exhibit 2001 WO 2009108147

Document IPR2019-00207, No. 2001-32 Exhibit - Exhibit 2001 WO 2009108147 (P.T.A.B. Feb. 14, 2019)
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2007 Exhibit: Declaration of Elizabeth B Hagan in Support of Patent Owner Almirall, LLCs Motion for Admission Pro Hac Vice

Document IPR2019-00207, No. 2007-38 Exhibit - Declaration of Elizabeth B Hagan in Support of Patent Owner Almirall, LLCs Motion for Admission Pro Hac Vice (P.T.A.B. Mar. 20, 2019)
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2004 Exhibit: Exhibit 2004 Redline Comparison of Declaration

Document IPR2019-00207, No. 2004-35 Exhibit - Exhibit 2004 Redline Comparison of Declaration (P.T.A.B. Feb. 14, 2019)
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1035 Exhibit: Poster Abstracts for the Journal of the American Academy of Dermatology 2017 Annual Meeting served October 4, 2019 Part 2

Document IPR2019-00207, No. 1035-97 Exhibit - Poster Abstracts for the Journal of the American Academy of Dermatology 2017 Annual Meeting served October 4, 2019 Part 2 (P.T.A.B. Oct. 18, 2019)
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1038 Exhibit: Proposed Joint Pretrial Order

Document IPR2019-00207, No. 1038-102 Exhibit - Proposed Joint Pretrial Order (P.T.A.B. Oct. 18, 2019)
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2013 Exhibit: Exhibit 2013 Del Rosso 2007

Document IPR2019-00207, No. 2013-44 Exhibit - Exhibit 2013 Del Rosso 2007 (P.T.A.B. Aug. 9, 2019)
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2032 Exhibit: Exhibit 2032 Strauss 1991

Document IPR2019-00207, No. 2032-63 Exhibit - Exhibit 2032 Strauss 1991 (P.T.A.B. Aug. 9, 2019)
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2062 Exhibit: Exhibit 2062 Gilmore Deposition Transcript 2019 07 25

Document IPR2019-00207, No. 2062-93 Exhibit - Exhibit 2062 Gilmore Deposition Transcript 2019 07 25 (P.T.A.B. Aug. 9, 2019)
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2018 Exhibit: Exhibit 2018 James 2005

Document IPR2019-00207, No. 2018-49 Exhibit - Exhibit 2018 James 2005 (P.T.A.B. Aug. 9, 2019)

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1010 Exhibit: PDR Aczone Gel 5%

Document IPR2019-00207, No. 1010-9 Exhibit - PDR Aczone Gel 5% (P.T.A.B. Nov. 6, 2018)

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1051 Exhibit: December 2010 IIG Database

Document IPR2019-00207, No. 1051-112 Exhibit - December 2010 IIG Database (P.T.A.B. Nov. 1, 2019)

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2052 Exhibit: Exhibit 2052 EU DGME 2010

Document IPR2019-00207, No. 2052-83 Exhibit - Exhibit 2052 EU DGME 2010 (P.T.A.B. Aug. 9, 2019)

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2058 Exhibit: Exhibit 2058 Curriculum Vitae of Dr David Osborne

Document IPR2019-00207, No. 2058-89 Exhibit - Exhibit 2058 Curriculum Vitae of Dr David Osborne (P.T.A.B. Aug. 9, 2019)

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