Q
`
`unguages: Enghsh
`De~rttnfflt Ml"">lh~dogy
`
`Uwe Christians, MD, PhD
`Professor, Anesthesiology
`Publications
`• Hunter SK. Fretdrmn R, Law AJ, Chmtians U, Holzm.,n JBW, Johnson z. Hoffman MC. Mat«nal CortKOSlffOldS and
`depression during gestation and deueased fetal heart rate v.mabtliry. Neurorepo<t 2021 Oct 6:32(14n 170-1174. PubMtd
`f>MIO: 3428444S
`• Mlyn,? G. De Bloois E, Dabtle,1 O. Chrisrians u. Di?vtt~r &nd v.aliddtion of an LC-MS/MS assay for rhe qwntif1<<1rion of
`aUopregnanolOne aoo its progeS!@f"OOe denved isomers. precurSOC's, and con:1SOl/corusone 1n pr~rq. Anal BIOanal
`Chtm. 2021 Sep:41)(21);5427-$438. PubMed PMIO: 34279681
`• HuntffSK. Hoffmar MC. McCarthy L D'AleuandroA. Wpwa A. Noonan K. Chnst1aru: u. Nalumuh-Mpungu E. 2eisel SM. Law
`AJ, Freedman R. TargetlngTrearmenrs to Heoilth Oi~ntits. Sc"hizophr 8111t 2021 Jul 8:47(4):88(>.887. PubMt<I PM1D:
`33940629
`• Chavaot A.Jourdil Jf. JQLM: T. Christians U. fonrose X. Stanke-Ubesque F. A $1mple t1nd easy-to>perform liquid
`chrom.nography-rmss s~tromttry method for th-e quanufkauon of tJcrollmus aod its m,ei;abolit-es in human whole blood.
`Appliea1ion to the dttermirlcltion of mttabolic ratios in kidney tran~plant ptttient$. J Chromarogr B Analyt Technol Siomed
`life sc,. 2021 Apr 8:1173:122698. (Epub ahead of print] PubM-ed PMIO: 33878532
`• sempio c. Klitwlner J. Jackson M. Freni F. Shillingburg R.. Hurchison K. Bktwtll LC. Christ~ns u, Klawiner J. An.tlysis of 14
`endocannabmo1ds ~nd endocaMabrnoid congeners In human pbsma usrng column S'Mlchmg high p,erfOf'mance
`atmospheric presstr e chemical ioriization liquid chrOO\iltogr.Jphy,mass spe<rrometry. Anal &O<lnal Chem. 2021
`May:413(12):3381·3392. PubMed PMID: 33817753
`• Baliga MM, Kia-wine· J, Christians U, Hopp K. Choochol M. G1tome< SY, Cadnapaphomchai MA. Klawiner J. Metabolic profilina
`rn ch1tdren and young adults wnh autosornal dominant potycysuc kidney disease. sc, Rep. 2021 Mar 23:t 1{1):6629. PUbMed
`PMIO; 33758231
`• Sempio C, Almaraz,Qu1nones N,JackSOn M, Zhaow, Wang GS, LluY, LeeheyM, Knupp K. Klawitter J, Chnsuansu, Klawm~ J.
`Simul1aneous Quartifs<arion of 17 C.Jnnabinoids bY LC•MS-MS in Human Plasmc1. J Anal Toxico4. 2021 Mdr 23 !Epub <11heiK1
`of pnmJ PubMed PMID: 337S4 IS4
`• Sempio c. SldV,u?II LC. HUl(hison K. HuesM MA. K1awitt,!r J, ChristiMS u. Hen!hOf'n TK. Using Population PharmKokineuc
`Modeling to Esuma,e Exposure to ?9 Tettahydl'ocannabinol man Obsef'Vaoonal StUO/ of Cannabis smokers in Colorado.
`Ther Drug Morut. 2C21 At.Jg 1;43(4J:536-S4S. PubMed PMII); 33656464
`• Hum«SK. Hoffmar MC, McCarthy L. D'AlessandroA. W,Jrwa A. Noonan K. Chnstians U, Nalomuli,Mpungu E, Zeise! SH, Law
`~- Freedman R. 8t.)ck American Mat~n.ll Prenatal Choline, Offspring Gtstatiooal Age a t 8uth. and DevelOpment.JI
`PredIspos1t1on to Mental Illness. Sch1zophr 8'.JII. 2021 Jul 8;47(4):896·90S. PubMed PMID: 331846S3
`• Cl.:IVljo Cf, Oliva AM Dingmann C. Kaizer A. Chr1suans U, Burger E. Patel 1/, Kleck 0, Vogel SA, S(ott AK.Janik DJ,Jamt$on LC,
`G1nde AA. Tox1co~ ScrtenIng Tes1ing In Pauems undergomg Spine surgery: A PrOSl)KtlW ~auonal PJlot S1udy. Ther
`Ol'Ug Monit.2021 F~ 1:43(1):136-138. PubMed PMIO: 33181620
`• Freedman R. Hu mer SK, Noonan K. Wyrwa A. Chnsuans u, Uw /IJ, Hoffman MC. Maternal Prenatal Depression In
`Pregnancies With Ftmale and Male Fetuses and Oevelopmen1al Assodauons With (-reactive Protein and Corti$0f. Biol
`Psychlauy Cogn NeurOS<I NeuroImaging. 2021 MJr.6(3):310-320. Pub Med PMIO: 33060035
`• Ye H. Minhajttddin M. Krug A. Pei$. Choo CH, Culp-Hill R.. Ponde,r J. 0t 8'oois E. S(hniedewind 8. Amaya ML lngu11a A.
`S1ewns BM, PoUy,e.a DA. Chrlsnans U, Grimes HL. O'Alessandro A.JOf'dan CT. The Hepatic MKro-environmem Uruquely
`Prottcts Leukemia Cells 1hrough Inouct1on of Grow,h ind >Uf'/111aI Parhw~s Mediated by LIPG. oncer DIS.COIi. 2021
`Feb;11(2):SOO•Sl9. PubMed PMIO: 33028621
`• Stmpio C, w,more :. Palmer C. Bunik M. Henthorn TK. Chr1stIans u. Kla'Mtter j. Detec11on ol C.Jon,)bU''IOIOS b)' LC-MS-MS
`and ELISA In BreastM1lk.J Anal foxIco4. 2021 Aug 14;45(7):686-692. PubMed PMID: 33002141
`• MIruno T, Mc.Phatl 6T, ~matkarS, Wexelblatt s. Wold L Chnst1ans U, Akmbl HT, I/inks AA. Ph)ISIOIQgl( Indirect Respons.e(cid:173)
`MOdellnJ.! to Dewit~ Bupreoorph1ne Pharmacodynafl'IICS In Newborns Trea1ed for Neonatal OptOid W11hdraw.ll S}'Tldromt.
`Cltn PharmacOl<inet 2021 F&);60(2):249,.259. PubMed PMIO: 32939690
`• Van Hoogdalem MW.John.son TN, Mc?h.!11I BT, K.llmatkar s. Wexelblatl SL. Ward LP, Chnstlans u. AkInbl HT, VInks M M!ZIJno
`T. Ph)'SiOIOgt(aMy,based pharmacokinetK modeling 10 1nvesttg,1te the effect of ma1ur.Jt1on on buprtnorphine
`pharmacoktne11cs m nMboms wnh neonatal opi01d withdrawal syndrome. Clin Pharmacol Thtr.
`• pttHS E, ,',,iai;Nair L MostSOIIA I. Chnstiar.s U. semp10 C. Klawltttr J. Land MH, Ware MA. Turcone C, 60M•M1ller MO.
`Pharmacokmeucs of carmabIchromene in a medKal cannabis product also contaIrnns cann.sbldiel and ?9
`telr.Jhydrocannabmol: a piloc Study. Eur J Clln Pharmaco4
`• Cawthon 0/, Coop-er I<. Huen C. Uoret A. 1/illar-MatalT'IOf'os E, Stokes L. Chnsuans U, Schuler M, Yazdani SK. Pre Chnt<al
`
`lnvest1ga11on or Liquid Pa<lItilxet '°' Local Drug Delivery: A Pilot Study. PharrN<:eutK.Jls (Ba~). 2020 Nov .28;13(12). Put>Med
`PMID: 33260517
`• HunierSK. Hoftmar MC, Mccarthy L O'AJessanctroA. w,rw, A. Noonan K. Cht~rians u. Nalomoli•Mpungu E. Zeise! SH. Law
`~- Frffdman R. 81.ttk Amencao MatNrwl Prenatal Choline, Offspnng Gestaoonal Age at Birth. and Devetopm«ital
`Pred1sposnion to Mental lllnt-SS.. Schilophr Bull. 2020 Nov 13. (Epul> ahead Of print} Pul)Med PMIO: 33184653
`• d.lVIJO CF, Ohva AM Om.gmann C, Ka1ler A, Chr,suans U, Surgei- E, Patti 1/, Kle(k(J, 1/0gd SA. SCOtl BK.Ji rnk DJ,Jarnaon LC.
`G1nde M Toxicology S<reening Testing In Pa11en1s Undergoing Spm,e SVrgery: A Prospectl\/t ~rva11ona1 Pilot s.,uoy. Tuer
`Oru8 MomL 2020 Nov 9. (Epub ahead of pnntJ PubMed PMID: 33181620
`• Frttdman R. Hunter SK. Noon.n K. Wyrwa A. Christians u. Law AJ, Hottman MC. Miltef'n.11I Prtn<l{<ll Depression in
`PrtgNnC•~S With F,male and Male Fetuses and Oev,e.loprnental AssocIat,ons W,th C react,v,e. Protein and Cort,sol. BIOi
`Psy(hliltry Cogn NeuroscI Neurounagmg. 2020 Aug 13, [Epub ahead Of prIn!) PubMed PMIO: 3306003S
`• Ye H, Mmhaiuddm M, Krug A. Pe, S, Chou CH, Culp,H1II R. Ponde-r J, De BtOOis E, Schruedewind B, Arnay11 ML. lnguva A
`s1evens BM. POltyf>a DA. Chtisnans U, Gr1~ HL O'Alessanclro A.JorOMl CT. The hepatic: miuoenvirOMlf'f'lt untqutty
`prOlects leukeim.t C!lls through induction of grOVr'th and survival pathways. mediated by UPG. Cancer O.scov. 2020 Oct 7.
`(Epub ahead Of prIrt) PubMed PMIO: 33028621
`• Seml)!O C. W)'rMfe ;. Palmer C, Buruk M, Hentho.-n Tl<. Chnst,a1\S U. Klb'Mtter J. Dt{e(Uon of Cannab,notds by LC,MS,MS
`and ELISA In sreastM1lk.J Anal TOXl(<)I. 2020 (kt 2. !Epub ahead or pnnt) PubMed PMJO: 33002141
`• Mizuno T, McPhad 6T, Kamatk.ar S, Wexelblatl S. W~rd L Chf1St1ans U, Akinbl Hl, I/inks AA. PhyslOlog,c: lndlre<:I RH~
`Modthng ro Oewite Buprcnorpt11ne Pharm.xodyn.lmKS Ill Newborns TrcJted Tor Ne<>o.1t-ll Op!Old W11hdtaw.ll SyndrorrK!'.
`Chn Ph<1rm.K.Okinel 2020 Sep 17. (Epub ahead of prIn1J PubMed PMIO: 32939690
`• Frymoyer A. V.ln Mwrs KP. Drover DR Klawitter J, CMstiJns u. ChOck VV ToeoptiyUme oos,ng and pharmac0k1ne1s<s for
`rtoal protecuon ,n neonatts vmh hypoxK·•Schemic ~nc~phalopa1hy undergo.rig 11'werapeut1c hypochet'ma. Pied,a1r Res. 2020
`Dec;88(6):871•8n. Pl.lbMed PMJO: 32919393
`• Chns11ans U. Roger Jelhffe MD. KP, F/4.4PS Obituary. The-r Orug Monit. 2020 Aug 10. {Epub a~<XJ of prinl) Pub Med PMIO:
`32796388
`• Schmedewlnd B, Mtyer EJ, Chmtians U. Long Term Perfom1ance of Laboralory Develop@<! Liquid Chromatography 1,mdem
`Mass Spectrometrylesrs and ,1 Food and Drug Admirns1rat1on-Approved lmmunoass.y for the Ther.:,peutic Drug
`Moo,lor1ogof Evtrd,mus. Ther Drug Mo~l. 2020Jun;4~3J:421,426. PubMed PMID; 32427781
`• Jell11ft R, Chrisuans i.J. The New Oire<t-ActIng Or.ti AnllC0,)8Ul.mtS N~ 10 be MQ(iltOf'edl. Ttw," Drug Monll. 2020
`Jun;42(3):3S7-3S9. PIJbMed PMID: 32427780
`• ChriS.ri,1ns U. Hetithom TK. WJlson PO. Odlench M, Eli.3SSon E. In Memoriam: Prolessor folke SfOqvist. Ther Of\lg Mon1t.
`2020 AP< 1 S. (Epub Wad of print} PubMtod PMID: 32304489
`• ~ I E. Erwin M, Cawthon CV. SCh.llf C. Fedor N. Rayl T, Wilson 0. ChriSl:l.lns U, Regis.re< TC. Geary RL S.lUIJ. Yi\Zd.Mil $1(. Pre(cid:173)
`Cltmcal l1We~l1S4tKX1 of Ker at~.:,:, an b<:1piei,t of Druti Coated 8.illwnS. Molecules. 2020 M<llr 31 ;2S(7). PubMed PMID:
`32244375
`
`9/28/22, 6:21 PM
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`Faculty Profile | School of Medicine | University of Colorado Denver
`
`https://som.ucdenver.edu/Profiles/Faculty/Profile/4832
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`1/5
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`Bausch Health Ireland Exhibit 2005, Page 1 of 5
`Mylan v. Bausch Health Ireland - IPR2022-01104
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`• Wang G~ 80ur~ UWA. KJ.!IWIU~r J. 5e-ffll)IO C. CMj)O'l,!ln K. Knupp K. w,~pe M►. ~gell L {.hnsMns u. lt'OndrCI J. Heard K.
`8.ljaJ L. Disposition or Or.ii Cannabidiot-Rkh Cannabis Exrracts 1n Chlltlnm with El)llcpsy. Cltn Phanr\¥ok1ncr. zo20
`Aug;S9(8):ICIOS·1012 PubMtd PMID: 32048179
`• SempiO (. HVCStiS MA,. M,kulkh-G1lber"tson SK. KlaWiner J. CMStl.)nS U, HC'ntt\ol"n TK Popvl.ition ph.1rmacok1nct1C modeling
`of plc'ls.rN ?9 lt"lrc'lhydrOCdnnc'lbmol and an M.t~ and lllc'IC~ mt'tc'lboti l" following contro!l"d vnokf'd Cdnr1c'lbiS
`admirustr,uioo. Br J Clm PharmacOI. 2020 M.lr:86(3~611 -619. PutlMed PMIO: 31747464
`• Shokal! T. Harrmann M. Dava11 8. Klawitter J. KldW!tt"r J. Chnst1ans u. l •~rllSlrol1mus mdabobc pathwa,ys r"'1'1S1ted
`X(?n()t)louc.a. 2020Jun;50(6):640-653. PubMed PMID: 31596164
`• D.Jvarr B, KotKhc'I N. daviJO CF. ThomaSll. Rzasa Lynn R G.!ilink1n JL. Ct1nst1ans U, 5'!mp10 C. A ~1tivf' LC MS/MS "5!.ay fOf
`the Qu.w1fi(.1!1()11 or Methadone and llS Mct.:ibohtf?S ,n [)(te'(I Blood Sp,;>tS: Com~•iSon With Plasm.,. Thtf Drug Mo~t. 2020
`ff'ob;42(1):118-128. PubMf'd PMIO: 3 1318842
`• Wang GS. souroe OWA. Klawlttet J. ~PIO c. cnapman K Knupp K Wi'ffipt' MF. Borgelt l. (Msnans u. He.xef K. Ba},lj L.
`Oispos,tlOf"I of oral Cle ltd 9 1e1rahydrocannabil'IOI {THC) m ch,ldren receiving cMnabts "xtrac1s for epilepsy. Clm Tox,col
`(Phil:i.). 2020 ~;58{2):124-128. PutlMed PMID: 311 11749
`• An aµl)l"OltCh to btornafker d1sc~ry of unnab1s uSt ut1hzmg pr0tl!'01r1c, n~atdomte. and lil)ldorntc analys~ C<inn
`Cannab RPS 2020
`• Albffl-otJ S. BuggsV. Schrnt'dewind 0. Sobhan, K. Chnst1ans u. Kelty KA. ~r.,pnit,cdrug morncor1ngof
`1mmunosuppressancs. In: Tox:ieotogy c.ises ror the ClinlGill anti Forenslc: Labor.acory. Ketha H. G-;rg U (eds) EISCV1er ¼demic
`Pres. San Oif'8o {2020~ pp. 317 332.
`• Hinckley JD, s.lb.l l R.:lymond K, 8¥tels K. l<l.lWltt(>I' J. ChriSIJ.)nS u, Hoi;,fer C. An Approach to 8iomafker O.scove,y Of
`Can11dbiS Use Uullrmg Proteoin.c, Me<dbolOOMC. and lll)ldom.c Analyses. Cannabis (Mnabmold Rie-s. 2020 Jun 19. [Epub
`.lhe.ld or pnnt] PutiMed PMIO: 33998853
`• C<M'thon CV. (~ K. Hllf'll c. Uore< A Villar Matamoros E. S1okts L Chnstlbns u. Schuler M. Vdlcldn1 SK. Pr~ ChmCcll
`lnvtStlg.ltlOO or llqulll P~ILt.lXel lor Local Ot'ug Othvery: A Pilot SN<:fy. llh.)nnacevuc.:its (B.lS(>li 2020 NO',/ 28;13(12). Puf.)Mt,d
`PM!O: 33260517
`• Frymoyer A, V,;1n Meurs KP, Drover DR. l(J,1win~ J. Chns11,lns U, ChOck VY. TheophyU1nt tlosmg and pfl.lrm.lCOl<.tnetics lor
`r~ prO(KIIOn ,n nf'OMtes w11h hypoxic•1schermc encephalopathy unde1going thf'rapell(1C hypotherma. Ped,atr R~. 2020
`Dec;88(6):871-877. PutiMed PMID: 32919393
`• SChni~nd 8. Meyer EJ, Chns11ans U. Long lerm Perforf'l"lclnct of LabOr-'lory-~~ LCM5/MS TeslS and an FD~(cid:173)
`apprO\/ed l1TWT11,Jr'I0.1S$.l}' lor the ~r.;ipa1tlc On.Jg Morutonng or Everol 1mus. Tiler Or'\lg Mon,1. 2019 ()(t 7. [Epub ahe.ad or
`pnntJ PubMed PM10: 31S967S4
`• Shofc.lt1 T, HJrtm.ann M, a.wan 8. Klawitter J, KklWltter J. Chns11ans u. T,efllSlrol1mus Metabolic: P:11hWays Revisited.
`Xeoobtol,ca. 2019 OCI 9;:1 30. [Epub ahe.Jd ofpnntJ PubMed J>MID: 31~)96164
`• Weinberg A, Huo V, K.lc.inek o, P.ltel I(, WJttS OH, W,lr.1 0 , Hoff1nan RWI, Kkl'Mttef J, Chnsuans u. Bl'iC!f Report, M.ll1<tf"S or
`Sponlan~ Pr'f"t"rm Othv~ lfl ~ n Living with HIV. Rf'!atJOl)Stup With PrOI"~ Inhibitors and Yll<1n11n 0. J Acqu,r
`lmmu™? Oelic Syndr. 2019{)(t 1;82(2):181-187. PubMed PMID: 31513074
`• O.Warr B, Kottthc'I N. Clavi10CF. Thomas1J, Rzasa Lynn R G.!illnkmJL Chnst1ans U, St'mp10 C.ASEN51T1VE LC MSIMSASSA"t
`FOR THE QUANTIFICATION OF METHADONE AND ITS METABOLITES IN DRIED BLOOD SPOTS: COMPARISON WITH PLASMA.
`Ther Drug Morut. 2019JIA 15. (Epubah"adof prnll] PubMMS PMID: 31318842
`• KIAWlttef J, Kl.,lv.'lrter J. Pennington A, K1(kp.itnd( B, ROd.a G, Korecha NC, Thurman JM, Chtistkms u. <:ycloph1l1n O knockovr
`ptotKls t h e~ kKkr.ey agan'ISt cydospor1n A n'ICIUC~ Ox1dal~ strt-Ss. Arn j PhySKII R"na1 Physiol. 2019 5ep
`1;317(3):F68H694. PubMcd PMIO: 31188033
`• Wang GS, Bourne OWA, Klawitt"r J, 5"mpio C. Chc'lpman K, Knupp K, W1~J'>" MF, Borgf'lt L. Christians U, H".Jrd K. 8"J"J L.
`Oispos111on or oral ~lt.l-9 retrahy(lroc.annablnol (THCl in Children receiving cann..lblS ex1raets !Of epilepsy. Chn Toxicol
`(Ph.la) 2019 May 21::1,5. {Epob<11head ofprmt) PubMed PMIO: 31111749
`• Brun<?! M. van Gelder T, kbt:rg A, H.autrOld V, Hcssel!nk DA. LJngman t .. lc-ma1rre F. M."irqu« P, Stger (. ShlpkOV.l M, Vinks
`A Wallemacq P. W1eiand E. W0tllard JS. Barten MJ. Budd" K Colom H. (11eterl"'1 MT, E~ns L.Johnson-Davis KL Kun1d11 PK.
`M..lCPhee I, MasUda S. M.llheW BS. M1ll.1nO, Miruno T, Moes OAR, Mol\l:h.)U(I C, Nocet,o. PaWlnskl T. Pleoref N, van S.Cha!k R,
`Sorn.-riertf C. Vt-the NT. de Winte r B, Christians U. Be(g.ln S. Thf'fapeut"c Drug Moo1tonng of Tacro!amus-PerSOr\ahz.ed
`Therdpy: second Con~us Rcpon. Ther 0<ugMon1t. 2019Jun;41(3):21)1-307. PubM(!(f PMIO: 31045868
`• Golomb BA, Kosl1k HJ, Chnsllan~ U. R1tchl" J. W11son P. Elkins N. KldwiltN J. Klawill"r J. Sn"Nth D. R"f)ln" JE. [>@,pres~
`pros1agl.and1os and leukotnenes 111 wt er ans wi.th Gulf w.ir illness. J Environ Sc• Health 8. 2019;S4(8J:623-639. Pub Med PMID·
`31033394
`• Kcner AC, Kl.1Wltter J. HIidreth KL ChnSllans u, Pulrtam I(, l<Otlrt WM, Ri"USCh JEB, Moreau KL. Elevated plasma hOmocySle1ne
`c'lnd cr-,te1n" a," associa1f'd mlh ~odothel1c'II dys.funct,on across ~,auSdl ~ldges 111 healthy~. J Appl Physiol (198S)
`2019Jun 1;126(6t.1533-1S40. PutlMl.'<I PMIO'. 308%3S7
`• l.Jchv.Jr A. Tr~mblay S, Naik D. llpscombj. King E, Vinks M, Chr1st1am U. Alloway RR. Ev;,!uat1onof Cl1111cc,l and Safety
`Outcomes Followmg Uncontrolle(I T,1crol1mus Conversion in Adult Transp(.lnr Re<:1p1ents. Pharmacotherapy. 2019
`M.ty;39(5~S64-S7S. PubMed PMIO: 30892704
`• Sh1pkova M, CMsti,,ns U. lmprOV1ng Therapeutic Dect$10ns: Pharm.xOftynamiC Monitoring as ,ln Integral Part of Thef'apeutlC
`Drug Mon1tor,ng. The( Drug Mon1l 2019ApJ;41{2):1 1 I 11 4. PubMed PMIO: 30883504
`• Freedman R, Hunter SK. L.aw Al, Wagner BO, O'Aless.:mdro A, Chnst~ns U, Noonan K, Wyrw.:i A, Hottm.:m MC. H~her
`Gc!>stat10nal Cholmto l~ls 1n M.>Jternal lnfKttOn Ar" ProtKtM' for lnfanl Bra,n OtVt!lopnlf"nt.J Pf'di.atr. 2019 May:208.19&
`206.e2. PUtlMe<I PMIO: 30879727
`• Van HQ\/f' JLK. Fr~uf CL. Ftctooglu C. P"na LDM. Moreau KL. HenthcN·n TK. Christians u. Jiang H. Cowa,n TM, Young SP. Hit"
`M, Friederich wm, Sl.lbler SP, Spector EB, KronqulSt KE, ThOm.asJA, Emmett P, Mamngton MJ, Pyle L, CreJdon-SWIOdeJl G,
`wm,pe MF. M>lclf'an KN. Siornark"rs of ox1datM' stress. 1nf\amrriaoon. and vascular dysfull(t1on 1n 1nh"n1ed cystathronrot
`13,.syntha~ clefic1ent hOmocyStm1,.1ri.1.1nd the impact ol 1st1.mne trcarnlf:11t 111 a ph.ase 112 human chnteal tf'i.11. J Inherit Met ab
`Dis. 2019Mc'ly;42(3):424 437. Pu~ PMID: 30873612
`• Van Hove JLK. F<ech.luf CL. Fic1C1oglu C, Pena LOM. More.:tu Kl, Henthorn TK, Chnsuans u, Ji.lng H, Cow.ln TM, Young SP, Hite
`M. Fnecknch MW. St.Jblf'f SP. Spector EB. Kronqu1st KE, Thomas jA, Emmett P. Harrington MJ. Pyl" L Creadoo-Swindell G.
`W('ITlpe MF, Maclean KN Biorrwricers of oxidative stress. 1nflarrvnation. and vascul.lr ctysluncnon 1n mhcrlled c:ystath10111ne
`6 -syJ'ltha~ deficient h0mocyst1nuria dnd the 1rnp.ac.1 of taunf'\e t("atrl'lt1'1t K"I a phase 112 hutna n cM.cal tr~. J 1nht-nt Mt-tc'lb
`Dis. 2019M.iy;42(3):424-437. PubMe(t PMIO; 30873612
`• Emoto C, John~ TN. Hahn D, ChnstJans U. Allowa,y RR, V111ks AA. Fukudc'I T. A lh@orl"lical Physlologic.ilty Based
`Phafm.Koklneuc Approach 10 As<enam Covariates Explam1ng the Large? lntcrpanent Vclfklbtlny m Ti1Crot1mus O.sposmon.
`CPT PharrMComt-tncs Syst Ph.armacol. 2019 May:8(5):273-284. PubMNI PMIO: 30843669
`• Leino l>J), King EC. Jiilng w, Vin ks AA. K\awittcr J, Chnstians U, Woodle ES, Allow.l)' RR. Rohan JM. ~ment of 1acrol1mus
`mtr1tPc'lt1"'1t variability m stable M!ht"fN'lt lran~Ltlnl rKIP,NllS: Establ1~.t11ng ba~ bne values. Arn J Transplant 2019
`May;l9(S):1410-1420. PubMed PMID: 30506623
`• Sempio C. L,nclley E, IOawmer J. Chnstldns U. Sowle< RP. Adga1e Jl. All5 '~ W, -'wdz,e,ayk L Fischer S. Bainbridge J.
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`9/28/22, 6:21 PM
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`Faculty Profile | School of Medicine | University of Colorado Denver
`
`https://som.ucdenver.edu/Profiles/Faculty/Profile/4832
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`2/5
`
`Bausch Health Ireland Exhibit 2005, Page 2 of 5
`Mylan v. Bausch Health Ireland - IPR2022-01104
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`chromarograpt,y.randcm mass spectrometry merhOd tor tht> determina11on of p,oteto.unt>ound tacr011mus ITT hrnnom
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`Neu1opsychophanl'l<lcology. 2018 k-b;43(3}:S83-S89. PubMed PMIO: 20825423
`• HeIschm.lnn S. Christians U. V.1hd.1r1on of 1he cell lme LS180 a,; ,1 model fOf srudy of the gasrromresunar roi iuty of
`rnycophe'OOJ1( acid. XeoobK)llC,l, 2018 May:48(5):433,441. Pub Med PMI D 28489504
`• Davlds.onJA. Pfeifer z. Frank B, Tong S, Urt).:)n TT, Wisch~ PA, Mou ran1 P, L.lndeck B, Chnstians U. Kl,3wmer J.
`Metabolomic fmgerpnn11ng of Infants Undergoing Cardiopulmooory Bypass Changes tn Metobotic Pathways and
`AsS.OCl<.lflOO \Nith Mortalny ¥Id C,mhac lmeostve Care Urnt Lcogth of Sr ay. J Am He,lrt ASSOC. 20\S 0cc 18;7(24):('(1107 11
`PubMed PMID: )OS61257
`• Pedroso AP, DornellasAPS,de Sou1aAP, PagottoJF, OyaIlld LM, Nascmiento CMO, KJawn:ter J, CtmstIans U, T,ishIm.i AK.
`Fbbeiro EB. A proteom1Cs-metabolomt(S approach 1ndtc<1te chdnges"' hypo(ha!an'Nc glutamate·~BA rnetabohsm of Jdult
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`• Klawitter J. Hddre1h KL Christians U, Kohn Wt,,\ Moreau K.L A relauve L...irg,nme defic,eocy comnbuces co endothelial
`dysfunCtlOn a(fOSS the stages of lhe menop,av~l lransitlOO. Physiol Re-p. 2017 Sep:5( 17~ PubMed PMID: 28904082
`• Kl.-w.,itter J, Pennington A.. Klawnter J, fhurrTlo)nJM, Chns1ians U. Mmxho;,ndnal cydophlhn D ..ihl.11100 is associated With the
`3(1Nall00 of AkVp70$6K Pi)thWd'flrl the mouse kidney. Sci ~p 2017 Sep 5:7(1):1()540. PubMed PMIO: 28874678
`• Schroeder T, PI..intados1 CA, No.ltd• MJ, Autmi1gu1nc J, Cohen.Wdkow~ ZS M, H.Jm1ltoo Kt., Bell C, Kl,.i'Mlter J, Christi.ms U,
`lrwm DC, Noveck RJ. Safety ,md Ergogerac Prope,lJes of Combined .Arot1'\0phylhne and Ambri$entan ITT HYPollkl Chn
`Ph.irm.-.c~Thef. 2017 Au,g 31 [Ept.Jbahe.:idof pnmJ PubMed PMID: 2MS7147
`• Kem WR. Qlmcy A Johnson L. Hamsj. Wagflef BO. Buchanan RW. Christians U. Freedman R. Pha1rnac0k1net1C LImItattonson
`Effects of ..in .A.lpha7,Nicoonic Receptor AgonIst in Schlzophrenta: Ranckimized Trial wI1h ..in Extcnded•Retease Formula non
`Neuropsychoplwrmacology. 2017 Au& 21. (Epub ahead of pnnt) PvbMt:d PMIO: 2882S423
`• Klepacki J. [).'.Ivan 8. Sool~ M. Lizarraga R, Chnsuans u. A Htgtuhroog:hpm HPL(.MSIMS Assay lor the Oet<?Cl'IOO,
`QuantffK'.at1on and Sunutraneous Structural Confrrmat100 of 136 Drugs and Metabolites m Human Urtr1e. T~ Drlll!, Mornt
`2017 Oct;39(S~S6S.S74. PubMed PMIO: 28650900
`• Klawittet' J, Semp,o C. MOl'le,n S. De Bloos E. Kl~kl J. Hem.horn r. Let~ MA. Hoffenbfrg EJ. Knupp K. Wang GS. Hoofer C.
`Kinney G, Bowler R, Forem.1n N, GalmkmJ, Chnsrians U, KI.JW!rter J. An ,1-.tmospherte Pressure Chem1Cal lornzauon MS/MS
`A.Ssay Usrng Oohne Extrac11on f<>r the Anafysis or 11 Cannablf'IOlds and Metabohtes In Hu,nan Pldsma and Urnlt. Ther Drug
`Monu. 2017 Oc:t:39(S):SS6,.564. PubMed PMJO. 28640062
`• Hets(hmann S. Christians U. Vahda11on of the cell hoe LS180 as a model fof Slucty or the gastro1nte.tt0al toxicity of
`mycophcno hc ac1d. Xcnobiortea. 2017 May30;:1.9 [Epob ahead ofprnt) PubMed PMIO: 28489504
`• Stral'ld TE. Khia~ru HZ. SO.co A. R.W1lorr D. Zhao v. HarY11lton KL Chfistians U. l<l.Jwitler J, Nove<k RJ. P1ctntc1do!.1 CA. Bell C.
`ltwin 0, Schroeder T. The novet comt)jna1100 of1heophylllne and b.:lmbutc<ol ..is ,1 potential trearmem of hypoxcm1a in
`hum.ins. CanJ Physlol Pharmacol. 2017 Sep;95(9J:1009-1018. PubMed l'MIO: 28467859
`• Atigh MK, Turner E, Christians U, Yazd..inl SK. The USt' ol Ml cxduslOO pi~oo c..ithelet' to delivet" paclnaxel to the an:cr1al
`Wdll. (drd1ovasc Ther 2017 Aug:35(4). PubMed PMJO: 2844S62S
`• OIWanTS, l1Chv,;1r AB, LemoA.D, VinksAA Chns1ians U, Shields AR, Carch MA, Fuku,d;! T, Miz1,1no T, Kai~T, Woodle ES,
`Alloway RR. PharnliKokmetic and phd,macogenetic analysis of 1mmuocl'$Uppressive <1ge-nts after lapa,oscopte sl~
`gasrre<comy. Clm Transpl.1m. 2017 Jvn;3t(6). PubMed PMID: 28342282
`• HetSChrnann s. Dr1e-<:iatkowska M. Hansen K. Leibfntz O. Chnst1<1ns u The ImmvnosopPfessam Mycophe1\0lic Acid Alters
`NlXleottde and 1JpId Me1,1bolism lf1 an Intestinal CeU Model. Sci Rep. 2017 Mc:tr 22;7:45088. PubMed PM!O: 283276S9
`• Pedroso/41'. Souza AP. OornellasAP. OyamaLM. Nascimento CM. Santi)SGM. R<MJC. 8eftollaRP. Klaw,tterJ. Chnswnsu,
`Tashnna AK, RIbeIro ES. lntrat,JIPnne GrOWlh Resrm;IIQfl Programs the HypothalaffM.IS of A(lult Male R.us: lmcgr,1ted An.'.llysls
`of ProteomK ctr'ld Metabolom,c C>.Jta.J Proteome Res. 2017 Af)f 7;16(4J:151S 1S25. PubMed PMID: 28314371
`• Kl.lWftte< J, Seres T, Penrnngton A.. Seany JT, Kl.lwittCf J, Christians U. Atil.luon of Cydoph!lm O Rt-suits In an Ac1rvauon ot FA.K.
`Akt. and ERK Pathwaysm the Mouse Hea1tJ Cell Bicxh~. 2017 sep;l l 8(9):2933-2940. PubMed PMlD: 28230282
`• Mishra N, WangP, Goldsrmlh 0, Zh.lo X. Xue V, Chns11..ins U, Mmas~an BA.. EverofImus does not prevent Lafora body
`fo,mat1or, ,n murIne Lafora disease NeurOI Gene1. 2017 Feb:)(ne127. PubMed PMIO: 28097224
`• M1ZtJno T, Fokuda T, ChrtSuaos U, Pet"entesrs JP, fi;lt.tladI M, Vin ks AA Pc,putauon ph.lrmacok1net1cs of U!o1S1r~ 1mus .md
`sirohmu!> mchddren Wlth re<unent sohd lumours: a report from the Chdd, en's OncologyGf<>1.1p 8rJ Chn Pharrna<ol. 2017
`M.ly:83(SP097.l 107. PubMcd PMIO: 28000286
`• .A.lloway RR, Vmks M. Fukuda T. MtlUno T. King EC. Zoo Y. Jiang W, Woodle ES. Treroblay S. Kl<JW1tter J. Klawitter J. Chns.t,ans
`U. BloequNalcnc:e between innovator and generic 1ac:rolimus In hver and kidney transpl..int re<Ipient!o: A randomrzed,
`cros~ clin1Cal tnal, PLOS Med 2017 Nov;14(11J:e1002428. PubMed ~MIO: 29135993
`• Emoto C, Fukucl,1 T, M11vno T, Schrnedewmd B, Chnslians U, A.d,,lms OM. 'lmlksA.A.. CharacterIz111g the DeYelopmeotal
`Trajectory of Slrolimus Cleaf<1nce m Neonates and lnf.-mts. CPT Pharnl,!,eomeirks Syst Pti.annacol. 2016 Aug;5(8):4 I 1 7.
`PubMed PM1D: 27501453
`• Klepacki J. Klawiuer J. Klawitter J. Karimoou, Fa,dA ThurrnanJ. ln&leG. Patel 0. ChriStians U.Arrnn<1 acids ma targeted
`Yer~ a non.1arge1cd merabobnics LC-MS/MS assay. Are the results< ons,stt'flt?. Clin Biochem. 2016 Sep;49(1).14):9SS.61.
`PubMed PMID: 27288551
`• O'Connor S, Zhang YI., Chnsoans U, Mornson JE Jr. Friesen RH. Rermfc,,tanil <1nd propolol undergo ~rauon and tayenng
`~ mo1ed mt~ same syringe for 1otal inrravenousanest:ht.-sia. Pctedjatr Andes.th, 20t6Jul;26(7):703•9. PulJMed PMID
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`• Seger C, Shlpkova M. Christians U. Sillaud EM. Wang P, HOit r:N-1. Oruneit M, k'.vnkki PK. Pawinskr T, Langman u. Marquet P.
`OetlCliCh M, Wieland E, W~llcmacq P. Assvnng the Propet' A.n.llytlC.11 Perlonn.lnce of Measvremem Prcxedures fOf
`lmmunosuppressive Drug ConcemratiOns in Clinical Practice: Recommo~ndations of the In1emational A.ssociauoo of
`Tht.>rapevuc Drug Morntonng -1nd Chnical ToxtCology lmmunos.uppre~rve Drug Sc1em1lic Commmee. Ther Drug Monn. 2016
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`• Brunet M, ShIpkov,1 M, van Gelder T, Wieland E, Sommerer C. Sudde K H.aufr01d V, Chri~ians U. Lopez.Hoyos M. Bart en MJ,
`Befgan S. Picard N. Mill.in L6pe10. Mdfquet P, HeS$elink DA Noceti 0, Pawinski T. wallemacq P. Qellerkh M. Barcelona
`Consensus on 8iom.,M(er.B..,s«I JmmunoS1JpprcssNe On.igs M~r,.,gem1'1'1t In Solid Qrg.,r, Transplanr.mon. Ther Otug Monh.
`2016 A,pr:38 Suppl 1:$1-20. PubMed PMIO: 26977997
`• Rep1neJE, Wilson P, E:lkms N, Klawitter J, Christians U, Peters B, Sffllth OM. Inhalation ol two put,:mve Gull WaftoxIns by
`mrce.J Environ Sci HeJlth 8 2016;$1(6):366,7), PubMed PM!(): 2Msos;is
`• F~1e CK, ~ A, Schn~nd B. Haug A.nonsen J, Kl.,wtter J. Chnsti<ins U. ~opment of hq1J1d chfomatogr.lphy·
`tandem mass $pe(ttomeuy ~hOds for the quantitation of AniSdk'5 sim~i protrins in fiSh. J Chromatogr A. 2016 feb
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`• Shipkova M. LOl>t'l OM. P1cct1d N. Noceti 0. Sommer er C, Christians U. \Meland E. Arlctlytk<tl AweclS of lhe lmpletnemation
`of 810fflarkers In Clmic."1I Transpl.in1.a11on. Ther Drug Mornt. 2016 Apr.30 St.Jppl 1:SS0.92. PubMed PMIO: 26418704
`• Christians u . KJawiuer J. Klawittet' J. 8ioma1kers in Transplantation--Prote<lO'lfCs ar,d Metabokimks. Thet' Ofug Mon1t. 2016
`Apr,38 Suppl 1 :S70.4. PubMed PMIO'. 2(,418702
`• Hadom1tzky M. Bosche K. Wifth T. Suc:k B. Beeu o. Chrt'>t1ans u . Schnie~nd 8. Lockemann L GuntUrkun a , Engler H,
`SchedlOINSki M. Memory.upd.,11ng ,)l)r~t~ tXl'1naion of le.,med imrrllno$UPf)fCSSIOr'1. Br.,In Beh.w lmmt.Jn. 2016
`Feb;52:40 8. PubMed PMID: 26386321
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`lmrnunosuppi-essant Tacr~imus on D1'1ed Blood Spots Using LC MSJM!;.J Vis Exp 201S NOV 8;(10S).. PubMed PMlD:
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`
`9/28/22, 6:21 PM
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`Faculty Profile | School of Medicine | University of Colorado Denver
`
`https://som.ucdenver.edu/Profiles/Faculty/Profile/4832
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`3/5
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`Bausch Health Ireland Exhibit 2005, Page 3 of 5
`Mylan v. Bausch Health Ireland - IPR2022-01104
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`• Shipkova M, L6pez OM. Picard N, Noceti 0. Sommer er C, ChristklM U, IMela!'ld E. ANAL VTICAL ..SPECTS OF THC
`IMPt.EMENTATION OF 8I0MARKERS IN CLINICAL TAANSPI.ANTATION. Ther Drug Mon1t. 201 SJul 30. (Epub -,head of prin1J
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`• Klawitter J. McF,;1nn K. Pennington AT, W,)ng W, Kl,)w,ner J. Chnsri.1ns U, Schrier RW, Gn~r 8, CadM~photnchaI MA
`Pro'Vastatin Therctpy and Biomarker Changt>S in Children and Voong Adults with Autosomal Oominc1m Pofylystic: Kidney
`Oise<'lse. 0 1nJ Am Soc Nepl,rol. 2015 Stp4;10(9):1534-41. PubMed PMID: 26224879
`• SChniedewind B. Niede,lecMer s, Galinkin JL .lOhnson-Oavis KL Chnsti;ms u, Meyer EJ. Loog-term cross-validauoo of
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`• Klawitter J, Nashan B. Chnslt.lns U. Everohmus i>nd sirohmus m uansphnti>tion-related but d1fferenL Expen OpIn Drug Sat.
`2015Jut14(7):105S-70. PubMed PMID: 25912929
`• Klep.,cki J, Klawmcr J. Kl.:lwitter J. Thu~nJM. Chnstklns U. A higli,pertorm<'lnce hquid chrOIT"latogr<'lphy·t<'lndem m.1ss
`spectrometry,~sed targeted met.ibolomks kid~ dysfunction marke,r parw-1 in human urine. din Chim Acta. 2015 Jun
`1S;446:43•53. PubMed PMID: 2S871999
`• 8osche K. Weissenborn K. Christians U. Witzke O. Engler H. Sdi~lov.-s~J M. H.l<laml\Zky M. Nt>urobehavioral consequer,ces.
`ol small moferule•drug ImmunosuppresS1on. Neurophann.xology. 201 S Sq):96(Pt A):83-93. PubMcd PMlD: 25529273
`• Emoto c. Fukuda T. Mizuno T. Cox 5. Schnledewind B. Christians u. Wkleoiann SC. Fisher' MJ. Weis!> 8. PeremtsiSJ. VinksAA.
`Age,dependem c~nges in sirolImus metabolite form.,uon in p,uients with nc-urofibrOl'Tkltos1s type: 1. Ther Dfug MonIt. 201 s
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`• Shokau T, Bodenberger N. ~
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`neg,3uve