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`Q:
`
`1
`
`Exhibit 2041
`Slayback v. Sumitomo
`IPR2020-01053
`
`

`

`frightening enough to have caused them to break down and act in a bizarre manner. Patients experiencing these
`
`symptoms for the first time may be able to hide them for a while, but this becomes more difficult as the psychotic
`
`process sets in and their outer actions begin to reflect their inner perceptual distortions.
`
`Schizophrenia is not generally recognized to be occurring until after truly odd and irrational behaviors are
`
`expressed during what is called a "psychotic break", or "first break". Though the schizophrenic person's internal
`
`experience during psychosis may be terrifying, it is the outward symptoms characteristic of the psychotic break
`
`that are noticed by family members and others: changes in self-care, sleeping or eating patterns, weakness, lack of
`
`energy, headaches, changes in school or work performance, strange sensations, and confused, strange, or bizarre
`
`thinking that gets expressed as bizarre behavior. Keep in mind, however, that the actual break with reality may
`
`occur prior to the time that people around the psychotic person have noticed that something is seriously wrong.
`
`The schizophrenic symptom-rich period following the psychotic break is sometimes called the 'active-phase' or,
`
`alternatively a period of 'florid' psychosis. The term florid means "flowering" and the term is a metaphorical usage
`
`denoting that the psychosis is the end result or goal of the schizophrenic illness, just as the bloom is the end result
`
`or goal of a flowering plant.
`
`When schizophrenia does occur, it often becomes a chronic condition that continues throughout the remainder of
`
`life with varying degrees of intensity. The "first break" may be the last break if the case of schizophrenia is mild and
`
`if treatment is administered promptly and continued as directed by a psychiatrist (a medical doctor specializing in
`
`mental health issues). More typically, however, the first break leads to a pattern of varying periods of relative
`
`recovery (which are termed 'residual' phases) and periods of new active-phase psychosis that continue throughout
`
`the remainder of patients' lives.
`
`I
`
`Disability and Schizophrenia (https://www.mentalhelp.net/schizophrenia/and-disability/)
`
`Dual Diagnosis: Chronic Mental Illness and Addiction (https://www.mentalhelp.net/schizophrenia/dual-diagnosis-
`
`chronic-mental-illness-and-addiction/)
`
`Evidence That Schizophrenia is a Brain Disease (https://www.mentalhelp.net/schizophrenia/evidence-its-a-brain-
`
`disease/)
`
`Historical and Contemporary Understandings of Schizophrenia
`
`(https://www.mentalhelp.net/schizophrenia/understanding/)
`
`Information on Schizophrenia and Support Services (https://www.mentalhelp.net/schizophrenia/support/)
`
`Institutionalization and Deinstitutionalization with Schizophrenia
`
`(https://www.mentalhelp.net/schizophrenia/institutionalization-and-deinstitutionalization/)
`
`Positive Symptoms of Schizophrenia: The Disorganized Dimension and Negative Symptoms
`
`(https://www.mentalhelp.net/schizophrenia/disorganized-dimension/)
`
`Schizophrenia Related Pages
`
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