Medications : National Multiple Sclerosis Society
`
`9/18/2019
`
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`Medications
`
`In this article
`> Overview
`
`> MyLng the disease course
`
`> Mgiflgfiam
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`
`> Additional resources
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`Overview
`
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`Medications are used in multiple sclerosis (MS) to modify the disease course, treat relapses — also called attacks or
`
`exacerbations — and manage symptoms. Along with the other essential components of comprehensive MS care, these
`
`medications help people manage their MS and enhance their comfort and quality of life.
`
`Modifying the disease course
`
`The following US Food and Drug Administration (FDA) approved disease modifying therapies for MS have been found
`
`through clinical trials to reduce the number of relapses, delay progression of disability, and limit new disease activity (as
`
`seen on MRI).
`
`> lnjectable medications
`> Avonex (interferon beta-1a)
`
`Betaseron (interferon beta-1b)
`
`QM (glatiramer acetate)
`
`m (interferon beta-1b)
`
`Glatiramer Acetate Injm (glatiramer acetate -generic equivalent of Copaxone 20 mg and 40 mg doses)
`
`Mpg (glatiramer acetate - generic equivalent of Copaxone 20mg and 40mg doses)
`
`figfly (peginterferon beta-1a)
`
`Rebif (interferon beta-1a)
`
`> Oral medications
`
`Aubagig (teriflunomide)
`
`Gilenyg (fingolimod)
`
`Tecfidera (dimethyl fumarate)
`
`Mavenclad (cladribine)
`
`> Infused medications
`
`> Lemtrada (alemtuzumab)
`
`https://www.nationalmssociety.org/Treating-MS/Medications
`
`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 1
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`1/5
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`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 1
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`

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`9/18/2019
`
`Medications : National Multiple Sclerosis Society
`
`> Novantrone (mitoxantrone)
`
`> Ocrevus (ocrelizumab)
`
`> Iysabri (natalizumab)
`
`Following the treatment plan that you and your healthcare provider have established is the best possible strategy for
`
`managing your MS:
`
`> Early and ongoing treatment with disease-modifying therapy is supported by the MS Coalition which includes the
`
`National MS Society. This evidence-based Consensus on Disease-Modifyi_ng Therapifi (.pdf) may be useful when
`
`discussing treatment options with your healthcare provider and advocating with insurers for access and coverage.
`
`This paper was last updated March 2017.
`
`> The American Academy of Neurology (AAN) has developed guidelines for starting, switching and stoppi_ng disease
`
`modifymg therapifi for adults with clinically isolated syndrome, relapsing-remitting MS and progressive forms of
`
`MS. The National MS Society and Multiple Sclerosis Association of America has endorsed these guidelines.
`
`> For help in managing the costs of these medications, read about the patient assistance mgrams offered by the
`
`pharmaceutical companies.
`
`Managing relapses
`
`MS flpses are caused by inflammation in the central nervous system that damages the myelin coating around nerve
`
`fibers. This damage slows or disrupts the transmission of nerve impulses and causes the symptoms of MS. Most relapses
`
`will gradually resolve without treatment.
`
`For severe relapses (involving loss of vision, severe weakness or poor balance, for example), which interfere with a
`
`person’s mobility, safety or overall ability to function, your healthcare provider may recommend treatment with high dose
`
`oral or intravenous corticosteroids. Corticosteroids do not have any long-term benefit on the disease.
`
`Medication options include:
`
`> High-dose intravenous Solu-Medrol® (methylprednisolone)
`
`> High-dose oral Deltasone® (prednisone)
`
`> HP. Acthar Gel (ACTH)
`
`Managing symptoms
`
`A wide variety of medications are used to help manage the symptoms of MS. Below are common symptoms of MS and
`
`the medications used to treat those symptoms.
`
`Under certain circumstances, some healthcare providers may use medications to treat MS that have FDA
`approval for other diseases -- also called "off-label" use. Over the past few decades, several medications
`have been used off-label in MS.
`
`
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`Bladder Problems
`
`Dysfunction
`
`> Botox (onabotulinumtoxin A)
`
`> DDAVP Nasal Spr_ay_ (desmopressin)
`
`https://www.nationalmssociety.org/Treating-MS/Medications
`
`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 2
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`2/5
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`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 2
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`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 3
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`

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`4/5
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` !
`
`9/18/2019
`
`Medications : National Multiple Sclerosis Society
`
`Emotional Changg
`
`> Nuedexta (dextromethorphan + quinidine)
`
`Fatigfi
`
`> Adderall (dextroamphetamine and amphetamine)
`
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`
`> Egiol (carbamazepine)
`> Trilept_al (oxcarbazepine)
`
`> Amantadine
`
`> Mgflmodafinil)
`
`> m (fluoxetine)
`
`> Ritalin (methylphenidate)
`
`Itching
`
`> Vistaril (hydroxyzine)
`
`Pain
`
`Qymbalta (duloxetine)
`
`Effexor (venlafaxine)
`
`Elavil (amitriptyline)
`
`Lamictal (lamotrigine)
`
`Lyflmregabalin)
`
`> > > > >
`
`> Neurontin (gabapentin)
`
`> Pamelor;Av_enty_l (nortriptyline)
`
`Sexual Problems
`
`> % (tadalafil)
`
`> % (vardenafil)
`
`> M (alprostadil)
`
`> Prostin VR (alprostadil)
`
`> M (avanafil)
`
`> V_iaig@ (sildenafil)
`
`§pasticity_
`
`> Baclofen
`
`> Botox (onabotulinumtoxin A)
`
`> Dantrium (dantrolene)
`
`> Klonopi_n (clonazepam)
`
`> Valium (diazepam)
`
`> Zanaflex (tizanidine)
`
`https://www.nationalmssociety.org/Treating-MS/Medications
`
`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 4
`
`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 4
`
`

`

`Medications : National Multiple Sclerosis Society
`
`9/18/2019
`
`Tremors
`
`> Laniazid - Nydrazid (isoniazid)
`
`> Klonopi_n(clonazepam)
`
`Walking_(Gait) Difficulties
`
`> A_mpyfi (dalfampridine)
`
`Additional resources
`
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`
`Learn more about treatment options by watching these videos. Additional videos on specific treatments
`are available on the treatment's web page.
`
`> What You Need to Know About Natalizumab (Iysabri®)
`
`> Guideline: Disease Modifyi_ng Therapies for Multiple Sclerosis - American Academy of Neurology_
`
`Hidden Link
`
`https://www.nationalmssociety.org/Treating-MS/Medications
`
`

 


` 

  

 
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`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 5
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`5/5
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`MYLAN PHARMS. INC. EXHIBIT 1075 PAGE 5
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