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`UNITED STATES PATENT AND TRADEMARK OFFICE
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`
`ARKEMA INC. AND ARKEMA FRANCE
`Petitioner,
`v.
`
`HONEYWELL INTERNATIONAL INC.,
`Patent Owner.
`
`PGR2016-00011
`Patent No. 9,157,017
`
`PATENT OWNER’S FIFTH AMENDED APPENDIX OF EXHIBITS
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`

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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`Description
`Exhibit No.
`Exhibit 2001 Declaration of Donald Bivens
`
`Exhibit 2002 Curriculum Vitae of Donald Bivens
`
`Exhibit 2003 U.S. Patent No. 5,182,040 to Bartlett et al.
`
`Exhibit 2004 U.S. Patent No. 5,516,446 to Bivens and Yokozeki
`
`Exhibit 2005 U.S. Patent No. 5,648,017 to Bartlett et al.
`
`Exhibit 2006 U.S. Patent No. 5,725,791 to Bivens et al.
`
`Exhibit 2007 U.S. Patent No. 5,968,406 to Bartlett et al.
`
`Exhibit 2008 U.S. Patent No. 7,914,968 to Minor et al.
`
`Exhibit 2009 U.S. Patent No. 7,959,825 to Minor et al.
`
`Exhibit 2010 Wilson, C. L. et al., Abstract: Man's Impact on the Global
`Environment: Assessment and Recommendation for Action.
`Report of the Study of Critical Environmental Problems (SCEP),
`MIT Press, Cambridge, Mass. (1970), available at:
`http://hdl.handle.net/1969.3/26655
`
`Exhibit 2011 A. Hammond, Book Review of W. Matthews et al., Study of
`Man's Impact on Climate (SMIC) Report, Inadvertent Climate
`Modification, MIT Press, Cambridge, Mass. (1971), SCIENCE
`Vol. 176, available at: http://science.sciencemag.org/content/
`176/4030/38.2
`
`Exhibit 2012 V. Ramanathan, Greenhouse Effect Due to
`Chlorofluorocarbons: Climate Implications, SCIENCE:
`American Association for the Advancement of Science, Vol.
`190 (1975), available at: http://science.sciencemag.org
`
`Exhibit 2013
`
`J. Calm and D. Didion., Trade-Offs in Refrigerant Selections:
`Past, Present, and Future, ASHRAE/NIST Refrigerants
`Conference (October 1997)
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`1
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`Exhibit 2014 B. Newell and T. Newell, In Situ, Real Time Oil Concentration
`in a Mobile Air Conditioning System, NI Tech Bulletin 001,
`Newell Instruments, Inc.
`
`Exhibit 2015 ACURA Service Bulletin, R-134a Refrigerant A/C System, Sept.
`29, 1992 for model NSX Legend, year 1993
`
`Exhibit 2016
`
`2013 ASHRAE Handbook Fundamentals, SI Ed., Chapter 29:
`Refrigerants, Table 3
`
`Exhibit 2017 Dometic, Material Safety Data Sheet, March 25, 2015
`
`Exhibit 2018
`
`ICI Americas, Inc., PAG-46, Material Safety Data Sheet (Feb. 9,
`1999)
`
`Exhibit 2019 Presentation, Exposure Limits: TLVs, BEIs, PELs, RELs,
`WEELs, ERPGs and OELs, available online at:
`http://isites.harvard.edu/fs/docs/icb.topic156420.files/Exposure_
`Limits
`
`Exhibit 2020 U.S. Patent No. 6,516,837 to Thomas et al.
`
`Exhibit 2021 Pate, Michael, et al., Miscibility Of Lubricants With
`Refrigerants, Final Report, Iowa State University of Science
`and Technology Department of Mechanical Engineering (July
`1993)
`
`Exhibit 2022 Crown, S.W., et al., A Comparison Study of the Thermal
`Performance of R12 and R134a, International Refrigeration and
`Air Conditioning Conference (1992)
`
`Exhibit 2023 Uemura, S., et al., Characteristics of HFC Refrigerants,
`International Refrigeration and Air Conditioning Conference
`(1992)
`Exhibit 2024 Brown, J. Steven, et al., The fluorinated olefin R-1234ze(Z) as a
`high-temperature heat pumping refrigerant, International
`Journal of Refrigeration 32, 1412-1422 (2009)
`
`Exhibit 2025 Case Law of the Board of Appeal of the European Patent Office
`(Seventh Edition, Sept. 2013)
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`Exhibit 2026 Bristol Compressors, Medium and Low Temperature Retrofit
`from R502 to R404A/R507, Application Bulletin 125 (Release
`date Oct. 20, 1995)
`
`Exhibit 2027 Wilson, C. L. et al., Man's Impact on the Global Environment:
`Assessment and Recommendation for Action. Report of the Study
`of Critical Environmental Problems (SCEP), MIT Press,
`Cambridge, Mass. (1970)
`
`Exhibit 2028 Matthews, W., et al., Study of Man's Impact on Climate (SMIC)
`Report, Inadvertent Climate Modification, MIT Press,
`Cambridge, Mass. (1971)
`
`Exhibit 2029 Case Law of the Board of Appeal of the European Patent Office
`(Seventh Edition, Sept. 2013)
`
`Exhibit 2030 ASHRAE Standard, Designation and Safety Classification of
`Refrigerants, American Society of Heating, Refrigerating and
`Air-Conditioning, Inc.(Nov. 18, 2009)
`
`Exhibit 2031 United States Environmental Protection Agency’s Office of
`Pesticide Programs, Summary of the IBT Review Program (July
`1983)
`
`Exhibit 2032 Manual for Investigation of HPV Chemicals, Chapter 3: Data
`Evaluation
`Exhibit 2033 TSCA Filing, Refrigerant 1243zf; TNO Quality of Life Report:
`A sub-acute (28-day) inhalation toxicity study with 3,3,3,-
`trifluoroprop-1-ene (HFO 1234zf) in rats (Dec. 3, 2010)
`
`Exhibit 2034 Clayton Jr., J. Wesley, Chapter 9: The Mammalian Toxicology
`of Organic Compounds Containing Fluorine (1996)
`
`Exhibit 2035 U.S. Patent No. 5,569,797 to Fu et al.
`
`Exhibit 2036 U.S. Patent No. 5,001,287 to Fernandez et al.
`
`Exhibit 2037 ECETOC Technical Report No. 103: Toxicity of Possible
`Impurities and By-products in Fluorocarbon Products
`(December 2008)
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
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`Exhibit 2038 U.S. Patent Application No. 13/939,233
`
`Exhibit 2039 Transcript of Mar. 29, 2016 telephone proceedings before the
`Board
`Exhibit 2040 Transcript of Nov. 28, 2016 teleconference with the Board
`
`Exhibit 2041 Transcript of Nov. 29, 2016 teleconference with the Board
`
`Exhibit 2042 US Patent Publication No. 2012/0292556 A1
`
`Exhibit 2043 Brown, J. Steven, HFOs: New, Low Global Warming Potential
`Refrigerants, ASHRAE Journal (August 2009)
`Exhibit 2044 Brown, J. Steven, Low Global Warming Potential Refrigerant
`Options for Unitary Equipment, ASHRAE Winter Conference
`(2011)
`Exhibit 2045 Beattie, Roger J., et al., Investigation of Low GWP Refrigerant
`Interaction with Various Lubricant Candidates, Purdue
`University (2012), available at
`http://docs.lib.purdue.edu/iracc/1223
`Exhibit 2046 Domanski, Piotr A., et al., NIST, Transition to Low-GWP
`Refrigerants: Options and Tradeoffs, Florida International
`University (April 1, 2016)
`Exhibit 2047 McLinden, Mark O., NIST, Thermodynamic Analysis for Low-
`GWP Refrigerants, ASHRAE Winter Conference (Jan. 19,
`2014)
`Exhibit 2048 Deposition Transcript of Dr. William J. Brock (Dec. 1, 2016)
`
`Exhibit 2049 Deposition Transcript of Dr. J. Steven Brown (Dec. 8, 2016)
`
`Exhibit 2050 Brown, J. Steven et al., Comparative analysis of an automotive
`air conditioning systems operating with CO2 and R134a,
`International Journal of Refrigeration (2002)
`
`Exhibit 2051 Brown, Steven J., Potential R-114 Replacement Refrigerants,
`ASHRAE Transactions, Vol. 114 (2008)
`Exhibit 2052 Brown, J. Steven, et al., Thermodynamic properties of eight
`fluorinated olefins, International Journal of Refrigeration,
`(2010)
`Exhibit 2053 Clodic, Denis, Automobile Air-conditioning: Environmental
`Stakes and Future Technical Options, Journal of Cold and Air-
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
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`
`
`conditioning (May 2008)
`
`Exhibit 2054 Clodic, Denis, et al., Characteristics and Performances of New
`Refrigerants, ADEME Technical Day (Sept. 23, 1999)
`
`Exhibit 2055 Ember, Lois R., et al., Tending the Global Commons, C&EN
`(Nov. 24, 1986)
`
`Exhibit 2056 EPA Approves New Coolant for Car AC Systems/Better climate
`protection without harming the ozone layer, available at
`https://yosemite.epa.gov (Feb. 28, 2011)
`
`Exhibit 2057 Fisher, Donald A., et al., Model calculations of the relative
`effects of CFCs and their replacements on global warming,
`Nature, Vol. 433 (April 5, 1990)
`
`Exhibit 2058 Takizawa, Kenji, et al., Flammability assessment of
`CH2=CFCF3: Comparison with fluoroalkenes and
`fluoroalkanes, Journal of Hazardous Materials (2009)
`Exhibit 2059 Kondo, Shigeo, et al., Flammability limits of olefinic and
`saturated fluoro-compounds, Journal of Hazardous Materials
`(2009)
`
`Exhibit 2060 Howe-Grant, Mary (Editor), Fluorine Chemistry: A
`Comprehensive Treatment (1995)
`
`Exhibit 2061 French Patent, No. 0 495 543 A1 (1992)
`
`Exhibit 2061A French Patent, No. 0 495 543 A1 (1992) with certified
`translation
`Exhibit 2062 Gad, Shayne C., et al., Inhalation Toxicity of
`Hexafluoroisobutylene, Toxicology and Applied Pharmacology
`(March 31, 1986)
`
`Exhibit 2063 GM First to Market Greenhouse Gas-Friendly Air Conditioning
`Refrigerant in U.S., available at: http://www.gm.com (July 23,
`2010)
`Exhibit 2064 Refrigerant Selection and System Design – the role of HFCs,
`Institute of Refrigeration, Guidance Note 18 (April 18, 2009)
`
`5
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`Exhibit 2065 US Patent Publication No. 2011/0312101 A1
`
`Exhibit 2066 William L. Kopko, Beyond CFCs - Extending the Search for
`New Refrigerant, Proceedings of ASHRAE’s 1989 CFC
`Technology Conference (1989)
`Exhibit 2066A William L. Kopko, Beyond CFCs - Extending the Search for
`New Refrigerant, Proceedings of ASHRAE’s 1989 CFC
`Technology Conference (1989)
`Exhibit 2067 McLinden, Mark O., et al., Quest for Alternatives: A molecular
`approach demonstrates tradeoffs and limitations are inevitable
`in seeking refrigerants, ASHRAE Journal (December 1987)
`Exhibit 2067A McLinden, Mark O., et al., Quest for Alternatives: A molecular
`approach demonstrates tradeoffs and limitations are inevitable
`in seeking refrigerants, ASHRAE Journal (December 1987)
`Exhibit 2068 Reserved
`
`Exhibit 2072
`
`Exhibit 2069 Amendment and Response for Stable Formulated Systems with
`Chloro-3,3,3,-Trifluoropropene, U.S. Patent and Trademark
`Office, Serial No. 12/667,121 (Dec. 29, 2009)
`Exhibit 2070 Amendment and Response for Heat Transfer of Oxygenated
`Lubricant with Hydrofluoroolefin and Hydrochlorofluoroolefin
`Refrigerants, U.S. Patent and Trademark Office, Serial No.
`14/715,753 (May 19, 2015)
`Exhibit 2071 Lindley, Andrew A., et al., Consideration of Hydrofluoroolefins
`(HFOs) as potential candidate medical propellants, Mexichem
`Fluor (April 2010)
`Jones, J. (Inventor), Nearly Azeotropic Mixtures to Replace
`Refrigerant 12, NASA Tech Brief from JPL New Technology
`Report, Vol. 16 (August 1992)
`Exhibit 2072A Jones, J. (Inventor), Nearly Azeotropic Mixtures to Replace
`Refrigerant 12, NASA Tech Brief from JPL New Technology
`Report, Vol. 16 (August 1992)
`Exhibit 2073 Reisch, Marc S., Perkins Medal Goes To Ian Shankland,
`Chemical & Engineering News (July 23, 2008)
`Exhibit 2074 Brown, J. Steven, Preliminary Selection of R-114 Replacement
`Refrigerants Using Fundamental Thermodynamic Parameters
`(RP-1308), HVAC&R Research, Vol. 13 (2007)
`Exhibit 2075 European Patent Application No. 0 430 171 A1 (Nov. 27, 1990)
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
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`Exhibit 2076 U.S. Patent No. 5,136,854 (Aug, 11, 1992)
`
`Exhibit 2077 U.S. Patent No. 5,744,052 (April 28, 1998)
`
`Exhibit 2078 U.S. Patent No. 6,258,292 (July 10, 2001)
`
`Exhibit 2079
`
`Exhibit 2081
`
`Exhibit 2082
`
`Exhibit 2083
`
`Exhibit 2084
`
`Exhibit 2085
`
`Exhibit 2086
`
`Carvalho, Suely, et. al., Alternatives to High-GWP
`Hydrofluorocarbons, Institute for Governance & Sustainable
`Development
`Exhibit 2080 Wang, Linda, Rajiv Singh Wins Schoellkopf Award, American
`Chemical Society, Chemical & Engineering News, Vol. 87,
`Issue 12 (March 23, 2009)
`UNEP, 2002 Report of The Refrigeration, Air Conditioning and
`Heat Pumps, Technical Options Committee, Montreal Protocol
`On Substances that Deplete the Ozone Layer (2002)
`Fischer, S.K., et al., Energy and Global Warming Impacts of
`CFC Alternative Technologies, AFEAS & DOE (December
`1991)
`Specifications for Fluorocarbon Refrigerants, Air-Conditioning
`and Refrigeration Institute (2006)
`Henne, Albert L., et. al., Fluorinated Derivatives of Propane
`and Propylene, Department of Chemistry at the Ohio State
`University (1945)
`Haszeldine, R. N., Reactions of Fluorocarbon Radicals, Part V,
`Alternative Syntheses for Trifluoromethylacetylene (3:3 3-
`Trifluoropropyne), and the Influence of Polyfluoro-groups on
`Adjacent Hydrogen and Halogen Atoms, University Chemical
`Laboratory, Cambridge (April 10, 1951)
`P. L. Houston, Chemical Kinetics and Reaction Dynamics,
`Chapter 2: The Rates of Chemical Reactions (April17, 2000)
`(available at
`http://www.cosbkup.gatech.edu/group/chem780/CHAPT2.pdf)
`Exhibit 2086A P. L. Houston, Chemical Kinetics and Reaction Dynamics,
`Chapter 2: The Rates of Chemical Reactions (April17, 2000)
`(available at
`http://www.cosbkup.gatech.edu/group/chem780/CHAPT2.pdf)
`Keck Graduate Institute online textbook (available at
`http://sbw.kgi.edu/sbwwiki/_media/sysbio/labmembers/hsauro/s
`ystemsandsynthetic_biology3.pdf)
`
`Exhibit 2087
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`Exhibit 2088
`Exhibit 2089
`
`Exhibit 2090
`Exhibit 2091
`
`Exhibit 2092
`
`Exhibit 2093
`
`Exhibit 2094
`Exhibit 2095
`
`Exhibit 2096
`
`Exhibit 2097
`
`Exhibit 2098
`
`Exhibit 2087A Herbert M. Sauro, Spring 2008: Systems and Synthetic Biology,
`Week 1, PowerPoint 3,
`http://sbw.kgi.edu/sbwWiki/_media/sysbio/labmembers/hsauro/s
`ystemsandsynthetic_biology3.pdf.
`U.S. Patent Publication No. 2011/0012052 A1 (Jan. 20, 2011)
`Amendment and Response with Request for Continued
`Prosecution by Arkema, Inc. re U.S. Patent Publication No.
`2011/0012052, Serial No. 12/667,140 (Dec. 29, 2009)
`U.S. Patent No. 5,152,845 (Oct. 6, 1992)
`Action on Ozone, Ozone Secretariat, United Nations
`Environment Programme (2000)
`Studies in Geophysics: Energy and Climate, National Academy
`of Sciences, available at
`https://www.nap.edu/catalog/12024/energy-and-climate-studies-
`in-geophysics (1977)
`Didion, David A., et al., Role of refrigerant mixtures as
`alternatives to CFCs, Rev. Int. Froid, Vol. 13 (May 13, 1990)
`Declaration of Margaret H. Whittaker
`Directive 2006/40/EC of the European Parliament and of the
`Council Relating to emissions from air-conditioning systems in
`motor vehicles and amending Council, Directive 70/156/EEC,
`Official Journal of the European Union (May 17, 2006)
`Klimisch, H.-J., et al., A Systematic Approach for Evaluating the
`Quality of Experimental Toxicological and Ecotoxicological
`Data, Regulatory Toxicology and Pharmacology (1997).
`Bhatti, M.S., A Critical Look at R-744 and R-134a, Mobile Air
`Conditioning Systems, Reprinted from Automotive Climate
`Control Design Elements (SP-1239) (1997)
`Arkema Beefs Up Chemicals; Eyes Acquisition of Acrylics
`Assets, Chemical Week Business and Finance News (2008)
`Exhibit 2098A Arkema Beefs Up Chemicals; Eyes Acquisition of Acrylics
`Assets, Chemical Week Business and Finance News (2008)
`VDA Annual Report (2011)
`Recognizing our Heroes of Chemistry, American Chemical
`Society, available at
`https://www.acs.org/content/acs/en/funding-and-
`awards/awards/industry/heroes.html (2016)
`Declaration of Richard Winick, U.S. Patent and Trademark
`Office, In re Reexam Control Nos. 95/002,189 and 95/002,204,
`
`Exhibit 2099
`Exhibit 2100
`
`Exhibit 2101
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`PGR2016-00011
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`
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`Exhibit 2102
`
`Exhibit 2103
`
`Exhibit 2104
`
`Exhibit 2105
`
`Exhibit 2106
`
`Exhibit 2107
`Exhibit 2108
`
`Exhibit 2109
`
`Exhibit 2110
`
`Exhibit 2111
`Exhibit 2112
`
`Exhibit 2113
`Exhibit 2114
`
`Exhibit 2115
`Exhibit 2116
`
`
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`U.S. Patent No. 7,534,366 (Filed Sept. 12, 2012)
`Declaration of Richard Winick, U.S. Patent and Trademark
`Office, In re Reexam Control No. 95/002,030, U.S. Patent No.
`8,065,882 (Filed Aug. 20, 2012)
`Declaration of Raymond Thomas, U.S. Patent and Trademark
`Office, In re Reexam Control Nos. 95/002,189 & 95/002,204,
`U.S. Patent No. 7,534,366 (Filed Sept. 12, 2012)
`Schulze, Christian, et. al., Transient evaluation of a city bus air
`conditioning system with R-445A as drop-in -- From the
`molecules to the system, International Journal of Thermal
`Sciences (2015)
`Li, Xinzhong, et. al., Optimization of Heat Exchanger for
`High Glide Blend: Condenser model and its application in
`optimization for AC6 , SAE International (Oct. 31, 2012)
`Enrique Peral-Antúnez (Chairperson), MAC Refrigerant Blend
`Cooperative Research Program Update, SAE International
`(Oct. 31, 2012)
`Factsheet 19, Hydrofluoroolefins, EFCTC (June 2011)
`Commercial CO2 Refrigeration Systems : Guide for Subcritical
`and Transcritical CO2 Applications, Emerson Climate Study
`(2015)
`Chemours Congratulates the Parties to the Montreal Protocol
`for HFC Amendment Agreement, Chemours Article (Oct. 17,
`2016)
`Honeywell Scientists Recognized As “Heroes of Chemistry” For
`Development Of Low-Global-Warming Refrigerant , Honeywell
`Press Release (June 17, 2016)
`AHRI Past Programs -- 21CR Program, MCLR Program (2011)
`Halocarbons: Environmental Effects of Chlorofluoromethane
`Release, Committee on Impacts of Stratospheric Change,
`Assembly of Mathematical and Physical Sciences National
`Research Council, National Academy of Sciences (1976)
`Darryl D. DesMarteau Curriculum Vitae
`Peroxide formation in glycol ethers, Dow Answer Center, The
`Dow Chemical Company, available at
`http://dowac.custhelp.com/app/answers/detail/a_id/11446/~/pero
`xide-formation-in-glycol-ethers (Nov. 15, 2011)
`U.S. Patent No. 5,355,695 to Kawaguchi et al. (Oct. 18, 1994)
`Hudlický, Miloš, Organic Fluorine Chemistry, Dept. of
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`
`
`Exhibit 2117
`
`Chemistry, Virginia Polytechnic Institute and State University
`(1971)
`Exhibit 2116A Hudlický, Miloš, Organic Fluorine Chemistry, Dept. of
`Chemistry, Virginia Polytechnic Institute and State University
`(1971)
`Amendments and Remarks to the Claims in Response to Office
`Action Mailed May 29, 2014, in re Patent Application No.
`14/225,588 (Aug. 29, 2014)
`Sealed Glass Tube Method to Test the Chemical Stability of
`Materials for Use within Refrigerant Systems, ASHRAE
`Standard (2007)
`U.S. Patent No. 5,419,144 to Kawaguchi et al. (May 30, 1995)
`
`Exhibit 2118
`
`Exhibit 2119
`
`Exhibit 2120
`Exhibit 2121
`Exhibit 2122
`
`Exhibit 2123
`Exhibit 2124
`
`U.S. Patent No. 5,746,933 to Ishida et al. (May 5, 1998)
`U.S. Patent No. 6,299,792 B1 to Feiring et al. (Oct. 9, 2001)
`The Exponetial Growth of HFO-1234yf in Automotive Air
`Conditioning, Opteon YF, The Chemours Company (2016)
`U.S. Patent Application No. 2013/0296617 A1 (Nov. 7, 2013)
`Atiyeh, Clifford, Global Cooling: Mercedes to Debut Air
`Conditioning with CO2 Refrigerant, Hearst Communications,
`Inc. (Oct. 26, 2015)
`Exhibit 2125 Margaret H. Whittaker Curriculum Vitae (2016)
`Exhibit 2126
`Declaration of Donald Bivens (December 15, 2016)
`Exhibit 2127
`Filov, V.A. (General Editor), Hydrocarcons Halogenated
`Hydrocarbons, Harmful Chemical Substances Handbook (1990)
`(English translation of Exhibit 2155)
`Acute Toxicity Data, RTECS (2016)
`Huttenlocher, Dietrich F., Chemical and Thermal Stability of
`Refrigerant-Lubricant Mixtures with Metals, prepared for The
`Air-Conditioning and Refrigeration Technology Institute (Oct.
`9, 1992)
`Standard Test Method for Acid and Base Number by Color-
`Indicator Titration, ASTM International (2006)
`Sheppard, William A., et al., Organic Fluorine Chemistry
`(1969)
`Exhibit 2131A Sheppard, William A., et al., Organic Fluorine Chemistry
`(1969)
`Chambers, Richard D., Fluorine in Organic Chemistry,
`Interscience Monographs on Organic Chemistry (1973)
`
`Exhibit 2128
`Exhibit 2129
`
`Exhibit 2130
`
`Exhibit 2131
`
`Exhibit 2132
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`Exhibit 2133
`Exhibit 2134
`
`Exhibit 2135
`
`Exhibit 2136
`
`Exhibit 2137
`
`Exhibit 2132A Chambers, Richard D., Fluorine in Organic Chemistry,
`Interscience Monographs on Organic Chemistry (1973)
`Chambers, Richard D., Fluorine in Organic Chemistry (2004)
`Chambers, Richard D., et al., Nucleophillic Reactions of
`Fluorinated Alkenes, Topics in Current Chemistry, Vol. 192
`(1997)
`Exhibit 2134A Chambers, Richard D., et al., Nucleophillic Reactions of
`Fluorinated Alkenes, Topics in Current Chemistry, Vol. 192
`(1997)
`Chambers, Richard D., et al., Reactions of Novel Unsaturated
`Fluorocarbon, Journal of Fluorine Chemistry (2000)
`Exhibit 2135A Chambers, Richard D., et al., Reactions of Novel Unsaturated
`Fluorocarbon, Journal of Fluorine Chemistry (2000)
`Bartlett, Sheena, et al., Reactions Involving Flouride Ion, Part
`20, Competition between Isomerization and Nucleophilic Attack
`on a Perfluoroalkene (1980)
`Chambers Richard D., et al., Free Radical Chemistry, Part 9,
`Approaches to Fluorinated Polyethers Model Compound Studies
`(March 23, 1999)
`Exhibit 2137A Chambers Richard D., et al., Free Radical Chemistry, Part 9,
`Approaches to Fluorinated Polyethers Model Compound Studies
`(March 23, 1999)
`Chambers, Richard D., et al., Free-radical chemistry Part XII,
`Radical reactions of trifluoroethene, Journal of Flourine
`Chemistry (April 19, 2000)
`Dyatkin, B.L., et al., Reactions of Fluoroolefins with
`Electrophilic Reagents, Flourine Chemistry Reviews, Vol. 3
`(1969)
`HFO-1234yf encounters resistance as R-134a replacement for
`A/C, SAE International, available at http://articles.sae.org/8074/
`(April 14, 2010)
`Clayton Jr., J. Wesley, Fluorocarbon Toxicity and Biological
`Action, Toxicity of Anesthetics (1967)
`Clayton Jr., J. Wesley, The Mammalian Toxicology of Organic
`Compounds Containing Fluorine, Handbook of Experimental
`Pharmacology (1966)
`Commandeur, J.N.M., et al., Nephrotoxicity and Hepatotoxicity
`of 1,1-Dichloro-2,2-Difluoroethylene In the Rate: Indications
`for Differential Mechanisms of Bioactivation, Biochemical
`
`Exhibit 2138
`
`Exhibit 2139
`
`Exhibit 2140
`
`Exhibit 2141
`
`Exhibit 2142
`
`Exhibit 2143
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`PGR2016-00011
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`Patent Owner’s Fifth Am. Appendix of Exhibits
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`
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`Exhibit 2144
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`Exhibit 2145
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`Exhibit 2146
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`Exhibit 2147
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`Exhibit 2148
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`Exhibit 2149
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`Exhibit 2150
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`Exhibit 2151
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`Exhibit 2152
`Exhibit 2153
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`Exhibit 2154
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`Pharmacology, Vol. 36 (June 24, 1987)
`E.W. Cook and J.S. Pierce, Toxicology of Fluoro-olefins,
`Nature, Vol. 242 (March 30, 1973)
`Kennedy Jr., G. L., Toxicology of Fluorine-containing
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`Potter, C.L., et al., Effects of Inhaled Chlorotrifluoroethylene
`and Hexafluoropropene on the Rat Kidney, Toxicology and
`Applied Pharmacology (Jan. 9, 1981)
`Purchase, Iain F.H., Fraud, errors and gamesmanship in
`experimental toxicology, Toxicology (2004)
`Representative publications of Dr. Darryl DesMarteau relating
`to EPA and EPRI Initiatives
`Danishevskiy, S.L., et al., Toxicology of Some Fluoro-Organic
`Compounds, Foreign Technology Division (1989) - English
`Translation
`Exhibit 2149A Danishevskiy, S.L., et al., Toxicology of Some Fluoro-Organic
`Compounds, Foreign Technology Division (1989) - original
`Russian
`Final Test Results, Fluoroalkenes, EPA, Federal Register, Vol.
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`Shabecoff, Philip, EPA Threatens to Suspend Approval of
`Pesticides Over Test Flaws, The New York Times (July 12,
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`U.S. Patent Publication No. 2011/0001080 A1 (Jan. 6, 2011)
`Standard Test Method for An American National Standard Acid
`and Base Number by Color-Indicator Titration, ASTM
`International, Designation 139/98 (2006)
`Protection of Stratospheric Ozone: Change of Listing Status for
`Certain Substitutes Under the Significant New Alternatives
`Policy Program, EPA, Federal Register, Vol. 80, No. 138 (July
`20, 2015)
`[Foreign Document] Vrednie Chemichescie Veshevsta,
`Galogenproisvodnie Ugledorov (1990) (original Russian of
`Exhibit 2127)
`Exhibit 2156 William B. Deichmann and Horace W. Gerarde, Toxicology of
`Drugs and Chemicals (1969)
`Exhibit 2156A William B. Deichmann and Horace W. Gerarde, Toxicology of
`Drugs and Chemicals (1969)
`EPA Health Effects Test Guidelines, Acute Inhalation Toxicity
`
`Exhibit 2155
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`Exhibit 2157
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`PGR2016-00011
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`Exhibit 2158
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`Exhibit 2159
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`Exhibit 2160
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`Exhibit 2161
`Exhibit 2162
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`Exhibit 2163
`Exhibit 2164
`Exhibit 2165
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`Exhibit 2166
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`Exhibit 2167
`
`Patent Owner’s Fifth Am. Appendix of Exhibits
`
`(August 1998)
`Papasavva, Stella, et al., Estimated 2017 Refrigerant Emissions
`of 2,3,3,3-tetrafluoropropene (HFC-1234yf) in the United States
`Resulting from Automobile Air Conditioning, Environmental
`Science Technology (Oct. 26, 2009)
`Vamvakas, Spyridon, et al., Metabolic Activation of the
`Nephrotoxic Haloalkene 1,1,2-Trichloro-3,3,3-Trifluoro-1-
`Propene By Glutathione Conjugation, Biochemical
`Pharmacology, Vol. 38, No. 14, pp. 2297-2304 (1989)
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`Perfluoroisobutylene, Drug and Chemical Toxicology, 1525-
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`Declaration of Dr. Darryl Desmarteau
`Office Action Summary, Application No. 14/225,588, U.S.
`Patent and Trademark Office (Filed March 26, 2014)
`U.S. Patent No. 7,084,315 B2 to Corr et. al. (Aug. 1, 2006)
`Reserved
`U.S. Pat. App. No. 10/694,273 11-10-2008 - Rule 132
`Declaration of Rajiv Singh
`Excerpts of Deposition Transcript of Dr. Rajiv R. Singh (Sep.
`17, 2011) from litigation in the Eastern District of Pennsylvania
`between Arkema and Honeywell, Civ. A. No. 2:10-cv-2886
`Declaration of Joseph Posillico in support of Patent Owner’s
`Motion for Leave to Request a Certificate of Correction
`
`Exhibit 2168
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`Patent Owner’s Proposed Request for a Certificate of
`Correction
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`Exhibit 2169
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`U.S. Provisional Patent Application No. 60/693,853
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`Exhibit 2170
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`U.S. Patent Application No. 11/475,605
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`Exhibit 2171
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`U.S. Patent Application No. 11/850,025
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`PGR2016-00011
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`Date: January 10, 2020
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`Patent Owner’s Fifth Am. Appendix of Exhibits
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`Respectfully submitted,
`
`
`
` /s/ Greg LoCascio
`Gregg F. LoCascio, P.C. (Reg. No. 55,396)
`Noah Frank (Reg. No. 67,279)
`glocascio@kirkland.com
`noah.frank@kirkland.com
`KIRKLAND & ELLIS LLP
`1301 Pennsylvania
`Avenue, N.W.
`Washington, DC 20004
`Telephone: (202) 389-5000
`Fax: (202) 389-5200
`Attorneys For Patent Owner
`
`
`
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`CERTIFICATE OF SERVICE
`The undersigned hereby certifies that a copy of the foregoing Patent
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`Owner’s Fifth Amended Appendix of Exhibits and newly designated Exhibits
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`2167-2171 were served on the 10th day of January, 2020, via electronic mail
`
`directed to counsel of record for the Petitioners:
`
`Mark D. Sweet
`
`Mark J. Feldstein
`
`Erin M. Sommers
`
`mark.sweet@finnegan.com
`
`mark.feldstein@finnegan.com
`
`erin.sommers@finnegan.com
`
`Charles W. Mitchell
`
`charles.mitchell@finnegan.com
`
`
`
`Arkema_PTAB@finnegan.com
`
`/s/ Greg LoCascio
`Greg LoCascio
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`