Information

Search millions of cases and get court filings, fast docket alerts, and case analytics.

Request a Demo or create your account.

Lawyer? Your firm may have a group account, ask us and we'll let you know.

Click below for detailed party information:

Patent Owner

Halozyme, Inc.

Petitioner

Merck Sharp & Dohme LLC

alt+h	Toggle this page.
alt+u	Toggle Upcoming Events view.
alt+e	Export the docket to Excel.
Filtering / Searching the Docket
ctrl+f	Filter the docket.
ctrl+shift+f	Search docket and documents.
alt+s	Toggle between "Show Only" filtering modes.
alt+d, ctrl+f	System ctrl+f
escape	Clear while in docket filter.
Interactive Timeline
alt+t	Show / re-center case timeline.
alt+↑	Zoom in
alt+↓	Zoom out
alt+←	Pan left
alt+→	Pan right

Merck Sharp & Dohme LLC v. Halozyme, Inc.

PGR2025-00024 | Patent Trial and Appeal Board

Interested in this case?

Request a Demo Track this case, and find millions of cases like it, let us show you how.

Filed Feb. 21, 2025

Case Type Post Grant Review

Status Pending

Challenged Patent 18/68,218

Patent No. 12,060,590 assignments

Tech Center 1600

Art Unit 1656

Inventors Ge WEI, Qiping Zhao, H. Michael Shepard, Robert James Connor

Last Updated: 10 seconds ago

Filing Date	#	Filing and Exhibits
Entries matching. Show All.
3/4/2025	03-04-2025-Patent_Owner	Patent Owner Notice: Power of Attorney 3: Patent Owner's Power of Attorney Patent Owner Notice: Mandatory Notice 4: Patent Owner's Mandatory Notices
2/21/2025	02-21-2025-Petitioner	Petitioner Petition: as filed 1: Petition for Post Grant Review of U.S. Patent No. 12,060,590 Petitioner Notice: Power of Attorney 2: Petitioner's Power of Attorney Petitioner Exhibit 1001: U.S. Patent No. 12,060,590 Petitioner Exhibit 1002: File History of U.S. Patent No. 12,060,590 Part 1 Petitioner Exhibit 1002: File History of U.S. Patent No. 12,060,590 Part 2 Petitioner Exhibit 1002: File History of U.S. Patent No. 12,060,590 Part 3 Petitioner Exhibit 1003: Declaration of Dr. Michael Hecht Petitioner Exhibit 1004: Declaration of Dr. Sheldon Park Petitioner Exhibit 1005: U.S. Patent No. US7,767,429 Petitioner Exhibit 1006: Chao, Structure of Human Hyaluronidase-1 (2007) Petitioner Exhibit 1007: WO/2010/077297, published July 8, 2010 Petitioner Exhibit 1008: Stern, The Hyaluronidases: Their Genomics, Structures, & Mechanisms (2006) Petitioner Exhibit 1009: Jedzrejas, Structures of Vertebrate Hyaluronidases (2005) Petitioner Exhibit 1010: Zhang, Hyaluronidase Activity of Human Hyal1 (2009) Petitioner Exhibit 1011: Arming, In vitro Mutagenesis of PH-20 Hyaluronidase from Human Sperm (1997) Petitioner Exhibit 1012: Bordoli, Protein Structure Homology Modeling Using SWISSMODEL (2008) Petitioner Exhibit 1013: Frost, Recombinant Human Hyaluronidase (rHuPH20) (2007) Petitioner Exhibit 1014: Branden & Tooze, Introduction to Protein Structure (1999) Part 1 Petitioner Exhibit 1014: Branden & Tooze, Introduction to Protein Structure (1999) Part 2 Petitioner Exhibit 1015: Table Associating ’590 Patent to Corresponding ’731 Application Petitioner Exhibit 1016: Steipe, Consensus-Based Engineering of Protein Stability (2004) Petitioner Exhibit 1017: Green, Computer Graphics, Homology Modeling, and Bioinformatics (2010) Petitioner Exhibit 1018: Chica, Semi-rational Approaches to Engineering Enzyme Activity (2005) Petitioner Exhibit 1019: Hardy, Assessment of Contraceptive Vaccines Based on Recombinant Mouse Sper Petitioner Exhibit 1020: Pomering, Restricted Entry of IgG (2002) Petitioner Exhibit 1021: Baba, Mouse Sperm Lacking Cell Surface Hyaluronidase PH-20 (2002) Petitioner Exhibit 1022: Primakoff, Reversible Contraceptive Effect of PH-20 Immunization (1997) Petitioner Exhibit 1023: Tung, Mechanism of Infertility in Male Guinea Pigs Immunized with Sperm Petitioner Exhibit 1024: Rosengren, Recombinant Human PH20 (2018) Petitioner Exhibit 1025: U.S. Patent No. 9,447,401 Petitioner Exhibit 1026: U.S. Patent Application No. 13/694,731 Petitioner Exhibit 1029: Gmachl, The Human Sperm Protein PH-20 Has Hyaluronidase Activity (1993) Petitioner Exhibit 1030: Sills, "Retraction," Science, 319:569 (2008) Petitioner Exhibit 1031: Yue, Loss of Protein Structure Stability as a Major Causative Factor (2005) Petitioner Exhibit 1032: Wang & Moult, SNPs, Protein Structure, and Disease (2001) Petitioner Exhibit 1033: Marković-Housley, Crystal Structure of Hyaluronidase (2000) Petitioner Exhibit 1034: "Negative Results," Nature: Editorials, 453:258 (2008) Petitioner Exhibit 1035: Lins, Analysis of Accessible Surface of Residues in Proteins (2003) Petitioner Exhibit 1036: Hayden, Chemistry: Designer Debacle (2008) Petitioner Exhibit 1037: Benkert, Toward the Estimation of the Absolute Quality (2010) Petitioner Exhibit 1038: Schwede, SWISS-MODEL: An Automated Protein Homology-Modeling Server (2003) Petitioner Exhibit 1039: Alberts, Molecular Biology of the Cell, Chapter 3 (2007) Petitioner Exhibit 1040: He, NMR Structures of Two Designed Proteins with High Sequence Identity Petitioner Exhibit 1041: Alexander, A Minimal Sequence Code for Switching Protein Structure (2009) Petitioner Exhibit 1042: Ruan, Design & Characterization of a Protein Fold Switching Network (2023) Petitioner Exhibit 1043: Sievers, Fast, Scalable Generation of High-Quality Protein (2011) Petitioner Exhibit 1044: Mihel, PSAIA – Protein Structure and Interaction Analyzer (2008) Petitioner Exhibit 1045: Redline Comparison of the ’731 and ’590 Specifications Petitioner Exhibit 1046: Beasley & Hecht, Protein Design: The Choice of de Novo Sequences (1997) Petitioner Exhibit 1047: Xiong, Periodicity of Polar and Nonpolar Amino Acids (1995) Petitioner Exhibit 1048: Hayden, Key Protein-Design Papers Challenged (2009) Petitioner Exhibit 1049: KEGG, DRUG: Hyaluronidase (human recombinant) Petitioner Exhibit 1050: Pace & Scholtz, A Helix Propensity Scale (1998) Petitioner Exhibit 1051: U.S. Patent Application No. 61/631,313 Petitioner Exhibit 1052: U.S. Patent Application No. 61/796,208 Petitioner Exhibit 1053: Hom_pre2011 Petitioner Exhibit 1054: Hom_pre2011_header Petitioner Exhibit 1055: Hom_pre2011_header_clean Petitioner Exhibit 1056: Hom_pre2011.fasta Petitioner Exhibit 1057: Ph20_pre2011.aln-clustal_num Petitioner Exhibit 1058: Ph20_pre2011 Alignment html Petitioner Exhibit 1059: Leisola & Turunen, Protein Engineering: Opportunities and Challenges (2007) Petitioner Exhibit 1060: Hecht, De Novo Proteins from Designed Combinatorial Libraries (2004) Petitioner Exhibit 1061: Rosengren, Clinical Immunogenicity of rHuPH20 (2015) Petitioner Exhibit 1064: Collection of BLAST Webpages from the Internet Archive Petitioner Exhibit 1065: Collection of Clustal Omega Webpages from the Internet Archive Petitioner Exhibit 1066: Collection of SWISS-MODEL Webpages from the Internet Archive Petitioner Exhibit 1067: Collection of PyMol Webpages from the Internet Archive Petitioner Exhibit 1068: Declaration of Jeffrey P. Kushan Petitioner Exhibit 1069: Swiss Model Printout of PH20 Model Petitioner Exhibit 1070: Swiss Model Printout of PH20 Model with L307W Mutation Petitioner Exhibit 1071: Swiss Model Printout of PH20 Model with L307S Mutation Petitioner Exhibit 1072: Swiss Model Printout of PH20 Model with L307T Mutation Petitioner Exhibit 1073: Swiss Model Printout of PH20 Model with L307V Mutation Petitioner Exhibit 1074: Swiss Model Printout of PH20 Model with L307Y Mutation Petitioner Exhibit 1075: Swiss Model Printout of PH20 Model with L307G Mutation

Supplemental Search

Search for PTAB Motions

PTAB Analytics

TTAB Analytics

Basic Search

Filters

Party Search

Advanced

Selected Courts

Recently Selected Courts

Find PTAB Decisions

PTAB Analytics

Special PTAB Alerts

Orange Book

Directly Search Federal Courts

Search Trademark ...

Search millions of cases and get court filings, fast docket alerts, and case analytics.

Request a Demo or create your account.

Lawyer? Your firm may have a group account, ask us and we'll let you know.

Patent Owner

Petitioner

Keyboard shortcuts

Filtering / Searching the Docket

Interactive Timeline

Merck Sharp & Dohme LLC v. Halozyme, Inc.

PGR2025-00024 | Patent Trial and Appeal Board

Interested in this case?

Alert Sharing

STEP 2 of 2

Choose your membership type

Flat-Fee

Pay-As-You-Go Monthly

Add your payment information

Login or Join

Enter your corporate Email

Thousands of your peers are saving time and gaining a competitive advantage with Docket Alarm.

Join Docket Alarm to perform smarter legal research.

Download this document and millions of others instantly with a Docket Alarm membership.

Join Docket Alarm and start performing smarter legal research.

Start tracking this docket instantly with a Docket Alarm membership.

Join thousands of your peers and start performing smarter legal research.

STEP 1 of 2

Millions of Documents | 15 Seconds to Signup

Hi !

Welcome to Docket Alarm

Welcome to Docket Alarm!

Explore Litigation Insights andManage Your Cases

Reset Password

What is PACER?

Why do I need it?

What will I be charged?

Do other courts have fees?

Basic Free Access

Welcome

Thank you

Check Firm Account

Explore Litigation Insights and
Manage Your Cases