~ National Library of Medicine
`~ Na!101UJI Cento, lot B«>tecflnoJogy lnformaf,on
`
`My Bibliography uwe_chrisUans·,a;b1;ogr.,phy
`
`• MyNCBI
`
`0 Manas:• cit ations ...,.
`
`L)
`
`1/19
`
`Log'"
`
`Page [D of7
`
`..
`
`► ►►
`
`303 citations, Sort by newest to oldest v
`
`0 SempioC, Wymore E, Palmer(, Bunik W, Henthorn TK, Christians u, Klawitter J. Detection or Cann3bin0tds by LC-MS-MS and ELISA in Breast Milk. J Anal
`Toxicol. 2021 Aug 14;45(7):686-692. doi; 10.1093/jatfbkaal42. PubMed PMID: 330t)2141.
`
`0 Hunter SK, Hoffman MC, McCarthy L, O'AlessandroA, Wyrwa A. Noonan K, Christi:1ns U. Nakimuli•Mpungu E, Zeisel SH, Law AJ, Freedman R. Black
`American Maternal Prenatal Choline, Offspring Ge5tation~I Age at Birth, and Developmental Predisposition to Mental Illness. Schizophr Bull. 2021 Jul
`8;47(4):896-905. doi: 10.1093/S(hbuVsbaal7 l. PubM~ PMID:33184653; PubMedCentr31 PMCID: Pt.tC8266582.
`
`0 Frffdmi!in R. Hunter SK, Noonan K, Wyrwa A, Christians U, law AJ, Hoffman MC. llatemat Prenatal Depression in Pregnancies With Female and Male
`F~u5esand Developmental Msociatior.s With C•rtactive Prot~n and Cortisol Si:>! Psychiatry Cogn Neurosci Neuroimaging,. 2021 Mar;6(3):310·320. doi:
`10.1016/ j.bpsc.2020.08.003. Epub2020Aue 13. Pubt.ted PMID: 33060035; PubMed Central PMCID: PMC7881057.
`
`0 Clavijo CF, Oliva AM, Dingmann C, Kaizer A, Christians U, Burger£, Patel V, Kleck CJ, Vogel SA, Scott BK, Janik OJ,Jameson LC, Ginde AA. Toxicology
`Screening Testing in Patients UndergoirigSpineSurgery:A Prospective Observational Pilot Study. Ther Drug Monit. 2021 Feb 1;43(1):136·138. doi:
`10.1097/FT0.0000000000000837. PubMed PMID: 33181620; PubMed Central PMCIO: PMC7803444.
`
`0 Ye H. Minhajuddin M, Krug A, Pei S, Chou CH~ Culp•Hill R, Ponder J, De Bloois E, S<hniedewind 8,Amaya ML, lnguva A, Stevens BM, Pollyea DA, Christians
`U, Grimes Hl, O'Alessandro A. Jordan CT. The Hepatic Microenvironment Uniquely Protects Leukemia Cells through Induction of Growth and Survival
`Pathways Mediated by UPG. Cancer Oiscov. 2021 Feb;ll(2):500-519. doi: 10.1158J'21.S9-8290.CD-20-0318. Epub 2020 Oct 7. PubMed Pt-.tlD: 33028621;
`Pub Med Ceoual PMCID: PMC78S8222,
`
`0 Mizuno T, Mc.Phail BT, Kamatkar S, We.xelblatt S, Ward L, Christians U, Akinbi HT, \.'inks AA.. Physiologic Indirect Response Modeling to Describe
`Buprenorphine Pha1macodynamics in Newborns Treated fo1 Neonalal Opioid Withdrawal Syndrome. Clin Pharmacokinel 2021 Feb;60(2):249·2S9. doi:
`10.1007/s40262-020-00939-2. PubMed PMID: 32939690; PubMed Central PMCID: PMC8489161.
`
`0 Frymoyer A, Van Meurs KP, Drover OR, Klawitter J, Christians U, Chock VY. Theophytline dosing and phannacokinet1cs for renal protection in neonates
`Wlth hypo:-:ic-ischemic encephalopathy undercoing therapeutic hypothermia. Pediatr Res. 2020 Dec:;88(6):871•877. doi: 10.1038/s41390-020·01140-8.
`Epub 2020 Sep 12. PubMed PMID: 32919-393; Pub Med Central PMCIO: PMC7704857.
`
`0 cawthon CV, Cooper K, Huett C, LloretA, Villar-Matamoros E, Stokes L. Christians U, Schuler M, Yazdani SK. Pre-Clinical Investigation of Ltquid Paclita,rel
`for local Drug Delivery: A.Pilot Stody. Pharmaceuticals (Basel). 2020 Nov28;13(12). doi: 10.3390/phl3120434. PubMed PMIO: 33260517; PubMed Central
`PMCIO: PMC7760562.
`
`0 Ne-ely M, Bayard 0, van Guilder M, Schumitzky A. In Memoriam; Roger JeUiffe. MO. FCP. fAAPS. Ther OrugMonit. 2020 Oct 1;42(5):658--659. doi:
`I0.1097/FT0.0000000000000798. PubMe<I PMIO: 32796388.
`
`0 Wat1g GS, Bou me DWA, Klawitter J, Sempio C, Chapman K, Knupp K. Wempe MF, Borgelt L, Christians U, Leonard J, Heard K, Bajaj L. DispMition of 0ml
`Cannabidiol-Ric.h Cannabis Extracts in Children with Epilepsy. Clin Pharmacokinet. 2020 Aug;59(8):1005-1012. doi: 10.1007/s40262-020-00869-z. PubMed
`PMID: 3204al79.
`
`0 Jelliffe R, Christians U. The New Di~ct-Acting Oral Anticoagulants Need to be Mo1itoredl. Ther Drug Mo nit. 2020 Jun;42(3):357-359. doi:
`10.1097/ FT0.0000000000000745. PubMed PMID: 32427780.
`
`0 Goel E, Erwin M, Cawthon CV, Schaff C, Fedor N, Rayl T, Wilson 0, Christii!in.s U, Register TC, Geary RL, Saul J, Yazdani SK. Pre-Clinical Investigation of
`Keratoseasan Excipient or 0mg Coate<! Balloons. Molecules. 2020 Mar 31;25(7). doi: 10.3390/molecules25071596. PubMed PMlD: 32244375; Pub Med
`Central PMCID: PMC7180741.
`
`0 Sempio C. Huestis MA. Mikulich-Gilbertson S~ Klawitter J, Christians U, Henthorn TK. Population pharmacokinetic modeling of plasma 69-
`tetrahydrocannabinol and an active and inactive metabolite following controUec smoked cannabis administration. Br J Clin Pharmacol. 2020
`Mar;86(3):611·619. doi: 10.1111/ bcp.14170. Epub 2020 Jan 20. PubMed PMIO: 31147464; PubMed Central PMCID: PMC7080615.
`
`0 Oa\i'ilri B, Kotecha N~ Clavijo CF, Thomas JJ, Rzasa-Lynn R, Galinkin Jl, Christians U, Sempio C. A Sensitive LC-MS/MS Assay for the Quantification of
`Methadone and its Metabolites in Oried Blood Spots: Comparison With Plasma. Ther- Drug Mon it. 2020 Feb;42(1):118-128. doi:
`I0.1097/FT0.0000000000000674. PubMe<I Pl\410: 31318842.
`
`0 Wane GS, Bou me DWA, Klawitter J, Sempio C, Chapman K, Knupp K. Wempe MF, Bo,e,elt l, Christians U, Heard K, Bajaj l. Disposition of oral delta-9
`tetrahydrocannabinol (THC) in children receivin& cannabisextr.!lct:s for epilepsy. Clin Toxicol (Philal. 2020 Feb;58(2}:124•128- doi:
`I0.1080/IS563650.2019.1616093. Epub 201~ May 21. PubMed PMIO: 31111749.
`
`0 Sempio C, Lindley E, Klawitter J, Christians U, Bowler RP, Adgate Jl, Allshouse w.Awdziejczyk L, Fischer s, Bainbridge J, Vandyke M, Netsanet R, Crome T,
`Kinn,ey GL. Surface Detection of THC Attributable to Vaporizer Use in the Indoor Environment. Sci Rep. 2019 Dec 9;9(1):18587. doi: 10.1038/s41598·019·
`551S 1-5. PubMed Pf.110: 31819131: PubMed Central PMCID: PMC6901S7S.
`
`0 ~draw AP, Ooirn~lh,s APS, de Suuu AP, P-dg,ullo JF, Oyama LM, Nascim~11lo CMO, KJawitte, J, Clui~'"tians U, Ta~hima AK. Ribei,o EB. A p,uteumtQo(cid:173)
`metabolomics app,oach indicates changes i-n hypothalamic glutamate-GABA metabolism of adult female rats submitted to ir'ttrauterine growth
`restriction, Eur J Nutr. 2019 Dec;58(8):3059-3068.doi: 10.1007/.s00394-0IS-18Sl-6. Epub 2018Nov7. PubMed PMIO: 30406389; PubMed Central PMCIO:
`PMC6842332.
`
`n Weinbere A. Huo Y. Kacanek 0. Patel K. Watts OH. Wara 0. Hoffman RM. Klawitter J. Christians U. Brief Reoort: Markers of Soontaneous Preterm Oetiverv in
`https://www. ncbi. nl m. nih. gov/myncbi/12extkpeOjlg mf/bibliography/pub lie/
`
`917/2022
`
`Bausch Health Ireland Exhibit 2006, Page 1 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01102
`
`

`

`2/19
`
`Wom en Living With HIV: Relation~hip W,th Protea~ lnhibito~ and Vitamin O.J Acquit Immune Oefic Syndr. 2019 Od 1;82(2):181-187. doi:
`10.1097/ QAl.0000000000002111. PubMed PMID: 31513074; PubMed Central PMCll: PMC6760328.
`
`0 Klawitter J, Klawitter J, Pennington A, Kirkpatrick 8, Roda G, Kotecha NC, Thurman JM, Christians U. Cyclophilin O k nockout protects the mouse kidney
`against cyclosporin A-induced oxidative stress. Am J Physiol Renal Physiol. 2019 Sep 1;317(3):F683•F694. doi: 10.1152/ajprenal.00417.2018. Epub 2019
`Jun 12. PubMed PMIO: 31188033.
`
`0 Brunet M, van GelderT,AsbergA, HaufroidV. Hesselink DA, Lane.man L, Lemaitre F, Marquet P1 5e&erC, Shipkova M, VinksA, Wallemacq P, Wieland E,
`WoiUard JB, Barten MJ, Budde K, Colom H, Dieterten MT, Elens L, Johnson-Davis <L, Kunicki PK, MacPhee I. Masuda S, Mathew BS, Milliin 0, Mizuno T,
`Moes DAR, Monchaud C, Noceti 0, Pawinski T. Picard N, van Schaik R. SommererC, Vethe NT, de Winter B. Christians U, Berg.an S. Therapeutic Drug
`Mof'titoring of Tacrolimus-Personalized Thtorapy. Second Consensus ReporL Ther Drug Monit. 2019Jun;41(3):261-307. doi:
`10.1097/FT0.0000000000000640. Review. PubMed PMIO: 31045868.
`
`0 Keller AC, Klawitter J, Hildreth Kl, Christians. U, Putnam K. Kohrt WM, Reusch JE6, Moreau KL Elevated plasma homocysteine and cysteine .11e associ:Jted
`with endothelial dysfunction across menopausal stages in heallhy women. J Api::I Ph ysiol {1985). 2019 Jun 1;126(6):1533--1540. doi:
`10.1152/ japplphysiol.00819.2018. Epub 2019 Mar 21. Pub Med PMID: 30896357; PubMed Central PMCIO: PMC6620665.
`
`0 Lich11ar A, Tremblay S, Naik 0, Lipscomb J, Kiing E. Vinks AA, Christians U, Alloway RR. Evalua,tion of Clinical iiind Safety Outcomes Following Uncontrolled
`Tacrolimus Convt'1'l1on m Adult Transplant Recipit'nts. Pharmacotherapy. 2019 May;39(5):564-575. doi: 10.1002/ phar.2260. Epub 2019 Apr 15. Pub Med
`PMID: 30892704.
`
`0 Frttdman R, Hunter SK, Law AJ, Wagner 80, O'Alessandro A, Christians U, Noonan K. Wyrwa A, Hoffman MC. High.er Gestational Cholin~ Le\lels m
`Maternal Infectio n Are Protective for Infant Brain Development. J Pediatr. 2019 May,208:198-206.e2. doi: 10.1016/j.jpeds.2018.12.010. Epub 2019 Mar 14.
`PubMed PMID: 30879727; PubMed Central PMCID: PMC6707520.
`
`0 Van Hove J LK, Freehauf CL, Ficicioglu C, Pena LOM, Moreau KL, Henthorn TK. Christi.ans U, Jiang H, Cowan TM, Young SP, Hite M, Friederich MW, Stabler
`SP, Spector EB, Kronquist KE, Thomas JA.. Emmett P, Harrington MJ, Pyle l, Creac'on-Swindell G, Wempe MF, Maclean KN. 81omarke~ of oxidative stress,
`inflammation, and vascular dysfunction in inherited cystathionine J3-$yntha!iedeficieot homocystinuria and the impactof taurine treatmt'nt in a phase
`l/2 human clinical ltial. J Inherit Metab Dis. 2019 May:42(3):424-437. doi: 10.lOOZ,jimd.12085. Epub 2019 Apr 11. PubMed PMID: 30873512.
`
`0 Emoto C, Johnson TN, Hahn 0, Christians U, Alloway RR, Vinks M, Fukuda T.A Tt-teoretlcal Physiologically-Based Pharmacokinetic Approach to Ascertain
`Covariates Explaining the large lnterpatient Variability in Tacrolimus Oispos1t1on, CPT Pharmacometrics Syst Pharmacol. 2019 May,8(5):273-284. doi:
`10.1002/psp4.12392. Epub 2019 Mar 7. PubMed PMIO: 30843669; PubMed Central PMCID: PMC6539708.
`
`0 Leino AO, King EC, Jiang W, Vin ks AA. Klawitter J, Christians U, Woodle ES,Allowi!l'j RR, Rohan JM. Asse$smentof tacrolimus intrapatiiMt variability in
`stable adhe,ent cra,nsplant recipients: Establishing baseline values.. Am J Transpl:1nt. 2019 May,19(5}:1410-1420. doi: 10.1111/ajt.15199. Epub 2018 De<:
`26. ?ubMed PMIO: 30506623.
`
`0 Golomb BA, Koslik HJ, Christians U, Ritchie J, Wilson P, Elkins N, Klawine, J, Kla~itter J, Smith 0, Repine JE. Depress~ prostaglandins and leukotrienes
`in VC!:lcrans with Gulf War ill11~s. J Environ Sci Health B. 2019i54(8):623 639. doi: 10. 1080/03601234.2019.1596001. Epub 2019 Apr 29. PubMcd PMID:
`31033394.
`
`LJ Shipkova M, Christians U. Improving Therapeutic Oeosions: Phatmacodynamic Nonitaringas an Integral Part.of therapeutic Drug Monitoring. Ther Drug
`Monit. 2019 Apr;41(2): l 11~114. doi: 10.1097/Fl'D.0000000000000627, PubMed PMIO: 30883504; PubMed Central PMCIO: PMC6481676.
`
`0 Davidson JA., Pfeifer Z. Frank B, Tong S, llrba n TT, Wischmeyer PA, Mourani P, LaOOeck 8, Christians U1 J<lawitter J. Metabolomic Fingerprinting of1nfants
`Unde rgoing Cardiopulmonary Bypass: Changes in Metabolic Pathways and Association With Mortality and Cardiac Intensive Care Unit Length of Stay. J
`Am Heart.Assoc. 2018 Dec I8:7(l 4):e010711. doi: 10.ll61/JAHA.118.010711. Pub"'ed PMID: 30561257; PubMed Central PMCID: PMC6405618.
`
`0 Turner E, Erwin M. Atigh M, Christians U, Saul JM, Yazdani SK. In vitlO and i11 vivo Ass~ment or Ketatose as a NO\lel Exc.ipient of Paclitaxel Coated
`Balloons.. Front Pharmacol. 2018;9:SOS. doi: 10.3389/ fphar.2018.00808. eCollection 2018. PubMed PMIO: 30104972; PubMed Central PMCID: PMC6078047.
`
`0 Jalal 0, Renner B, Laskowski J, Stites E, Cooper J, Valente K. You Z, Perrenoud l, l e Quintre-c M, Mohamed I, Christians U, Klawitter J, Undorfer MA, Taylor
`RP, Hole rs VM, Thurman JM. Endothelia'. Mic:roparticl~ and Systemic Complement Act,vatron in Patients With Chronic Kidney Disease. J Am Heart Ass.cc.
`1018. Jul 13;7(14). doi: 10.1161/JAHA.117.007818. PubMed PMID: 30006493; PubMed Central PMCIO: PMC6064828.
`
`0 Heischmann S, Gano LB, Quinn K, Liang LP, Klepacki J, Christians U, Reisdorph N Patel M. Retulation of kynurenine metabolism by a ketogenic d1eL J
`lipid Res. 2018 Jun;59(6):958-966. doi: 10.1194/jlr.M07925L Epub 2018 Mar 31. P .JbMed PMID: 29605816; PubMed Central PMCIO: PMC5983405.
`
`0 Tum er EA, Atigh MK. Erwin MM,Christians u. Yazdani SK. Coating and Pharmaco.,jnetic E\laluation of Air Spray Coated Drug Coated Balloons, Cardio\lasc
`Eng lechnol. 2018Jun;9{2):240-2SO. doi: 10.1007/s13239-018-0346-l. Epub 2018 Mal" 1. Pub Med PMIO: 29497966; PubMed Central PMCIO: PMCS99043S.
`
`0 Goot BH, Kaufman J, Pan Z. Bourne DWA, Hickey F, Twite M. Galin kin J, Christians U. ZukJ, da Cl'\.IZ EM. Morphine Pharrnacokinetics in Children With
`Down Syndrome Following Cardiac surgery. PediatrCrit Care Med. 2018 May,19(5):459-467. doi: 10.1097/ PCC.0000000000001537. PubMed PMIO:
`29547456.
`
`0 Goetz L, Laskowski J, Renn" B, Pickering MC, J<ulik L, Klaw;tte,r J, Stites E, Christians V, van der VlagJ, Ravichandran K, Hoters VM, Thurman JM.
`Complement factor H protects mice from ischemic acute kidney injury but is not critical for conlroHlnccomplement activation by glomerular lgM, Eur J
`tmmunol, 2018 May;48(S):791·802. doi: 10.1002/eji.201747240. Epub2018 Feb22 PlJbMed PMIO: 29389016; PubMed Central PMCIO: PMC5992014.
`
`0 Schroeder T, Piantadosf CA, Natoli MJ, AutmizguineJ, Cohen•Wolkowiecz.s M, Hamilton Kl, Bell C, Klawitter J, Christians U, Irwin DC, Noveck RJ. Safety
`and Ergogenic Properties of Combined AminophyHine and Ambrisent:an in Hypro·ia. CHn Pharmacol Ther. 2018 May:103(5):888-898. doi: 10.1002/cpt.860.
`Epub 2017 Oct 17. PubMed PMIO: 28857147; PubMed Central PMCIO: PMC5947522.
`
`0 Heischmann S, Christians U. Validation of the cell line LS180 as a model for study of the gastrointestinal toxicity of mycophena1k acid. Xenobiotica, 2018
`May;48(5};433-44l. dui; 10.1080/ 00498254.2017.13295ti7. Eµub 2017 May 30. Pul.Jt.te,d PMIO: 28489504.
`
`[l Bittersohl H, Schniedewind B, Ch,istians U, Luppa PB. A ~imple and highly sensifive on-line column extraction liquid chromatography-tandem mass
`sp«1rometry method for the determination of protein•u!lbound tacrolimus ,,, human plasma samples. J Ch,omatog.r A. 201 8Apr 27;1547:45-52. doi:
`10.1016/j.chroma.2018.03.010. Epub 2018 Mar 7. PubMed PMIO: 295-14893.
`
`https://www. ncbi. nl m. nih. gov/myncbi/12extkpeOjlg mf/bibliography/pub lie/
`
`917/2022
`
`Bausch Health Ireland Exhibit 2006, Page 2 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01102
`
`

`

`3/19
`
`n Mclay JS, Engelhardt T, Mohammed BS. Cam,ron G, Coh•n MN, Galinkin JL, Chr,stians U. Avram MJ, Henthorn TK, Dsida RM, Hawwa AF,Anderson BJ.
`
`Th• pharmacokinetics ofinlravonous kelorolac in cl1ildrenaged 2 months to 16 ,·ears: A population analysis. PaediatrAnaesth. 2018 Feb;28(2):80·86. doi:
`10.1111 / Jl"n . 1330,. Fpub ,017 Dec '1 . PubMed PMID: ,9,66.'i._lq_
`
`0 Ktm WR, Olincy A, Johnson L, Harris J, Wagnor BD, Buchanan RW, Christians U, F·.,dman R. Pha11nacokinetic Limitations on Effocts ol an Alpha7-
`
`Nicotinic Receptor /\gonist in Schizophrenia. Randomized Trial with an Extended Release Formulation. Neuropsychopharrnacology. 2018 Feb;43l3):S83-
`589. doi: !0.1038/ npp.2017.182. Epub20l7 Aug 21. PubMed PMID: 28825423; PubMed Central PMCID: PMC5770760.
`
`0 Lesche 01 SigurdardottirV, Leichtle AB, Nakas CT, Christians U, Englberger L, Fied ler M, LargiaderCR. Mohacsi P, Sistonen J. Targeted and global
`pharm ac.ometabolom,c.s in e"Jerohmus-based ImmunosuppressIon: assodat100 of co•medicat1on and lysophosphat1d)'lcholines with dose reqwremenL
`Metabolomics, 2017 Nov 25;14(1):3. doi: I 0.1007/ sll306-017· 1294·B. PubMed PM ID: 30830337,
`
`0 Alloway RR, VioksAA, Fukuda T. Mizuno T, King EC, Zou Y, Jiang W, Woodle ES, Tremblay S, Klawitter J, Klawitter J, Christians U. Bioequivalence between
`innovator and gen,ric tacrolimus in live.rand kidney t,ansplant recipients: A rar,domized, crossover clinical trial. PLoS Med. 2017 Nov;l4 (ll):el002428.
`doi: l0,1371/ journal,pmed.1002428 • .Colltction 2017 Nov. PubMed PMID: 29135993; PubMed Central PMCID: PMCS685573,
`
`0 Klepacki J, Davari B, Boulet M, Lizarraga R, Christians U. A High·throughput HPLC•MS/MS Assay for ihe Detection, Quantification and Simultan•ous
`
`Structural Confirrnabon of 136 Drugs and Metabolites in Human Utine. Ther Drug Mon it. 2017 Oct;39(5):565•574. doi: I0.1097/ FTD.000000000000042g,
`Pub Mod PMIO: 28650900.
`
`0 Klawitter J, Sempio C, Morlein S, De Bloois E, Klepacki J, Henthorn T, Leehey MA, HoHenberg EJ, Knupp K, Wang GS, Hopfer C, Kinney G, Bowler R,
`Foreman N, Galinkin J, Christians U, Klawitter J.An ,\tmospheric Pressure Chemkal Ionization MS/MS Assay Using Online Extraction rorthe Analysis of 11
`Cannabiooids and Metabolites in Human Plasma and Urine. Ther Drug Monit. 20: 7 Oct;39(5) :556-564. doi: 10.I097/ FTD.0000000000000427. PubMed
`PM ID: 28640062; PubMed Central PMCID: PMC5600652.
`
`D Klawitter J, Pennington A, Klawitter J! Thurman JM, Christians U. Mitochondria[ cyc.lophilin D ablation i.sassociated with the activation of Akt/p70S6X
`
`pathway in the mouse kidney. Sci Rep, 2017 Sep 5;7(1):10540. doi: I0.1038/ s4!598-017-I0076•9. PubMed PMID: 28874678; PubMed Central PMCID:
`PMC5585384.
`
`0 Klawitter J, Hi ldreth K~ Christians U, Kohrt WM, Moreau Kl. A relative L-arginineo:teficiency contributes to endothelial dysfunction across the stages of
`
`the menopausal transition, Physiol Rep, 2017 Sep;5(17). doi: 10.I4814/ phy2,134C9, PubMed PMIO: 28904082; PubMed Central PMCID: PMC5599867.
`
`0 Strand TE, Khiabani HZ, Boico A, Radiloff D. Zhao V, Hamilton Kl, Christians U, Klawitter J, Novec.k RJ, Piantadosi CA, Bell C, Irwin 0, Schroeder T. The
`
`novel combinacion of theophylline and bambuterol asa potential treatment of hypoxemia in humans. Can J Physiol Pharmacol. 2017 Sep;95(9):1009·
`1018, doi: 10.1139/ cjpp-2016-0635. Epub 2017 May 3. PubMed PMID: 28467859,
`
`D Klawitter J~ Seres T, Penning.ton A, Beatty JT, Klawitter J, Christians U. Ablation ol Cydophilin D Results in an Activation of FAK,Akt. and ERK ?athway~ in
`
`t he Mouse Heart. J Cell Biochem. 2017 Sep;l1B(9):2933-2940. doi: 10.1002/jcb.25947. Epub 2017 Apr 12. PubMed PMID: 28230282.
`
`D Atigh MK. Turner E., Christians Ut Yazdani SK. The use of an o«.lusmn perfusion c.atheter to deliver pacl1taxel to the arterial wall. Cardiovasc Ther. 2017
`
`Aug;35(4). doi: 10.llll/ 1755·5922.l2269. PubMed PMID:28445625; PubMed Central PMCID: PMC5511576.
`
`0 Grenz A, Bauerle JD, Dalton JH, Ridyard D, BadulakA, Tak E, McNamee EN, Clambey E, Moldovan R. ReyesG, Klawitter J, Ambler K, Magee K, Christians U,
`Brodsky KS, Ravid K, Choi DS, Wen J, Lukashev D, Blackbum MR, Osswald H, Coe IR, Nurnberg B, HaaseVH, Xia Y, Sitkovsky M, Eltzschig HK. Equilibrab.o
`nudeoside transpo,te< I (EN•ll regulates postischemic blood Row during acute kidney injury in mice. J Clin Invest. 2017 Jun 1;127(6):2438, doi:
`10.ll72/JCl94890. Epub 2017 Jun l. PubMed PMlD: 28569735; PubMed Centra l PMCID: PMC5451218.
`
`Page 0 of7
`
`' ...
`
`FOlLOWNCBI
`
`https://www.ncbi.nl m.nih. gov/myncbi/12extkpeOjlgmf/bibliographylpublic/
`
`9f7/2022
`
`Bausch Health Ireland Exhibit 2006, Page 3 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01102
`
`

`

`~ National Library of Medicine
`~ Na!101UJI Cento, lot B«>tecflnoJogy lnformaf,on
`
`My Bibliography uwe_chrisUans·,a;b1;ogr.,phy
`
`• MyNCBI
`
`0
`
`4/19
`
`Log'"
`
`Page 0 of7 H
`
`4
`
`► ►►
`
`303 citations, Sort by nl!'West to oldest v
`
`0 Oiw;in lS, Lic:hvar AB, Leino AO, Vinks M. Christians U, Shields AR, Cardi MA. Fukuda T, Mizuno T, Kaiser T, Woodle ES, Alloway RR. Pharmacokinet1c and
`ph,nmacogenetic analysis of immunosuppres.sive agenu a~er laparoscopic slee'f'e gastrectomy. Clin Transplant. 2017 Jun:31(6). doi: 10.llll/ctr.12975.
`Epub 2017 May 2. Pub Med PMIO: 28342282.
`
`0 Mizuno T, Fukuda T, Christians U, Perentesis JP, Fouladi M, Viriks AA.. Population pha,macokinetits of temsirolimus and sirol~mus in children with
`recur're-nt solid tumours: a rt'port from the Ctiildr~n·soncology Group. B1· J Clin Pharmacot. 2017 May;83(5):1097-1107. doi: 10.1111/bcp.13181. Epub
`2016-0ec 20. PubMed PMIO: 28000286; PubMed Central PMCIO: PMC.5401981.
`
`0 ~roso AP, Souza AP, Dornellas AP, Oyama LM, Nascimento CM, Santos GM, Rosa JC, Bertolla RP,. Klawitter J, Christians U, Tashima AK, Ribeiro EB.
`Intrauterine Growth Restriction Programs th-e Hypothalamus of Adult Male Ra~ Integrated Analysis of Proteomic and Metabolomic Data. J Proteome Res.
`2017 Apr7;16(4):15l5·lS25. doi: 10.1021/acs.jproteome.6b00923. Epub 2017 Mar30 .. PubMed PMID: 2831437 1.
`
`0 1-ieischmann S, Dzieciatkowska M, Hansen K. Leibfritz 0, Christians U. The lmmunosuppre.ssant MycophenolicAod Alters Nucleotide and lipid
`Metobohsm 1n an lntestmal Cell Model. Sci R,ep. 2017 Mar 22;7:45088. doi: 10.1038/srep45088. PubMed PMIO: 28327659; PubMed Central PMOD:
`PMC5361167.
`
`0 Mishra N, Wang P, Goldsmith D, ZhaoX, Xue Y, Christians U, Minassian BA. Everolimus does not prevent La fora body formation 1n murine Lafora disease.
`NeurolGenet. 20!7 Feb;3(1):e127. doi: 10.1212/ NXG.000000000000()127. eCollection 2017 Feb. PubMed PMID: 28097224; Pub Med Central PMCID:
`PMC5224705.
`
`0 ChKkley W, Oeza MP, Klawitter J, Romero KM, Klawitter J, Pollard SL. Wise RA, Christians U, Hansei NN. Identifying biomari<ers for asthma diagnosis
`usit1g targeted metabolomics approaches. R,espirMed. 2016 Oec;12l:59·66. doi: 10.1016/ j.rmed.2016.10.011. Epub 2016 Oct 21. PubMed PMIO: 27888993:
`PubMed Central PMCID: PMC5516646.
`
`0 Klepacki J, Klawitter J, Klawitter J. Karimpour•Fard A. Thurman J, Ingle G, Patel C, Christians U. Amino acids in a targeted ve-rsus a non-tarcet!d
`metabolomics LC-MS/MS as.say. Are the resu lts consistent?. Clin Blochem. 2016S!P;49(13-14):955-61. doi: 10.1016/j.clinbiochem.2016.06.002. Epub 2016
`Jun 8. PubMed PMIO: 27288551; PubMcd Cetitral PMCIO: PMC6047903.
`
`0 Emoto C, Fukuda T, Mizuno T, Schniedewind B, Christia.mo U, Adams OM. Vinks M Characterizing the Developmental Trajectory of Sirolimus Clearance m
`Neonates and Infants.. CPT Pharmacometrics Syst Pharmacol. 2016 Aug;S(S):411-7. doi; 10.1002/psp4.l2096. Epub 2016 Aug, 8. PubMed Pt.110: 27501453;
`PubMed Central PMCID: PMC4999604.
`
`0 O'Co-nnor S. Zhang Vl, Christians U. Morrison JE Jr, Friesen RH. Remifenta11il and propofol undergo separation and layering when mixed in the same
`syringe for total intravenous anesthesta. Pae--diatr Anaesth. 2016 Jul;26(71:703·9. doi: 10.llll/ pan.12917. Epub 2016 May S. PubMed PMIO: 27146802.
`
`0 Sege-r C, Shipkova M, Christians U, BiUaud EM, Wang P, Holt OW, Brunet M, Kunicki PK, Pawif'lski T, Langman LI, Marquet P, Oellerich M, Wieland E,
`Wallemacq P. Assuring the Proper Analytic:al Perlormance of Measurement Procedures for 1mmur1osuppressive Drug Concentrations in Oinical Practice:
`RK0mmendatio1\s of !he lntemalionatAssodation of Therapeutic Orug Monitoring .and Clinical Toxicology lmmunosuppres~ve Orug Scientific
`Committee. Ther Drue Monit. 2016 Apr,38(2):170•89. doi: 10.1097/ FTD.0000000000000269. Review. PubMed PMIO: 26982493.
`
`0 Bn.tnet M, Shipkova M. vanGelderT, Wieland E, SommererC, Budde K, Haufroid\', Christians U, L6pez·Hoyos M, Barten MJ, Bergan S, Picard N, Mittan
`L6f)f!z 0 , Marquet P, Hesselink DA, Noceti 0, Pawinski T, Wallemacq P, Oellerich M. Barcelona Consensus on Biomariu~r-Base,d lmmunosuppre.ssive Drue,s
`Management in Solid Organ Transplantation. Ther Drug Monit. 2016Apr;38 Suppl l:S1·20. doi: 10.1097/FT0.0000000000000287. Review. PubMed PMIO:
`2697'7997.
`
`0 Shipl<ova M, L6pez OM, Picard N, Noceti 0, Sommerer C, Christians U, Wieland E. Analytical Aspects of the Implementation of Biomarke:rs in Clinical
`Transplantation. Ther Drug Monit. 2016Apr;38 Suppl 1:580·92. doi: 10.1097/ FT0.:>000000000000230. Review. PubMed PMIO:: 26415704.
`
`0 Christians U, Klawitter J, Klawitter J. Biomarkers in Trans.plantation-Proteomic.s and Metabolomics. Ther Drug Monit. 2016 Apr;38 Suppl 1:S70•4. doi:
`I0.1097/FTD.0000000000000243. Rev;ew. PubMed PMID: 26418702; PubMed Censral PMCID: PMC4769975.
`
`0 RepineJE, Wilson P, Elkins N, Klawitter J, Christians U, Peters B, Smith OM. lnhalction of two putative Gulf War toxins by mice. J Environ Sci Health 8.
`201&:51(6):366·73. do;: !0.1080/03601234.2016.ll42318. Epub 2016Mor 7. PubM,d PMIO: 26950528.
`
`0 Fzeste CK, Moen A, Schniedewind 8, Haue,Anonsen J, t<lawitter J, Christians U. Development of liquid chromatography-tandem mass spectrometry
`methods for the quantitation of Anisakis simplex PfOtelns in fish.J Chromatogr A. 2016 Feb 5;1432:58•72. doi: 10.1016/j.chroma.2016.01.002. Epub 2016
`Jan 6. PubMed PMIO: 26787163.
`
`0 Hadamitzky M, Bosche K. Wirth T, Bock B, Beetz 0, Christians U, Sc.hniedewind B, LUckemann L, Gi.inturki.in 0, Engler H, Schedlowski M. Memory(cid:173)
`updating abrogates extinction of learned immunosuppression. Brain Behav lmmun. 2016 Feb;52:40·48. doi: 10.1016/j.bbi.2015.09.009. Epub 2015 Sep 18.
`PubMed PMID:26386321.
`
`0 Clui:.U.,ns U, Vi11k5AA. l.mg111<n1 LJ, Chuke W , Wallen1acq P, V"dll Gelder T, Re11je11 V, Ma1quel P, Meye1 EJ. h11p.td ur LiJlJorctlu1y P1ddk"e:S u11
`lnterlaboratory Variability in Therapeutic Drug Monitoring of tmmunosuppressive Orugs.. Ther Drug Mon it. 2015 Oec;37(6):718-24. doi:
`10.1097/ FT0.0000000000000205. PubMed Pl\110: 26291980.
`
`0 Shokati T, Bod~nberger N, Gadpaille H, Schniedewind B, Vinks AA,Jiang W, Alloway RR, Christians U. Quantification of the lmmunosupp,es!.ant
`Tacmlimus on Dried Blood Soots Usine: LC-MS/MS. J Vis Exo. 2015 Nov 8:flOS):e52424. doi: 10.3791/52424. PubMed PMIO: 26575262: PubMed Centt'21l
`https://www. ncbi. nl m. nih. gov/myncbi/12extkpeOjlg mf/bibliography/pub lie/
`
`917/2022
`
`Bausch Health Ireland Exhibit 2006, Page 4 of 19
`Mylan v. Bausch Health Ireland - IPR2022-01102
`
`

`

`5/19
`
`PMCID: PMC4692696.
`
`0 Kb,wittPr J , Mri:-,.nn K, Pfonninetnn AT, Wane W, KlawittPr J , (hri!tti:oin< ll, SrhriPr P.W, GitomPr R, ('.-,dn-'!J1;iphnrnd1:ti MA. Pr:11,,;v,t.atin Thl"mpy ;mrl
`Biomarker Changes in Children and Youne;Adult~ W1th Autosomal Dominant Pol,cystic Kidney Disease. Clin J Am Soc Nephrol. 2015 Sep 4;10(9):1534•41.
`do;: 10.2215/CJN.11331114. EPtJb2015 Jul 29. PubMod PMIO: 262241179; PubMod Central PMCIO: PMC4559520.
`
`0 BOsc.heK, Weissenborn K, Christians U, Witzke 0, Engler H, Schedlowski M, Hadamitzky M. Neurobehavioral consequences of small molecule-druc
`immunosuppression. Neuropharmac.oloo. 201SSep:96(ptA):83-93.doi: 10.1016/j.neuropharm.2014.12.008. Epub 2014 Dec 19. Review. PubMed PMID:
`25529273.
`
`0 Klawitter J, Nashan 8, Christians V. Eve.rolimus and sirolimus in tram:plantation·relmted but different. Expert Opin Drug Saf. 2015 Jul;14{7):1055-70. doi:
`10.!517/ 14740338.2015.!040388. Epub2015Apr26. Rev;ew. PubMed PMID:25912929: PubMod Central PMCIO: PMC6053318.
`
`0 Klepacki J, Klawitter J, Klawitte r J, Thurman JM, Christian5 U. A hi&h-perfonmm~ liquid chromatography·btnde:m mass spectrometry•based targeted
`metabolomits kidney dysfunction markerpanE-1 in human uiine. Clin Chim Acta. 2015 Jun 15;446:43-53. doi: 10.1016/ j.ca.2015.04.005. Epub 2015 Apr 11.
`PubMed PMID: 25871999; PubMed Central PMCID: PMC6028022.
`
`0 Schniedewind 8, Niederlechne:r S, Galinkin J L, Johnson•Oavis KL. Christians U, Meyer EJ. Long-term cross-validation of e:verolimus therapeutic drug
`monito,ingassays: the Zortracker study. The, Drug Monit. 2015Jun;37{3):296-303. doi: 10.1097/nD.0000000000000191. PubMed PMIO; 25970506;
`PubMed Central PMCID: PMC4820066.
`
`0 Emoto C, Fukuda T, Mizuno T, CoxS, Schniedewlnd B, Christians U, Widemann BC, Fisher MJ, Weiss B, Perentesis J, Vin ks AA. Age-dependent changes in
`sirolimus metabolite ronnation ,n patients with neurofibromatosis type 1. Ther Drug Monit. 2015 Jun:37(3):395-9. doi: 10.1097/ FT0.000000000000013.0.
`Pub Med PMID: 25162215; NIHMSID:NIHMS621105.
`
`0 Klawitter J, Reed-Gitomer BY, McFann K. Pennington A, Klawitter J, Abebe KZ, Klepacki J, Cadnapaphornchai MA, Brosnahan G, Chonchol M. Christians U,
`Schrier RW. l:ndothelial dysfunction and oxidatwe stress m polycystic kidneydiseasf!. Am J Physiol Renal PhysioL 2014 Dec l:307(11):Fll98·206. doi:
`10.1152/ajprenal.00327 .2014. Epub 2014 Sep 18. PubMed PMID: 25234311; PubMed Central PMCIO: PMC4254971.
`
`0 Klawitter J, Bek S, Zakaria M, Zeng C, Hornberger A, Gilbert R, Shokati T, Klawitter J, Christians U, Boemsen KO. Fatty acid desaturation index i n human
`plasma: com~nson of different analytical methodologies for the evaluation of diet effects. Anal Bioanal Chem. 2014 Oct;406{25):6399-408. doi:
`10.1007/s00216-014·8020-4. Epub 2014 Aug 13. PubMed PMIO: 25116600.
`
`0 F~ CK, Jonscher KR, Dooper MM, Egge-Jaicobsen W, Moen A, Daschner A, Egaas E, Christians V, Charac;terisation of potential no\lel atle,gens in the fish
`p<irasiteAm.solos simplex. Eu PA Open Proteom. 2014 Sep;4:140•15S. doi: 10.1016/j.eu prot.2014.06.006. PubMed PMIO: 27110489; PubMed Central PMCtO:
`PMC4840464.
`
`0 Gardner LA, Klawitter J, Gregory MA, Zaberezhnyy V, Baturin 0, Pollyea OA, Takebe N, ChristiansU, Gore L, OeGregori J, Porter CC. lnhibit,ioJ1 of caldneurin
`combined with dasatinib has direct and inditect anti-leukemia effects against BCR-ABLl(+) leukemia. Am J He matol. 2014 Sep;89(9):896-903. doi:
`10,1002/ajh,23776, Epub2014 Jun 19, PubMcd PMID: 241191015; PubMe<I Central PMCIO: PMC4134764.
`
`0 Femandez-Bustamante A, Klawitter J, Repine J[, Ag;azio A, Janocha AJ, Shah C, II.loss M, Dou,tas IS, Tran ZV, [rzurum SC, Christians U, Seres T. [erty effttt.
`of tidal volume on lung injury biomarkers in su,gical patients with healthy lungs. Anesthesiology. 2014 Sep;121(3):469·81. doi:
`10.1097/ALN.0000000000000301. Pubt.ted PMIO: 24809976; PubMed Central PMCIO: PMC4165799.
`
`0 Shihab F, Christians U, Smith L, Wellen J ~ Kaplan 8. Focus on mTOR inhibitors and tacrolimus in renal transplantation: pharmacokineti"cs. exposure-(cid:173)
`response relationships, and clinical outcomes. Transp\ lmmunoL 2014 Jun;31(1)~22-32. doi: 10.1016/ j.trim.2014.05.002. Epub 2014 May 24. Review.
`PubM~ PMIO: 24861504.
`
`0 Klawitter J. Klawitter J, Mcfann K, Pennington AT, Abebe Kl, Brosnahan G, Cadnapaphomc hai MA, Chonchol M, Gitomer B, Chtistians U1 Schtie<RW.
`Bioactrve lipid mediators in polycystic kidney disease. J Lipid Res. 2014 Jun;55(6::t139-49. doi: 10.l 194/jlr.P042176. Epub 2(113 Dec 16. PubMed PMIO:
`24343898; PubMed Central PMCIO: PMC4031945.
`
`0 Tak E, Ridyard D, Kim JH, Zimmerman M, WernerT, Wang XX, Shabeka U, Seo SW,Christfans U, Klawitter J, Moldovan R, Garcia G, Levi M, Haase V, Ravid K,
`Eltz.schig HK. Grenz A.. CD73·dependent generation of adenosine and endothelialAdora2b signaling attenuate diabetic neph,opathy. J Am Soc: Nephrol.
`2014 Mar:25(3):547-63. doi: 10.1681/ASl'J.2012101014. Epub 2013 Nov 21. PubMed PMIO: 24262796; PubMed Central PMCIO: PMC393S577.
`
`0 Klawitter J, Klawitter J, Schmitz V, Shokati T, Epshtein E, Thurman JM, Christians U. Mycophenolate mofetil enhances the negative effects of sirollmus and
`tacrohmuson rat kidney cell metabolism. PloS One. 2014;9(1):e86202. doi: l0.1371/ joumal.pone.0086202. eCollection 2014. PubMed PMIO: 24497939;
`PubMed Central PMCIO: PMC3907404.
`
`0 Rennier 8, Klawitter J, Goldberg R, McCullough JW, Ferreira VP, Cooper JE, Christfans U, Thurman JM. Cyclosporine induces endothelial cetl release of
`complement•activating mic.toparticles. J Am Soc: Nephrol. 2013 Nov;24(1U:1849-62 •. doi: 10.1681/ASN.2012111064. Epub 20 13 Oct 3. PubMed PMIO:
`24092930; PubMed Central PMCIO: PMC3810078.
`
`0 Frasse:tto L, Floren L Sarin B, Browne M, Wolfe A, R~and M, Stock P, Carlson l , Chris'tians U, Benet L Chan&es in clearana, 110h..1meand bioavailabilityof
`immuuosuppress.ants when &iven 'N1lh HAART in HIV·l infected liver and kidney l tansptanl recipients. Biopharm Drvg Oispos. 2013 Nov;34(8J;442•51. doi:
`10.1002/ bdd.1860. Epub 2013 Sep 12. PubMed PMIO: 24030928; PubMed Central PMCIO: PMC4018225.
`
`0 Pian P, Labovitz E, Hoffman K, Clavijo CF, Rzasa Lynn R, Galin kin J l, Vinks AA, Malik P, Christians U. Quantification of the 5-lipoxygenase: inhibitor zile:uton
`in human plasma using high perfonnance liquid chromatoJ:r.iphy·t811dem mass spectrometry. J Chromatogr BAnalyt Technol Biomed Life Sc;i. 2013 Oct
`15;937:79-83. doi: I0.1016/ j.jchromb.2013.0lt014. Epub 2013Aug 28. PubMed PMIO: 24029553.
`
`0 Femandez-Bustamante A, Klawitter J, Wilson P, Elkins ND, Agazio A, Shibata T, Uchida K, Christians U, Repine JE. Early 1nc~se in alveolar macrophage
`prostag1andin 15d·PGJ2 precedes neut,ophil recruitment into lungs of cytokine- nsufftated rats. Inflammation. 2013 Oct;36(5):1030-40. doi:
`10.1007/ sl0753-013-9635· x.. PulJM~ PMID: 23616184.
`
`0 Taylor RR. Hoffman Kl, Sc.hniedewind B, Clavijo C, Galin kin JL, Christians U. Comparison or the quantification of acetaminoph