Dr. Reddy’s Laboratories, Inc. v. Celgene Corp.
`IPR2018-01509
`Exhibit 2033, Page 1
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`Dr. Reddy’s Laboratories, Inc. v. Celgene Corp.
`0
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`Exhibit 2033, Page 2
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`kI)a. are expressed on B and T cells. endothelial. epithelial.
`and dendritic cells. fibroblasts. kcratinocytes. and chondro—
`cytes. They are inducible in I244 hours by cytokines such as
`gamma interferon. interleukin-1B. and tumour necrosis factor-
`0. Example (human. precursors):
`lCAM~l major group rhi-
`novirus receptor: database code lCALHUMAN. 532 amino
`acids (57.76 kDa). [CAM-2 lur CD101). of molecular mass
`556.5 kDa. are constitutively expressed on endothelial cells.
`some lymphocytes. monocytes, and dendritic cells. Example
`(human): database code |CA2_HLIMAN. 275 amino acids
`(30.6: kDa). lCAM-3 (or C050). of molecular mass “6.7140
`kDa. are constitutively expressed on monocytes. granulocytes.
`and lymphocytes; upon physiological stimulation they become
`rapidly and transiently phosphorylated on scrine residues. Ex-
`ample (human): database code [CALHLTMAN 547 amino
`acids (59.32 kDa).
`ICD (in clinical t'hcriii’xiryl uhhr. for isocitrate dehydrogenase
`(EC l.I.t.4ti,
`ice the solid form of water that can exist at temperatures below
`the triple point of water (273.16 K at lUl 325 Pa).
`iceberg a metaphor used to describe an interpretation of the
`anomalous entropies of solution of noble gases and other non-
`polar substances in water. suggesting that water tends to organ-
`ize itself into quasi-solid supramolecular structures around the
`molecules of such substances. in the case ofalkyl compounds.
`this tendency increases markedly with the length of the alkyl
`chain.
`ICE-like protease any of a family of endopeptidases that
`structurally resemble interleukin-13 commmse (ICE). They are
`involved in apoptosit. being implicated in the proteolysis that
`causes cell death.
`Icoll
`l or CCK cell any of a group of cells. widely distributed
`in the duodenal and jejunal mucosa. that produce cholecysto-
`ltinin. So named because their histological features are inter-
`mediate between those of 8 calls and L cells. 2 uhhr.
`jar
`inclusion cell. See also lvcell disease.
`I-coll disease or inclusion-cell disease or mucolipidosis ll an
`autosomal recessive disease in which most of the lysosomes in
`the connective tissue (fibroblasts) contain large inclusions of
`glycoaminoglycans and glycolipids as a result of the absence
`of several
`lysosomal hydrolases. These enzymes. which are
`synthesized in the endoplasmic reticulum. are secreted into the
`extracellular medium rather than being directed to the lyso<
`somes. This is due to the absence of a mannose 6-phosphatc
`marker on the carbohydrate moieties of these hydrolases be-
`cause of a deficiency in an enzyme required for mannose phos—
`phorylation. The failure of the phosphorylation in the ('M'
`Golgi network means that the enzymes are not segregated by
`the iniinnosc 5-pliosphate receptors into the appropriate transport
`vesicles in the trans Golgi network. The patients have an ab-
`normally high level of lysosomal enzymes in their sera and
`body fluids. A milder form of l-cell disease is Hurler's pol)-
`dystrophy (Nude! syndrome).
`ice point the temperature at which ice melts. It is taken as the
`temperature (27],IS K) at which ice and water are in equilib-
`rium at standard pressure (101 325 Pa). It was used as a refer-
`ence temperature on the (‘elsms scale. but the kelvin is based
`instead on the temperature at the triple point of water (273.16 K ).
`ICF uhbr, for intracellular lluid.
`lchthyotocin an alternative name for isotocin.
`icosa+ or I'ht-jbri» a mutt/I icos+ romh. form recommended for
`denoting twenty or twenty times. Also (formerly): eicosao.
`eicos+. (Note: the eicosla)+ variant is still always used for the
`(Tm fatty acids and skeletally related compounds. e.g the
`eicosanoids.)
`icoudeltahodron (pl. icosldeltabedra) any solid geometrical
`
` tl lX iltii
`
`iri'mboljm l iso (def. 3); (as a prefix or superscript in symbols
`and abbreviations for iso compounds or groups; c.g. isopropyl
`can be symbolized as iPr or Pr‘). 2 the chemical group 2-
`isopentenyl; 3.3-dimethylallyl
`(as a prefix to a single-letter
`symbol for a nucleoside residue to deSignate substitution of
`the base. as in M). 3 the square root of~~-l.
`isi'mhuljbr 1 electric current (alternative to I). 2 van‘t Hoff fac-
`tor.
`
`lxymbol for I iodine. 2 an iodo group in an organic compound
`3 a residue of the a-amino acid i-isoleucine (alternative to
`He). 4 a residue of the ribonucleoside inosine (alternative to
`lno).
`I .rymholfor I electric current (preferred alternative to i). Z in-
`tenstty; the subscripts e (for energetic). p (for photon). or v
`(for visible) may be added to distinguish between radiant in-
`tenstty. photon intensity. and luminous intensity. respectively,
`3 ionic strength: the subscripts c or m may be added to indi-
`cate whether it is expressed based on concentration or molal-
`ity respectively. 4 the inductive effect of a particular chemical
`group in an organic compound.
`IA .V)’I71btll_f-(Ir N°-(2-isopentenyl)adenosme. a hyponnodiliod base.
`IAA ahbr. for indole-3—acetic acid or indoleacctate.
`IAN ahbr. for indoleacetonitrile.
`IAP abbr. for islet-activating protein; .i't’t‘ pomissis toxin.
`iatrogenic describing a condition or disease induced uninten-
`tionally by a physician through his or her diagnosis. manner.
`or therapy. fiintrogenicity n,
`l-band abhr. for isotropic band. The l-bands of striated muscle
`contain the thin filaments and correspond to the light bands.
`The name derives from the fact that they are isotropic in po-
`larized light. Soc also urcomore.
`IBMX ahhr. for isobutylmethylxanthine.
`Ibuprofen 2-(4’isobutylphenyl)propionic acid; a nonsteroidal
`anti-inflammatory agent of the substituted propionic acid
`type; others of this type are flurbiprofen. kaloprolen. and
`naproxen. They inhibit the cyclooxygenase activity of prosta-
`glandin-ondopemxide synthese. reversibly over short time inter-
`vals. followed by time—dependent irreversible inactivation. due
`probably to conformational rather than covalent changes. The
`racemic mixture is present
`in many over-the—countcr drugs.
`but the ('Sl-enantionier is the active form. Prtlprlt’lul‘ll' mum's
`include: Advil: Brufen; Motrin,
`
`
`
`(Si-ibuproten
`
`it: or i.c. (1th (or iiitracutaiieous or intracutancously
`IC ahhr. for internal conversion
`l) of an
`IO“ 1 the median inhibitory concentration (in mol l.
`antagonist. re the concentration that reduces a spec‘ified re-
`sponse to 5(% of its former value; nnnpure EC”. 2 the median
`inhibitory concentration (in mol L“) of an agent (agonist or
`antagonist). i.e. the concentration that causes a 50“.» reduction
`in the specific binding of a radioligand.
`ICAM abbr. for intercellular adhesion molecule: any of several
`type I membrane glycoproteins of the immunoglobulin super-
`family. They act as ligands for leukocyte adhesion to target
`cells.
`in conjunction with “AA: in fact LFA-l—lCAM links
`mediate adhesron between many cell
`types. There are three
`
`