Subject compositions can be adjusted to optimize the dermal delivery profile of dapsone to effectively treat dermatological conditions and improve the efficiency of pharmaceutical products applied to the skin.
It has been used to treat skin diseases characterized by the abnormal 15 infiltration of neutrophils, such as Dermatitis herpetiformis, linear IgA dermatosis, pustular psoriasis, pyoderma gan grenosum, acne vulgaris, and Sweet's Syndrome.
Skin conditions that can be treated using some com positions, products and methods described herein include, but are not limited to, acne, rosacea, folliculitis, perioral derma titis, photodamage, skin aging, psoriasis, ichtiosis, atopic der- 40 matitis, treatment of chronic wounds, bed sores, keratosis piralis, scars, including surgical and acne scars, sebaceous cysts, inflammatory dermatoses, post inflammatory hyper pigmentation, eczema, xerosis, pruritis, lichen planus, nodu lar prurigo, eczema, and miliaria.
Example 1 Table !lists two formulations (containing equivalent levels of diethylene glycol monoethyl ether) that show the impact of 25 acrylamide/sodium acryloyldimethyltaurate copolymer based thickener on dapsone particle size.
Additional examples containing alternate neutralizer Materials Anti-oxidants and chelating agents such as sodium met abisulfite, citric acid and EDTA were added to formulations to help slow down or completely stop any impurity formation.