`Education and Employment
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`John L. Wood
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`2013- Robert A. Welch Distinguished Professor of Chemistry and Cancer Prevention and Research Institute of Texas
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`Scholar, Baylor University
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`2006-2013 A. I. Meyers Professor of Chemistry, Colorado State University
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`1998-2006 Professor of Chemistry with Tenure, Yale University
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`1997-1998 Associate Professor of Chemistry (non tenured), Yale University
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`1993-1997 Assistant Professor of Chemistry, Yale University
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`1991-1993 American Cancer Society Postdoctoral Fellow, Harvard University
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`1985-1991 Ph.D., Organic Chemistry, University of Pennsylvania, Philadelphia, PA.
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`1980-1985 B.A., Chemistry, University of Colorado, Boulder, CO.
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`Honors and Awards
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`Invited Overseas Lecturer, Universities of Switzerland Summer School 2013
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`Katritzky Award in Heterocyclic Chemistry (ISHC) 2009
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`3éme Cycle Lectureship, University of Basel 2009
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`Distinguished Behringer Simon Lecturer, ETH Zurich 2009
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`Amgen Faculty Award 2005, 2006, 2007, 2008, 2009
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`Japanese Society for the Promotion of Science Fellow 2008
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`American Chemical Society Arthur C. Cope Scholar Award, 2004
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`Yamanouchi USA Faculty Award 1998, 1999, 2000, 2001, 2002, 2003
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`Merck Faculty Award 2000, 2001, 2002
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`Kitasato Microbial Chemistry Medal 2001
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`Bristol-Myers Squibb Foundation Research Award 1998-2001
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`Pfizer Research Award 1997-2001
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`Zeneca Excellence in Chemistry Award 1998
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`Dreyfus Teacher Scholar Award 1998
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`Novartis Chemistry Lectureship 1997-1998
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`Alfred P. Sloan Foundation Fellow 1997
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`Parke-Davis Distinguished Michigan Lecturer 1997
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`Bristol-Myers Squibb Research Award 1997
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`Glaxo-Wellcome Young Chemistry Scholar Award 1996-1998
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`Eli Lilly Young Faculty Award 1996-1997
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`Invited Visiting Professor, University of Auckland New Zealand 1997
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`Invited Guest Editor, Tetrahedron Symposium in Print on Synthetic Methods V 1997
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`NSF CAREER award 1996-2000
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`Yale University, Junior Faculty Fellowship, 1996-1997
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`American Cancer Society, Junior Faculty Award 1994
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`Camille and Henry Dreyfus New Faculty Award 1993
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`American Cancer Society Postdoctoral Fellowship 1991-1993
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`National Institutes of Health Postdoctoral Fellowship 1991-1993 (declined)
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`University of Pennsylvania Dean's Dissertation Fellowship 1989-1990
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`Distinguished Organic Chemistry Teaching Award 1986
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`B. A. in chemistry, Summa Cum Laude in Chemistry, 1985
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`Professional Service:
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`Chair, International Conference on the Chemistry of Antibiotics 2015
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`Chair, 16th Tetrahedron Symposium, Berlin 2015
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`Chair, 16th Tetrahedron Symposium Asia Edition, Shanghai 2015
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`Elected Vice Chair/Chair 2012/2013 Gordon Conference on Heterocyclic Chemistry
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`Elected to the Board of Editors, Organic Syntheses Inc. 2011-2019
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`Elected Member at Large, ACS Division of Organic Chemistry Executive Committee 2008-2011
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`Co-Organizer NSF Workshop on Organic Synthesis and Natural Products Chemistry 2007-2009
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`NIH Study Section (SBCB), Member 2006-2010
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`NIH Study Section, ad hoc, Med. Chem. 2005
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`NIH Special Study Section 2002, 2003 2004
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`Consultant: Rib-X Pharmaceuticals. 2002-2004
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`Associate Editor for the Americas: Tetrahedron Letters 2001-present
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`Consultant: Amgen 2006-2008
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`Consultant: Wyeth-Ayerst 2000-2004
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`Consultant: Eli Lilly: 2000-2001
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`American Cancer Society, External Grants Review Panel, ad hoc, 1997
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`NSF CAREER award referee 1997-2002, 2007
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`NIH Study Section, ad hoc, Med. Chem. A, 1999
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`American Cancer Society, External Grants Review Panel, member, 1999-2004
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`Beckman Foundation, Beckman Scholars Review Panel 1999.
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`Publications From Independent Career
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`“Total Synthesis of (±)-Aspergilline A” Nakhla, M. C.; Wood, J. L. J. Am. Chem. Soc. 2017, ASAP.
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`“Total Synthesis of (±)-Phomoidride D” Leung, J. C.; Bedermann, A. B.; Njardarson, J. T.; Spiegel, D. A.; Murphy,
`G. K.; Hama, N.; Twenter, B. M.; Dong, P.; Shirahata, T.; McDonald. I M.; Inoue, M.; Taniguchi, N.; McMahon, T.
`C.; Schneider, C. M.; Tao, N.; Stoltz, B. M.; Wood, J. L. Angewandte Chemie International Edition 2017, In Press.
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`“Total Syntheses of (+)-and (-)-Tetrapetalones A and C” Dhanjee H. H.; Kobayashi, Y.; Buergler, J. F.; McMahon, T.
`C.; Haley, M. W.; Howell, J. M.; Fujiwara, K.; Wood, J. L. J. Am. Chem. Soc. 2017, 139, 14901.
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`“Collaborative Total Synthesis: An Approach to (±)-Hippolachnin A Enabled by Quadricyclane Cycloaddition and
`Late-Stage C-H Oxidation” McCallum, M. E.; Rasik, C. M.; Wood, J. L.; Brown, M. K. J. Am. Chem. Soc. 2016,
`138, 2437-2442.
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`“A Palladium Pi-Allyl Cascade Toward Fused Tricyclic Systems en Route to Tetrapetalone A” Dhanjee, H. H.; Haley,
`M. W.; McMahon, T. C.; Kobayashi, Y.; Fujiwara, K.; Wood, J. L. Tetrahedron 2016, 72, 3673-3677.
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`“Amos B. Smith, III: chemist collaborator and mentor” Wood, J. L. Journal of Antibiotics 2016, 69, 189. (Editorial).
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`“Synthetic Studies Toward Citrinadin A: Construction of the Pentacyclic Core” McCallum, M. E.; Smith, G. M.;
`Matsumaru, T.; Kong, K.; Enquist Jr., J. A. Wood, J. L. Journal of Antibiotics 2016, 69, 331-336.
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`“Synthetic Applications and Methodological Developments of Donor-Acceptor Cyclopropanes and Related
`Compounds” O’Connor, N. R.; Wood, J. L.; Stoltz, B. M. Israel Journal of Chemistry 2016,56, 431.
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`“Harry Hirschal Wasserman” Wood, J. L. Tetrahedron Letters 2015, 56, 2977. (Editorial)
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`“Chemoselective Intramolecular Carbonyl Ylide Formation through Electronically Differentiated Molonate Diesters”
`Nakhla, M. C.; Lee, C.-W.; Wood, J. L. Organic Letters 2015, 17, 5760-5763.
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`“Metformin Suppresses Gluconeogenesis by Inhibiting Mitochondrial Glycerophosphate Dehydrogenase” Madiraju,
`A. K.; Erion, D. M.; Rahimi, Y.; Zhang, X.-M.; Braddock, D. T.; Albright, R. A.; Prigaro, B. J.; Wood, J. L.; Bhanot,
`S.; MacDonald, M. J.; Jurczak, M. J.; Camporez, J.-P.; Lee, H.-Y.; Cline, G. W.; Samuel, V. T.; Kibbey R. G.;
`Shulman, G. I. Nature 2014, 510, 542.
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`“Synthetic Studies Toward the Citrinadins: Enantioselective Preparation of an Advanced Spirooxindole Intermediate”
`Matsumaru, T.; McCallum, M. E.; Enquist Jr., J. A.; Smith, G. M., Kong, K., Wood, J. L. Tetrahedron 2014, 70,
`4089-4093.
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`“Collaborative Synthesis” Wood, J. L. Nature 2014, 509, 203 (News and Views)
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`“An Enantioselective Total Synthesis and Stereochemical Revision of (+)-Citrinadin B” Kong, K.; Enquist, Jr., J.A.;
`McCallum, M.; Smith, G. M.; Matsumaru, T.; Menhaji-Klotz, E.; Wood, J. L. J. Am. Chem. Soc. 2013, 135, 10890-
`10893.
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`“Toward the Synthesis of Phomoidride D” Murphy, G. K.; Shirahata, T.; Hama, N.; Bedermann, A.; Dong, P.;
`McMahon, T. C.; Twenter, B. M.; Spiegel D. A.; McDonald, I. M.; Taniguchi, N.; Inoue, M.; Wood, J. L. J. Org.
`Chem. 2013, 78, 447-489.
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`“Wharton-Fragmentation-Based Approach to the Carbocyclic Core of the Phomoidrides” Murphy, G. K.; Hama, N.;
`Bedermann, A.; Dong, P.; Schneider, C. M.; McMahon, T. C.; Tao, R. N.; Twenter, B. M. Spiegel, D. A.; Wood, J. L.
`Organic Letters 2012, 14, 4544.
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`“The First Synthesis of an Epidiselenodiketopiperazine” McMahon, T. C.; Stanley, S.; Kazyanskaya, E.; Hung, D.;
`Wood, J. L. Organic Letters 2012, 14, 4534.
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`“Total Syntheses of (±)-Securinine and (±)-Allosecurinine” Chen, J.-H.; Levine, S. R.; Buergler, J. F.; McMahon, T.
`C.; Medeiros, M. R.; Wood, J. L. Organic Letters 2012, 14, 4531.
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`“Welwitindolinone is Well Worth It” Wood, J. L. Nature Chemistry 2012, 4, 341. (News and Views)
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`“A Scalable Formal Total Synthesis of Dehydrogliotoxin” McMahon, T. C.; Stanley, S.; Kazyanskaya, E.; Hung, D.;
`Wood, J. L.” Tetrahedron Letters 2011, 52, 2262.
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`“AAK1 Identified as and Inhibitor of Neuregulin-1/ErB4-Dependent Neurotrophic Factor Signaling Using Integrative
`Chemical Genomics and Proteomics” Kuai, L.; Ong, S.-E.; Madison, J. M.; Wang, X.; Duvall, J. R.; Lewis, T. A.;
`Luce, C. J.; Conner, S. D.; Pearlman, D. A.; Wood, J. L.; Schreiber, S. L.; Carr, S. A.; Scolnick, E. M.; Haggarty, S.
`J. Chemistry and Biology 2011, 18, 891.
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`“Synthetic Studies Toward Providencin: Efficient Construction of a Furanyl-Cyclobutanone Fragment” Stevens, S. J.;
`Bérubé, A.; Wood, J. L. Tetrahedron 2011, 67, 6479.
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`“Welwitindolinone C Synthetic Studies. Construction of the Welwitindolinone Carbon Skeleton via a Transannular
`Nitrone Cycloaddition” Freeman, D. B.; Holubec, A. A.; Weiss, M. W.; Dixon, J. A.; Kakefuda, A.; Ohtsuka, M.;
`Inoue, M.; Vaswani, R. G.; Ohki, H.; Doan, B. D.; Reisman, S. E.; Stoltz, B. M.; Day, J. J.; Tao, R. N. ; Dieterich, N.
`A.; Wood, J. L. Tetrahedron 2010, 66, 6647.
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`“An Enantioselective Approach to the Securinega Alkaloids: The Total Synthesis of (+)-Norsecurinine and (+)-
`Allonorsecurinine” Medeiros, M. R.; Wood, J. L. Tetrahedron 2010, 66, 4701.
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`“A One-Pot, Base-Free Annelation Approach to -Alkylidene--butyrolactones” Kitson, R. R. A.; Taylor, R. J. K.;
`Wood, J. L. Organic Letters 2009, 11, 5338.
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`“Progress Towards the Total Synthesis of (±)-Actinophilic Acid” Vaswani, R.; Day, J.; Wood, J. L. Organic Letters
`2009, 11, 4532.
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`“Spirolactone Syntheses Through A Rhodium-Catalyzed Intramolecular C-H Insertion Reaction: Model Studies
`Towards the Synthesis of Syringolides” Navarro-Villalobos, M.; Wood, J. L. Tetrahedron Letters 2009, 50, 6450.
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`“Total Syntheses of (+)- and (-)-syringolides 3 and of (+)- and (-)-syributins 1,2 and 3” Navarro-Villalobos, M.;
`Wood, J. L.; Jeong, S.; Benson, C. L.; Zeman, S. M.; McCarty, C.; Weiss, M. M.; Salcedo, A.; Jenkins, J.
`Tetrahedron 2009, 65, 8091.
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`“Identifying the Proteins to Which Small-Molecule Probes and Drugs Bind in Cells” Ong, S.-E.; Schenone, M.;
`Margolin, A.; Li, X.; Do, K.; Doud, M.; Mani, D.; Kuai, L.; Wang, X.; Wood, J.; Tolliday, N.; Koehler, A.;
`Marcaurelle, L.; Golub, T.; Gould, R.; Schreiber, S.; Carr, S. Proc. Nat. Acad. Sci. 2009, 106, 4617.
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`“Evolution of a Synthetic Strategy: Total Synthesis of (±)-Welwitindolinone A Isonitrile” Reisman, S.E.; Ready, J.
`M.; Weiss, M. M.; Hasuoka, A.; Hirata, M.; Tamaki, K.; Ovaska, T. V.; Smith, C. J.; Wood, J. L. J. Am. Chem. Soc.
`2008, 129, 2087.
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`“Expanding the Scope of Trialkylborane/Water Mediated Radical Reactions” Medeiros, M. R.; Schacherer, L. N.;
`Spiegel, D. A.; Wood, J. L. Organic Letters 2007, 9, 4427.
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` “Pyrrolysin Analogues as Substrates for Pyrrolysyl-tRNA synthetase” Polycarpo, C. R.; Herring, S.; Bérubé, A.;
`Wood, J. L.; Söll, D.; Ambrogelly, A. FEBS Letters 2006, 580, 6695.
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`“Progress Toward the Total Synthesis of Bacchopetiolone: Application of a Tandem Aromatic Oxidation/Diels-Alder
`Rection” Bérubé, A.; Drutu, I.; Wood, J. L. Org. Lett. 2006, 8, 5421.
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`“Total Synthesis of (±)-Welwitindolinone A Isonitrile” Reisman, S. E.; Ready, J. M.; Hasuoka, A.; Smith, C. J.;
`Wood, J. L. J. Am. Chem. Soc. 2006, 128, 1448.
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`“Deoxygenation of Alcohols Employing Water as the Hydrogen Atom Source” Spiegel, D. A.; Wiberg, K. B.;
`Schacherer, L. N.; Medeiros, M. R.; Wood, J. L. J. Am. Chem. Soc. 2005, 127, 12513.
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`“Increasing the Kinase Specificity of K252a by Protein Surface Recognition” Schneider, T. L.; Mathew, R. S.; Rice,
`K. P.; Tamaki, K.; Wood, J. L.; Schepartz, A. Organic Letters 2005, 7, 1695.
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`“Rhodium Perfluorobutyramide (Rh2(pfm)4): A Synthetically Useful Catalyst for Olefin Aziridinations” Keany, G. F.;
`Wood, J. L. Tetrahedron Letters 2005, 46, 4031.
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`“An Aminooacyl-tRNA Synthetase that Specifically Activates Pyrrolysin” Polycarpo, C.; Ambrogelly, A.; Bérubé,
`A.; Winbush, S. M.; McCloskey, J. A.; Crain, P. F.; Wood, J. L.; Söll, D. Proc. Nat. Acad. Sci. 2004, 101 (34),
`12450.
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`“Total Synthesis of Ingenol” Nickel, A. Maruyama, T.; Tang, H.; Murphy, P.; Greene, B.; Yusuff, N.; Wood, J. L. J.
`Am. Chem. Soc. 2004, 126, 16300.
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`“A Mild and Efficient Synthesis of Oxindoles: Progress Towards the Syntheses of Welwitindolinone A Isonitrile”
`Ready, J. M.; Reisman, S. E.; Hirata, M.; Weiss, M. M.; Tamaki, K.; Ovaska, T. V.; Wood, J. L. Angew. Chem. Int.
`Ed. Engl 2004, 43, 1270.
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`“The Art of Innovation in Organic Chemistry: Synthetic Efforts Toward the Phomoidrides” Spiegel, D. A.;
`Njardarson, J. T.; McDonald, I. M.; Wood, J. L. Chemical Reviews 2003, 103, 2691.
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`“Rhodium-Catalyzed Synthesis of C(3) Disubstituted Oxindole: An Approach to Diazonamide A” Sawada, T.;
`Fuerst, D. E.; Wood, J. L. Tetrahedron Lett. 2003, 44, 4919.
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` “Application of Phenolic Oxidation Chemistry in Synthesis: Preparation of the BCE Ring System of Ryanodine”
`Wood, J. L.; Graeber, J. K.; Njardarson, J. T. Tetrahedron 2003, 59, 8855.
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`“Inhibitors of NF-kB Signaling: Design and Synthesis of a Biotinylated Isopanepoxydone Affinity Reagent”
`Shotwell, J. B.; Koh, B.; Choi, H. W.; Wood, J. L.; Crews, C. M. Bioorg. Med. Chem. Lett. 2002, 12, 3463.
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`“The K252a Derivatives, Inhibitors for the PAK/MLK Kinase Family, Selectively Block the Growth of RAS
`Transformants” Nheu, T. V.; He, H.; Hirokawa, Y.; Tamaki, K.; Florin, L.; Schmitz, M. L.; Suzuki-Takahashi, I.;
`Jorissen, R. N.; Burgess, A. W.; Nishimura, S.; Wood, J.; Maruta, H. The Cancer Journal 2002, 8, 328.
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` “Synthesis of (-)-7S)-and (+)-(7R)-K252a Dimers” Kazuhiko Tamaki, Elliott W. D. Huntsman, Dejah T. Petsch and
`John L. Wood Tetrahedron Letters 2002, 43, 379.
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`“Total Synthesis of Luminacin D” J. Brad Shotwell, Evan S. Krygowski, John Hines, Brian Koh, Elliott W. D.
`Huntsman, Hui Won Choi, John S. Schneekloth Jr., John L. Wood and Craig M. Crews Organic Letters 2002, 4,
`3087.
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`“CP-263,114 Synthetic Studies. Construction of an Isotwistane Ring System via Rhodium Carbenoid C-H Insertion”
`David A. Spiegel, Jón T. Njardarson, John L. Wood Tetrahedron 2002, 58, 6545.
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`"Reactive Dienes: Intramolecular Aromatic Oxidation of 3-(2-Hydroxyphenyl)-propionic Acids" Ioana Drutu, Jón T.
`Njardarson, John L. Wood Organic Letters, 2002, 4, 493.
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`"An Expeditious Approach Toward the Total Synthesis of CP-263,114" Jon Njardarson, Ivar MacDonald, David
`Spiegel, Munenori Inoue, John L. Wood Organic Letters, 2001, 3, 2435.
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`"Evolution of a Synthetic Approach to CP-263,114" Jon Njardarson and John L. Wood Organic Letters 2001, 3,
`2431.
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`"Effiecient Syntheses of Novel C2'-Alkylated (±)-K252a Analogs" Kazuhiko Tamaki, J. Brad Shotwell, Ryan D.
`White, Ioana Drutu, Dejah T. Petsch, Thao V. Nheu, Hong He,Yumiko Hirokawa, Hiroshi Maruta, and John L. Wood
`Organic Letters 2001, 3, 1689.
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`"Progress Towards the Total Synthesis of Ingenol: Construction of the Complete Carbocyclic Skeleton" Heifeng Tang,
`Naeem Yussuf, John L. Wood Organic Letters 2001, 3, 1563.
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`"Progress Toward the Total Synthesis of Kalihinane Diterpenoids" Ryan D. White and John L. Wood. Organic
`Letters 2001, 3, 1825.
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`"Catalyst-based Control of [2,3] and [3,3] Rearrangement in a-Diazoketone-derived Propargyloxy Enols" George A.
`Moniz and John L. Wood J. Am. Chem. Soc. 2001, 123, 5095.
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`"Reactive Enols in Synthesis 2: An Efficient Total Synthesis of (+)-Latifolic Acid and (+)-Latifoline"Ioana Drutu,
`Evan Grabowski, John L. Wood J. Org. Chem. 2001, 66, 7025.
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`"Total Synthesis of Epoxysorbicillinol" Brian D. Thompson, Naeem Yusuff, and Derek A. Pflum J. Am. Chem. Soc,
`2001, 123, 2097.
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`“A Chemical Switch for Inhibitor-Sensitive Alleles of Any Protein Kinase” Anthony C. Bishop, Jeffrey A. Ubersax,
`Dejah T. Petsch, Dina P. Matheos, Nathanael S. Gray, Justin Blethrow, Eijl Shimizu, Joe Z. Tsien, Peter G. Schultz,
`Mark D. Rose, John L. Wood, David O. Morgan, and Kevan M. Shokat Nature, 2000, 407, 395.
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`"Efficient Stereoselective Syntheses of Isopanepoxydone and Panepoxydone: A Re-Assignment of Relative
`Stereochemistry" J. Brad Shotwell, Shaojing Hu, Eva Medina, Megumi Abe, Roger Cole, Craig M. Crews, and John
`L. Wood Tetrahedron Lett. 2000, 41, 9639.
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`"Synthesis of C(3) Benzofuran-Derived Bis-Aryl Quaternary Centers: Approaches to Diazonamide A" Douglas E.
`Fuerst, Brian M. Stoltz, John L. Wood Organic Letters 2000, 2, 3521.
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`"Total Synthesis and Protein Kinase Activity of C(7) Methyl Derivatives of K252a" John L. Wood, Dejah T. Petsch,
`Brian M. Stoltz, Elizabeth M. Hawkins Daniel Elbaum, David R. Stover Synthesis 1999, 1529.
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`"Rhodium Carbenoid-Initiated Claisen Rearrangement: Scope and Mechanistic Observations" John L. Wood and
`George A. Moniz Organic Letters 1999, 1, 371.
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`"Application of Reactive Enols in Synthesis: A Versatile, Efficient and Stereoselective Construction of the
`Welwitindolinone Carbon Skeleton" John L. Wood, Alexandra A. Holubec, Brian M. Stoltz, Matthew M. Weiss, Julie
`A. Dixon, Brian D. Doan, Mohammed F. Shamji, Jennifer M. Chen, and Timothy P. Heffron J. Am. Chem. Soc. 1999,
`121 6326.
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`"Development of a Rhodium Carbenoid-Initiated Claisen Rearrangement for the Enantioselective Synthesis of a-
`Hydroxy Carbonyl Compounds" John L. Wood, George A. Moniz, Derek A. Pflum, Brian M. Stoltz, Alexandra A.
`Holubec, and Hans-Juergen Dietrich J. Am. Chem. Soc. 1999, 121 1748.
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`"Design and Implementation of an Efficient Synthetic Approach to Pyranosylated Indolocarbazoles: Total Synthesis
`of (+)-RK286c, (+)-MLR-52, (+)-Staurosporine, and (-)-TAN-1030a" John L. Wood, Brian M. Stoltz, Steven N.
`Goodman, Kenolisa Onwueme J. Am. Chem. Soc. 1997, 119, 9652.
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`"Design and Implementation of an Efficient Synthetic Approach to Furanosylated Indolocarbazoles: Total Synthesis
`of (+)- and (-)-K252a" John L. Wood, Brian M. Stoltz, Hans-Juergen Dietrich, Derek A. Pflum, and Dejah T. Petsch
`J. Am. Chem. Soc. 1997, 119, 9641.
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`"An Approach to Chiral Tri-Substituted Olefins: Synthesis of the C(1)-C(7) Segment of Halichomycin" Erin E.
`McCann, Glenn Janes, Craig Ortsey, and John L. Wood Tetrahedron Letters 1997, 38, 303.
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`"Glycosylated Indolocarbazole Synthesis" John L. Wood, Brian M. Stoltz, Hans-Jürgen Dietrich, Derek Pflum
`International Patent Application Publication Number WO 97/07081
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`"The Total Synthesis of (+)-RK-286c, (+)-MLR-52, (+)-Staurosporine, and (+)-K252a." John L. Wood, Brian M.
`Stoltz, Steven N. Goodman J. Am. Chem. Soc. 1996, 118, 10656.
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`"The Synthesis of Desamido Analogs of Staurosporine, RK-286c, and TAN-1030a." John L. Wood, Brian M. Stoltz,
`Kenolisa Onwueme, and Steven N. Goodman Tetrahedron Lett. 1996, 37, 7335.
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`"The Stereoselective Ring Contraction of a Pyranosylated Indolocarbazole. A Biosynthetic Link Between K252a and
`Staurosporine?" Brian M. Stoltz.; John L. Wood Tetrahedron Lett. 1996, 37, 3929.
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`"A Ring Expansion Approach to Pyranosylated Indolocarbazoles" Brian M. Stoltz and John L. Wood Tetrahedron
`Lett. 1995, 36, 8543.
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`"The Total Synthesis of (+)- and (-)-K252a" John L. Wood, Brian M. Stoltz, and Hans-Jürgen Dietrich J. Am. Chem.
`Soc. 1995, 117, 10,413.
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`"The Total Syntheses of (+)- and (-)-Syringolides 1 and 2" John L. Wood, Susan Jeong, Annalee Salcedo, and
`Jonathan Jenkins J. Org. Chem. 1995, 60, 286
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`Publications From Postdoctoral Work, Harvard University
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`"Total Syntheses of Di- and Tri-O-Methyl Dynemicin A Methyl Esters" Jack Taunton, John L. Wood, and Stuart L.
`Schreiber J. Am. Chem. Soc. 1993, 115, 10378.
`
`
`21. "Application of the Allylic Diazene Rearrangement: Synthesis of the Enediyne-Bridged Tricyclic Core of Dynemicin A"
`John L. Wood, John A. Porco, Jr., Jack Taunton, Angela Y. Lee, Jon Clardy, and Stuart L. Schreiber J. Am. Chem. Soc.
`1992, 114, 5898.
`
`
`
`
`
`Publications From Graduate Work, University of Pennsylvania
`
`
`20.
`
`
`19.
`
`
`18.
`
`
`17.
`
`
`
`"Pyrrolinone-Based Peptidomimetics" Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb,
`Terence Keenan, John L. Wood, Mark Guzman, Alexander Pasternak U.S. Patent 5,770,732.
`
`"(+)-Trienomycins A, B, C, and F and (+)-Mycotrienins I and II: Relative and Absolute Stereochemistry" Amos B.
`Smith, III, John L. Wood, Weichyun Wong, Alexandra E. Gould, Carmelo J. Rizzo, Joseph Barbosa, Kanki
`Komiyama, Satoshi Omura J. Am. Chem. Soc. 1996, 118, 8308.
`
`"Total Synthesis of (+)-Trienomycins A and F via a Unified Strategy" Amos B. Smith, III, Joseph Barbosa, Weichyun
`Wong, John L. Wood J. Am. Chem. Soc. 1996, 118, 8317.
`
`"Pyrrolinone-Based Compounds" Ralph Hirschmann, Amos B. Smith, III, Paul Sprengeler, Ryan C. Holcomb,
`Terence Keenan, John L. Wood, Mark Guzman U.S. Patent 5,489,692.
`
`NEPTUNE GENERICS EX. 1003 00006
`
`

`

`16.
`
`
`15.
`
`
`14.
`
`
`13.
`
`
`
`12.
`
`
`11.
`
`10.
`
`9.
`
`8.
`
`
`7.
`
`
`6.
`
`
`5.
`
`4.
`
`
`3.
`
`
`2.
`
`1.
`
`
`
`
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`
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`
`
`"Total Synthesis of (+)-Trienomycins A and F" Amos B. Smith III, Joseph Barbosa, Weichyun Wong, and John L.
`Wood J. Am. Chem. Soc 1995, 117, 10,777.
`
`"Design and Synthesis of Nonpeptide Peptidomimetic Inhibitors of Renin" Amos B. Smith, III, Ryouichi Akaishi,
`David R. Jones, Terence P. Keenan, Mark C. Guzman, Ryan C. Holcomb, Paul A. Sprengler, John L. Wood, Ralph
`Hirschmann, M. Katherine Holloway Biopolymers (Peptide Science) 1995, 37, 29.
`
`"General Photoisomerization Approach to trans-Benzobicyclo-[5.1.0.]octenes: Synthetic and Mechanistic Studies"
`Amos B. Smith, III, John L. Wood, Terence P. Keenan, Nigel Liverton, and Melean Visnick J. Org. Chem. 1994, 59,
`6652.
`
`"De Novo Design, Synthesis, and X-ray Crystal Structures of Pyrrolinone-Based b-Strand Peptidomimetics" Amos B.
`Smith, III, Mark C. Guzman, Paul A. Sprengeler, Terence P. Keenan, Ryan C. Holcomb, John L. Wood, Patrick J.
`Carroll, and Ralph Hirschmann J. Am. Chem. Soc. 1994, 116, 9947.
`
`"The Design, Synthesis, and Crystal Structure of a Pyrrolinone-Based Peptidomimetic Possessing the Conformation of
`a b-Strand: Potential Application to the Design of Novel Inhibitors of Proteolytic Enzymes" Amos B. Smith, III,
`Terence P. Keenan, Ryan C. Holcomb, Paul A. Sprengeler, Mark C. Guzman, John L. Wood, Patrick J. Carroll, and
`Ralph Hirschmann J. Am. Chem. Soc. 1992, 114, 10673.
`
`"Synthesis and Rearrangement Reactions of the First trans-Homotropone" Amos B. Smith, III and John L. Wood J.
`Am. Chem. Soc. 1992,114, 10075.
`
`"Novel Structures of a trans-Cyclooctene and trans-Fused Cyclopropane Generated via Photoisomerization of a gem-
`Dichlorocyclopropyl Benzo--cycloheptenone" John L. Wood, Patrick J. Carroll, and Amos B. Smith, III J. Chem.
`Soc., Chem. Comm. 1992, 1433.
`
`"Total Synthesis of the Cytotoxic Macrocycle (+)-Hitachimycin" Amos B. Smith, III, Thomas A. Rano, Noritaka
`Chida, Gary A. Sulikowski and John L. Wood, J. Am. Chem Soc. 1992, 114, 8008.
`
`"(+)-Hitachimycin: Stereochemistry and Conformational Analysis" Amos B. Smith, III, John L. Wood, Carmelo J.
`Rizzo, George T. Furst, Patrick J. Carroll, Jerry Donohue, and Satoshi Omura J. Am. Chem. Soc. 1992, 114, 8003.
`
`"Isolation and Structure Determination of (+)-Trienomycin F. An Endgame Synthetic Strategy for the Trienomycin
`Family of Antitumor Antibiotics" Amos B. Smith, III, John L. Wood, Alexandra E. Gould, Satoshi Omura, and
`Kanki Komiyama Tetrahedron Lett. 1991, 32, 1627.
`
`"(+)-Mycotrienins I and II: Relative and Absolute Stereochemistry" Amos B. Smith, III and John L. Wood
`Tetrahedron Lett. 1991, 32, 841.
`
`"A Versatile, Efficient Synthesis of (-)-(2S, 3R, 4S)-2-Amino-1-cyclohexyl-3,4-dihydroxy-6-methylheptane, The
`Abbott Pseudodipeptidyl Insert" John L. Wood, David R. Jones, Ralph Hirschmann, and Amos B. Smith, III
`Tetrahedron Lett. 1990, 31, 6329.
`
`"Aphidicolin Synthetic Studies, 2. 2D-NMR Analysis of (+)-Aphidicolin and Its Degradation Products 3a,18-
`Dihydroxy-17-noraphidicolan-16-one and 3a,18-iso-propylidenedioxy-17-noraphidicolan-16-one. Complete 1H and
`13C assignments" Carmelo J. Rizzo, John L. Wood, George T. Furst, and Amos B. Smith, III J. Nat. Prod. 1990, 53,
`735.
`
`"(+)-Trienomycins A, B, and C: Relative and Absolute Stereochemistry" Amos B. Smith, III, John L. Wood,
`Weichyun Wong, Alexandra E. Gould, Carmelo J. Rizzo, Shinji Funayama, and Satoshi Omura J. Am. Chem. Soc.
`1990, 112, 7425.
`
`"Solution and Crystal Structures of (+)-Hitachimycin (Stubomycin)" Amos B. Smith, III, John L. Wood, Carmelo J.
`Rizzo, George T. Furst, Patrick J. Carroll, Jerry Donohue, and Satoshi Omura J. Org. Chem. 1990, 55, 1133.
`
`"An Efficient Photochemical Approach to the trans-Bicyclo[5.1.0]octene Ring System." John L. Wood, Nigel J.
`Liverton, Melean Visnick, and Amos B. Smith, III J. Am. Chem. Soc. 1989, 111, 4530.
`
`NEPTUNE GENERICS EX. 1003 00007
`
`

`

`Invited Lectures
`
`Given
`1. Mount Holyoke College (October 1993)
`2. Natural Products GRC (July 1995)
`3. GRC, Heterocyclic Chemistry (July 1995)
`4. Eastman Kodak Inc. (July 1995)
`5. Glaxo-Wellcome Raleigh NC (September 1995)
`6. Merck Inc. West Point, PA (October 1995)
`7. Pfizer Inc. Groton, CT (October 1995)
`8. Cephalon Inc. West Chester, PA (November 1995)
`9. SUNY Stony Brook (November 1995)
`10. The University of Connecticut (November 1995)
`11. Smith-Kline Beecham (December 1995)
`12. Boehringer-Ingelheim (February 1996)
`13. U. of Chicago Abbott Symposium (April 1996)
`14. Eli Lilly, Indianapolis IN (May 1996)
`15. GRC Reactions and Processes (July 1996)
`16. NSF workshop, natural products (June 1996)
`17. CUNY Hunter College (September 1996)
`18. U. Mass., Dartmouth (September 1996)
`19. Syracuse University (November 1996)
`20. University of California, Irvine (December 1996)
`21. Ciba-Geigy Corporation (January 1997)
`22. Vertex Inc. (January 1997)
`23. Connecticut College (February 1997)
`24. U. of Illinois, Urbana-Champagne (February 1997)
`25. Boston College (February 1997)
`26. Wesleyan University (February 1997)
`27. ACS Symp., Creativity in Synthesis (April 1997)
`28. CUNY Queens College (March 1997)
`29. exas A&M University (April 1997)
`30. University of Texas, Austin (April 1997)
`31. Rice University (April 1997)
`32. Wayne State University (April 1997)
`33. University of Toledo (April 1997)
`34. University of Michigan (April 1997)
`35. Michigan State University (April 1997)
`36. Parke-Davis, Ann Arbor, MI (April 1997)
`37. University of Auckland (May 1997)
`38. Waikato University (May 1997)
`39. Canterbury University (May 1997)(
`40. Keio University (May 1997)
`41. The Kitasato Institute (May 1997)
`42. Tokyo University (May 1997)
`43. Yamanouchi Pharmaceutical Company (May 1997)
`44. Keynote Speaker 1997 NERM (June 1997)
`45. Proctor and Gamble Colloquium (August 1997)
`46. Merck Rahway (August 1997)
`47. American Cyanamid (September 1997)
`48. Wyeth-Ayerst (September 1997)
`49. Sloan-Kettering (September 1997)
`50. Schering-Plough Corporation (October 1997)
`51. Bristol-Myers Squibb (October 1997)
`52. Glaxo-Wellcome (October 1997)
`53. University of Pennsylvania (October 1997)
`54. Sacred Heart University (October 1997)
`55. The University of Pennsylvania (October 1997)
`56. Upjohn (November 1997)
`57. University College London (November 1997)
`58. University of Southampton (November 1997)
`59. University of Glasgow (November 1997)
`60. Nottingham University (November 1997)
`61. Merck Harlow (November 1997)
`62. Sepracor (December 1997)
`63. Roche (December 1997)
`64. R.W. Johnson (December 1997)
`65. Dupont Ag. & DuPont Merck (January 1998)
`66. Novartis, Basel (February 1998)
`67. Novartis Vienna (February 1998)
`68. Brandeis University (February 1998)
`
`69. Searle (March 1998)
`70. Eli Lilly (March 1998)
`71. Vanderbilt University (April 1998)
`72. Washington University (April 1998)
`73. The Unviersity of Arizona (April 1998)
`74. U. of Colorado-Syntex/Roche Symp. (May 1998)
`75. Harvard University (May 1998)
`76. University of Toronto (May 1998)
`77. Smith-Kline Beecham (June 1998)
`78. Vion Pharmaceuticals (July1998)
`79. Neurogen Corporation (July 1998)
`80. The Karolinska Institute, Stockholm (October 1998)
`81. Glaxo-Wellcome (October 1998)
`82. Zeneca Pharmaceuticals (October 1998)
`83. Boston University (October 1998)
`84. New York Academy of Sciences (November 1998)
`85. Bristol-Myers Squibb (November 1998)
`86. University of Pittsburgh (November 1998)
`87. MIT (December 1998)
`88. University of Missouri (January 1999)
`89. Bristol-Myers Squibb (March 1999)
`90. University of Virginia (April 1999)
`91. Chiral-99 (April 1999)
`92.Sternbach Symposium, Roche (May 1999)
`93. Wyeth-Ayerst (June 1999)
`94. Toyama University (November 1999)
`95. 14th Annual Nozaki Conf. (Kyoto, November 1999)
`96. University of California, Berkeley (October 1999)
`97. Sankyo, Tokyo (January 2000)
`98. RIKEN Bioprobes Conf., Tokyo (January 2000)
`99. Yamanouchi, Tskuba (January 2000)
`100. Chiba Univeristy, Japan (January 2000)
`101. Caltech (January 2000)
`102. USC (January 2000)
`103. Univeristy of Rochester (February 2000)
`104. Albany Molecular Research Inst. (March 2000)
`105. Rensselaer Polytechnic Institute (March 2000)
`106. Indiana University (April 2000)
`107. Eli Lilly (April 2000)
`108. Heterocycles Gordon Conference (July 2000)
`109. Princeton Symposium (September 2000)
`110. RW Johnson (October 2000)
`111. Manhatten College (October 2000)
`112. University of Montreal (November 2000)
`113. Pacifichem 2000 (December 2000)
`114. Array Biopharma (December 2000)
`115. Scripps (February 2001)
`116. University of Utah (March 2001)
`117. University of Wisconsin (March 2001)
`118. North Jersey Symposium (April 2001)
`119. Merch West Point (September 2001)
`120. Dow Agrochemical (October 2001)
`121. University of Chicago (October 2001)
`122. Tishler Symposium, Tokyo (November 2001)
`123. Sankyo Pharmaceuticals (November 2001)
`124. Sepracor Symposium (March 2002)
`125. Caltech (March 2002)
`126. Chinese Academy of Sciences, Beijing (April 2002)
`127. Locus Pharmaceuticals (May 2002)
`128. Abbott (May 2002)
`129. IUPAC ICOS, Christchurch (July 2002)
`130. UT Southwestern (September 2002)
`131. Texas A&M (September 2002)
`132. W.S Johnson Symposium, Stanford (October 2002)
`133. UC Santa Cruz (October 2002)
`134. Phil. Organic Chemists Club (January 2003)
`135. Locus Pharmaceuticals (January 2003)
`136. 3-D Pharmaceuticals (February 2003)
`137. Purdue Univeristy (March 2003)
`138. ACS Ernest Guenther Award Symp. (March 2003)
`139. Univeristy of Iowa (April 2003)
`140. Scherring Plough (May 2003)
`
`NEPTUNE GENERICS EX. 1003 00008
`
`

`

`141. Iowa State University (October 2003)
`142. National Organic Symposium (June 2003)
`143. Haverford College (September 2003)
`144. Smith College (September 2003)
`145. Banff Organic Chemistry Conference (2003)
`146. Amgen (November 2003)
`147. University of Michigan (December 2003)
`148. Kitasato Institute (February 2004)
`149. Yamanouchi (February 2004)
`150. Oregon State University (April 2004)
`151. University of Oregon (April 2004)
`152. McGill University (May 2004)
`153. Merck Rahway (May 2004)
`154. Bayer West Haven (May 2004)
`155. Stereochemistry GRC (June 2004)
`156. IUPAC, ICOS Nagoya (August 2004)
`157. ACS Cope Award Symp. (August 2004)
`158. Pfizer St. Louis (September 2004)
`159. Oppolzer Symposium Geneva (October 2004)
`160. University of Illinois Chicago (October 2004)
`161. University of Minnesota (November 2004)
`162. Millenium Pharmaceuticals (November 2004)
`163. UCLA (December 2004)
`164. University of Arizona (February 2005)
`165. Johnson and Johnson, San Diego (February 2005)
`166. Pfizer, Ann Arbor (March 2005)
`167. Wayne State University (March 2005)
`168. Guenther Award (Satoshi Omura, March 2005)
`169. Bürgenstock Meeting (April 2005)
`170. Colorado State University (April 2005)
`171. SUNY Buffalo (May 2005)
`172. Northwestern University (May 2005)
`173. Canadian Chem Conf, Saskatoon (May 2005)
`174. Pfizer, Groton CT (September 2005)
`175. Astra-Zeneca, Boston (September 2005)
`176. Dupont Agricultural (January 2006)
`177. Franklin and Marshall (January 2006)
`178. Vertex (April 2006)
`179. Harvard University (April 2006)
`180. Roche, Palo Alto (May 2006)
`181. Takeda Pharmaceuticals (May 2006)
`182. Astellas Pharmaceuticals (May 2006)
`183. Tetrahedron Symposium, Kyoto (May 2006)
`184. Shiorin Pharamaceuticals (May 2006)
`185. French American Chemical Society (June 2006)
`186. Heterocycles GRC (July 2006)
`187. University College Lo