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`0 Sempio C, Wyniofe £, PaolmerC, Bunik,.,, Henthorn TK, Christia,ns U, Klawitter J. Detection of Cannabinoids by LC-MS-MS and ELISA in Brea,5t.Milk. J Anal
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`Toxicol. 2021 Aug 14;45(n:68&692. doi: 10.1093/ jatjbkaa142. PubMed PMID: 330)2141.
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`0 Hunter SK, Hoffman MC, McCarthy L, D'AlessandroA, Wyrwa A, Noonan K, Christi !Ins U, Nakimuli-Mpun1u E, Zeis.el SH, LawAJ, Freedman R. Black
`American Maternal Prenatal Choline, Offsprin& Gestatior'lal Age at Birth, and Devdopmentat PrtdispoS1tion 10 Mental Illness. Schizophr Butt. 2021 Jul
`S;47(4):896-90S. doi: 10.1093/schbuVsbaal71. PubM~ PMI0:33184653; PubMed Central PMCID: PMC8266582.
`
`0 Frttdman R, Hunter SK, Noonan K, WyrwaA, Christians U, LawAJ, Hoffman MC. l.1atemal Prenatal Depression in Prer.nanci~ With Female and Male
`FetuJes and OevelopmtontalMsociatiOfls With C·rf'<1ctive Prot~n and Cortisol Bi :>I PsyrhiatryCogn Nauosci Ntouroimaeine,. 2021 Mar;613):310·320. doi:
`10.1016fi.bpsc.2020.08.003, Epub 2020Aue 13. PubJ.ted PMIO: 33060035; Pub Med Central PMCIO: PMC7881057.
`
`D Clavijo CF, Oliva AM, Dingmann C, Kaizer A, Christians U, Burger E, Patel V, Kt eek CJ, Vogel SA. Scott BK, Janik OJ, Jameson LC, Ginde AA. Toxicology
`Sc1eening Testing in Patients Underg.oi~C Spine Surgery: A Prospective Obse<vational Pilot Study. Ther Drug Monit. 2021 Feb 1;43(1):136-138. doi:
`10.lMT/nD.0000000000000831. PubMed PMIO: 33181620; PubMed Central PMC 10: PMCTS03444.
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`n Ye H, Minhajuddin M, Krug A, Pei S, Chou CH, Culp-Hill R, Ponder J, DeBloois E, Si:hniedewind 8, Amaya ML, lnguva A,Stevens BM, Pollyea DA, Christians
`
`U, Grimes HL, O'Alessandro A.Jordan CT. The Hepatic Microenvironment Uniquety Protects Let1kemia Cells through Induction of Growth and Sun1ival
`Pathways Mediated by UIPG. Cancer Oiscov. 2021 Feb;l1(2):500·519. doi: 10.1158.'2159·8290.C0·20-0318. Epub 20200d 7, PubMed PMIO: 33028621;
`PubMed Central PMCIO: PMC7858222,
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`D Mizuno T, McPhail BT, Kamatkar S, Wexelblatt S, Ward L. Christians U, Akinbi Hl, \.'inks AA.. PhystOlogic Indirect.Response Modeling to Describe
`Buprenorphine Pha1maoodynamia in Newborns Treated fo1 N~natal Opioid Withdrawal Syndrome. Clin Pharmacokinet. 2021 teb;60!2):249-259. doi:
`10.1007/s40262-020-00939-2. PubMed PMIO; 32939690; PubMed Central PMCIO: PMC8489161.
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`0 Frymoyer A, Van Meurs KP, Drover OR, Klawitter J. Christians U, ChockW. Theophyllinedosin& and pharmacokinet1cs for renal protection in neonates
`with hypoxic-ischemic encephalopathy under&oing therapeutic hypot h~ia. Pe:diatr Res. 2020 Oec;88(6):871·877. doi: 10.1038/s41390·020·01140-S.
`Epub 2020Sep 12. PubM~ PMlD: 32919-393; Pub Med Central PMCID: PMC7704857.
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`0 Cawthon CV, Cooper K, Huett C, LloretA, Villar-Matamoros E, StokesL, Christians U, Schuler M, Yazdani SK. Pre-Clinical tnvestigationof Liquid Padit.».el
`for Local OJ'ug Delivery. A P,lot Swdy. Pharmaceuticals (Basel). 2020 Nov28;13jl:!J. doi: 10.3390/phl3120434. PubMed PMIO: 33260517; PubMed Cenfral
`PMCID: PMC7760562.
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`0 Neety M, Bayard D. van Guilder M. Schumitzky A. In Memotiam; Roger Jtlliffe, MD, FCP, FAAPS. The, Drug Mo nil 2020 Oct 1:42(5):658-659. doi:
`l0.1097/nD.0000000000000798. PubMed PMIO: 32796388.
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`0 Wa11g GS, Bourn!!' DWA, Klawitttr J,SempioC, Chapman K, Knupp K, Wempe MF, Borgelt L, Christians U, Leona,d J, Heard K, Bajaj L. Disposition or oral
`Cannilbidiol-Rich Cannabis Extracts in Chi[dr~ with Epilepsy. Clin Pharmacokind. 2020Aug;59(8):1005-l012. doi; 10.1007/s40262-020-00869-z.. PubMed
`PMI0:32048179.
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`0 Jelliffe R, Christians U. The New Threet-Acting Oral Anticoagolants Need to be Mo 1itoredi. TherOrug Mo nit. 2020 Jun;42(3):357-3S9. doi:
`10.1097/ FT0.0000000000000745. PubMed PMIO: 32427780.
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`0 Goel E, Erwin M, Cawthon CV, Schaff C, l=edor N, Ray1 T, Wilson 0, Christians U, Re-iistec TC, GearyRL, Saul J, Yazdani SK. Pre-Clinic.al Investigation of
`Keratose as an Exc,pient of Drug Coated 8altnons. Molecules. 2020 Mar 31;25(7). doi: 10.3390/ molecules25071596. PubMed PMID: 32244375; Pub Med
`Central PMCIO: PMC7180741.
`
`0 Sempio C, Huestis MA, Mi kulich-Gilbertson SK, Klawitter J , Christians U, Menthom TK. Population pharmacol;Jnetic mod~ing of plasma M
`tetrahydrocannabinol and an active and inactive metabolite following controllec smoked cannabis administration. Br J Clio Pharmacol. 2020
`Mar;86{3):611·619. doi: 10.ll ll/bcp.14170. Epub 2020 Jan 20. PubMed PMIO: 31i'47464; PubMed Central PMCIO: PM008061.S.
`
`0 Davari B, Kotecha N, Clavijo CF. Thomas JJ, Rzasa-Lynn R, Ga link.in Jl. Christians U, Sempio C. A Sensitive LC-MS/MS Assay fot the Quantification of
`Methadone and its Metabolites in Dried Blood Spots: Comparison With P(asma. Ther Drug Monit. 2020 Feb;42(1):118-128. doi:
`10.1097/nD.0000000000000674. PubMed PMID: 31318842.
`
`0 Wan, GS, Bourne OWA, Klawitter J, SempioC, Chapman K, Knupp K. Wempe MF, Borcelt L, Christians U, Heard K, Bajaj L. Disposition of oral delta-9
`tetrahydrocannabinol (THC} in children r~iving cannabis extracts for epilepsy. Clin Toxicol{Phita). 2020Feb;58(2):124•128. doi:
`10.1080/ 15563650.2019.1 616093. Epub 2019 May 21. PubMed PMID: 31111749.
`
`D Sempio C, Lindley E. Klawitter J, ChristiansU, 8owter RP, Adgate JL,Allshousew. Awdziejczyk L. Fischer S, Bainbridee J, Vandyke M, Netsanet R, Crume T,
`KinneyGL. Surfa~ Detection of THCAttributabte to Vaporizer Use in the Indoor Environment. Sci Rep. 2019 Dec 9;9(1):18587. doi: 10.1038/s4159S·Ol9·
`55151·5. PubMed PMIO: 31819131: PubMed Central PMCID: PMC690157S.
`
`D Pedroso AP, Dornellas AP'S, de Souza AP, Pagotto JF, Oyama LM, Nascimento CMC,, Klawitter J, Christians U, Tashima AK, Ribl!'iro EB. A proteomics(cid:173)
`rnetabolomics approach indicates changes in hypothalamic glutamate-GABA metabolism of adult rem ale rats submitted to intrauterine growth
`restriction. Eur J Nutr. 2019 Dec;S8{8):3059-3068.doi: J0.1007/!>00394-018·1851-6. Epub 2018 Nov 7. PubMed PMIO; 30406389; PubMed Central PMCIO:
`PMC6842lll.
`n Weinbere: A.. Huo V. Kacaf'!ll!'k 0. Patel K. Watts OH. Wara 0. Hoffman RM. Klawitter J. Christians U. BriefReoort; Markers ofSoontaneous Preterm Deliverv in
`https://www.ncbi.nlm.nih.gov/myncbi/12extkpe0jlgmflbibliographylpublic/
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`9/7/2022
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`Women Living With HIV: Relatiom;hip W th ProtHse Inhibitors and Vitamin D. J Acquir Immune Defic Syndr. 2019 Oct 1:82(2):181·187. doi:
`10.1097/ QAl.0000000000002111. PubMed PMID: 31513074: PubMe<I Central PMCI>: PMC6760328.
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`0 Klawitter J, Klawitter J, Peoninaton A, Kirkpatrick 8, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin D knockout p1otecu the mouse kidney
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`against cyclosporin A-induced oxidative st.-ess. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683~F694. doi: 10.1152/ ajprenal.00417.2018. Epub 2019
`Jun 12. PubMe<I PMID: 31188033.
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`0 Brunet M. van Gelder T, Ast>er& A, Haufroid V, Hesselink DA, Lan&man L, Lemaitre F, Marquet P, Sq.er C, Shipkova M, Vinks A, Wallemacq P, Wieland E,
`Woillard JB, Barten MJ, Budde K, Colom H, Dieterten MT, Elens L, Johnson-Davis {L, Kunicki PK, MacPhee I, Masuda S, Mathew BS, Milliin 0 , Mizuno T,
`Moes DAR, Monchaud C. Noceti 0, Pawinski T. Picard N, van Schaik R, Somme,.er C, Vet he NT, de Winte r 8, Christians U. Bere:an S. rherapevtic Dn.11:(cid:173)
`Monitoting of Tacrolimf.Js•Personalized Therapy: Se(ond Con$NISU$ ~port. Ther Drug Mon it. 2019 Jf.Jn;41{3):26l·307. doi:
`10.1097/ R0.0000000000000640. Review, PubMed PMI0:31045868.
`
`0 Ketler AC, Klawitter J, Hildreth Kl, Chri5tians U, Putnam K. Kohrt WM. Reusch JES, Moreau KL £1evated plasma homocysteine and cys.teirie are a)soci:Jted
`with endothelial dysfunction across menopausal stages in healthy womera. J ApJ:I Physio l (1985). 2019 Jun 1;126(6):1533-1540. doi:
`10.1152/ japplphysiol.C)0819.2018. Epub 2019 Mar 21. PubMed PMIO; 30896357; PubMed Central PMCIO: PMC6620665.
`
`0 Lichvar A, T~ mblay S, Naik D, Lipscomb J , King E. Vin ks AA, Christians U, Alloway RR. Evaluation of Clioical and Safety Outcomes Following Uncontrolled
`
`TacrolimusConversion ,n Adult Transplant Recipients. Pharmacotherapy. 2019 May;39(5):564-575. doi: 10.1002/ phar.2260. Epub 2019 A+,r 15. PubMed
`PMID: 3 0892704.
`
`0 Frttdman R, Hunter SK, Law AJ, Wagn~ BO, D'Alessandro A, Christians U, Noonan K, Wyrwa A. Hoffman MC. Higher Gestational Choline le~ets 111
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`Maternal Infection Are Protective for Infant Brain Development. J Pediat r. 2019 May;208;198-206.e2. doi: 10.1016/j.jpeds.2018.12.010. Epub 20 19 Mar 14.
`Pub Med PMIO: 30879727; PubMed Central PMCIO: PMC6707520.
`
`0 Van Ho"e JLK, Freehauf CL, Ficicioglu C, Pena LDM, Moreau KL, Henthorn TK, Christians U, J iane: H, Cowan lM, Young SP, Hite M, Friederich MW, Stabler
`
`SP, Sped:or EB, Kronquist KE, ThomasJA. Emmett P, Harrington MJ, Pyte L, Creac::on•Swindell G, Wempe MF, Macl ean KN. 81omarke~ofox1dative stress,
`inflammation, and vascular dysfunction in inherited cystathK>nine B-synthue deficient homocystinuria and the impact of ta urine treatment in a phase
`112 humall clinical trial. J Inherit Metab Dis. 2019 May:42(3):424-437. doi: 10.1002/jimd.12085. Epub 2019 Apr 11. Pu bMed PMID: 30873612.
`
`0 Emoto C, J ohnson TN, Hahn D, Christia ns U, Alloway RR, VinksAA, Fukuda l . A Theoretlcat Physiologically-Based Pharmacokioetic Approach to Ascertain
`COVBri.-~ Explaining the large tnlf'rp.Jtient Vari.Jbility in T.iicro\imus Oispos,t,on CPT Pharmacometrics Syst Pharm1KOI. 2019 l•fay;B(S}:273-284. doi·
`10.I002/ psp4.12392. Epub 2019 Mar 7. PubMed PMI0:30843669; PubMedCent ral PMCID: PMC6539708.
`
`0 Leino AO, Kine EC,Jia ngW, Vin ks AA., Klawitte r J, ChristiansU, Woodle ES, Alloway RR, Rohan JM. Assessment of tacrolimus intrapatient variability in
`stable adherent transplant recipients: Establishing baselin! 11alues. Am J Transphnt. 2019 May, 19(5):1410-1420. d oi: 10.1111/ajt.15199. Epub 2018 Ott
`26. PubMed PMID: 30506623.
`
`0 Golomb BA, Koslik HJ, Christians u, Ritchie J, Wilson P, Elkins N, Klawitter J, KlaY.itte r J , Smith D, Repine JE. De,pre~ prostaglaodins a nd leukotrienes
`in veterans with Gulf War illness. J Environ Sci Health 8. 2019;54(8):623 639. doi: 10.1080/ 03601234.2019.1596001. Epub 2019 Apr 29. PubMcd PMIO:
`31033394.
`
`LJ Shipkova M, Christians U. lmpro11ing Therapeutic Oeosions: PharmacodynamicMonitoringas an Integral Part of Therapeutic Drug Monitoring. Ther Drug
`Monit . 2 019Apr;41{2):l ll-114, doi: 10.1097/RD.0000000000000627. Pf.JbMed PMIO: 30383504; P ubMed Central PMCIO: PMC6481676.
`
`0 Davidson JA, Pfeifer Z. Frank B, Tong S, Urban TT. Wischmeyer PA, Mourani P, Landeck B, Christiam. U, Klawitter J. Metabolomic Fingerprinting of Infants
`Vnderg,oing Cardiopulmonary Bypass; Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J
`Am Heart Assoc. 20 18 Dec 18;7(24);e0107ll. doi: 10.1161/JAHA.118.010711. P ubMed PMIO: 30561257; PubMed Central PMCIO: PMC6405618.
`
`0 Turner E, Erwin M, Atigh M, Christians U, Saul J M, Yazdani SK. In vitro and in 11i110 ~ment of Keratose as a NO¥el Excipieot of Paditaxel Coated
`Balloons. Front Pharma cot. 20 18;9:808. doi: 10.3389/fphar.20 18.00S08. eCollection 2018. PubMed PMID: 30104972; PubMed Central PMCIO: PMC6078047.
`
`0 Jalal 0, Renner B, Laskowski J, stites E, Cooper J, Valente K, You Z, Pe rrenoud l, Le Quintre-c M, Muhamed 1, Christians U, Klawitter J, Lindorf er MA, Taytor
`RP, Holers VM, Thurman JM. Endothelia, Mic10panicle!. and Systemic Complement Activation in Patienu With Chronic Kidney Disease. J Am Heart Assoc.
`1018Jul 13;7(14). doi: 10.1161/JAMA..117.007818. PubMed PMIO: 30006493; PubMed Central PMCIO: PMC6064828.
`
`0 He ischmann S, Ga no LB, Quinn K, Liang LP. Klepacki J, Christians U, Reisdorph N. Patel M. Regulation of kynurenme metabolism by a ketogenk diet. J
`Lipid Res. 2018 J un;S9(6):958-966.doi: 10.l 194/j lr.M079251. Epub 2018 Mar 31. P JbMed PMID: 29605816; PubMed Central PMCIO: PMCS98340S.
`
`0 Turner EA, Atigh MK. Erwin MM, Christians U, Yazdani SK. Coaling and Phannaico.,jnetic Evaluation of Air Spray Coated Drug Coated Balloons. Cardiovasc
`
`Eng Technol. 20 18Jun;9(2):240-250. doi: I0. 1007/sl3239--0I8--0346-1. Epub 2018 Mar 1. PubMed PMID: 29497966; PubMedCentral PMCID: PMCS99<k35.
`
`0 Goot BH, Kaufman J, Pan Z. Bourne DWA, Hickey F, Twite M, Galinkin J, Christians U, ZukJ, da Cruz EM. Morphine Pharmacokinetia in Children With
`Down Syndrome F"ollowlngCardiac surgery. PediatrCrit Care Med. 20 18 May:19(5):459-467. doi: 10.1097/PCC.0000000000001537. PubMed PflUD:
`29547456.
`
`0 Goeu L, Laskowski J, Renner B, Pickering MC, Kulik L. Klawitter J , Stiles E, Christians U, van dervtagJ, Ravichand ran K, Holers VM, Thurman JM.
`Complement ractor H protects mice hom i-schemicacute kidney injury but is not critical fGr controllin&:comptemtnt activation by ctornerular lgM. Eur J
`lmmuno t. 2018 May;48{5):791-802. doi: 10. 1002/eji.20 1747240. Epub2018 Feb22 PubMed PMIO: 29.389016; PubMed Central PMCIO: PMC5992014.
`
`0 Schroeder T, Piantados i CA, Natoli MJ, Autmizguine J , Cohen-Wolkowieczs M, Hamilto n KL, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ, Safety
`
`and Ergogenic Properties of Combined Aminophy'llinrand Ambrisentan in Hyproia. Clin P harmacol Ther. 2018 May;103(5):888•898. doi: 10.1002/cpt.660.
`Epub 20 17 Oct 17. PubMed PMID: 28857147; Pf.JbMed Central PMCID: PMC594752.2.
`
`0 Heisc:hmann S, Christians U. Validation of the cell line L5l80 as a modet fur study of the gastrointestinal toxicity of mycopheno1ic .lcid. Xe nobiotica , 2018
`M,,v;48(5):433-44L. dui; 10.1080/ 00498254.2017.1329567. Epub 2017 May 30. Pul,Me-d PMID: 28489504.
`
`0 Bitter~hl H, Schniedewind B, Christians v, Luppa PB. A ~imple and ~ighly sensitive on·line column extraction liquid d1romatography·tandem ma5$
`
`spectrometry method for the determination of protein•unbound tacrohmus in huma.n plasma sample s. J Chromatogr A. 2018 Apr 27;1547:45·52. do i:
`10.1016/j.chroma.2018.03.010. Epub 2018 Mar 7. PubMed PMIO: 2954-4893.
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`0 Mclay JS, Engelhardt T, Mohammed BS. Cameron G, Cohen MN, Galinkin JL, Chrie;tians U, Avram MJ, Henthorn TK, Osida RM, Hawwa AF, Anderson SJ.
`The pharmacokinetics olinlravonous ketorolac in children aged 2 months to 16 years: A population analys,s. Paedialr Anaesth. 2018 Feb;28(2):80·86. doi:
`10.lll l / pan.13302. Epub 2017 Dec 21. PubMed PMID: 29266539.
`
`0 Kem WR, OlincyA, Johnson L, Harris J, Wagner 00, Buchanan RW. Christians U, F·eedman R. Pharn,acokinetic Limitations on Effects of an Alpha7-
`Nicotinic Receplor Agonist in Schizophrenia: Randomized Triat wlth an £xtended··Release Formulation. NeuropsychopharmacoloCY. 2018 Feb;43 (3):SA3-
`589. doi: 10.1038/ npp.2017.182. Epub 2017 Aug 21. PubMed PMID: 28825423; PubMed Central PMCID: PMC5770760.
`
`0 Lesche 0, SigurdardottirV, Leichtle AB, Nakas CT, Christians U, Englberger L, Fiedler M, Largiader CR, Mohacsl P, Sistonen J. Targeted and global
`pharmacometabolom1c.s in evero[1mus-based 1mmunosuppress1off association of co-medicat.Jon and lysophosphat.Jdylcholines. with dose reqwrement.
`Metabolomic>. 2017 Nov 25:14(1):3. doi: l0.J007/ sll306-017· l294-8. PubMed PM ID: 30830337,
`
`D Alloway RR, VinksAA, Fukuda T. Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J1 Klawitter J, Christians U. Bioequivalence between
`innovator and generic t,crolimus in liver and kidney transplant rodpien
`: A randomized. crossover clinical trial. PloS Med. 2017 Nov;l4 IU ):el002428.
`doi: l0.1371/ journal.pmed.1002428. eCollection 2017 Nov. PubMed PMIO: 29135993; PubMed Central PMCID: PMC5685573.
`
`0 Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U. A High-throughput HPLC-MS/MS Assay for the Detection, Quantification and Simultaneous
`Structural Confirmation of 136 Drugs and Metabo lites on H11man u,ine. Ther Dru@ Mon it. 2017 Oct;39(5):565·574. doi: 10.1097/ FTD.0000000000000429.
`PubMed PM ID: 2B650900.
`
`0 Klawitter J, Sempio C, MOrlein s. Oe Bloois E, Klepacki J, He nth om T, Leehey MA, Hoffenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R,
`Foreman N1 GaUnkin J, Christians U, Klawitter J. An Atmospheric Pressure Chemical Ionization MS/MSAsYy Using Online Extraction for the Analysis of 11
`Cannabinoids and Metabolites in Huma n Plasma and Urine. TherDrug Monit. 20~ 7 Oct;39(5):556-564. doi: 10.1097/ FTD.0000000000000427. PubMed
`PM ID: 28640062; PubMed Central PMCID: PMC5600652.
`
`D Klawitter Jt Pennington A, Klawitter J1 Thurman JMJ Christians U. Mitochondria[ cyc.lophilin D ablation is associated with the activation of Aktjp70S6X
`
`pathway in the mouse kidney. Sci Rep. 2017 Sep 5;7(1):10540. doi: J0.1038/s4!59B-017-10076•9, PubMed PMIO: 28874678; PubMed Centra l PMCIO:
`PMC.5585384.
`
`0 Klawitter J, Hildreth K4 Christians U, Kohrt WMt Moreau Kl. A relative L-arginine deficiency contributes to endothelial dysfunction across the stages of
`
`the menopausal transition. Physiol Rep. 2017 Sep;Sl17). doi: 10.14814/ phy2.134C-9. PubMed PMID: 28904082; PubMed Central PMCID: PMC5599867.
`
`0 Strand TE, Khiabani HZ_. Soito~ Radiloff D, Zhao Y, Hamilton Kl, Christians U, Klawitter J, Noveck RJ, Piantadosi CA, Belt C, Irwin 0, SchroederT. The
`ngvel combina~Qn of theophylline and bambuterol as a potential treatment of h-;poxemia in humans. Can J Physiol Pharrnacol. 2017 Sep;95(9):1009·
`1018. doi: 10.Jl39/cjpp•2016·0635. Epub 2017 Moy 3. PubMed PMID: 28467859.
`
`0 Klawitter J, Seres T, Pennington A, Beatty JT, Klawitter J, Christians U. Ablation ol Cyclophilin D ~esults in an Activat,on of FAK, Aki. and ERK Pathways in
`the Mouse Heart. J Cell Biochem. 2017 Sep;ll8(9):2933· l940. doi: 10.1002/ jcb.25947. Epub 2017 Apr 12. PubMed PMID: 28230282.
`
`D Atigh MK. Turner E.. Christians U, Yazdani SK. The use of an ot:dusion perfusmn G:theter to deliver padit:axel to the arterial wall. Cardiovasc Ther. 2017
`
`Aui:;35(4). doi: 10.llll/ 1755-5922.12269. Pub Med PMID:28445625; PubMed Central PMCID: PMCSSll576.
`
`0 Grenz A, Bauerle JD, Dalton JH, Ridyard D, BadulakA, Tak E, McNamee EN, Clambey E, Moldovan R. Reyes G, Klawitter J, Ambler K, Magee K, Christians U,
`Brodsky KS, Ravid K, Choi OS, Wen J, Lu kashev D, Blackbum MR, Osswald H, Coe IR, Nurnberg B, Haase VH, Xia Y, 5itkovsky M, Eltzschig HK. Equilibrabve
`nucleoside transpo,te< l (ENTI) regulates post.schemic blood now durmg acute kidney injury in mice. J Clin Invest. 2017 Jun 1;127(6):2438, doi:
`10.J172/JCl94890. Epub 2017 Jun l. PubMed PMID: 28569735; PubMed C~ntral PMCID: PMC5451218.
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`0 Oiwan TS, Lichvar AB, Leino AD, Vinlu AA Christians U1 Shields AR, Cardi MA. Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR. Pharmacokinellc and
`pharmacogenelic analysis of immunosupprt5SIVe agents after laparoscopic slee'lle gastrectomy. Clio Transplant. 2017 Jun;31(6). doi: 10.1111/ctr.12975.
`Epub 2017 May 2. PubMed PMI0:28342282.
`
`0 Mizuno T, Fukuda T, Christians U. Perentesis JP, Fouladi M, Vin ks M. Population pha,macokinetics of temsirolimus a11d sirolimus in children with
`recunent wlid tumours: a 1eport from t he Child1en'sOncology Group. Br J Ctin Pharmacol. 2017 May;83l5):1097•1107. doi; 10.1111/ bcp.13181. Epub
`20160ec 20. PubMed PMID: 28000286; PubMed Centro! PM(ID: PMC540198L
`
`0 ~rosoAP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa J C, Bertella RP, Klawitter J, Chr istians U, Tashima AK, Ribeiro EB.
`Intrauterine G,owth Restriction Programs the Hypothalamus of Adult Male Raiu:; Integrated Analysisof Proteomic and Met.ibolomic Data. J Proteome Res.
`2017 Apr7;16(4):1515·1525. doi: 10.1021/ acs.jproteome.6b00923. Epub 2017 Mar 30. PubMed PMIO: 28314371.
`
`0 Heischmann S, Dzieciatkowska M, Hansen K. LeibfriU D, Christians U. The lmmunosuppressant f.1ycophenolicAc.id AlteB Nucleotide and Lipid
`
`M~tabohsm 1n an Intestinal Cell Model. Sci Rep. 2017 Mar22;7:45088. doi: l0.1038/ srep4.5088. PubMed PMID: 28327659; PubMed Central PMCID:
`PMC5361167.
`
`0 Mishra N, Wang P, Goldsmith D, ZhaoX, Xue Y, Christians U. Minassian BA. E\'erolimus does not prevent lafora body fonnat10n m n1urine lafora disease.
`
`Neurol <Genet. 2017 Feb;3(1):e127. doi: 10.1212/ NXG.0000000000000127. eColl ection 2017 Feb. PubMed PMID: 28097224; PobMed Central PMCID:
`PMCS224705.
`
`0 CheckleyW, Deza MP, Klawitter J , Romero KM, Klawitter J, Pollard SL, Wise RA, Christians U, Hansel NN. Identifying biom3rl<ers for asthma diagnosis
`u~ng tarceted metabo\omicsapproachtt RespirMed. 2016 Oec:121:59-66. doi: J0.1016/j.nn~.2016.10.011. Epub 2016 Oct 21. PubMed PMIO: 27886993:
`PubMed Central PMCIO: PMC5516646.
`
`0 Klepacki J, Klawitter J, Klawitter J. K.arimpour•fard A, Thurman J, Ingle G, Pat.el C, Christians U. Amino acids ,n a tara.eted versus a non-taree,ted
`
`melabolomics LC-MS/MS assay. Are the results consistent?. Clin Biochem. 2016 Sep;49(13•14);95S-61. doi: 10.1016/j.dinbiochem.2016.06.002. Epub 2016
`Jun 8. PubMed PMID: 27288551; PubMcd Central PMCIO: PMC6047903.
`
`0 Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christians U, Adams OM. Vin ks AA Ch.ir.acterizfng the- De\lelopmentat lraJectory of Sirolimus Clearance m
`
`Neonates and Infants. CPT Pharmacometrics Syst Pharmarol. 2016 l\ug;S(S):411-7. doi: l0.1002/ psp4,l2096. Epob 2016Aug8. PubMed PMID: 27501453;
`PubMed Central PMCID: PMC4999604.
`
`0 O'Connor S, Zhang Vl, Christians U, Morrison J E Jr. Friesen RH. Remifentanit aind propofol undergo ~paration and layering when mixed in the same
`syringe for totalintra~nou.s anesthem. PaediatrAnaesth. 2016Jul;26{71:703-9. doi: 10.1111/ pan.12917. Epub 2016 May S. PubMed PMID: 27146802.
`
`0 SegerC, Shipkova M, Christians U, BiUaud EM. Wang P. Holt OW, Brunet M, Kunicki PK, Pawiiiski T, Langman U, M a rquet P, OeUerich M, Wii!!land E,
`
`Wall em acq P. Assuring the Proper Analytical Performance of Measurement Proc~ures for lmmunosuppressive Drug Concentrations in Clinical Practice;
`Recomnll!!ndatioos of the International Association of Therapeutic Orug Monitonng and Clinical Toxicology lmmunosoppressive Drue, Scientific
`Commili.ee. Ther Drue Monit. 2016Apr,38(2):170·89. doi: 10.1097/ FT0.0000000000000269. Review. PubMed PMJD: 26982493.
`
`0 Brunet M, Shipkova M, vanGelderT, Wieland E, SommererC, Budde K, Haufroid \', Christians U, LOpez-Hoyos M, Barten MJ, Bergan S, Picard N, Mill.in
`L0~1 0 , Marquet P, Messelink OA, Noceti 0, Pawinski T, Walh!macq P1 Oellerich M. Barcelona ConSl!'nsus on Biomarkf!r•Based lmmunosuppnm:ive- Drugs
`Management in Sot id Organ Transplantation. Ther Drug Mon it. 2016Apr;38 Suppl 1:51·20. doi: J0.1097/ FT0.0000000000000287. Review. PubMed PMIO:
`26977997.
`
`0 Shipkova M, LOpez OM, Picard N, Noceti 0, Sommerer C, Christians U, Wieland E. Malytic.nl Aspects of the Implementation of Siomarkers in Clinic.ll
`Transplant~tion. TherOrvg Mon it. 2016Ap,r,38 Suppl l:S80·92. doi: 10.1097/TTO.l000000000000230. Review. PubMed PMIO: 26418704.
`
`0 Christians U, Klawitter J, Klawitter J. Biomarl<ers in Transplantation-Proteomics and Metabolomic.s. Ther Drug Monit. 2016Apr;38 Suppl 1:S70-4. doi:
`
`J0.1097/ FTD.0000000000000243. Review. PubMed PMID: 26418702; PvbMed Cemral PMCID: PMC4769975.
`
`0 Repine JE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith OM. tnhatztion of two putative Gulf War to:<ins by mice. J Environ Sci Health 8 .
`
`2016;51(6):J66.73. doi: 10.1080/03601234.2016.1142318. Epob 2016Mar 7. PubM!d PMIO: 26950528.
`
`0 Faeste CK, Moen A, Schniedewiod B, Haug Anonsen J, Klawitter J, ChriSlians U. Oevelopment of liquid chromatography-tandem mas.s .spectrometry
`methods for the quantitation of Anisakis simplex J)fOteins 1n fish_ J ChromatocrA. 2016 Feb 5;1432:58·72. doi: 10.1016/j.chroma.2016.01.002. Epub 2016
`Jan 6. PubMed PMID: 26787163.
`
`0 Hadamitzky M, Bosche K, Wirth T, Buck B, Beetz 0, Christians U, Schniedf!wind B. LUckemann L, Gi.inti.irkUn O, Engler H, Schedlowski M. Memory•
`updatineabrogatesextinct,on of learned immunosuppression. Brain Be-ha v lmmun. 2016 Feb;52:40-48. doi: 10.1016/j.bbi.2015.09.009. Epub 20 15 Sep 18.
`PubMed PMIO: 26386321.
`
`0 Cluislians U, Vink:.AA. La11g111an LJ, Cla,ke W, Wallemacq P, v,tn Geldet T, Renje n V, Ma,quel P, M~r EJ. lmp,.K:l ufL.tlJordlo,y P1dl.li\.-n u11
`lnterlaboratory Variability in Therapeutic Drug Monitoring of lmmunosuppressive Drugs. Ther Drug Mon it. 2015Dec;37(6):718-24. doi;
`10.1097/ n0.0000000000000205. PubMed PMID: 26291980.
`
`0 Sho~ati 1, Bodenberger N, Gadpaille H, Schniedewind B, Vinl<sAA,Jiang W, Alloway RR, Christians U. Qllantification ol thelmmunosuppressant
`
`Tacrolimus on Dried Blood Soots Usine: LC-MS/MS. J Vis Exe. 2015 Nov8:rt05\;e52424.doi: 10.3791/52424. PubMed PMI0:26575262: PubMed Central
`https://www.ncbi.nlm.nih.gov/ myncbi/12extkpe0jlgmf/bibliography/public/
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`9!712022
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`Bausch Health Ireland Exhibit 2006, Page 4 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01103
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`1:=J Klawitter J , Mcfann K, Pennington AT, Wang W, Klawitter J , Christians U, Schrier P.W, Gitomer B, Cadnapaphomc.h ai MA. Pravastatin Therapy and
`BiomarkerChang,es in Children and Youna Adultc; W1th Aulosomal Dominant Pol)'C)'stic K.clney Disease. Clin J Am Soc Nephrot 2015 Sep 4;10(9):1534•41.
`doi: 10.2215/CJN.11331114. Epob 2015 Jul 29. PubMNi PMID: 26224879; PubMed Central PMCID: PMC4559520.
`
`0 Bose.he K, Weissenborn K. Christians U, Witzke 0, Engler H, Schedlowski M, Hadamitzky M. Neurobehaviofal consequences of small molecule-dru&
`
`immunosuppressioo, Neuropharmacology. 2015 Sep:96(ptA):83·93.doi: 10.1016/j.neuropharm.2014.12.008. Epub 2014 Dec 19. Revi~-PubMed PMIO:
`25529273.
`
`0 Klawitter J, Nashan 8, Christians U. Everolimus and sirolimus in transplantation-related but different. Upert Opin Drug Saf. 2015 Jul;l4(7):1055•70. doi:
`10.1517/ 14740338.2015.1040388. Epub2015Apr 26. Review. PubMed PMID: 25912929; PubMed Central PMCtD: PMC6053318.
`
`0 Klepacki J, Klawitter J, Klawitter J, Thu1man JM, Christians U. A high-~rform ance liquid chromatography•tande m man speclfometry-based 1argeled
`metabolomics kidney dysfunction marker panel in human u1ine. Clin Chim Acta. 2015Jun 15;446:43-53. doi: 10.1016/ j.cca.2015.04.005. Epub 2015Apr 11.
`Pub Med PMID: 25871999; PubMed Central PMCID; PMC6028022.
`
`0 Schniedewind B, Nieder1echner S. Gallnkin JL, Johnson-Davis KL, Christians U, Meyer EJ. Long-term cross·validalion of everolimus therapeutic d1 ug
`monito,ing assays: the Zortracker study_ Ther Drug Monit. 2015Jtm;37(3):296-303. doi: 10.1097/ FT0.0000000000000191. PubMed PMI0:25970506;
`PubMed Central PMCID: PMC4820066.
`
`0 Emoto C, Fukuda T, Mizuno T, Cox S1 Schniedewind B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vin ks AA. Age-dependent changes in
`sirolimus metabolite formation in patients.with neurofibromatosis type L Ther Drug Monit. 2015 Jun;37(l ):395-9. doi: 10.1097/TTD.000000000000013.0.
`Pub Med PMID: 25162215; NIHMStD:NIHMS'62110S.
`
`0 Klawitter J, Reed-Gitomer BV, Mcfann K, Pennington A, Klawitter- J, Abebe Kl, Klepacki J, Cadnapaphornchai MA~ Brosnahan G, Chonchol M. Christians U,
`Schrier RW. Endotheliatdysfunction and oxidative stress m polycystic kidney<hsHse. AmJ Physiol Renal PhysioL 2014 Dec 1;307(11):Fl198-206. do.i:
`10.l 152/ajprenal.00327.2014. Epub 2014 Sep 18. PubMed PMIO: 25234311; PubMed Central PMCID: PMC425497L
`
`0 Klawitter J, Bek S, Zak.aria M, ZengC, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boemsen KO. F'atty acid desaturation index in human
`~asma: companson of different anatytica! methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct;406(25~:6399-408. doi:
`10.1007/s00216-014-8020•4. Epub 2014 Aug 13. PubMed PMIO: 25U6600.
`
`0 F~e CK. Jonsche r KR, Ooo~rMM, Ecge-Jacobsen W, Moen Ai OaschnerA, Egaas E. Christians U. Ct4lracterisaticn of potential novel aller3ens in ihe fish
`parasitcMiSol<.1$ $imp/ex. Eu PA O~n Proteom. 2014 Sep;4:140-155. doi: 10.1016/j.euprot.2014.06.006. Pub Med PMIO: 27110489; PubMtd Ce<ttr&I PMCIO:
`PMC4840464.
`
`0 Gardner lA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin D, Polly~ OA, Takel:11! N, Christians U, Gore L, DeG,rqori J, Porter CC. Inhibition of caldneurin
`combined with dasatinib has direct and indi,ect anti•leukemiae:ffec.ts against BCR·ABLl( .. l leukemia. Am.J Hema10L 2014 Sep;89(9):896·903. doi:
`10.1002/ajh.23776. Epub 2014 Jun 19. Pub Med PMlD: 24891015; PubMed Central PMCIO: PMC4134764.
`
`0 rernandez-Bustamante A, Klawitter J, Repine J[, ~azio A, Janocha AJ, Shah C, No.ss M, Douglas IS, Tran ZV, [rzurum SC, Christians U, Seres T. [nrlyeffttt
`of tidal vofumeon lung injury biomarkers in su1gical patients with healthy lung.s. Anesthesiology. 2014 Sep;l21(3):469-8L doi:
`10.1097/AlN.0000000000000301. PubMed PMID: 24809976; PubMedCentral PMCID: PMC4165799.
`
`0 Shihab F. Christians U, Smith L, Wellen JR, Kaplan B. Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokinetics, exposure-(cid:173)
`resoonse relationships, and clinical outcomes. Transpl lmmunol 2014 Jun;31(1)~22-32.doi: 10.1016/ j.trim.2014.05.002. Epub 2014 May 24. Review.
`Pub Med PMID: 24861504.
`
`0 Klawitter J, Klawitter J, McFann K, Pennington AT, AbebeKZ, Brosnahan G, Cadnapaphornc hai MA, Chonchol M, GitomerB, Christians U, Schrier RW.
`Bioacti've lipid mediators In polycystic kidney disease. J Lipid Res. 2014Jun;55{6::1139-49. doi: 10.1194/jlr.P042176. Epub2013 Dec 16. PubMed PMIO:
`24343898: PubMed Central PMCID: PMC4031945,
`
`0 Tak E, Ridyard D, Kim JH, Zimmerman M. WernerT, Wane XX, Shabeka U, Seo SW,Christians U, Klawitter J, Moldovan R,Garda G, Levi M, HaaseV, Ravid K,
`Elt:zschig HK, Grenz A. CD73-dependenl e,eneratioo of adenosine and endotheliaCAdora2b signaling attenuate dia betic nephropathy. J Am Soc Nephrot.
`2014 Mar,25(3):547·63. doi: 10.1681/ASN.2012101014. Epub 2013 Nov 21. Pub.Med PMIO: 24262796; PubMed Central PMCIO: PMC3935577.
`
`0 Klawitt,er J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhanres the negative effects of sirollmus and
`tacrolimuson rat kidney cell metabolism. PloSOne. 2014;9(1):e86202. doi: l0.1371/ journal.pone.0086202. eCollection 2014. PubMed PMID: 24497939;
`Pub Med Central PMCID: PMC3907404.
`
`0 Renner B, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christi;,ns U, Thurman JM. Cydosporine induces endothetialceU release of
`complement•activatingmiaoparticles. J Am Soc Nephrol. 2013 Nov;24(ll);l849.fi2. doi: 10.1681/ASN.2012111064. Epub20130ct 3. PubMe-d PMIO:
`24092930; PubMed Central PMCID: PMC3810078.
`
`0 fn,,ssettol, Flore n L, Sarin 8, Browne M, Wolfe A, Rotand M, Stock P, Carlson L, Christians U, Benet L Chan1es i11 r=learana, volvmtand bioavailabilityof
`immunosupp1essa11U when civt.n w,th HA.ART in HIV·l inftctied hvet and kidney transplant recipie11t£. 8iopharm O(ug Dispos. 2013 Nov,34(8):442•51. doi:
`10.1002/ bdd.1860. Epob 2013 Sep 12. PubMed PMIO: 24030926; PubMed Central PMCIO: PMC4016225.
`
`0 Pian P, labovitz E. Hoffman K, Clavijo CF, R.Za$o\ Lynn R, Galinkin JL, Vinks A.A, Malik P, Christie,ns U. Q1,.1i!lntification oftht.S-lipoxygenase inhibitor zi1e\Jton
`in human plasma using high performance liquid chromatography-lBodem mus spectrometry. J Chromalogr BAnalyt Tec.hnol Biomed Ufe Sci. 2013 Oct
`15;937:19'-83. doi: 10.1016/j.jchromb.2013.08.014. Epub 2013Aug 28. PubMed PMIO: 240295S3.
`
`0 Fernandez-Bustamante A, Klawitter J, Wilson P, Elkins NO,Agazio A, Shibata T9 Uchida K, Christians V, Repine J E. Early increase in alveotarmacrophage
`prostai:{andm l!>d·PGJ2 precedes neutrophil recruitment into lungs of cytokine- nsufflated rats. Inflam