`Date Filed: February 8, 2019
`Paper No. 10
`
`
`
`
`
`
`
`
`
`
`
`Filed On Behalf Of:
`
`Sanofi Mature IP
`
`By:
`
`Daniel J. Minion
`dminion@venable.com
`212-218-2100
`
`
`
`UNITED STATES PATENT AND TRADEMARK OFFICE
`________________
`
`BEFORE THE PATENT TRIAL AND APPEAL BOARD
`________________
`
`NEPTUNE GENERICS, LLC
`Petitioner,
`v.
`AVENTIS PHARMA S.A.
`Patent Owner.
`________________
`
`Case IPR2019-00136
`U.S. Patent No. 5,847,170
`________________
`
`
`
`PATENT OWNER’S EXHIBIT LIST
`
`
`
`
`
`
`
`
`
`
`PATENT OWNER’S EXHIBIT LIST
`
`
`
` Pursuant to 37 C.F.R. § 42.63(e), Patent Owner respectfully submits the
`
`following current exhibit list.
`
`Exhibit Description
`
`de Bono et al., “Prednisone plus cabazitaxel or mitoxantrone for
`
`metastatic castration-resistant prostate cancer progressing after docetaxel
`
`2001
`
`treatment: a randomised open-label trial,”
`
`376:1147-54, Lancet, 2010 (“deBono”)
`
`Sanofi Press Release, Phase III Data Showing Improved Survival with
`
`Jevtana® (cabazitaxel) Injection in Second-Line Advanced Prostate
`
`2002
`
`Cancer Published in The Lancet – Results of the Phase III TROPIC
`
`Global Study Published, (Oct. 9, 2010, last accessed Jan. 23, 2019 at
`
`http://www.news.sanofi.us/press-releases?item=118536&printable)
`
`2003
`
`United States Patent No. 5,229,526 (“’526 patent)
`
`2004
`
`United States Patent No. 5,319,112 (“’112 patent”)
`
`2005
`
`International Patent Application Publication No. WO 94/18164
`
`Ojima et al., “Synthesis and biological activity of 3’-alkyl- and 3’-
`
`2006
`
`alkenyl-3’-dephenyldocetaxels,” 4(21): 2631-34, Bioorg. & Medicinal
`
`Chem. Lett., 1994 (“Ojima”)
`
`
`
`1
`
`
`
`Exhibit Description
`
`Graham L. Patrick, Ch. 7, “Drug Development,” in An Introduction to
`
`2007
`
`Medicinal Chemistry, (Oxford University Press, eds., 1995)
`
`Dolatrai M. Vyas, Ph.D. & John F. Kadow, PhD., Ch. 6 “Paclitaxel: A
`
`2008
`
`Unique Tubulin Interacting Anticancer Agent,” in Progress in Medicinal
`
`Chemistry 32, (Ellis & Luscombe, eds.) (“Vyas”)
`
`Vrignaud et al., “Preclinical Antitumor Activity of Cabazitaxel, a
`
`2009
`
`Semisynthetic Taxane Active in Taxane-Resistant Tumors,”
`
`19(11):2973-83, Clin. Cancer Res., 2013 (“Vrignaud 2013”)
`
`Defendants’ Post-Trial Brief, filed in Sanofi-Aventis U.S. LLC et al. v.
`
`2010
`
`Fresenius Kabi USA, LLC, 3:14-cv-017869-MAS-LHG, D.I. 272-1
`
`(D.N.J. Nov. 1, 2017)
`
`Mylan Labs. Ltd. v. Aventis Pharma S.A., IPR2016-00627, Paper No. 1
`
`2011
`
`(Petition) (P.T.A.B. Feb. 17, 2016) (“Prior Petition” or “Mylan IPR”)
`
`2012
`
`RESERVED
`
`2013
`
`RESERVED
`
`Kingston, Ch. 15, “Recent Advances in the Chemistry and Structure—
`
`2014
`
`Activity Relationships of Paclitaxel,” in Taxane Anticancer Agents, ACS
`
`Symposium Series Vol. 583, pp. 203-16 (“Kingston”)
`
`
`
`2
`
`
`
`Exhibit Description
`
`Rowinsky et al., “Taxol: the First of the Taxanes, an Important New
`
`2015
`
`Class of Antitumor Agents,” 19(6): 646-62, Semin. Oncol., 1992
`
`(“Rowinsky”)
`
`Stierle et al., Ch. 6, “Bioactive Metabolites of the Endophytic Fungi of
`
`Pacific Yew, Taxus brevifolia,” in Taxane Anticancer Agents, ACS
`
`2016
`
`Symposium Series, Vol. 583, pp. 81-97 (Georg et al., eds., 1994)
`
`(“Stierle”)
`
`2017
`
`RESERVED
`
`W. Mellado et al., Preparation and Biological Activity of Taxol
`
`2018
`
`Acetates, 124 BIOCHEM. BIOPHYS. RESEARCH COMM. 329 (1984)
`
`2019
`
`U.S. Patent No. 5,352,806
`
`Mylan Labs. Ltd. v. Aventis Pharma S.A., IPR2016-00627, Paper No. 10
`
`(P.T.A.B. Aug. 23, 2016)
`
`Mylan Labs. Ltd. v. Aventis Pharma S.A., IPR2016-00627, Paper No. 12
`
`(P.T.A.B. Jan. 26, 2017)
`
`Excerpted transcript of the May 12, 2016 videotaped deposition of Dr.
`
`Hervé Bouchard, at 177:1–181:25
`
`3
`
`2020
`
`2021
`
`2022
`
`
`
`
`
`Exhibit Description
`
`Excerpted transcript of the September 27, 2017 trial testimony of Dr.
`
`Hervé Bouchard, at 1004–09; 1042–58
`
`2023
`
`
`
`Date: February 8, 2019
`
`
`
`
`
`
`
`Respectfully submitted,
`
`By: /Daniel J. Minion/
`Daniel J. Minion (Reg. No. 53,329)
`Venable LLP
`1290 Avenue of the Americas
`New York, NY 10104
`Tel: 212-218-2538
`Fax: 212-218-2200
`DMinion@Venable.com
`
`Attorney for Patent Owner,
`Sanofi Mature IP
`
`
`
`4
`
`
`
`
`
`
`
`
`
`
`
`
`
`CERTIFICATE OF SERVICE
`
`The undersigned hereby certifies that copies of the PATENT OWNER’S
`
`EXHIBIT LIST were served on February 8, 2019 as follows:
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`VIA ELECTRONIC MAIL
`Alexander E. Gasser (Reg. No. 48,760)
`Sarah Spires (Reg. No. 61,501)
`Paul J. Skiermont (pro hac vice to be requested)
`Skiermont Derby LLP
`1601 Elm Street, Suite 4400
`Dallas, Texas 75201
`Phone: 214-978-6600
`Fax: 214-978-6601
`agasser@skiermontderby.com
`sspires@skiermontderby.com
`pskiermont@skiermontderby.com
`
`Mieke Malmberg (pro hac vice to be requested)
`Skiermont Derby LLP
`800 Wilshire Blvd., Suite 1450
`Los Angeles, California 90017
`Phone: 213-788-4500
`Fax: 213-788-4545
`mmalmberg@skiermontderby.com
`
`
`
`
`
`
`
`
`
`
`
`
`
`By:
`
`
`
`/Daniel J. Minion/
`Daniel J. Minion
`Reg. No. 53,329
`
`
`Dated: February 8, 2019
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
Accessing this document will incur an additional charge of $.
After purchase, you can access this document again without charge.
Accept $ Charge
Still Working On It
This document is taking longer than usual to download. This can happen if we need to contact the court directly to obtain the document and their servers are running slowly.
Give it another minute or two to complete, and then try the refresh button.
A few More Minutes ... Still Working
It can take up to 5 minutes for us to download a document if the court servers are running slowly.
Thank you for your continued patience.
This document could not be displayed.
We could not find this document within its docket. Please go back to the docket page and check the link. If that does not work, go back to the docket and refresh it to pull the newest information.
Your account does not support viewing this document.
You need a Paid Account to view this document. Click here to change your account type.
Your account does not support viewing this document.
Set your membership
status to view this document.
With a Docket Alarm membership, you'll
get a whole lot more, including:
- Up-to-date information for this case.
- Email alerts whenever there is an update.
- Full text search for other cases.
- Get email alerts whenever a new case matches your search.
One Moment Please
The filing “” is large (MB) and is being downloaded.
Please refresh this page in a few minutes to see if the filing has been downloaded. The filing will also be emailed to you when the download completes.
Your document is on its way!
If you do not receive the document in five minutes, contact support at support@docketalarm.com.
Sealed Document
We are unable to display this document, it may be under a court ordered seal.
If you have proper credentials to access the file, you may proceed directly to the court's system using your government issued username and password.
Access Government Site
