`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3415 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3415 of 7113
`
`
`
`
`
`
`
`
`
`
`
`SSOAgDUESIQ“SoLIsNpuUypeoTwsyDpue‘olea8ed“BY(S007)OTE-GLE“6“SOOTJuaUdopPAdg2YCISOY
`
`
`
`
`
`
`
`
`
`IL6Lased“S'7(S861)PLOL-L96L‘LOL“Ureyury‘Pf‘UonoRoy
`
`
`
`
`
`
`
`
`
`
`
`TLoINIseULVYgJOFsssoolgUOnVOUNMONVY“Te19URSNUITNTYy
`
`
`
`
`
`‘BIOfp“SuxnyJuel|joshojeuyajozeey“ye1ssnurpyoy
`
`
`
`
`
`‘LObSortsosed3-4(6S6L)LOFIPor‘Pe“AUSIMIeYD
`
`©c
`
`
`
`
`
`[solo]Trsao]‘tz-si
`
`
`
` jonpoidy
`
`
`TLIZ-OL-0WeedLLL.
`TemueyjopunodwosveSursudmos
`
`
`
`THIETS66,9a10)Ley)MTEL)AipreATy
`
`
`
`
`
`[rZ00]‘(so0zANN)OTIS910/S007‘ONBOnRATTQN,1WAIeg“§'
`
`
`
`
`
`
`
`
`
`
`
`&RIAJUSBYJOS[NIUVWJOAON®JOSISOIPUAS[BIO],“]e16Jjosuy
`
`
`
`SUPTAA-SUOUILUT-GHomspeAATEpNSAaTOUTeIUYat}JOUOTRIIPOW!
`
`
`
`ueys-UosnegsLeuIUIASYIeNssjoureNUyouy,“ye19ALeLOPy
`
`
`
`
`
`
`
`
`
`segsadedByW861)LO9S-PEss'Zs“ASHUIaY
`
`
`
`
`
`payIpop]&BIAIOWONUEUTSEpure¢1Z°R9--AKOOG-¢|aingAjpeoiide)JosiseqadAs‘sulpueyseisorgauepuizueg“ye18Uy]
`
`
`
`‘SIQ[‘UoTsesySIA-SUOTULIA-yuOmspeAyJENSTOLUeIUT
`
`
`
`TOG]oBed“(4punoduros)768]
`
`
`
`
`O]dINOYfSATIOSTASOINIGJRIsUSTypukJBAONvBseUOTIRZTTOAY
`ased‘oessqeBq(pO0T)7061-068!‘(9)69“AnsiUusy“FQ
`
`
`
`
`
`‘yf‘(ynsoidary)¢[-EFJosisoyyUAS‘sulposovjoigsuapulpizusg
`
`
`
`
`
`
`
`
`presUldsayas“FOOTSY]HRSo[qeidoooeATTRoTINeavULIEYdBJO
`
`Suistidurosssaoord&Aqparedasdstianpord
`
`Wao"
`
`Nef
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3416 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3416 of 7113
`
`
`
`
`
`
`
`
`CNYSHIIONN‘AULSHNATHDOINVDUOTVLNAIYadxg“Ppoonuey
`
`
`
`
`
`
`
`
`
`SSLERl-1SLsesedByC1461)881-81‘SHNOINKDL,
`
`
`
`PELLTIsoved3g(6861)PET-LTZL“HOMLIVAd
`
`
`
`
`
`
`
`STE-ZZESANNOANO;)INVOUOAOAMISINTHOOMNALS“PUA
`
`
`
`
`
`‘ezeo8edFy(F661)
`
`
`
`
`
`sofedBy(0007P?pxZ)SSIES]“AWLSIAAHDOINVDYO‘souos
`
`
`
`
`
`“SSTHEST
`
`
`
`
`
`GNVSCOHLAY“SISHHINAGJINVOUOGAINVACY‘UOsuoyy
`
`
`
`
`
`
`
`
`
`
`
`SY]LO]AVIPSWLDUT[LIOAL@JOVNOYONSYIASjason“feany
`
`
`
`
`
`
`
`
`
`SSO01JNURBIQ‘sonoiqnuywouadeaqiey[AUISPL-B]JOsisouqUAs
`
`
`
`
`
`
`
`
`
`TERaoEd‘S|(900T)TES-67S“OLJourdojsaag%Yseasay
`
`
`
`
`
`
`
`
`
`“SSLsoded3°57(6661)SSL-SSZ“AMISINGHODINVOIG‘T2105
`
`
`
`
`
`
`
`
`
`“SAQOHNHOS£,AYOLVHOUYTTOINVOYDOLNOLLONGOALNE“RIAR
`
`‘Spoased37(661)Bro
`
`LSL
`
`
`
`WH)surzesodid(jAdosdyAusyd-¢)-p-[jAyle[Axoyjou(pAusydosonyy
`
`
`
`
`
`-p)siq]-Z|-,JosonSoyeuyourppedig‘ouezursig
`
`
`
`
`
`‘gaopodsuesysuiumedogou)Jo]spursirryAiulgeyYstEy(6G6Z1
`
`
`
`
`
`
`
`Jo|deseyUlppAovlsolgpuestuoseluyJo\dasayTysuexoquoIy,
`
`
`
`
`
`
`
`“6LTS‘Bb“WBUDpopf“‘SaAMRALECTULINJOZUagjoUOTIENTEAg
`
`
`
`pue‘digsuonejoyAAyoy-sinjoruys“sisoyjuds‘Istuosy
`
`
`
`
`
`
`
`JO}suBinjozusgSumoy-enqdJowaurdopaac‘ouyg
`
`
`
`
`
`
`
`‘PLebILESabed84(C007)PLEPLER“SpWeYyD“pan
`
`
`
`
`
`
`
`Lpunoduios“pEzs-6Lz¢sesed3°q(S007)pots
`
`
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3417 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3417 of 7113
`
`
`
`
`
`
`
`
`
`
`
`aingAqeaydgjoSISOTIUAS“SUIPUBSEsoldSsuopulzuag“TewurT;HO=HOSPHOSELISUBSTTA“£100[AtUloteda
`
`
`‘SIQ‘¢VONIRsySHEA-SUOLUy-qVOspeAAJensfoure.yOySAISHPUT'SOFaepesoues!dBRIOUIStyaJsyz(D)
` ‘LOv1-SOrl
`O]WNOYsanyoopasolojselouerpuePAaoneBseuUOTEZISAD
`
`
`osed“joelsqe8(O07)ZOGI-O68IT“(9)69“AusHUayQBIC
`
`
`
`
`uvyy-uosnegSLOUUIASYIepnsajouwRUyoy“ye7Ayeucyy
`
`
`'¢“‘Qransoidaiy)s[-E9JosiseqyadSs‘suypoAovlolgsuepulpizueg
`
`
`
`
`~jAqouourany-¢-(+)-($)JosIsayUdgaAToopasonueugwy“Ying|
`
`
`
`
`
`1L6L980d“3'Y(S861)PLEL-LOGL“LOL“WldYD“ary‘f‘UOTORaY
`
`SLM-SUOWLU-YHOMSPEAAJE[MOSJOWIBIVULSY]JOUOTEIPO
`saInaiy“(SOOTHOW)OFS$800/SO0T‘ONUOTROTIQh,JuoIe'§7/
`
`
`
`
`
`
`
`
`‘BIOfUOTBUAROIPAYIUJOWUIASYBIAPloyaOURXOUTAUIaUI-¢
`
`
`
`BRIAJURYIOOINQUY[AGH]BJOSISSYIUAS[BIOL“YeJOOsu
`
`
`[rzoo]“(seozAIN£)OLIS9L0/S007ONUONBoTgngWeed$4
`poyIpoy&BIAJolWUGUeUTSlypue¢,Z°RO--AKOA-<S|‘.a**c!*"inexnoa.neoe
`
`
`‘BIO‘f‘SUIXIYJOeLYJOssojeuyspozenay,“je1asnuRPDy
`
`soded“Sq(6561)LOPL-POrl‘vz“AusraryD
`
`
`
`V~TulDigJoyaouasgjoyYsoq]SUBIOISAUESOOTPULL
`
`
`‘PE-LELssesed3g(CO0T)PELS-LELS“39“WAYS
`
`s6ssaed3'q(1861)L09S-pasezs“ANsitusYgD
`
`‘ofe4‘ya@qqda.én
`
`
`
`auyi“Axoyye(£9-14)Jo“Taye(69-19)Ayiouosonyuy‘olonyy
`
`
`
`Ayuo‘Axouaydpoinysqns10AxousydSiyyyeu]OSTAdIdot)TTA
`
`
`ounqm‘Axoyye(9-19)Jo“pAxe(es-19)TAqISuIOJONTLT“O.1ONyy
`
`
`
`{AWCURY)JOgIOdeSTUONINSGNSOA)URYIOlJouJey)OSTAOId
`
`
`
`“O10U9SO1Y}JOOMY‘QUOAgpoIntasgnsAypeuondoAxouaud(7)
`
`
`
`‘O1O]YO9914]JOOM]‘alloAqBulayewWoreay]UGpain|ysqns
`
`
`
`
`Ayjeuonde[AdosdjAusydao‘[AyjoyAuoud“[Azuagq“[Auoyd(¢)
`
`
`JOsuies34}Sulag‘AqjotuJoussoIpAyosePypurefyuayAr
`
`
`
`
`
`‘TOKLased‘(7punodwos)76g
`
`“\uetayyIp
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3418 of 7113
`
`feeeeebconebJew
`
`TZLTTOL0FWed{[],|yokeFunepAypeueWLMFPaIngonyjsJopunoduoovBuyeyAyye(e}
`
`
`
`
`
`‘{soto]Ltsoo]‘zz-st(a
`
`
`
`(uotsuadsnssurpezueg4Ulyporusd)
`
`TUeynqueyJopunodiwosevsonpodof
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3418 of 7113
`
`
`
`
`
`
`
`
`[EsqnsIVULeY_JOJSSAI01gUOWBOYLINGMON)Y“yejoURS
`
`
`
`
`
`
`
`‘JAyyeue]1ayI]O91BSjLANTySqnsom]UR]d40UNJOUTeg)OsiAaud
`
`OY}JOJQJVIPOWUJUT[VIOAIG&JOsinayoneyAGAon“yenA
`
`
`
`
`
`
`“Axqe(S9-T)€OF|AqpoimmnsansAyeuoydejAyyRopOAa(+9
`
`
`
`
`
`SD)(1)StoyasoyuoyeyQCDO™CEHHOCH)(9)
`
`
`
`
`
`SSIso1LJMULSIO“SoMIsNpUyT[RaTUOYDpue‘eleased‘S'q(CONT)OTE-GLE“6“SOOTWetudopeAaT®YOIBAsOY
`
`
`
`
`
`
`
`
`
`Jo“HS(HO)HDCHO)(9)
`
`
`
`“HOHO"HOHO'SP(P)
`
`
`
`
`
`
`
`SSDIDURTIQ‘ssNoIgnuywuousdeqiv’y[AUIS-BLJOsIsOmIUAS
`
`
`
`
`
`
`
`
`
`‘Tegased“Ay(9007)TE8-678“O]JusWdoporag YyomRosay
`
`
`
`
`
`
`
`SZE-TZE.“SANAOdNODSINVOUQJOAWLSINTHIOAUALS“PHA
`
`
`
`
`
`‘TeeaBed3(P66T)
`
`ONVSHTdfNRAULSTAAHDDINVOUOTVLINAWEATTXeL“‘POOMILEY
`
`
`
`
`94)YUMJUIIE]IpJosuesay)Buisg‘oJony40“JAq}oul‘ussoIpAg
`
`PELLT1SodedBY(6861)PEI-LZI“AOLLOVUd
`
`
`$1JOYJOoy)WaYMAOO1ONYslPypurefyJosuoTey]Oslaoid
`
`
`
`‘OOM,JOWaROIpAY
`
`ONYSGOHLAIN“‘SISHHINASDINVOUOGAONVACY‘uosuo
`
`
`
`
`
`
`
`STSpy“TAUIOUEIOVABOIPAYSTyyUPTO“AyIO-'SyOIONEGAO
`
`SSLEST-18lsadedSq(L61)881-841‘SANOINHOAL
`
`
`
`
`
`B10“fydiryeoPye:fyst7pure‘dnoisSunsejoidyoyosyeue
`
`
`
`-010HO-Gye?10YEGHO-»stYAS[AujawAxoyAueryi-¢(¢)
`
`
`
`
`
`queFypuefyulareym“fy-giry-opuery-gify-oJosinaxdul
`
`
`
`
`
` “SSIES|sosedSq(00GZ‘pepao)SS[-€S]“AWLSTINGHDDINVOUG“souos
`
`
`
`
`
`
`
`
`
`WA)surzersdid(AdoidAuayd-¢)-p-[TAugja[Axoyjou(;Ausydoronyy
`
`
`
`
`
`-p)siq|-z|-[Josonsoyeuysuipuiadig‘ourzurasig
`
`
`
`‘groodedBy(S661)SFO
`
`
`
`“SENOINHIEAT,AVOLVAGEYTDINVIUOOLNOLLONGOULNY“BRIARg
`
`
`
`
`
`LSE
`
`
`
`
`
`“oolSasedFg(6661)SSL-SSL‘AULSTINTHDDINVOUG‘Telos
`
`
`
`
`
`
`
`
`
`‘¢Jopodsuely,surmedogay)JoyspuesryAuuyyysl(60671
`
`
`
`
`
`
`
`‘pLeb-LLepsaded“Sy(ZOO)PLEP-LLEP“SpWRU)“Paw
`
`
`
`
`
`
`
`
`
`JojdacoyUpAoesoLgpurswosewyloWessyTysveNOqUIOSY
`
`
`
`
`
`
`
`JO}suzmjozusgSuljoy-jendjoluswudojsacq‘ouyg
`
`
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3419 of 7113
`
`
`
`Jo‘Axoyja(yAuaiyl-¢€)-7(€)
`
`
`
`“yAtpo(pAung-Z)-Z(Z)
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3419 of 7113
`
`
`
`
`
`
`
`“6LTS‘Qh“Way‘Pel‘f“‘SOATIBALIGUBIRJOZUS|JOUDOWRABA
`
`
`
`puv‘diysuoneayATATAY-oINIONNS“siseqAS‘smosy
`
`
`
`
`
`
`
`
`
`-jAtjowourtuy-¢-(+)-(§)JosisomJUASBATIOOTaSONUeUUYng
`
`
`
`BIOfGonVussoipAPOuWUWASYBIAployalouexayjAyjoUl-¢
`
`
`
`
`
`
`
`‘PE-LELSsabed“By(COOT)PELE-LELS“89“UIEYD
`
`
`
`WOTQUITDIG10JsouarajayYsaqySUBTIISASOOTOULL
`
`
`
`
`
`
`
`
`
`(ucisuadsnsaunpezusg9UT][IOTUSd)
`
`
`
`TULC-OLOSWeedLIL,
`
`
`
`
`
`‘aseq&YqiM(2)daysJoTFTBynuoyJojonpoiday}SurzAyjorpay(q)
`
`
`
`sandy(ooocjUdw)OFSS800/S007ONUONeOTGNgJuaTed“$f
`
`
`
`.
`
`
`
`
`
`
`
`‘{Tsoto]Tisoo]“7-s1
`
`
`
`[pzoo]“(S607AMDOLIS9LO/SOOT‘ONBONRoQNgWak,‘SFY
`
`
`
`
`
`
`
`uryy-uosnegolowuwAsyJeyNoojoureUysyy,“ye1Aueuoy
`
`
`
`
`
`
`
`
`
`O}]SINOYSAMIAPSsol1agfesisusryPUBJSAONBseuoyEzypA
`
`
`
`
`
`
`
`‘¢‘Quunsoidery)$]-LQJosisouquAs‘sulpAoRiolgouspuIpizusg
`
`
`
`
`
`
`
`
`
`
`
`
`
`aded‘joeisqeSq(pO0T)ZOGT-0681“(9)69“ANsTUETSIG
`
`
`
`
`
`POLLIPO|ABBLAJOWOIURUYSITPUB¢{7@9--AXOOGT-S|angATeondgJosisouJUASsuipuvlSeisoigsuepulzueg“[eyowi
`
`‘BIQ(ff‘UOLOROYSILAA-SUOWALIG-YLIOMsSpRAAJByNOOOUreIUY
`
`
`
`
`
`
`
`ossoBedSq(1861)LO9S-Poss‘Zs“AnsIWOYS
`
`
`
`BRIAJUSSJOO[NIUY[OAON&JosisoyqUAS[eo]“ye19Yosuy
`
`
`
`
`
`SOA-SUGUIUTA-YOMSDEAAIVTNOOPOMIBNUY9G]JOUOTROTFIPOPY
`
`&
`
`
`
`‘FO6LS8ed‘(Czpunodwos)7687
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3420 of 7113
`
`
`
`"LpunodwospEzs-6Lzssesed“3'q(S007)P6TS
`
`
`
`
`
`
`
`Leenbeeenennneeeneeeeeeeeennnnnnannennnnneeneeennnat
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3420 of 7113
`
`
`
`
`
`
`
`
`
`
`
`SSWIIURSIQ)‘SoLIsHpUyfeolUsYTpue‘elea8ed“FY(SOOT)OTE-GLE“6“SOOTWoUdojosogWYIVISOY
`
`
`
`
`
`
`
`
`
`JeonNsORURYJOJssso01gUOneOTUNgMONYW“Te19UeSnMYy
`
`
`
`
`
`
`
`“LOFI-Sorlsesed“3°(6S61)LOPI-pOrE‘pz“ANsIUIaYy
`
`
`
`
`
`
`
`
`
`‘BIQf‘SUIXNYJUR]JJOssoTenyayozea“yeJosnuepoOy,
`
`
`
`
`
`Si]JO]BWRIPSUUAIWY[eIOALY&JOsINOYoNeqWASPao“yewaa
`
`
`
`
`
`
`
`
`
`SSOOO17DTULBIQ“SSHOIqninymauadeqiey[AMP]-B]JosisayUAs
`
`
`
`
`
`
`
`
`
`‘egoded3'q(9007)TE8-67B‘OT“Wuomdojasacy2YyoIvosay
`
`
`
`
`
`CNVSCOHLAYSISHHLNASDINVDYGGAONVACY“LOSUC]A
`
`
`
`
`
`
`
`
`
`
`
`CNYSHION-AULSTNGHSOINVOYOTV.LNAINTaddXL“‘pooAUey
`
`
`
`"PEI-LTLSe8edBy(686DPEl-LTL“AOWOWad
`
`
`
`
`
`SSLESI“BlsosedSq({L61)88I-SL1‘SANOINHOAL
`
`
`
`STETZE“SANNONODJINVDYOHOAULSINSHIOAMALS‘PHS
`
`
`
`
`
`‘eeaBed“Fy(paah)
`
`
`
`
`
`‘SST-ESL
`
`
`
`sased“Sy(0007“PSpZ)SSI-ES|“AWLSUNAH,)DINVDUO“seuOs oo
`
`
`
`
`
`-SofsaSedSy(6661)8SL-SSL‘AUISTINGITDINVDUG“]eL0S
`
`
`
`
`
`LSL
`
`
`
`‘SANOINHOALAUOLVUOY’]OINVIUOOLNOLLINGOWLNE“BIARg
`
`
`
`
`
`
`
`
`
`-p)stq|-z]-]gosonSopeuyoulpuodig‘ourezupsng
`
`
`
`‘groadedBF(S661)8r9
`
`
`
`
`
`Wad)suizeisdid(|AdoudyAuoyd-¢}-p-[fAujo[Axoujou(jAusydoionyy
`
`“¢‘FoQuodsueiysuiedocyoy]JO]spuesryApauyySIE(60671
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3421 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3421 of 7113
`
`
`
`
`
`
`PLEpLeysasedBy(7007)PLER-ILER“Sp“WsyQpay
`
`
`
`
`
`
`
`sueInjozusgSuijoy-jencJoyuowdoypaog“ouygJo|daaayUIpPAoRIsolgpueistuoseyiojdasoyTYsURKXOqMOIY]JOj
`
`
`
`
`
`
`
`
`
`
`
`
`
`Ueyy-uosnegssUNUASYyJepNespurenuyayy“ye1Apo,
`
`
`
`O}]SINOYsaysaposolayg[eIIUENHpueJaAoN&seuUOTEZTOAD
`
`
`
`
`
` 768|aped‘orysqe“By{P00Z)TO61-0681‘(9)69“Ausimayy“Fg¢‘(yensoidary)
`
`
`
`
`
`
`$1-LJOSISSUAS‘sUTPADRIOIgGuapUIpizuog
`
`
`
`‘TOGosed“(,punoduios)
`
`
`
`
`
`angATjeandgJosisoyJUAg‘SUIPUR[seisolgouEpUTZUeg“[e19Ur]
`
`
`
`‘S1Q‘f‘UOTDeaYBNIA-SUOURATT-YOmspeAJEiNIe}ourRNU]
`
`PolIpoP]&VIAJoWONWEeUsypue$1Z‘g9-p-AKOSG-¢
`
`
`
`
`
`Sessaned“S'g(1861)1O9G-PESe7SANSIWEY
`
`
`
`
`
`
`
`[rzo0]“(S607AINE)OTISOTO/SO0T‘ONUOnRsTTqQngjae$y
`
`
`
`
`
`
`
`
`
`saInsly“(SOOTIUdY)OFSS800/S00T‘ONBonoAngWwaled$79
`
`
`
`
`
`
`
`
`
`‘tsotol‘Lisoo]“zz-s
`
`
`
`
`
`pue‘digsuonesyALANSY-oInjonns‘sissywAsjs1u0Sy
`
`
`
`
`
`
`
`‘Lpunodwod“pezs-oLz¢sosedFy(SOOT)HOTS
`
`
`
`
`
`
`
`
`
`-JAWeWMIOUTIOW-¢-C4)-(S)}JOSiseqIUASSsaloeposonueUgWySng
`
`
`
`
`
`‘BIO‘¢UoTEussOIpAYIUUUTASYBIAploysouexayAyOW-¢
`
`
`
`
`
`“‘pEe-Leessosed“Sq(£007)PELS-LELS“99“WEYD
`
`
`
`VrMUL[lg1OJ9uaIIJoYYSoq]SUBLOISAYCQOZPUL
`
`
`
`
`
`
`
`
`
`TLIZ-OL:07WasedL11,
`
`
`
`(ucisuedsnssuryyezusg5wiyporaad)
`
`
`
`
`
`WIOFO}_aseqBYY(y)daysJoyonposday}Suo9eq09(9)
`
`pee
`
`i
`ou)
`WHE
`
`SyB[NWUIOFJO
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3422 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3422 of 7113
`
`
`
`
`
`
`
`
`
`
`
`SY]10]SIRIPSULIOJUT[LIOALYBJOoyNOYsysyASPAond“yeyanA
`
`
`
`
`
`‘61¢eaded“3(S007)OTE-BLE‘6‘SOOTJUsUdoppAsg
`
`
`
`
`
`
`
`
`
`
`
`ssnawed)‘sonoiquiywouedeaqiesy[AYIaPA-B]JOsisayAs
`
`
`
`‘7egaBed‘Sy(9007)TE8-67Z8‘OL“TUamdopaacy3Yareasay
`
`
`
`
`
`
`
`
`
`TPYDIBASIYSSOOlyBULSIQ“somisnpuyfeorwmayDpue
`
`
`
`
`
`
`
`
`
`
`
`
`
`1462882dSF(S861)PLOL-LOGL“LOT“WOYD“UrYf“UonDBOY
`
`
`
`
`
`jLOTINSICLTVYJoysseaoiguOMeAyLINgMANY“Te16WeSsnuTtLYy
`
`
`
`
`
`‘BIQf‘SuIxnyJuejgJOsfojeuyspozeney,“jejosnurypyy
`
`
`
`
`
`‘LOpl-SorlsosedBy(6S6L)LOFL-PORL‘Pz“AusEuOYD
`
`
`
`BRIAJUSDYIOO[NYUY[OAONBJOSISSJUASTRIO]“ye19FOIsuy
`
`
`
`
`
`SNA-SUOUIIUT-YHIOMSPeAATENOSTOUTeIUTst]JouoTeSTTPoyy
`
`
`
`
`
`
`
`CNVSCOHLAIAL‘SISAHINASDINVDUGGAONVACTY“Wosuoyy
`
`
`
`
`
`
`
`
`
`
`
`SSIESI-181sesedSq(161)881-821‘SANOINHDAL,
`
`
`
`
`
`
`
`
`
`CINYSHIdIONR(ARLSBAGHDINVOHOTVLNAINREAXYY‘POOAUELY
`
`
`
`‘PEL-LZIsaBed3°q(6861)PET-LTL“SOMLIVad
`
`
`
`
`
`‘TeLos oy.
`“SHOOINHOELAYOLVAOEY’TOINVYDAOOLNOLLONGOULNE“BIAR
`
`
`
`
`
`
`BL}SSL-S6LSAISTNAHDDINVEO
`
`‘Ezeaded3(r66l)
`
`LS
`
`
`
`‘gpgased8](8661)849
`
`
`
`OTE-CCE“SGNNOdNODOINVOUGAOAMLSTANAHDOAAALS“polyp
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3423 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3423 of 7113
`
`
`
`
`
`
`
`
`
`ased‘jovlsqe“3°(007)TO6L-06S!‘(9)69“ANsTUaYD“SIG
`
`
`
`
`
`
`
`TOSeBed“(1punoduros)7681
`
`
`
`
`
`
`
`‘Lpunoduios“pezs-6LzssesedB°q(S007)PETS
`
`
`
`JoidaseyulpaAcrisolypuejsuokewylojdesayzysuRXOquiONy]
`
`
`
`
`
`
`
`~6LTS‘Sp“WAYpopf“‘SaaAneAuaGUBINJozHagJouoTENeaq
`
`
`
`
`
`pue“diysuoiejoyAATY-sinjorLiyg“STSOUTUASAsTUOSYy
`
`
`
`
`
`
`
`404SuBINJOZUDE]Suyoy~jeNc]Jojusuidojoaagy‘ouug
`
`
`
`“PLEb-LLEpsased8-9(7007)PLEF-ILE“Sb“WeYD“pa
`
`
`
`
`
`
`
`
`
`Wah)surzeredid(AdodjAuayd-¢)-p-|AyeAxoyjew(Ausydosonyy
`
`
`
`‘¢‘Jepodsuvlyaurtaedogoy)JoyspuesryAugyUF(66671
`
`
`
`
`
`-p)siq|-z|-[Josangoyjeuysurpuadig‘ouezusiug
`
`
`
`
`
`
`
`~|AUJSUIOULLUY-¢-(+)-(S$)}JOSISSYyIUASSAloojssonueUgUy“ung
`
`
`
`
`
`‘BIOf¢UOHBUHOIpPAPTOINOULAIASYBIAPIgyBIOUBXIYTAYIA-¢
`
`
`
`
`
`PE-TELssededB'y(C007)FELS-LELS“89“WEY
`
`
`
`
`
`
`
`V~TGUfoigJoyaouoiajoyysoq]SuBOIsSAYdCOOTPUL
`
`
`
`(uotsuadsnsouTyyezueg9uTToruad)
`
`
`
`
`
`
`
`samnsy‘(So0T[HAV)GrSss00/SONT“ONUOnRaTTQngJuaIeg“Sf
`
`
`
`
`
`
`
`
`
`
`
`.Tsolo]‘Tisoo]‘te-sT
`
`
`
`
`
`uUByy-uOsNE,YOLJSUIWIASYJEyNoojOWRU,oy,“jeyoAUBUOY
`
`
`
`
`
`O}JNOYsASIAsoiNg[eisusrypuwJBAoNBseUOTeZTOAD
`
`
`
`‘fe(mmsoidary)o[-E9JOsisauyUAS‘supoAovjolgsusepulpizucg
`
`
`
`
`
`
`
`[rzoo](soozAMP)OLLS9LO/SO0ZONHONROTTGQN,Ieleg“Sr
`
`
`
`
`
`TLAZ-OL-0TWeedLIL,
`
`O}plowueyzias(9)daysuipswuoyyesouSunovosAzpeuondo(p)
`
`Leeeeeennnnnneeeneeeeeeeeennnnnnnannennnneneneeennnnt
`
`‘]BINWIO]JopuncduwlassyULIGF
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3424 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3424 of 7113
`
`
`
`
`
`
`
`
`
`
`
`‘LOVL-sorlsaded3°94(6561)LOPE-POPl“Pe“AusruegD
`
`
`
`
`
`
`
`
`
`[L6ie8edBY(C861)PLEL-LOGL“LOL“WeyQwy‘f‘uoTDRaYy
`
`
`
`
`
`
`
`
`
`‘SIO‘f‘SUIXNYWUe]gJOssoyeuyopozeNay“ye16snuR_YS
`
`
`
`
`
`BRIATUSYJOOFAUY[AONBJOSISOYUASfelO],“Te79YoOsUy
`
`
`
`SUPA-SUOLILW-ULIOMSDEAA,JEMOOfOWBAUEDU]JOUOBOYIPO)
`
`
`
`‘SIQ)fUOTeAyySNITAA-SUOUTY-YLIOMsSpeAAIETMOOTOUTeTUT
`
`
`
`S6S¢asedSq(1861)LO9S-PéSSTS“ANSIMAGD
`
`
`
`
`
`polIpoy]BBIAINWOnURUTSifpue617'eg-f-AKOa-<¢|aingATjeondgjostsayjudg‘suipuelsesorg
`
`auapurzuag“feyoary|
`
`
`
`
`
`
`
`[ROWNSIPULIBLqdJO]SS9001gUONBIYUNgMANYW[B18uRANuMy
`
`
`
`WWYDIBISIYSSIIOLJBULTIC)“SOLNSNPUT[RATWIAY>pue
`
`
`
`
`
`
`
`‘oleoBed‘By(S007)OZE-OTE“6“SOOTHoUNdo}anagy
`
`
`
`
`
`
`
`
`
`dU}JO]SIVIPSULISPUTLJOAT&JOVNEYonNeUJUASjeAON“fe3981A,
`
`
`
`
`
`
`
`
`
`SSd90L,JDIURTIQ‘sonorqnuyweousedeqes[AUIS-B|JOSIsouUAS
`
`
`
`
`
`
`
`
`
`
`
`TERHETSA(9007)ZES-6ZB“OlWoudojsasgZWyoseasay
`
`
`
`
`
`CNVSCOHLAJN‘SISTHINASOINVOYOGAONVACY‘Uosuoypy
`
`
`
`
`
`
`
`
`
`
`
`SBIESI-1S1“By(1261)88I-8L1‘SANDINKDALseded
`
`
`
`
`
`
`
`‘TSLOsg “SSI1-CS]
`Bed“A37(666L)SSL°SSLAUISINGHOOINVOUQ
`
`
`
`
`
`
`0
`
`
`
`
`
`sodedSy(C007‘pepul)SSI-€S1]“AUWESINAHDOINVOUQ“souos
`
`
`
`
`
`
`
`
`
`STE-TTE.“SANNOdNO?)DINVOUOAOAULSIAGHOORUALS“Jer
`
`‘7Eaed“By(F66D)
`
`
`
`
`
`‘PET-LEISosed“Fy(6861)PEI-LTL“AOLLIVUd
`
`
`
`
`
`ONYSHTdIONRIG-AULSHNAHDDINVOUOTYLNAWTaadxX]“pPOOMIBHT
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3425 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3425 of 7113
`
`
`
`
`
`‘pLeb-LLepsosed"Sy(7007)PLEP-LLEP‘Sp“WeyD‘ps
`
`
`
`
`
`
`
`‘g¢Iayodsuely,sururedoguy)JoyspueasryAwuypyYay(60671
`
`
`
`
`
`
`
`
`
`WAH)surzriodid(AdoidjAuoyd-¢)-p-[Auyo[Axoyjou(Auoydoonyy
`
`
`
`
`
`~p)siei|-z]-|JosenSoyeuysuipuiedig‘ouezurasig
`
`
`
`
`
`“‘SANODINHOALAUOLVAOYTJOINVOUOOLNOLLINGOWLNE“Biaeg
`
`‘gP9abedBy(g661)Sr
`
`
`
`
`
`
`
`
`
`
`
`suUBINJOZUNgSuyoy-jenqgjojuswidojsasgq‘ouygJoidsooyulpAorisolgpueistwoseuyJoidaoay7ysueNOquIO’|JO}
`
`
`
`
`
`
`
`
`
`
`
`weyyf-uosnegsijeunedsyJepnssjowenuyouy,“je1Apeucyy
`
`
`
`
`
`mo
`
`
`
`
`
`
`
`[rZ00]“(S007AINE)OLLS9LG/SOOT“ONHONRSTTQngyuoIE,'§”
`
`
`
`
`
`
`
`
`
`
`
`“6LTS‘Bp“UIUDPAA[‘SOADRALAC]UBINJoZUSgJoUOTENTRAL
`
`
`
`pur‘dijsuoneayAPAOY-dlNOMAS“SISOUJUAS|JsUORYy
`
`
`
`
`
`
`
`
`
`‘£punoduros“p6zs-617Z5sased‘By(Sa07)POTS
`
`
`
`
`
`
`
`
`
`~jAujowournny-¢-(+-)-(§)JOSISSIUASsATIOOPBsONUeUGiy“yung
`
`
`
`‘BIOfUORPUaSOIPAYOWIOWUIASYBLAployslourxoyjAyIsU-¢
`
`
`
`
`
`
`
`‘pE-LELSSaBed“8'q(COOT)PELS-LELS“89“Way
`
`
`
`
`
`
`
`WoTQUIDIgJoysouaIgJoYYsoq_SURTDISAGSOOTPUL
`
`
`
`
`
`
`
`(uoTsuadsnssunpezueg©Upiorad)
`
`
`
`sandy“(soazEY)OPS$800/SO0T“ONUOnwIQngwaked$y
`
`
`
`
`
`
`
`
`
`‘[sotal‘Lisoo]‘77-91
`
`
`
`"24666SRO]YBSIJONpoIdpresul]BNW]
`
`‘TLIZ-OL0%WasedLIL.
`
`
`
`JOpunoduiosjoAyundayyulasay‘7weyJoyonpoldayy,°T
`
`
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3426 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3426 of 7113
`
`
`
`
`
`
`
`
`
`CNYSHTdIONRIG*AULSTNAADDINVOUOTHALNAWTfdKA“‘pooMuEpy
`
`
`
`
`
`
`
`
`
`
`
`
`
`Zoeased3(P66L)|SEE-ZTE.“SGNNOdINO’)DINVDUOAOAULSIAGHOOSUALS“JOA
`
`
`
`"PELLETsased3'y(6861)PEI-LZL“ADMLOWAd
`
`
`
`
`
`
`
`
`
`SSIESI-ISIsadedS-q(L161)88I-8L1‘SANOINKDAL
`
`
`
`
`
`
`
`
`
`GNVSCOHLAJX‘SISSHLNASDINVOUOGAONVACY“UOSuOjy
`
`
`
`
`
`
`
`Sf}OJSIWIPSUHOW][LJOATBJOVNOYDeuJUAGjeAoN“fe381A,
`
`
`
`
`
`
`
`
`
`‘61¢ofedBy(C007)TuOWdo}BAaqOZE-GLE“6“SOOT
`
`
`
`
`
`SSDIOIYDURBIO‘sanorquaywausdequeg|AYPOP-BLJosisauyuAs
`
`
`
`
`
`
`
`
`
`‘Tegsed“S|(9NNT)TES-6Z8“OLJaudojeaag3Yosessay
`
`
`
`
`
`®WYDIBISSYSSIIOAYSUES“SOLISHPU][BSWsY’)pues
`
`
`
`
`
`
`
`
`
`[LoLofed34(S861)FLOL“LOGL“LOL“WoYyDwy‘PfUOKoRAaY
`
`
`
`
`
`
`
`yRoOTINAULIVILJO]uoHwoyUNgMANYW“Te18URsnUMysssoolg
`
`
`
`
`
`
`
`‘BIQ‘fF‘SUIXTYTegJOsBoyeuyajozeney“ye10sNUEPD
`
`
`
`
`
`‘LOovl-sorlsased3°(65961)LOPI-POrL“pe“Ausiuteyg
`
`
`
`
`
`ased‘joelsqeSq(O07)ZTOGT-O68T‘(9)69“ANsTUREySIO
`
`
`
`
`
`
`
`
`
`POYIPOJA,BBIAJOWONURUYSTPDue¢{ZQQ~[jrAXOSET-S|aigAyeondgJosisoyUASsuipuelSejsoigsuapulzueg“jejoWY
`
`
`
`SIO(UoTIesySIILAA-SUOUTUTA-YLOMspEAAIepNIS[OUTe.LY
`
`
`
`C6gse8ed“Sq(2861)LO9S-PESS‘7S“ANSTEY
`
`
`
`
`
`BRIAWSSYJOO[NMUY[SAONBJOSISOUIUAS[RIO],“]e16Yosuy
`
`SOVM-SUOUUTY-UOMSPEAAJETMOOfOUBNUTBU]JoUOReOIpOY
`
`
`
`
`
`‘FO6LBed‘(zypunodwos)7681
`
`
`
`‘¢‘Cyrumsoidery)S[-EjosisayuAs‘surpAoRiolgouapulprzuag
`
`
`
`
`
`
`
`
`
`O}BMOYDAIAposolayyfesaarypuJOAONBseuoEZipAD|
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3427 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3427 of 7113
`
`
`
`
`
`
`
`
`
`
`
`
`seinsly“(S007[H4y)GrsSss00/SONZ‘ONUOnkoTQngJue,Sf]
`
`
`
`
`
`
`
`
`
`UlpAoeisorgpueIstuoseiyJoidssay7ysuexoquio.y],pue‘digsuonejoyAAOY-alnjonys“sisouqUAS‘|stu0dyJoldacay
`
`
`
`
`
`
`
`
`
`“PLEb-LLepsaved“Sq(7007)PLEP-ILEP‘Sh“BOYDpow
`
`
`
`
`
`
`
`JO}suBINJOZUSgSuISy-jengJoJueudopaaag“ouyg
`
`
`
`
`
`
`
`
`
`“SHNOINHDALAYOLVAOEYJOINVOUOOLNOLLONGOWLNE“BIARg
`
`‘gpoadedFy(S661)Bro
`
`LEL
`
`
`
`HWA)suszesodid(AdoidjAuoud-¢)-p-[paujo[Axoyjou(jAuoudosonypy
`
`
`
`
`
`-p)Siq|-Z|-[Josonsojeuysuipuodig‘ouezurosig
`
`
`
`‘fpdopodsueiysuiuedog3y310}spuesiyAuulyUBIH(60671
`
`
`
`
`
`
`
`
`
`-g¢zsaded3°(6661)8S2-SSL‘AULSINGHDDINVOUG‘TPELI0S
`
`
`
`
`
`
`
`
`
`
`
`
`
`sofedAq(0007papac)SST"ESTAMLSTINGHDDINVOUO“souor
`
`“CSTEST
`
`
`
`
`
`“6LTS“Rp“LUSUL)PSP[“SSANBALIOGURINJOZUSgJoUOMeN[eAq
`
`
`
`
`
`
`
`Lpunoduros“By(S007)“p6zs-6LzssanedPOTS
`
`
`
`
`
`
`
`
`
`
`
`~jAmououruny-¢-(+)-(§)JOsTsalpUAgaaTjoopasonueUgwyIng
`
`
`
`‘BIO‘f‘TONBUssoIpAYOWIOLUWASYBLAployalouRxoyAqIeUl-¢
`
`
`
`
`
`
`
`E-LELSSoBed“S'q(CO0T)PELS-LELS“89“Wey
`
`
`
`
`
`
`
`
`
`V~'1@UL|[D1g10}adusigjoyysoqSuBLISAUdCOOZOUL
`
`
`
`
`
`suTYIEZUSqFyUITTTOTUSd)
`
`
`
`NOSCHOI0“NO*“CHO)IG‘NO“CHONIO
`
`suzy,‘¢ (uoTsuddsns
`CLLZ-OL0%WaedLUE,STUSSRBUNLTAYLof]UlsayM‘7UysJoJonpaid
`
`
`
`on
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3428 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3428 of 7113
`
`
`
` £S8LE<In1SiSeded
`
`“BqC61)8l-BL1‘SHNOINHOEL
`
`
`
`
`
`
`
`GNVSCOFLAIAL“SISHHINASJINVDUYOGCHONVAGY‘UOSUOofy
`
`
`
`
`
`
`
`
`
`
`
`ueyy-uosnegoWewuUASYIepMosjoulenUyaypL“yeyaApeuoyy
`
`
`
`O}]SINOYSANISPPSOIAIGfesQUSLDPURJOAONLBseUOYEZYAD
`
`
`
`
`
`
`
`
`
`amed‘oeisqe“8'q(POOT)ZO6I-0681‘(9)69“AUSTWDOYBIOr‘Cyenqsoidoarp)
`
`
`$1-EOJosisouwsAs‘suloAovioigouopuipizusg
`
`
`
`
`
`
`
`
`
`
`
`singAyjeondgJosisoyJUAS“SUIPUR[SeisolgsUapUIZUSg“[e19UIT
`
`‘BIOf‘ucHORAYFUA-SUOUII-YLiOmspeAALeynoeOey
`
`polpopyBVIAIOWONURUTTsippue¢1Z‘eg-p]-AKosq-s]
`
`
`
`cogsatedSq(1861)LO9S-Passzs“Ansiusy
`
`
`
`‘TOGded‘(7punodwos)7681
`
`
`
`
`
`BRIAJUSSYJOOTNNUY[SAoN@JOsisoyAS[elo]“Te®ffoisuy
`
`SiM-SUOULUT-YIOMSpeAAIB[NOSjOWBAU]SU]JOUOREIIpoyy
`
`
`
`
`
`LL6Lased“3-7(S861)FLOL-LOGL“LOL“WeywyjfOMoRay
`
`
`
`
`
`
`
`
`
`
`
`fROMNAIULBJO]ssado1gUOWeITUNgMANY“feeouRSnNTIy
`
`
`
`
`
`‘SQ(SUNYJUB]]JOSHOLBUYBOZBNIALjeJOSNUB
`
`
`
`
`
`‘LOPT-Sorlsaded3°q(6961)LOPI-POrl“pe“Austmay9
`
`
`
`
`
`OY}JO]NVIPOULIOIY[eJOATT#JOsinaoAjOAoN“yeyO1A
`
`
`
`
`
`‘61ga8edSY(COOT)OTL-GLE“6“SOOTJUatUdo]sANCT
`
`
`
`
`
`2BYSBISTYSSOIGAYIULSIC)“SOMISNPUT[RsTWIAYDpue
`
`
`
`
`
`
`
`
`
`SSddO1gIULFIQ‘SanoiquuyweuadeqegJAUPY-BLJOsisemusg
`
`
`
`
`
`
`
`
`
`
`
`‘Teyased“S'g(9007)TE8-6Z8‘OTJuaurdojeaod2%Yoreasay
`
`
`
`
`
`
`
`
`
`
`
`lrzoo]“(se0zAINE)GLIS9L0/SO0T‘ONUOTeaTTQngJueleg'S’;
`
`
`
`
`
`
`
`
`
`TsotolLisoo]
`
`‘72-1|
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3429 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3429 of 7113
`
`
`
`
`
`
`
`eres
`
`
`
`sosedSy(O0GZPsput)SSL-ES|(AULSUNGHODINVDUO“souor
`
`
`
`SZE-TZE“SGNAOANODJINVOUOAOAUISUNIHOOMUALS“BUT
`
`
`
`
`
`czesned3(r6sl)
`
`
`
`‘PEL-LZ1sosedBI(6861)rEL-LZ1OLLOVad
`
`
`
`
`
`
`
`CNYSATIONGE-AULSTINAHDDINVOYOTVONAIAPSadyy‘POOMIREY
`
`
`
`
`
`
`
`“gLsaved‘S'(6661)8SL-SSL‘AULSINAHQOINVDUEG“T]2H0§
`
`
`
`
`
`
`
`
`
`
`
`WD)oulzersdid(jAdoidjAuayd-¢)-p-[Ayqe[Axoyjour(jAusydosonpy
`
`
`
`
`
`-p)siq|-z]-[Josansoyeuysuipuedig‘ouezurosig
`
`
`
`‘gpgated“Fy(S661)SFO
`
`
`
`“SANOINHIALAYOLVYOTY’TOINVDYOGLNOLLINGOULN]“BAB
`
`
`
`
`
`LGL
`
`
`
`surumedogapJoyspuesryAnuyyyysty(60671‘PLEbLLEpsased“8g(7007)PLEPLLEP“Sp“WAY“Pa,fJoyrodsuely,
`
`
`
`
`
`
`
`
`
`
`
`Jo|dasayTpAovisolgpuestuoseiyJoidesoyTYsueXOquIOJY
`
`
`
`
`
`
`
`JO}suvinjozuogSuyoy-jenqjojoudopasq“ouyg
`
`
`
`
`
`
`
`
`
`pure‘diyjsuonejayAranoy-amnpanns‘sisequdgjstuo0ay
`
`
`
`
`
`
`
`“ALTS‘BbWOYDpapf‘SOANBALOGURINJozUNgJouoTENjeAq
`
`
`
`1punodwos‘pazs-e.zssosedBy(S007)F67S
`
`
`
`
`
`
`
`
`
`~AIomOUTUTY-¢-(+)-(S)}JOSTSOYPASdaroopssonueugwy“Sng
`
`‘BIQ‘f‘UoTPUuaSoIpAynunauuAsyyBIAPOYSIOURKAUTAUIOUI-S
`
`
`
`
`
`
`"pe-Teigsased3°q(C007)PELS-LELS“89“WEYD
`
`
`
`
`
`VTQUT[HgJoysoucsajoyYseqSUBIIISAUASOOTPUL
`
`suIYyjeZUsg£4Uiy]Iolusd)
`
` (uolsuodsns
`
`wm
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3430 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3430 of 7113
`
`
`
`
`
`
`
`
`
`
`
`
`
`768[osed“oelsqe“Bq“(rO07)TO6T-0681“(O69“AtismUDYyQ“BIG
`
`
`JOHON81(q)daisulaseqoy}ulorayM“|we]Jojonpoldou,“p
`
`
`
`
`
`ueUosnegSOUIWASYJepNSapOwURUloy,yeJoAuELOpY
`
`
`
`
`
`O]SMOsAIepSAsoiolg[RIsuaLPUBJPAONBseuoTEZTOAy
`
`
`
`
`
`[rzo0l“(soozAMP)OLLS9EO/SO0ZONUOTeOTTQNGWale“S°
`
`
`
`
`
`[soto]‘Tisoo]‘zz-st
`
`
`
`
`
`
`
`‘¢‘(unsoidery)S{-EJosisoumudg‘surpoAdejorgsuapuriprzueg
`
`
`
`
`
`
`
`
`
`somnsy“(SOOT[HAY)OFSS800/S00T‘ONUOTROTIGngWord“$f
`
`
`
`
`
`TETLE-OL-0%WoledLTE,
`
`“HOPN
`
`‘ZOGBed‘(Cypunodwos)
`
`
`
`
`
`
`
`
`
`
`
`LL6LObed“BY(S861)PLOL~LOGL“LOL“WOYD‘Ury‘f“‘UOHOBOY
`
`
`
`
`
`jeounooelwsey,Joyssso0lgUOHROLNgMONVW“ye19ueSsnuNY
`
`
`
`
`
`
`
`
`
`
`
`QU)JO]SIVIPIUMUIAIU][LIOALY&JOS9INOYBHAAon“yejang,
`
`
`‘61¢sted“AY(S007)OTE-GIE‘6“SOOT
`
`
`
`
`
`JuoUIdopeAeg2YOIVISOYSS9IO1,JDIULSIQ“SSUISNPU]sROILUOYDpu
`
`
`
`
`
`
`
`
`
`SPIODULSICy“SOMOIGUUYUsuedeaqie5[AUIap]-e|JOsisouqUAS
`
`
`
`
`
`
`
`
`
`“LObT-SorTsoded“Bq(661)LOFI-POrE“Fz“ANsIureyD
`
`
`
`
`
`
`
`singAjjeondyjosisspuAs‘suipue[sejsolgsuepuizueg“|e39UIT
`
`
`
`‘RIQ‘ffWoTOROyANITA,-SUOTUUTA-YIOMspeAAIe[NOoOLURQUT
`
`POLIPOY&BIAIoWONURUTSI]PUR¢[T'BO-[\-AKNOag-¢]
`
`
`
`s6sgaded3'A(L861)109S-passTs“Ausituay
`
`
`
`
`
`BRIATUNISYIOO[NYUY[AONBJoSISSYJUAS[eC],“ye10Yosuy
`
`
`
`STHAYSUOLULUY-GHOASpeAyIB]NODPOUTRIVU]TSY]JOVORBIPO
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3431 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3431 of 7113
`
`
`
`
`
`
`‘Zegoded“Ay(9007)TE8-678“G]
`
`
`
`
`
`Tusuidojorag]7yoiwosay|
`
`
`
`
`
`CNVSCOHLAPY‘SISAHLNASOINVDYOGAONVACY‘uosuoyy
`
`
`
`
`
`
`
`
`
`
`
`ONYSHTdiONRIG-AULSTIWAHDDINVOUOTV.ONAINESadXH“‘POOMIeYW
`
`
`
`
`
`
`
`SZE-ZZESSGNAOdNODOINVOYOdOAWLSINFHOOAMALS“JONG
`
`
`
`
`
`‘TzeasedBq(pEsT)
`
`
`
`
`
`PELHLTLSoBedBy(6861)FEL-LEL“HOLLOVAd
`
`
`
`
`
`sosed‘Sy(Q0GTpsput)SSI-CS|AMLSTIINGHSDINVOUG“souor
`
`
`
`
`
`“GGI-EST
`
`
`
`SSLESI-181SasedSq({L61)88I-SL1‘SAMONHOTL
`
`
`
`
`
`
`
`
`
`“SLsaBed‘Sy(6661)SSL-SSL“AULSTNADDINVOUG“][P40g
`
`
`
`
`
`
`
`
`
`
`
`“SHNOINHOALAVOLVYGAVTDINVOAOGLNOLLINGOULNE“BlAeg
`
`‘gpgaded3'q(R661)Bro
`
`LL
`
`
`
`
`
`-p)stq|-z|-1Josansoyeuyouipnodig‘ourzursig
`
`
`
`WA)ourzvsadid(jAdomjAueyd-¢)-p-[fAqie[Axoujour(jAuaqdosonpy
`
`
`
`
`
`
`
`
`
`"¢‘sanodsueiyoumedocyayy10}spuesryAumyUST(60671
`
`
`
`PLEbILEbsesed“Sy(7007)PLEP-ILEP‘SpWINYD“psy
`
`
`
`
`
`
`
`JO}SuBINnjOZUSYSuyoy-jenqjojuswdopsasq“ouyg
`
`
`
`
`
`
`
`
`
`JoldasayUTpPAsvisolgpurisuOseyJOWWasgyTyWUeKOqUIOIY
`
`
`
`
`
`
`
`
`
`-6LZS‘Bp“WOYDpay]f‘SoATRALIOC]URINJoZuNgJoUOTIENeAg
`
`
`
`
`
`pure‘drysuonppeyALANIY-sIMAN.NG“SIseuUASsTIOSYy
`
`
`
`
`
`
`
`
`
`‘Lpunodwos‘p6zs-6izssesud“3's(S007)POTS
`
`
`
`
`
`
`
`tm
`
`
`
`
`
`JOSISYJUASDAOO}SsONUeUYUY“Ng“BIQf‘UOHBUSTOIPAL]FUIOUUASYBIAPloySIOURKXaUAgIOUF-S|~JAYIOWOULWY-¢-(4)-(§)
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3432 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3432 of 7113
`
`
`
`@x,
`
`
`
`"PE-LELSSavedBq(C07)PELS-TELS
`
`“BO“MUAYD|
`
`
`
`
`
`
`
`WYQUI[JIN1gJoysauaIOJAYyYsaSUBISISAULYSOOTMUL
`
` ayy,“5 (uoisuadsns
`“§°A [soto]
`O}IMOYSANISsololseouSL)puepOAONBwseuoTEZIPAY
`
`
`aged‘oulsqeAq(r007Z)ZOGI-0681“(9)69“AnstusYygB19
`
`
`
`
`ueyy-uosnegoLnouIWIASYJRpNOSTOWRIUTayy“ye1ARNO;
`
`
`
`‘¢‘Gragsoidaiy)C{-E9Josisamuds‘suypoAoejoigsuapUIpIzueg
`
`
`
`RO-S}-ANOBEI-C|singAjeondyjosisayAS‘suIpUL{SeIsolgsuepUIZuSg“[e19UIT
`
`
`VOMNSIVUIHIOyssaoo1gUOHBOUNGMANY“yeIeuesnumry|
`
`
`1L6L88dBy(S861)“WeaYyD“Ury‘f“‘GonovoyPLEL-LYGL‘LOT
`
`
`
`
`SHA-SUGUTLUG-ULIOMSDEAATeMO;OUTeUTau]JOUOTeSTIPOyy
`
`
`
`seINsTy“(SOOT[HAW)OFSS800/S00TONUOnRSTTGngWoe§;
`@BIAJUSSJONNY[PANBJOSIsSIUAS[RIOT“ye19Wosuy
`
`
`
`BIQfUONORIYSOLA-SUOLULUY-YHOASpRAAJB]NDS|OLUEUY
`
`
`
`‘BIOf‘suixnyJuejoshojeuyspozeoy,“yeJosnuRyApyy
`
`
`‘LOvI-SorlSoded“By(661)LOFL-POFL“pz“ANsTuyD
`
`
`POYIPOPL&VIAJOWONUEULSI]PUR¢17°
`607AINE)OLIS9LO/SOOT‘ONUOTBOT|QNGWake
`
`
`
`S6ssasudBq(1861)109S-rassTS‘AUsuY)
`
`
`
`
`“QUISA]~]“WUMIsoUseUU“OUTMTEYOWUON‘oUTeDOId“suTeON|S[AGOW
`
`
`
`-N“BIuOWUJOFuysisuosdnosws943WoT,pojooyas
`
`
`‘OUIWIB{OUBYIOIPpuz‘SULUIRJOURTION]‘OUTUIAIE-J
`
`
`
`sunypezusqOunyporued)
`
`‘TEIC-OL07WeedLIL,
`
`
`
`‘t1soo]‘tz-s1
`
`$1(9)daisUlgaseqoY}UloTayM‘]UTE;JoJonpord
`
`
`
`‘TOGBed‘Cypunodwuos}76
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3433 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3433 of 7113
`
`
`
`
`
`
`
`
`OY)JOJOPVIPOWISIUT[VIDAL€JOsinoyonogadgPao“ye91h
`
`
`
`
`
`
`
`
`
`
`
`SS00IgDULSIO‘sonoiquuywouadeqieg[AWIAPA-R]JosisomuAS
`
`
`
`
`
`
`
`
`
`‘7ga8ed“Sf(9007)TL8-6T8“OLTusuidojasacy2Yyouessoy
`
`
`
`HOUdoPADgwYoseasaySsooo1gTUESIQ“SoLISNpUy
`
`
`‘6LeaBed“BY($007)OZE-GIE‘6‘SOOT
`
`
`
`
`
`jvorasyypur|
`
`
`
`
`
`CNYSCOHLAIN]“SISHHLNASOINVDUGGAONVACY“UOsUCyy
`
`
`
`
`
`
`
`
`
`
`
`CNYSHTdIDNMG-AULSTAWAHDDINVOUOTV.LNAINTaddXH“‘poomsey
`
`
`
`
`
`
`
`SZE-TTE.“SAGNNOANODDINVDYOAOAWLSIAAHOOAMALS“[StE
`
`
`
`
`
`‘teased“3y(pe6T)
`
`
`
`‘PEI-LTIsosedSy(6861)FEI-LZI“HOULOVAd
`
`
`
`
`
`
`
`
`
`S81‘C8I-LRLsosed‘Sy(1161)8Bl-SL1‘SENOINHOaL,
`
`
`
`
`
`
`
`
`
`“SGSoBed“By(6661)SSL-SSLAULSINELHDINVDUQ[P10
`
`
`
`
`
`
`
`
`
`WH)ourzersdid(jAdoidypAuayd-¢)}-p-[fAyla[Axoyjoun(Auoydorony
`
`
`
`
`
`
`
`
`
`-p)siq|-z]-|Josondoyeuysuipuiodig‘ouvzulosig
`
`
`
`‘gy9aded3°(S661)BFS
`
`
`
`“‘SANOINHOATANOLVYORY’T]OINVOUOOLNOLLINCGOWLNG“elARg
`
`
`
`
`
`“ESL
`
`“SissajUASMERyLojdacoyUlppAovsolgpuRIsUOseIUYJOlds.0yTYBUBXOQUWUOIY|JO}
`
`
`
`pue‘diysuonepyAPATAy-omIon.nS
`
`
`
`supInjozuogSunoy-jenqJojuowdopasq“ouyg
`
`
`
`
`
`‘PLebLLepsosed“s'y(7007)FLEDLLEr“Sh“WYO“pony
`
`
`
`
`
`‘¢JoylodsurlysurmedoayJoyspuvsryAnuyyyuysiy(60671
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3434 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3434 of 7113
`
`
`
`
`
`
`WoTQULJO1g1oJsdussajoyYsaq_SUPIOISAY.TSOOTSUL
`
`
`
`
`
`-jAIsotuouruy-¢-(4)-(S}JOsIsomWASsatoopssonueuqwySng
`
`
`
`‘Big[Vonvuss01pAyoMpowUAsyBIAploysIOURXayAIIOW-¢
`
`
`
`
`
`
`
`‘PELELssased3y(C007)PELS-LELS“89“WY
`
`
`
`
`
`
`
`‘Lpunodwoo“pezs-6LZssoBedBy(SOOT)ETS
`
`
`
`
`
`“6L75‘BpWApayf‘S@anRALAGUBInjozuegJouOneNRAy|
`
`
`
` (uoisuedsns
`
`
`
`
`
`
`
`suTyyezusg9uypormed)
`
`
`
`TLIZ-OL0%WworedATI.
`
`
`
`JOJOH$1(p)datsulpro’oy]ureroym‘|tresJoyonpordoy,“oO FOSTH
`
`
`
`
`
`
`
`
`
`
`
`soinay(coo7JUdW)OFSS800/S00TONYOukoTTQngJuoTegSf
`
`O]BNOsanosjasoioig[ejouarypuwPaonvwseuUoOTEZTOADR
`
`aed‘joulsqe34(r00Z)7061-0681“(OJo9“AnsnusygBug
`
`
`
`
`ULyYEuosNegOLNOURUIASYIPpNSeTOLURNUTey“ye1AueUOyy
`‘¢‘Grugsoidasy)C1-L.9Josiseqiuds‘suyosoeioigsuspulpizusg
`
`
`
`
`
`
`
`
`
`
`
`
`TOG]aBed“(,punodwos)763}
`
`
`
`
`
`PoyIpopy&VIAJowWONURUTSIpPUR¢17'R9--AKOSG-S|angAypeotdyJosisayUAS‘suIpUEselso1gauepuizueg“Te138UT
`
`
`
`‘SIQfUOTRaYySNILAA-SUOLULY]-quomspeAJeNIS[OWe.QU]
`
`
`
`ossosedBq(W8al)109S-passZs“Ausimsy
`
`
`
`[rz00]“(soozAINE)OLIS9TO/SO07‘ONUONBoTgngwoe$7
`
`
`
`
`
`
`
`
`
`[soto]Lisco]‘c7-st
`
`
`
`BRIAJUORYIOIINYUYPACKBJOSISayUAS[BIO]“fe19Yolsuy
`
`
`
`
`
`
`
`
`
`IL6LS684ST(S861)PLEL-LOGL(LOT“WlsYO“Ury‘f“uoTRAy|SHVAA-SUOUTLU-YHOMSpeAATE[NOOTOUTLIVUToy]JOUONESTTpoyy
`
`
`
`
`
`O¢
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3435 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3435 of 7113
`
`
`
`
`
`
`
`
`
`
`
`SSWIIURSIQ)‘SoLIsHpUyfeolUsYTpue‘elea8ed“FY(SOOT)OTE-GLE“6“SOOTWoUdojosogWYIVISOY
`
`
`
`
`
`
`
`
`
`JeonNsORURYJOJssso01gUOneOTUNgMONYW“Te19UeSnMYy
`
`
`
`
`
`
`
`“LOFI-Sorlsesed“3°(6S61)LOPI-pOrt‘pz“ANsIulay
`
`
`
`
`
`
`
`
`
`‘BIQf‘SUIXNYJUR]JJOssoTenyayozea“yeJosnuepoOy,
`
`
`
`
`
`Si]JO]BWRIPSUUAIWY[eIOALY&JOsINOYoNeqWASPao“yewaa
`
`
`
`
`
`
`
`
`
`SSOOO17DTULBIQ“SSHOIqninymauadeqiey[AMP]-B]JosisayUAs
`
`
`
`
`
`
`
`
`
`‘egoded3'q(9007)TE8-67B‘OT“Wuomdojasacy2YyoIvosay
`
`
`
`CNYSHdIONR-AdLSHNGHSOINVOYOTV.LNANTeddXL“‘pooAUey
`
`
`
`
`
`
`
`"PEI-LTLSe8edBy(686DPEl-LTL“AOWOWad
`
`
`
`
`
`SSLESI“BlsosedSq({L61)88I-SL1‘SANOINHOAL
`
`
`
`STETZE“SANNONODJINVDYOHOAULSINSHIOAMALS“PUA
`
`
`
`
`
`‘eeaBed“Fy(paah)
`
`
`
`
`
`CNVSCOHLAYSISHHLNASDINVDUGGAONVACY“LOSUC]A
`
`
`
`
`
`
`
`
`
`
`
`
`
`‘SST-ESL
`
`
`
`
`
`sased“S'y(Q000Z“PSpZ)SSIES|“AULSUNAH,)DINVDUO“seuos oo
`
`
`
`
`
`-SofsaSedSy(6661)8SL-SSL‘AUISTINGIT)DINVDUG“}eL0S
`
`
`
`
`
`LSL
`
`
`
`‘SANOINHOALAUOLVUOY’]OINVIUOOLNOLLINGOWLNE“BIARg
`
`
`
`
`
`
`
`
`
`-p)stq|-z]-]gosonSopeuyoulpuodig‘ourezupsng
`
`
`
`‘groadedBF(S661)8r9
`
`
`
`
`
`Wad)suizeisdid(|AdoudyAuoyd-¢}-p-[fAujo[Axoujou(jAusydoionyy
`
`“¢‘FoQuodsueiysuiedocyoy]JO]spuesryApauyySIE(60671
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3436 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3436 of 7113
`
`
`
`
`
`
`76g|osed“joulsqeSq(FO0Z)TO6T-O681‘(9)69“AnsnueyaSIO
`
`E061a8ed“(,punodwo)
`
`
`
`
`
`
`
`
`
`
`
`aingAyRondgjosisayjuds‘suriputyselsoigauspuizueg“[e19ur]
`
`
`
`
`
`
`
`‘SIOfBOYIRsyySHUAA-SUOLUE-quomspeMJeNsepoure.nuy|PeTIPo|&VIAJOWOHUBUTSifPUBC{LT'B9-f]-AXOBG-S
`
`
`
`
`
`
`
`mipAoRisolgpueisuosewyiojdasoyTYSuURxXOqMOIY[,pue‘digsuonepsyAMATOY-oInjonas‘sIsayUASsosyJo\daagry
`
`
`
`
`
`
`
`
`
`
`
`
`
`JO}sueInjozuegSuijoy-jencJoyuewdoypaascy“ouyg
`
`
`
`PLEpLeysawedBy(7007)PLER-ILER“Sp“WsYyQpen
`
`
`
`
`
`
`
`URYy-vosnegOLMeMUASYIepNospOWENnUTey“ye1AyrenOy,y
`
`
`
`
`
`O]dNOYsanoojasoiajg[elouarnpeJBaon],wseUOTEZTOAD
`
`
`
`‘¢‘(yonsoideiy)C[-pJosisauuAs‘suipoAoevioigsuapulpizueg
`
`
`
`
`
`
`
`
`
`[rzoa]“(se0zAINE)OL1S910/S00ZONuOyBoyngJae,Sf
`
`
`
`
`
`
`
`
`
`‘{soro]Tisao]‘zz-s1
`
`
`
`
`
`SoINAY(SOOT[HdY)OFSS800/S00T‘ONUOnBTIQNguse”'§'/
`
`
`
`
`
`
`
`
`
`
`
`“6LZS‘BbWeg?)Pap]Pf‘SeayRALIAC]UeINjozusYgJouonENeAy
`
`
`
`‘Lpunodwoo“b6zZs-6Lzgsomed84(S007)OTS
`
`
`
`
`
`
`
`
`
`-JAWawOUTIOY-¢-C4)-(S}JOsiseqWuASSsaloaposonueugmySng
`
`
`
`
`
`‘BIO‘¢UoTeuasoIpAyIUUIUTASYBIAploysouexayAyOU-¢
`
`
`
`
`
`“‘pE-TELSsavedBy(€O0T)PELS-LELS“R9“Woy
`
`
`
`
`
`VrMUL[lg1OjsduaiajoyYSaQ)SUBIDISAY,COOTPYL
`
`
`
`
`
`
`
`(ucisuedsnssulyyezusg5uTppoToad)
`
`TLTS-OL-07WworedLT1,
`
`
`
`
`
`“0SLAECRYHOTSTLA,Wozoy‘7WTeySJoyonpoidoyyf
`
`
`
`
`
`*HO)Sisompedo}veyedQCDO7“HO-dH-?JoH-HO
`
`"|SEASpue
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3437 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3437 of 7113
`
`
`
`
`
`
`
`
`
`
`SSOOLTBULSIC“SOMISHpUTjeoTWUSYTpue‘elea8ed“AY(S007)OZL-6BLE‘6“SOOTJUsUdopAggWYOIVSSIY
`
`
`
`
`
`
`
`
`
`
`
`TLOMNIIVULVYgJOTsssoolgUOwVOUNMONVY“Te19URSNUNTYy
`
`
`
`“LOPT-Sortsosed“3A(6S61)LOPIport‘pe“ATSIUIAgD
`
`
`
`
`
`
`
`BRIAJUasyJooNNUY[aah]BJOSISJUASRIO]“ye19Josuy
`
`
`
`
`
`
`
`SUPAASUNT-GHOmspeAATepNoaTOUTeIUYoe}JOUOTRITIPOy
`
`
`
`IL6LanedSF(S861)PLEL-L96L“LOL“Weywy‘ffUonoRoy
`
`
`
`
`
`
`
`
`
`BIOf‘SULKNYJuRlYjosAojeuyajozeyoy“yeiosnuepoyy
`
`S6seoudByU/861)
`
`LO9S-Pass7S“AUSEOaY,)|
`
`
`
`
`
`Bi}JO]VLIPIUUISIUT[RIOALYBJOsNOYDHSqIGASPaon“Tewna
`
`
`
`
`
`
`
`
`
`SSB00IgDIULTIO“SOHOIqnuywouadeqrey[AUJOP-B]JOSIsaUAS
`
`
`
`
`
`
`
`
`
`‘TERyOded“Sq(9007)TEB-6TS“OTTuouIdopasog2yosvasoy
`
`
`
`
`
`CNVSCOHLA“SISAHLNASJINVOUGGAOINVACY“Wosuoypy
`
`
`
`
`
`
`
`
`
`
`
`ONYSATdIONTAg-AULSTINTHDBINVOUOTY.LNWaddXL“POOMIBAL
`
`
`
`
`
`
`
`STE-TZE“SANNGdINOY)DINVOUOJOAULSINGHIOAUNSLS“ENA
`
`
`
`
`
`‘7zeaded“Sy(P66L)
`
`
`
`
`
`PEI-LZISoBedBy(6861)PEL-LTIL“FOLLOVd
`
`
`
`
`
`SREESI-1SEsased“Sq(1161)S8I-SLL‘SHNOINHDAL
`
`
`
`
`
`sased“3°(QO00T“P9a2)SSI-EST“AULSINGH,)DINVDUQ‘souos
`
`
`
`
`
`
`
`‘SSl-€S
`
`
`
`
`
`
`
`‘SSNOINHOALAMOLVYGIYTOINVOUOOLNOLLGNGOWLN]“BAG|
`
`LSE
`
`
`
`
`
`~$¢_so8ed‘Sy(6661)BSL-SSLSAMISIWAHDDINVDNQ“][2140$
`
`
`
`
`
`
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3438 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3438 of 7113
`
`
`
`‘gpgaedBy(R66)
`
`
`
`sulyyezusg£yulppolusd)
`
`849|
` (uoisusdsns
`ased“jousqe“Sq(hOOT)ZO6L-O681“(Qo9“ARShMey“Bug|‘y‘(yronsoidaiy)
`
`
`
`
`
`
`O]BNOYSANAdasosajIg[PIoUaHpuewJAONLBseuOTEZTyIAg
`
`
`
`uryy-uosnegoLnediUASsYIepnoejoueluyeq“yeyeAeuoyy
`
`
`
`
`c[-[.9JosisamuAs‘suipoAoviolgsuapulpizueg
`
`
`WAH)ourzesadid(AdoudjAusud-¢)-p-[AqaAxoujour(jAusydoiony
`
`
`
`
`JOMaceyUlpIAdiso1gpuresimoeseuryiaydaseyTysuPXOqWMOIYT,
`
`
`-6L75‘Sp“WA‘papf‘SSAQRALISGUeINjJozuegjouonEnRAq
`
`
`-JAyjomoUTOY~-¢-(4.)-(S)JOsisaqyUASSATDapsanUBUTUyyang
`sainsiy“(O07INFY)OFSS800/SOOT‘ONUOTROTTQNWale,'§'
`
`
`
`
`
`
`
`
`
`‘¢Aopodsuesysunuedogoy}10;spuesryAouyyYsTy(606TZ1
`
`
`
`‘BIO‘¢UONBUaSOIpPALTOINSUIUIASYPEAploysiouexay[Aet-¢
`
`
`[rzoa]“(so0zATOL)OL1S9L0/S00ZONVONEATQNgwae$4
`
`
`
`PLeb-LLepsasedBy(7007)PLEP-LLEP“SbWeYDpe}
`
`
`
`
`WoTQUI[OgJOJ9UaIAJOYYSaqSUBIOISAYTSOOTPYL
`
`
`
`
`pue‘diysuonvpayAVANSy-oInjonNg“sisayUAS‘isTUuOsYy
`
`
`
`
`Jo]suemjozusgSuyay-jengjojuoudopaaog‘ouyg
`
`PE-LELSSaved“Sy(EO07)PELS-LELS“89“WEY
`
`
`-p)stq|-z|-]Josonsoyeuyourpuiadig‘ouezunsig
`
`
`
`
`‘Lpunodwos“p6z¢-6LZ¢sesed‘Sy(S007)FETS
`ELLT-OLOTFHALIL,|Opnpoursiousoopssaccidoy}uldisys‘|wepJolonpoudou,°g
`
`
`
`
`
`(2)doqysulpaonpold(qyP)eINUTEJJopunodurosay}FurAyund
`
`
`
`
`
`‘Tsolo]Trsoo]‘cz-s1
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3439 of 7113
`
`IPR2020-00769
`United Therapeutics EX2006
`Page 3439 of 7113
`
`
`
`
`
`CNYSHTIdION-AGLSHUNEHDDINVDAOTY.LNAINTaadXA“POOMUBH
`
`
`
`
`
`
`
`SBEERT-I8Esesed“Sq(1161)881-841SANOINHDA
`
`
`
`
`
`
`
`‘PEI-LZIsadedBY(6861)PEI-LTIFOMLOVad
`
`
`
`
`
` SSIES|sased
`
`
`
`
`‘S'q(ONOT“P2pyZ)SEL-ESL“ARLSUNEH)DINVDUQ“Sauos
`
`ws
`oy
`
`
`
`
`
`‘eeosud“S37“(P661)
`
`
`
`STE-TTE“SANAOdNODDINVOAOAOAWLSTIWAHSDOAM