Thus, it is imperative that the best use of the limited bulk is made, to support the continuing efforts of the synthetic chemists and the biologists, pursuing activity and toxicity screens.

Since any deviation front the horizontal (at saturation) is indicative of impurities, as higher drug loading either promotes or suppresses solubility, the USP uses this method to estimate the purity of meeamyia- mine hydrochloride.

The extent of solubility improvement then largely depends on any specific common ion interaction (section 2.7), particularly with the inorganics, and the size and polarity of the sulphonate or carboxylate counterion.

Group C comprises the fatty acids whose application is generally restricted to exploiting an oily form in topical preparations, soft gelatin capsules or i.m.

Nonetheless it is usually better to formulate with a salt since it will control the pH of the diffusion layer — the saturated, highly concentrated solution immediately adjacent to the dissolving surface.

Solid compositions of a similar type are also employed as filters in soft and hard-filled gelatin capsules; preferred materials in this connection also in- clude lactose or milk sugar as well as high molecular weight polyethylene glycols.

The method according to claim 8 wherein the anti- depressant is selected from amitriptyline, imi- pramine, sertraline, paroxetine, fluoxetine, bupropi- on, nelazodone, moclobemide, venlalaxine, phenelzine, tranylcypromine, and the pharmaceuti- cally acceptable salts and optical isomers thereof.

gastric acid hypersecretion, ulcers, pheo- chromocytoma, progressive supramuscular palsy, chemical dependencies and addictions (19;, dependencies on, or addictions to nicotine (and/or tobacco products), alcohol, benzodiazepines, barbituates, opioids or cocaine), headache, stroke, traumatic brain injury (TBl), psychosis, Huntington's Chorea, tardive dyskinesia, hyperkinesia, dyslexia, schiz- ophrenia, multi-inlarct dementia, age related cognitive decline, epilepsy, including petit mal absence epilepsy, senile dementia of the Alzheimer‘s type (AD), Parkinson‘s disease (PD), attention deficit hyperactivity disorder (ADHD) and Tourette's Syndrome in a mammal, comprising administering to a mammal in need of such treatment an amount of a compound of the formula I, or a pharrnaceutically acceptable salt thereof, that is effective in treating such disorder or condition.

Variations may nevertheless occur depending upon the weight and condition of the persons being treated and their individual responses to said medicament, as well as on the type of pharmaceutical formulation chosen and the time period and interval during which such administration is camed out.

Solid compositions of a similar type may also be employed as filters in gelatin capsules; preferred materials in this connection also include lactose or milk sugar] as well as high molecular weight polyethylene glycols.