[11-13] The most notable adverse effects of oral and bacterial components[2,3] but, until recently, the dapsone are haematological reactions, including inflammatory events were considered secondary oc- dose-dependent haemolysis and methaemoglobi- currences in the sequence of lesion development.
[5] These find- dehydrogenase (G6PD) deficiency are sensitive to ings support the classification of acne vulgaris as an these effects, since the absence of functional G6PD inflammatory skin disease as opposed to a keratino- can lead to haemolysis and denaturation of cyte/hyperproliferative disorder.
A subset of subjects then underwent a 14-day washout period and re- turned to the clinic for administration of a single dose of oral dapsone, given at the recommended 1 The use of trade names is for product identification purposes only and does not imply endorsement.
[9,13] In the studies reported here, We wish to acknowledge Christy Costello, ELS, and Denise haemoglobin levels remained stable throughout Galipeau, MSc, of QLT Inc., Vancouver, BC, Canada, who therapy with dapsone gel, and there were no ad- provided editorial assistance.
The oral comparison study was conducted in the General Clinical Research Center at the Pennsylvania State University College of Medicine, which was funded by National Institute of Health grants Mo1RR010732 and CO6RR016499.