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`(54)Title:
`
`PREPARATIONS STABILIZED OVER LONG TIME
`
`(54)§éfiJ‘-imshfil'- emaerznn
`
`(57) Abstract
`Stable G»CSF preparations showing a residual G—CSF ratio of 90 % or more afler a long-term storage test at 25 ”C for 3 months;
`showing a residual G-CSF ratio of 90 % or more afler a long—term storage test at 40 °C for 2 months; showing a residual GCSF ratio of
`90 % or more after an accelerated test at 50 r’C for 1 month; or showing a residual G-CSF ratio of 9D % or more after an accelerated test at
`60 “C for 2 weeks; and showing a ratio of the formation of the methionine residue-oxidized derivative of G~CSF of l % or less after an
`accelerated test at 50 °C for 1 month or afier an accelerated test at 60 ”C for 2 weeks. A method for inhibiting the formation of the
`methionine residue-oxidized derivative of a physiologically active protein having methionine residues characterized by adding methionine to
`a composition containing this protein.
`
`MAIA Exhibit 1006
`
`MAIA V. BRACCO
`
`IPR PETITION
`
`
`
`
`MAIA Exhibit 1006
`MAIA V. BRACCO
`IPR PETITION
`
`

`

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