`Exhibit  E  
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`Exhibit E
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`(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
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`(19) World Intellectual Property Organization
`International Bureau
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`1111111111111111 IIIIII 111111111111111 IIIII IIIII 11111111111111111111111111111 IIII
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`(43) International Publication Date
`5 July 2001 (05.07.2001)
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`PCT
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`(10) International Publication Number
`WO 01/47597 A2
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`(51) International Patent Classification 7:
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`A61N 1/00
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`(21) International Application Number: PCT/US00/34486
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`(22) International Filing Date:
`19 December 2000 (19.12.2000)
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`55303 (US). STAUFFER, Ronald, A.; 11448 300th
`Avenue, Princeton, MN 55371 (US).
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`(74) Agent: WOLDE-MICHAEL, Girma; Medtronic, Inc.,
`MS 301, 7000 Central Avenue Northeast, Minneapolis, MN
`55432 (US).
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`(25) Filing Language:
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`English
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`(81) Designated States (national): CA, JP.
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`(26) Publication Language:
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`(30) Priority Data:
`60/173,064
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`24 December 1999 (24.12.1999) US
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`English
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`(84) Designated States (regional): European patent (AT, BE,
`CH, CY, DE, DK, ES, FI, FR, GB, GR, IE, IT, LU, MC,
`NL, PT, SE, TR).
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`(71) Applicant: MEDTRONIC, INC. [US/US]; 7000 Central
`Avenue Northeast, Minneapolis, MN 55432 (US).
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`Published:
`Without international search report and to be republished
`upon receipt of that report.
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`(72) Inventors: STOMBERG, Charles, R.; 24101 Heath
`Avenue North, Forest Lake, MN 55025 (US). RINGOLD,
`Jean; 14531 Krypton Street Northwest, Ramsey, MN
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`For two-letter codes and other abbreviations, refer to the "Guid(cid:173)
`ance Notes on Codes and Abbreviations" appearing at the begin(cid:173)
`ning of each regular issue of the PCT Gazette.
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`1/) (54) Title: INFORMATION NETWORK INTERROGATION OF AN IMPLANTED DEVICE
`r-,..
`~ (57) Abstract: A communication system is provided which permits of communication between a deployed implantable medical
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`device (IMD) and a computing resource capable of storing and distributing patient and device data. A deployed IMD may be polled
`by a network interface external to the host patient, and data may be received by wireless communication. This data may be transmitted
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`0 to a computer for storage and distribution, and changes to a treatment or instruction regimen, or firmware or software upgrades, may
`> then be transmitted to the network interface for immediate or eventual loading into the IMD via wireless communication. The system
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`;;-,-- is adapted to provide communication service between multiple IMDs deployed in a patient or a number of patients.
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`WO0I/47597
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`PCT /US00/34486
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`7
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`The proliferation of patients with multi-implant medical devices worldwide
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`has made it imperative to provide remote services to the IMDs and timely clinical care
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`to the patient. The use of programmers and related devices to communicate with the
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`IMDs and provide various remote services has become an important aspect of patient
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`care. In addition to the instant invention, the use of programmers may be
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`implemented in a manner consistent with the co-pending applications detailed in the
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`foregoing Cross Reference to Related Applications, and assigned to the assignee of
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`the instant invention. In light of the disclosures of these incorporated references, the
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`present invention provides a vital system and method of delivering efficient therapy
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`and clinical care to the patient.
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`In a representative embodiment of the instant invention, one or more IMDs,
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`such as a pacemaker, defibrillator, drug pump, neurological stimulator, physiological
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`signal recorder may be deployed in a patient. The IMD may be equipped with a radio
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`frequency transmitter or receiver, or an alternate wireless communication telemetry
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`15
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`technique or media which may travel through human tissue. For example, the IMD
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`may contain a transmission device capable of transmitting through human tissue such
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`as radio frequency telemetry, acoustic telemetry, or a transmission technique that uses
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`patient tissue as a transmission medium. Alternately, an IMD may be deployed in a
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`configuration where a transmission or receiving device is visible externally to the
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`patient but is connected directly or via wires to the IMD. An external device, which
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`may generally be termed an IMD Network Interface (IMDNI), may be positioned
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`outside the patient, the IMDNI being equipped with a radio frequency or other
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`communication means compatible with the communication media of the IMD or the
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`IMD transmitter/receiver, which may be external to the IMD and may further be
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`external to the patient. In an illustrative embodiment of the subject invention, IMDNI
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`contains a radio frequency transmitter/receiver or similar radio frequency telemetry
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`device. Communication may be effected between the IMD transmitter/receiver and
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`the external IMDNI, e.g. via radio frequency. The IMDNI will be connected via a
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`wireless or physical communication media, e.g. via modem and direct dial
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`connection, with a data network, LAN, WAN, wireless, or infrared network. In an
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`alternate embodiment of the subject invention, the IMDNI may have a direct
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