"""-\. National Library of Medicine
`lllllf/ Ml(JOtl;IJ c-,,,., fot &o1«hn0Jogy /r,fom,,u,on
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`My Bibliography .,.,..,_,hri,t;,.,·,s;bliocraphy
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`4 MyNCBI
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`1119
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`Lao'"
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`Pa&t 0 of 7
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`i
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`303 citat,ons, Sort by n~st to otdtst v
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`7 Sempio C, Wymort E, Palmier C, Bunik "', Henthorn TK, Christians U, Klawitter J. DdKllOfl of Cannabiooids by LC-MS·MS and ELISA m Brust Milk. J Anal
`Toxicot. 2021 Aug 14;45(7):686-692. doi: 10.1093/ jatfbkaa 142. PubM~ PMIO: 33002141.
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`:=) Huntie-r SK. Hoffman MC, McCarlhy L, D'Alessandro A, W'f'\Ya A. Noonan K, Christi Jns U, Nal6muli•MP\Jn&u E, Zti~I SH, Law AJ, Freedman R. Black
`~ncan Mattma1 Prenatal ChoHnt, Offsprin& Gt-slationfll At,t at Bin.h, and ~lopm,enu,I PrtdispoSttson to Mtnut U!r.e.ss. Schizophr Bull. 2021 Jul
`8;47(4):896-905. doi: 10.1093/schbuVsbacal TJ. PubMt"d PMID: 331846S3; PubM~Cffltral PMCIO: PMC8266582.
`
`Frttdman R, Hunt tr SK, Noonan K, Wyr11a A, Christians U, Law AJ, Hoffman MC. Matttnal P~natal Oeprnsion in P~f\Cies With Fflnale and Malt'
`F~u~ and Developmental Associatiors W,th C-rtactive Protein and Cortisol Bbl Psychiatry Coen Na,rosci Neurotmaeine,. 2021 f.far:6(3):310-320. doi:
`10.1016fj.bpsc.2020.08.003. Epub 2020Aul, 13. PubMed P.MID: 33060035; PubMedCentrat PMCID: PMC7881057.
`
`7 Clavijo CF, OlivaAM,OingmannC, KaizerA,Christians U, S.urgier E, Pa tielV, Kleck CJ, V~ISA, Scott BK,Janik DJ, J a~ LC. Gin~M. ToxicoloC)'
`Sc,eening Te-sting in Patients unditreoir1,SpineSu,:er,:AProsp«tive Observational Pilot Stody. Ther Drue Monit. 2021 Feb 1;43(1):136·138.doi:
`10.1097/FT0.0000000000000837. PubMed PMIO: 33181620; P\Jbf.led Central PMCID: PMC7803"44.
`
`l Ye H, Minhajuddin M, Krua; A, Pei S, Chou CH, Culp-Hill R, Ponder J, De Btoois E, S<hniedewind B, AmaY11 Ml, !n1uva A, Stevens BM, Pollyea DA, Christians
`U, Grimes HL, O'.Alenandro A. Jordan CT. lhe Hepatic Microenvironment Uniquely Protects Leukemi.l Cells through Induct.on of Growth and Survival
`Pathw~ Mediated by LJPG. GancerOiscov. 2021 Feb;ll(l ):500-519. doi: 10.1158;2159·8290.C0·20-0318. Epub20200c.t 7. PubMed PMID: 33028621;
`PubMed Central PMCID: PMC7858222.
`
`__, Mizuno T, McPhaH BT, Kamatkar S, Wexelblatt S, Ward L, Christians U, AJtinbi HT, \1nksAA. Phys.iologic lndirectRHJ)Onse Modeling to De5Cfibe
`8uC)ffno1phine Phaimacodynamia in Newboms Treated fo, Neonatal Opioid withdrawal Syndromt'. Clin Pharmacokinet. 2021 Feb;60(2) :24!>-2S9. doi:
`10.1007/s40262-020-00939--2. PubMed PMIO: 32939690: PubMed Central PMCIO: PMC8489161
`
`~ Frymoyer A. Van "1eurs KP, Drover OR, Klawitter J. Christians U, Chock VV. Theophytline dosing and pharmacokulellC.S for renal p,otection in neonates
`with hypoxic-is-chemic lfflCephalopathy undergoing therapeutic hypothffmia. Pfltiatr Res. 2020 Dec;88(6):871·877. cloi: I0.1038/s41390·020-0114Cl-8.
`Epub 2020 Sep 12. PubMcd PMID: 32919-393; PubMcdCaitral PMCID: PMcn04857.
`
`J (a\vthon CV, Cooper K, Huett C, Lloret A, Villar-Matamoros E, Stokes L Christians U, Schuler M. Yazdani SK. Pre-Clinical ln-.,estigation of LiQu,d Pacliw.el
`for Local Dru& Del rvery. A Pilot Study. Pharmaceuticals (Sa~I). 2020 Nov28;13(12). doi: 10.3390/ phl3120434. Pub Med PMIO: 33260517; PubMed Ct-ntral
`PMCID: PMC1760S62.
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`I Ne-ety M, Bayard D. van Guilder M. Schumitzky A. In Me'11(M"iarn: Ro&er Jelliffe, MD, FCP. fAAPS. Ther Dru& Monit. 2020 Oct 1:42(5):658-659. doi:
`10.1097/FT0.0000000000000798. PubMed PMID: 32796388.
`
`Wan& GS, Bou me OWA, Klawittff J. Sempio C. Chapman K, Knupp K, Wempe Mf. Borg:tlt L. Christians U, L~nard J, Heard K, Bajaj L. DispositKln of Oral
`Can~bidiol-Ric:h Cannabis btt11cts in Children with Epilepsy. Clin Pharmacokinet.2020Aug;59(8):100S-1012. doi: 10.1007/$40262{)20-00869-L PubMed
`PMID: 32048179.
`
`i-i Jelliffe R, Christians U. The N~ Dirtd-Acting Oral Anticoagulant5 Need to be Mo1i1oredl Ther Drug Mo nit. 2020 Jun:42(3)!357-159. doi:
`10.1097/FT0.000000000000l745. PubMed PMID: 32427780.
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`_j Goel E, Erwin M, Cawthon CV, Schaff C, Fedor N, Rayl T, Wilson O, Christians U, Rqister TC, Geary RL, Saul J, Vazdani SK. Pte•Omical lnven,ption of
`Keratose as an bc:1pient of Drug Coated Balloons. Molecules. 2020 Mar 31;2517 ). doi: 10.l390/ mo{ecules2S071596. P\JbMed PMID: 32244375; Pub Med
`Central PMCID: PMC71807◄1.
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`..J Sempio C, Huestis MA, Mikulich-Gilbert.son SK, Klawitter J , Christians U, Henthorn TK. Population pharmaooMnttic m~ing of plasma 69
`tetrahydrocannabinol a nd an acti'lt' and inactive metabolite following controllec smoked unnabis ,11dmims.tration. Br J Clin Pharmacol. 2020
`Mar;86(3):611 ·61.9. doi: 10.1111/ bcp.14170. £pub 2020 Jan 20. PubMed PMIO: 31747464; PubMed Central PMCID: PMC7080615.
`
`1 Davari B, Kotecha N, Clavijo CF. Thomas JJ, Rzasa-Lynn R, Gal ink.in JL, Christians U, Sempio C. A St'nsitiv-e LC·MS/MS Assay for the Quantificat10n of
`Mt-ttwtdone and its Metabolites m Dried Blood Spots: Comparison With Plasma. Ther Drue. Mon it. 2020 Feb;42{1):118-128. doi:
`10.1097/FT0.0000000000000674. PubMed PMIO: 313188-t2.
`
`0 wane GS, Bou me OWA, Klawitter J, Sempio C, Chapman K. Knupp K. Wempe MF, Bora;elt L, Christians U, Heard K, Bajaj L Disposition of oral delta·9
`tW.hydrocannabin<>i (THC) in child~n recewing cann.abis extrtcts f0t epilepsy. Clin ToxtOOI (PhiU!II. 2020 Feb;58(2):124•128. doi:
`10.1080/ 15563650.2019.1616093. Epub 2019May 21. PubMed PMID: 31111749.
`
`J Sempio C. Lindley E, Klawittier J. Christians U, Bowler RP, Adgate JL, Allshouse W,Awdziejczyk L. Fischier S, Bainbf"idge J, Vandyke M. Netsanet R. Crume T,
`Kinney GL Surface Detection of THC Attributabte to Vaporize, Use-,n t~ Indoor Environment Sci Rep. 2019 Dec 9;9(1):18587. doi: 10.1038/s41598--019·
`5SI5l·S. PubMed PMID:31819131: PubMed Ct'ntral PMCIO: PMC6901S75.
`
`0 ~t.how AP, DOlm~llitSAPS, de Suuu AP, P-dt:Ullo Jf, 0yd111a LM, Ndl>cim~1tu CMO, Klawillt!I J, Cl1111,t.id11:i. U, Ta:i.hirnd AK, Ril.Jei, u EB. A l)fOU!olniu
`rnetabolomtCS .Jpproach indicat6 changes'" hypothalamK glulamalt'·GABA m&bolimi of adult female rats submitted to intraut~rine growth
`restriction. Eur J Nutr. 2019 Dec;58(8):3059-3068.doi: 10.l007/sOOJ94.018·1851-6. Epub 2018 Nov 7. PubMed PMID: 30406389; PubMed Ce:ntra1 PMCIO:
`PMC6842332.
`
`7 Weinbere A. HIJO Y. Katanek D, Patel K. Watu OH, Waf'il O, Hoffman Rt.I, Klawitter J. Christians U, Brief Reoort; M.vkffl of Soontaneous Prt'term Oe\iverv 1n
`https://www.ncbi.nlm.nih.gov/myncbV12extkpe0jlgmf/bibliography/public/
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`917/2022
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`Bausch Health Ireland Exhibit 2006, Page 1 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01104
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`2/19
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`Women Livitt,: With HIV: Re\atio11~ip W th Protease Inhibitors .and Vitamin 0. J AcQui, Immune Otfic Syndr. 2019 Oct 1:82{2):181-187. doi:
`10.1097/QAl.0000000000002111. PubMtd PMIO: 31513074; PubMtd Central PMCCI: Pf.1(6760328.
`
`C Klawitter J, Klawitter J, Pennlniton A, Kirkpatrick B, Roda G, Kotecha NC, Thurma n JM, Christians U. Cyclophilin D knockout protects the mous.e kidney
`a g11inst cydospo(in A-induced oxid.ltivt strHs.Am J Physiol Renal Physiol. 2019 Ses:, 1;317{3):F68l·F694.doi: 10.ll52/ajp(enaL00417.2018. Epvb2019
`Jun 12. PubMed PMIO: 31188033.
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`0 Brund M, van Gelderl, AsNrg A, Hau froid V, He-swlink DA, Lan1man L, lemailre F, Marquet P, Sqtt C, Shipkova M, Vin ks A, WallemKQ P, Wieland E,
`WoiU.ud JB, Bartel'1 MJ, Budde K, Colom H, Dieterten MT, Elens L, John~-Dalli,; <L, Kunicki PK, MacPhee I. Masuda S. Mathew BS, Milliin 0, Mizuno T,
`Mon OAR, Monchaud C. Noceti 0, Pawinski T, Pkard N, van Schaik R, Somme re< C, Vet he NT, de Winte< B, Christians U. Ber&an S. Therapeutic Dfuc
`M~ •to1in1 of Tacrolimus -Pefsonal1zed Thffllpy: Second Consensus Report. Thet"" DnJ& Mon it. 2019 Jun;41(3):261·307. doi:
`10.1097/FT0.0000000000000640. Revit."\'I. PubM,e,d PMJO: 31045868.
`
`Kelle r /\C, Klawitter J, Hildreth Kl, Christians U, Putnam K. Kohrt WM, Reusch JEE. Moreau KL E1~ted pla~a homocy!;teine and cys.teine are a1.SOCilted
`with endotlle\ial dysfunction KfOSS met1opausal stain in healthy women. J ApJ::I Physiot (1985). 2019 Jun 1;12616):1533-1540. doi:
`10.1152/ japplphysiol.00819.2018. Epub 2019 Mar 2L PubMed PMI0:30896357;PubMed Ce ntral PMCID: PMC6620665.
`
`fl lichvar A, T~mblay S, Naik. D, Lipscomb J, Kine E. Vink.s AA, Christians U, Alloway RR. Evaluat;on of Clio,cal and Safety Outcof'l\6 Follow,nc Oncontro41td
`T.crolimusConversion in Adult TransptantRecia,ients. Pharmacotherapy. 2019 May:39(5):564-575. doi: 10.1002/ phar.2260. £pub 2019A+J( 15. PubMed
`PM!(): 30892704.
`
`frttdman R, Hunt~r SK, Law AJ, wacntt 80, D'lllesundro A. Chrinians u, Noonan K. Wyrwa A. Hoffman MC. H,gherGtstational Cho Ii~ L!M!ls m
`"'ateinal Infection Ale Protechve for Infant Brain De11elopment. J Pediatr. 2019 May,208:198.-206.e2. doi: 10.1016/ j.jpeds.2018.12.010. [pub 2019 Mar 14.
`PubMed PMIO: 30879727; PubMedCentral PMCIO: PMC6707520.
`
`7 Van Hove J LK, Freehauf Cl, Ficicioglu C, Pena LOM, Moreau KL, Henthorn TK. Christians U, Jia n, H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler
`SP, Spector EB, Kronquist KE, Thomas JA, Emmett P, Hamncton MJ, Pyte L, Creacon-Swindell G, Wempe MF, Maclean KN. B1omar1tt'f!o of oxidative stress,
`innarnmatK>n, and vasculardysfunctioo in inhe.-ited cystathionioe f3~nthase deficient homocystinu,,. and t~ ;mpact oftaurioe treatment in a phase
`112 human clinical trial. J Inherit Metab Dis. 2019 May;42(3):424-437. doi: 10.1002/~md.12085. Epub 2019A.pr 11. PubMed PMIO: 30873612.
`
`= Emoto C, John50fl TN, Hahn 0, Christians U, Alloway RR, Vin ks AA, Fukuda T.A ThN»'eUcat Physioloeically·Based Pharmac.okinetic Approach to Ascertain
`
`Covariatt"s Explaining the Large lnt.e1patient Variability in Tacrolimus Oispo5,c,on . CPT Pharmacometrics Syst Pharmacol, 2019 Mty,8(5):273·284. doi:
`10.1002/psp4.12392, £pub 2019 Mtr 7. PubMed PMIO: 30843669; Pub Med Central PMCIO: PMC6539708.
`
`) Leino AO. Kin& EC, Jiang W, VinluM. Klawitter J , Christians U, Woodle ES, Alloway RR, Rohan JM. Assessment of tacrotinius intrap.alient vari.tbility in
`stable adhtrent trar'lsplant re-cipienu: Establist11n& baseline valuts. Am J Transphnt. 2019 May;l9(5):1410-1420. doi: 10.l ll l /•jt.15199. Epub 2018 Ot<:
`26. PubMed PMIO: 30506623.
`
`~ ~omb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawitter J, Klav.itter J, Smith 0, Repine JE. ~ressed prostaglaNlins and leukotr~es
`in vctcrnnsw1th Gulf War illn~. J En\liron Sci ttcalth B. 2019;5'4(8):623 639. doi; 10.1080/0360123-4.2019.1596001. Epub2019Apr 29. PubMcd PMIO:
`31033394.
`
`__; Shipkova M, Christians U. lmprovin&: The~peutic Deosions: Pha1macodynamk MoJ1ilorin& •s an lfllegral Part of fherapeubc Dru& Monitonng. Ther Dru&
`Monit. 2019Apr:41{2):l ll-114. dol: 10.1097/ nD.0000000000000627. PubMed PMIO: 30883504; PubMed Cenlral PMCIO: PMC6481676.
`
`Davidson JA, Pfeife r Z, Frank B, Too& S, Urban TT, Wischmeyer PA, Mourani P, Land eek B, Christians U, Klawitter J. Metabolomic Fingerprintint or Infants
`Under&0m1 Cardiopulmonary Bypass: Changes +n MetabolK Pathways and ~iatiorl With Mort.ably and Cardiac Intensive Care Urnt l~ngth of Stay. J
`Am Heart Assoc. 2018 Dec l8;7(24):e010711. doi: 10.1161/JAHA.118.010711. Pub Med PMIO: 30561257; Pub Med Central PMCID: PMC6405618.
`
`L.J Turner£, Erwin M, Ati&h M, Christians U, Saul Jt.,, Yazdani SK. In vitro aod ir'I lrivo ol.s.se.ssm~nt of Keratose as a NOYel Exc.ipient of P~litaxel Cobted
`Balloons.. Froot Pharmacol. 2018;9:808. doi: 10.3389/fphar.2018.00808. eColle<tion 2018. Pu~ed PMIO: 30104972: PubMed Central PMCIO: PMC6078047.
`
`'l Jal al O. Renner B, Laskowski J, Stites E, Cooper J, Valente K. You Z, Perrenoud L, Le Quin tree. M, Muhamed I, Christians U, Klawitter J. lindorler MA, Taylor
`RP, HolersVM, Thurman JM. Endothdia. Microparticl~and Systemic: ComplementActivallon in Pabents With Chronic KidneyOisea~e. J Am Heart Assoc.
`1018 J ul 13 ;7(14). doi: 10.1161/JAHA.117.007818. PubMed PMIO: 30006493; PubMed Central PMCIO: PMC6064828.
`
`::J Heischmann s, Gano LB, Quinn K. Lian& LP. Klepacki J, Christians U, Reisdorph N Patel M. Reiulation of kynurenine metabolism by a ketoeenic d1~ J
`lipid Res. 2018 Jun:S9(6):9S8•966. doi: IO.l 194/j lr.M079251. Epub 2018 Mar 31. P JbMed PMIO: 29605816; PubMed Central PMCIO: PMC5983405.
`
`0 Turner EA, Ati&h MK. Erwin MM, Christia1s U, Y3ldani SK. Coating cll'ld Pharmaco4-1~c Evaluation of ~r Spray Coated Drug Coated Balloons. cardio\la.sc
`En& Technot 2018 Ju11;9{2):240-2SO. doi: 10.1007/sl3239-018--0l46·1, £pub2018 Mar 1. PubMed PMIO: 29497966; PubMedCentral PMCID: PMCS990435.
`
`7 Goot BH. Kaufman J, Pan 2. Bourne OWA, Hickey F. Twite M, Galinkin J, CMitia ns u. Zuk J, da Cruz EM. Mo..-phi~ Pharmacok.inetio in Ctlildren W,th
`Down Syndrome F<>tlowin& C•rdiac Surgery. Pediatr Crit Ca~ Med. 2018 May; 19(5):4S9--467. doi: 10.1097/PCC.0000000000001537. PvbM,ed PMIO:
`295474S6.
`
`0 Goetz L. Laskowski J, Renner B, Pickeriii1 MC, Kulik l, Klawitter J, SlitH E, Christians U, var'! de< Via& J, Ravichandran K, Ho4ers VM, Thurman JM.
`Complement factor H protects mice from ischemic acute kidney Injury bot is not critical for controllin& complement activation by clomerular J&M. for J
`lmmunol. 2018 May,48(5):791·802. doi: 10.1002/eji.201747240. Epub 2018 Feb 22 Pub Med PMIO: 29389016: Pubf.ted Cenlral PMCID: PMC5992014.
`
`n SchroederT, Piantado~ CA, Natoli MJ, Autmiz&uine J, Cohen--Wolkowiecz.s M, Hamilton Kl, Bell C, Klawittu J, Christians U, Irwin DC, Noveck RJ. Safety
`
`and Ercocenic Properties of Combined Aminophytlioe and Ambrisentan in Hypm,ia. Clin Pharmacol Ther. 2018 May,103(5):888--898. doi: 10.1002/cpt.660.
`Epub 2017 Oct 17, PubMed PMIO: 28857147; PubMed Central PMCID: PMC594752:2.
`
`~ Heischmann S, Christians U. Validation of the ceU line LS18.0 as a model for study of the castrointestmal tox,city of mycophenolic ac,d. Xenobiotica. 2018
`M.ry;48(5):433-44L dui: 10.10&0/00498'254.2017.1329567. Eµub2017 Mc1y 30. PubMed PMID:28439504.
`
`J Bittiersoht H. Sc:hnM!'dewind 8. O,ristians U, luppa PB. A ~imple and highly ~nsiti\le on-line column utraction liquid chromato&,raphy-btndem mas.\
`s.pec1,romeuy method for tt,e dettfmination of p<oleir'l·unbound t6Crol,m11.S"' l'lum~n plasma sampltt. J Chromatou '4.. 2018 Apr 27:1547:45•52. doi:
`10.1016/j.chroma.2018.03.010. Epub 2018 Mar 7. PubMed PMID: 29544893.
`
`https:l/wwN.ncbi.nlm.nih.govlmyncbi/12extkpeOjlgmflbibliography/public/
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`9nl2022
`
`Bausch Health Ireland Exhibit 2006, Page 2 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01104
`
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`3/19
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`n Mclay JS, Engelhardt T, Mohammed BS. cameron G, Cohen MN, Galinkin JL, Christians U. Avram MJ, Hen th om TK, Dsida RM, Hawwa AF, Anderson BJ.
`
`The pharmacokinetics of intravenous kelorolac in children aged 2 months to 16 years: A population analysis. Paediatr Anaeslh. 2018 Feb;28(2):80·86. doi:
`10.1111/ pan.13302. Epub 2017 Dec 21. PubMed PMI □: 29266539.
`
`0 Kem WR. OlincyA, Johnson L, Harris J, Wagner 8D1 Buchanan RW, Christians U, F'eedman R. Pha1macokinetic Limitations on Effects of an Alpha7·
`Nicotinic Receptor A,goni.st: in Schizophrenia: Randomized Trial with an £xtend~d--Releas:e Formulation. Neuropsychopharmacoloe)'. 2018 feb;43 (3}:S83-
`589. doi: 10.1038/ npp.2017.182. Epub 2011 Aug 21. PubMed PMID: 28825423; PubMed Central PMCID: PMC5770760.
`
`0 Lesche D, SigurdardottirV, Leich tie AB, Nakas CT, Christians U, Englberger L, Fiedler M, Largiader CR. Mohacsi P, Sistonen J. Targeted and global
`phannacometabolom1c.s in eve.rohmus-based 1mmunosuppress1on: ass0Cfat1on of co•medicauon and lysophosphatJdylchotines with dose reqwremenL
`Metabolomics. 2017 Nov25;14(1):3. doi: 10.1007/ sl1306-Ql7•1294·8. PubMed PM ID: 30830337.
`
`0 Alloway RR, VinksAA, Fukuda T, Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S. Klawitter J, Klawitter J, Christians U. Bioequivalence between
`
`innovato, and genoric tacrolimus in liver and kidn")' t, ansplant recipient.,: A randomized, crossove, clinical trial. PLoS Med. 2017 Nov;l4(ll):el002428.
`doi: 10.1371/ joumal.pmed.1002428 . .Collection 2017 Nov. PubMed PMID: 29135993; PubMed Central PMCID: PMC5685573.
`
`0 Klepacki J, Davari 8, Boulet M, Lizarraga R, Christians U. A High-throughput HPLC•MS/MS Assay for the Detection, Quantification and Simultaneous
`Structural Confirmation of 136 Drugs and Metabolites in Human u,ine. Ther Drue Monit. 2017 Oct;39(5):565-574. doi: l0.1097/ FTD.0000000000000429.
`PubMed PMID: 28650900.
`
`0 Klawitter J, Sempio C, Morlein S, De Bloois E, Klepacki J, Henthorn T, leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, KinneyG, 8owler R,
`Foreman N, Galin kin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MSAs5.ay Using Online Extraction for the Analysts of 11
`Cannabino,ds and Metabolites in Human Plasma and Urine. TherDrug Monit. 20~7 Oct;39(5):5S6·564. doi: 10.1097/ FT0.0000000000000427. PubMed
`PM ID: 28640062; PubMed Central PMCID: PMC5600652.
`
`0 Klawitter J, Pennington A, Klawitter J1 Thurrnan JM 1 Christians U. Mitochondriat cyc.lophilin D ablation is. associated with the activation of Akt/p70S6K
`
`pathway in the mousek,dney. Sci Rep. 2017 Sep 5;7{1):10540. doi: 10.1038/s4!598-Ql7-10076-9. PubMed PMID: 28874678; PubMed Central PMCID:
`PMC5585384.
`
`0 Klawitter J, Hildreth K4 Christians U, Kohrt WM, Moreau KL A relative L•argininedeficiencycontributes to endothetial dysfunction across the stages of
`
`the menopausal transition. Physiol Rep. 2017 Sep;5(17). doi: 10.14814/ phy2.!34C-9. PubMed PMID: 28904082; PubMed Central PMCID: PMC5599867.
`
`0 Strand TE1 Khiabani HZ1 Boic.o A, Radiloff 0, Zhao Y, Hamilton Kl, Christians U, Klawitter J, Novec.k RJ, Piantadosi CA, Bell C, trwin 0, SchroederT. The
`
`novel combination or theophylline and bambuterol as a potential treatment of h'(poxemia in hllmans. Can J Physiol Pharmacol. 2017 Sep;95(9):1009·
`1018. doi: 10.ll39/ cjpp·2016-0635. Epub 2017 May 3. PubMed PMID: 28467859.
`
`0 Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation ol Cyclophilin D Results in an Activation of FAK, Akt. and ERK P'athways in
`
`the Mouse Heart. J Cell Biochem. 2017 Sep;ll8(9):2933· 2940. doi: 10.1002/j cb.25947. Epub 2017 Apr 12. PubMed PMID: 28230282.
`
`0 Atigh M~ Turner E. Christians U, Yazdani SK. The use of an ot:ciusion perfusion c.:theter to deliver pachtaxel to the arterial wall. Cardiovasc Ther. 2011
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`Aug;35(4). doi: 10.llll/ 1755-5922.12269. PubMed PMID: 28445625; PubMed Central PMCID: PMC5511576.
`
`0 Grenz A. Bauerle JD, Dallon JH, Ridyard D, Badulak A, Tak E, McNamee EN, Clambey E, Moldovan R. Reyes G, Klawitter J, Ambler K, Magee K, Christians U,
`Brodsky KS, Ravid K, Choi OS, Wen J, Lu kashev 0, Blackbum MR, Osswald H, Coe IR, Numberg 8, HaaseVH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrative
`nucleosid• transporte< l (ENTl) regulates postischemic blood now during acu e kidney injury in mice. J Clin Invest. 2017 Jun 1;127(6):2438, doi:
`10.1172/JCl94890. Epub 2017 J un 1. PubMed PMID: 21!569735; PubMed Central PMCID: PMCS451218.
`
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`9/7/2022
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`Bausch Health Ireland Exhibit 2006, Page 3 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01104
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`"""-\. National Library of Medicine
`lllllr/ Ml(JOIIM Canfw fot 8,ott,c.hnOk>gy lnf0tmar,on
`
`My Bibliography .,.,..,_,hri~i•n•'•Bibliocraphy
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`◄ MyNCBI
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`4/19
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`303 citations., Sort by newest to otdtst v
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`Li Diwan TS, lichvar AB, Leino /\0, \links M. Christians U, Sh~ ld~ AR, Cardi MA, Fukuda T, Miz.uno T, Kaise-l' T, Woodle ES, Alloway RR. Ph.>ffflacol.ine11c and
`pha,maco~ analysisol tmmunosuppn5S1~ agfflts. aft.~ taparoscopic sltt'fe pstn!ctomy. Clin Trans.plant. 2017 J un;ll(6). doi: 10.1 lll/ctr.12975.
`Epub 2017 May 2. PubMed PMID: 28342282.
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`_J Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M. Vin ks M. Population pharmacokint-t,cs of temsirolimus and sirolimvs .,, childrt-n with
`recun t"nt \<>lid t umc)1:rs: a uepo,t flom theChildnen'sOncologyGroup. Br J Clin Pharmacot. 2017 May-,83(5):1097-U07. doi: J0.llll/bcp. 13181. Epub
`2016 Dec 20. PubMtd PMID: 28000286; PubMed Centr.1I PUCIO: PMCS,401981.
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`~ Pedroso AP, Souza AP, Dornellas AP, Oyama LM, Nasc.i~to CM, Santos GM, Rosa J C, ~olla RP, Klawitter J , Christians U, Tashima AK, Ribeiro EB.
`h1tr.11uterine Growth R~trict1on Propams the 1-tyPOthalarnus of Adult Male Rats:: lntqrated Ana~is of Proteomic and f>!et.tbolomic Data. J Proteome Res.
`2017 Apr 7;16(4):1515·1.525. doi: I0.102l/acs.jproteome.6b00923. EPob 2017 Mar 30. Pub Med PMIO: 28314371.
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`= Heischmann S, OziK:iatkowska M, Hansen K, Leibfriu D, Christians U. The lmmunosuppr6.Sant Mycophenolic Ac.od Alters Nucleotide and Lipid
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`Ml"taboh,;m ma" lotestmal Cell Model. Sci Rep. 2017 Mar22;7:4508S. doi: l0.1031/ srep4S088. PubMed PMIO: 28327659; PubMed Ceotnil PMOD:
`PMC5361167.
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`_J Mi~ ra N. Wa n&P, Goldsmith O,ZhaoX. XueY,Cliristians U, Minassian BA. Ever°'imus~ not preveotLafOfitbodyfonnahon 1n murine Llforad,seax.
`NeurolGenet. 2017 Fe b;3(1):el27. doi: 10.1212/ NXG.0000000000000127. eCollection 2017 Feb. PubMed PMIO: 2809ID4; PubMed Central PMCIO:
`PMC5224705.
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`_, CheckleyW, Oeza MP, Kl.awitter J , Romero KM, Klawitter J, Pollard SL, Wise AA, Christians U, H.tnsel NN. Identifying biom.lrtters for .tsthma di.t&,lo5's
`using targeted metabolomic.sappro.achn.. ResJ>irMfli. 2016 Dec;l21:~66. dOt: J0.1016/j.rmed.2016.10.011. Epub 2016 Oct 21. PubMed PMID: 27888993:
`PubMed Central PMCID: PMCS516646.
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`:J Klepacki J. Klawitter J, Klawitter J, KarirnPQur-Fard A, Thurman J, ln&le G, Pat~ C, Christians U. Am;,ioac.ids ,n a tarzeted 'ttl'WS a non,tareeted
`metabolomics LC·MSi"'1S assay. Are the rnutt5 consistt>nt1. Clin Biochem. 2016 S!p;49(13-14):95S-61. doi: 10.1016/j.clinbtOChe m.2016.06.002. Epub 2016
`J un 8. PubMcd PMID: 27288S51;PubMed Central PMCID: PMC6047903.
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`Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians u. Adams OM, Vin ks AA. Characterizin& the Oewlopmental TraJectory of Sirotimus Clearance tn
`Neonates and lnfarils. CPT Pharmacometrics Syst Pharmacol. 2016Au&;5(8):411-7. doi: l0.1002fpsp4.12096. EPob 2016Au&8, PubMed PMIO: 27501453;
`PubMed Cenlral PMCIO: PMC4999604.
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`_J O'Connor S, Zhanc '11... Christians U, MorriSOf'I JE Jr, Frie~ RH. Remifentanit al'ld PfOpofol underio separation and la~rin& when mixed in the same
`syTin1.efOf tota\int ~nousanesthes.a. PaediatrAnaesth. 2016Jul;26(71:703-9. doi: 10.1111/pan.12917. Ep ub2016 May 5. PubMed PMID: 27146802.
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`[1 Stger C, Shipkova M, Christians U, Billaud EM. Wang P, Holt OW, Brune t M, Kun icki PK, P.twiAski T, Langma n U, MarQue t P, OeU~kh M, Wieland E,
`W.tllemacQ P. Assuring the Proper An;alytical Pertormance of Mt>asurement Proc.oedures for tmmun05Uppr'es.si~ Orut Concentrations in 0111ical Practice:
`Recommet'ldat10n:s of the lntema11onalAssoc,ation of Therapeutic Drug Monitonn& and Clinical Toxi<otoCY lmmunosuppressive On.I& Scient,fk
`Committee. Ther Dru& Monit. 2016A,pr.38(2):170·89. doi: 10.1097/ FTD.0000000000000269. Review. PubMed PMI0:26982493.
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`'=1 Brunet M, Shipkova M, van Geldt>rT, Wieland E, SommererC. Budde K, Haufroid\', Christia ns U, LOpez·Hoyos M, Barten MJ, Berpn S, Picard N, Mill.in
`L6 pez 0 , Marque! P, Hnselink DA, Noceti 0 , Pflwinski T, Wallemacq P. Oellerich K Barcelona Cons.emu,; on Biomaricer-~sed lmmunosuppreni,n, Dnit;s
`Ma11111ementin Sotid Orpn Transplantalton. Ther Dn,11 Mon it. 2016 Apr,J8SUppl 1:51•20. doi: 10.1097/ fT0.0000000000000287. Review. PubMed PMID:
`26977997.
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`7 Shipkova M, LoPez OM, Picard N, Noceti 0, Som merer C, Christians U, Wieland E. Malytical A.spects of the lmplt>mentation of Bio markers in Clinical
`Transplantation. TherDru1Monit. 2016Apr:38Suppl 1:580•92. doi: 10.1097/FTD.:>000000000000230. Review. PubMed PMtD: 26418704.
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`:J Christians U, Klawitter J , Klawitter J . Biomartters in Transplantation··Proteom,cs and Metabolomia. Ther Dru& Monit. 2016 A,pr;38 Suppl t:S70-4. doi:
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`10.1097/ FTD.0000000000000243. Review. PubM-ed PMID: 26418702; PubMed Cewal PMClO: PMC4769975.
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`_J Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Pete rs B, Smith OM. lnhalltion of two putat,ve Gulf War to/Ons by mice-. J Environ Sci Health B.
`2016:51(6):366-73. doi: 10.1080/03601234.2016.1142318. Epub2016 Mar 7. PubM !d PMID; 21:i9S0528.
`
`: ) Fa-ste CK, Moen A, Schnicdewincl B, Hau& Aoonsen J, Klawitter J, Christians U. OevdoPmeot of liquid chroma1ogaphy-tandem mass spectrometry
`methods for the quantitation of Anisak.is simplt'x proteins in fish . J Chromato:&r A. 2016 Feb 5:1432:58·72. doi: 10.1016/j.chroma.2016.01.002. Epub 2016
`Jan 6. PubMed PM ID: 26787163.
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`l Hadamitzky M, Bosche K, Wirth T, Buck B, Btttz 0 , Christians U, Schnit'dewind B. LUckemann L, GUntUrkiin O. Engler H, Schedlowski M. Mt'fTIOrf•
`updatina:abropte-s extinct ,on of learned immunosupprnsion. Bolin Beha¥ lmm~n. 2016 Feb;52:40~.doi: 10.1016/j.bbi.2015.09.009. Epub20 15Sep 18.
`PubMed PMIO: 26386321.
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`7 Cl11islii1r1s u, Vi11ks AA, La 111111a11 LJ, Cldlk\" W, W-dllelll<K(.I P, Y,111 (xoldN T, Rt'njt-n V, Ma,qu~ P, "'~' EJ. hl•p.K.1. orl.1Ju1.tto,yP1cK.li..:\"'.5 uu
`• lnter1a boratory V.a,iability in Therapa,tic Owe Monitonng of tmmunosuppreMNe Drugs. Ther Drue Monit. 2015 Oe<:;37(6):718·24. doi:
`10.1097/ nD.000000000000020S. PubMed PMID: 26291980.
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`L] Shok.tti l, Bodenbereer N, Gadpaille H, Schnied,ewind B, Vink.s AA. J ian& w, Alloway RR. Christi&ns U. Qu&ntifinlion ol the lmmuno~pptessant
`Tacro(imus on Dried Blood Soots Usine LC·MS1MS. J V,s Exo. 2015 Nov 8:!1051:e52424. doi: 10.3791/52424. PubMed PMID: 26575262: Pub Med Central
`https:/fww.N .ncbi .nlm.nih.gov/myncbi/ 12extkpe0jlgmf/bibliography/public/
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`9nl2022
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`Bausch Health Ireland Exhibit 2006, Page 4 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01104
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`5/19
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`PMCID: PMC4692696.
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`_=1 Klawitt~ J, Mcfann K, ~nnington AT, Wang W, Klawitter J, Christians U, Schritr P.W, Gito~ B, Cadnapaphomchai MA. Pravast.ltin Therapy and
`Biomark,er Chanies in Childrrn and YouncAdults with Autosomal Dominant ~)'C)'Stic Kidney OiSffse. Clin J Am Soc Ncphrol.. 2015 Sep 4:I0(9):1S34-41.
`doi: 10.2215/CJN.11331114. Epob 2015 Jul 29. PubMed PMID: 26224879; Pub Med Centre I PMCID: PMC4559520.
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`'7 Bosche. K, Weis~nbofn K. Christians U, Witz:!« O, En&ler M, Schedlowski M, Hadamitzky M. Neuro~haviotal consequences of small moleci,M-drur
`immun~upprnsioo. Neuropharmacot01y. 2015 Sep;96(Pl A):83·93. doi: 10.1016/j.nwropharm.2014.12.008. £pub 2014 Dec 19. Review. PubMed PMID:
`25529273.
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`_J Klawitter J, Nashan B, Christians V. Evtrolimus and sil"Olimus in transplant.ttion·related bvt different. Expert Opin Drug Saf. 2015 Jul;Hf7):105~70. dot:
`10.1517/ 14740338.2015.1040388. Epub 201SApr26. ~iew. PubMed PMIO: 25912929; PubMtd CMtral PMCIO: PMC6053318.
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`·1 Klepacki J, Klawitter J, Klawitter J, Thu,man JM, Christia,ns v. A h•&,h-~orm anc:e liquid chromatoeraphy•tandem man spectrometry-t»sed tarcettd
`meuibolomi~ kidney dysfvnction marl<u panel in human urine. Clin Chim Act\. 2:015 Jun 15;446:43·53. doi: 10.1016/j.cca.2015.04.005. Epub 2015 ~ 11.
`PubMNf PMID: 25871999; PubMed CMtral PMCI D: PMC6028022.
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`:J Schniedewind B, Niecler1echoer S. Gali11kin JL, Johnson•Oavis KL, Christians U, Meyer EJ. LonC tffltl uou-validation or everolimvs the,a~tic d•u&
`moo1tonnc assays.: the Zorttacker study. Ther Drue Moo it. 2015Jun;J7(3):296-303. doi: 10.1097/FTD.OOOOOOOOOOOOOHH. PubMed PMID: 25970506;
`PubMed Central PMCID: PMC4820066.
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`___, Emoto C, Fukuda T, Mizuno T, Cox S, Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, ~rentesis J, Vin ks AA. Age-dependent chan1~ in
`si1olimus metabolite format10111n patients with nt"l.lrofibromatosis type I. The r Dru1 Monit.201SJun;37(3):395-9.doi: 10.1097/ FTD.OOOOOOOOOOOOOllO.
`PubMed PMID: 25162215; NIHMSIO:NIHMS621IOS.
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`__J Klawitter J, Reed-Gitomer B'f, McFann K. Pennincton A, Klawitter J,A.bebe KZ,. Klepacki J, Cadna~phomchai MA, Brosna~n G, Choochol M. Christians U,
`Schrier RW. Endothelial dysfu(}(:tioo and ox.idat1Y1e stressm polycystic kidney dl.ffase. AmJ Physlol Renal Physiol 2014 Dec l:307(11):FU98-206.doi:
`IO.l lS2fajp,ena l.00327 .2014. Epub 2014 Sep lS. PubMed PMIO: 25234311; PubM!d Central PMCID: PMC4254971.
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`:J Klawitter J, Bek S. Zakaria M, Zen& C, Hom berger A. Gilbert R, Shokati T, Klawitter J, Christians U, Boe-rnsen KO. Fatty .tctd desaturatioo ,ndtx in human
`plasma: compauson or different analytical methodolo&1es for the evatuatroo of &et effects. Anal Bioanal Chem. 2014 Oct:406(2.S):6399-408. doi:
`10.1007/s-00216--01 4-8020-4. Epub 2:014Au& 13. PubMed PMtO: 25116600.
`
`=1 Faeste CK. Jonschcr KR, Dooper MM, E&,&e ·J;,cobsen W, Moel'I A, Oaschner A. Egaais E, Christians V. Char«terisation of potential novt\ alle1r;en, in the-fist,
`p;Hasite:.Anisalvs sfrnpJex. EuPAOJ)ffl Proteom. 2014 Sep;4:140-15S. doi: 10.1016fj.euprol2014.06.006. PubMed PMID: 27110489; PubMedCentral PMCIO:
`PMC4S40464.
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`7 Gardner LA, Klawittet" J, Grqory MA, ZaberezhnyyV, Baturin D, Pollyea DA, Ta kebe N, Christians U, Gore L, OeGrqori J. Poner CC. Inhibition of calcinetJrin
`combined \'II 1th dasatinib has direct and indi,ect anti·l~kemia effects acainst BCR-ABLll•) leukemia. Am J Hematol. 2014 Sep;89l9):896--903. d01:
`10,1002/ ajh.23776. Epub 2014 Jun 19. PubMed PMIO: 24891015; PubMed Cent ral PMCIO: PMC4134764.
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`- - 1 remandez-Oostamante A, Klawitter J , Repine J[. ,\&azio A, Jaooch.a AJ, Sh.ah C, Moss M, Douet as IS. Tran N, [rzurum SC, Christians U, Seres T. £.arty effect
`of t+d.31 volume on lune injury btomarken in su, gical patiel'lts with healthy lun&,S. A.nesthesiol:O&Y. 2014 Sep;l21(3):469-81. doi:
`10.1097/ALN.0000000000000301. PubMed PMID: 24809976; PubMed Central PMCID: PMC4165799.
`
`0 Shihab F, Christians U, Smith L, Wtllen J R, Ka~an B. Focus on mTOR inhibitors afld tac.,olimus 1n renal tr.lnsplantatioo: pharmacokintt10. e,:posure(cid:173)
`respansf' rtlation5.hips, and clin+cal outcomes. Transpl lmmonoL 2014 Jon;31(1)~22-32. doi: 10.1016/j.trim.2014.0S.002. Epub 2014 May 24. Review.
`PubMed PMIO: 24861504.
`
`=1 Klawitter J, Klawitt er J. Mcfann K. Pennincton AT, Abebe KZ, Brosnahan G, Cadnapaphomc.hai MA. Chonchol M, Gitomer B, Christians U, 5dlritt RW.
`Bioactl\lehpid mecfo1to~ln polycystic kidoey disease. J Lipid Res. 2014 Jon:5-5(6::1139-49. doi: 10.1194/jlr.P042176. £pub 2013 Dec 16. PubMed PMIO:
`24343898: PubMed Central PMCIO: PMC403194S.
`
`7 Tak E, Ridyard D. Kim JH, Zimmerman M. Weme-rT, Wane XX. Shabeka U, Seo SW, Christians U, Klawitter J, Mold<Wan R, Garcia G, Levi M, Haase V, Ravid K,
`Eltzschie HK. Grenz A. CD73•dependent ieneration of adenosine and mdothe liatAdo~2b signalin1 attenuate diabetic nephropathy. J Am Soc N~rot.
`2014 M.ar,25(3):541-63. doi: 10.1681/ASN.2012101014. £pub 2013 Nov 21. Pub Med PMID: 24262796; PubMed Central PMC1D: PMC3935577.
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`:J Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein £, Thurman JM, Christians U. Mycophenolate moft'til enhances the necative effects of 'l.1rolim1Js and
`tacrohmus on rat kidney «II met.Jbol1sm. Plo5 One. 2014;9{1}:e86202. doi: 10.1371[,ournal.pone.0086202. ~ollection 2014, Pub~ed PMID: 24497939:
`PubMed Cflltral PMCID: PMC3907404.
`
`_J Renner B, Klawittf'r J, Gold be re R, McCollou&h JW, Ferreira VP, Cooper JE, Christi.!ns U, Thorman JM. Cydosporine induces endothelial cell release of
`comple ment•activ.atio2. mic1opartides. J Am S0< Nephrot. 2013 Nov:24(11):1849~2. doi: 10.1681/ASN.2012111064. Epub 2013 Oct 3. PubMed PM!O:
`24092930: PubMedCentr.al PMCIO: PM0810078.
`
`[j Frassettol, Flore n L. B.arin B. Browr.e M. Wolfe A, Roi.and M. Stock P, Carlson L,Christians U, Benet L Chanen in dearana!, volume and biOl'Vailability of
`1mmu11osupp1essants when 1iw.11 \'II 1th HAART in HIV-1 inrect~d liver and kidney IJansplant t"Mipients. Biopharm Drue Dispos. 2013 Nov;34(8):442•51. doi:
`10.1002/bdd.1860. Epub 2013Sep 12. PubMed PMIO: 24030928; PubMed Central f>MCIO: PMC4018225.
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`L..J Pi.an P. Labovitz E, Hoffman K. Clavijo CF, Rzasa Lynn R, Galin kin JL, Vin ks AA, Malik P, Christians U. Quantification of the 5-lipoxycenase inhibitor zil~ton
`in human plasma u'l.in1 htgh perlom,ance liquid chromatoeraphy-t.indem mass. spectJ'ometry. J Chromato1r B Amtlyt Technol Biomed Life Sci. 2013 Oct
`15;937:79-83. doi: I0.1016/ j.jchromb.2013.08.014. Epub 20l3 Aut 28. PubMed PMID: 24029553.
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`:J Ff'mandez.-Bustamante A, Kl.awitter J , WIison P, E.lkins ND,Apzio A, Shib.ata T, Uchida K. Christians U, Repine JE. Early 1nc~se in atveotar mac,ophage
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`J)(osbctandm 15d-PGJ2 precedes neut,ophil 1ecruitmenl into lunes of cytoki ~- nsutflated rats. Infla mmation. 2013 Oct;:361S):1030-40. d