GastroPlus(TM) 5.2.0
`
`4/7/2022
`
`2:45:38 PM
`
`Azacitidine 400 mg
`
`Drug Name:
`
`Dose
`400
`
`IR: Tablet
`Dosage Form
`
`Subsequent Dose 0
`
`Subsequent Dose Interval
`
`
`
`0
`
`Calculated Particle Size Distribution
`
`Built‐in Solubility‐pH Model
`
`Peff: 
`
`
`
`0.51
`
`0.25 h
`Stomach transit time:
`
`3.2088 h
`Small intestine transit time:
`
`12.57225 h
`Colon transit time:
`
`
`Stomach volume: 50 mL
`
`Small intestine length: 306.14 cm
`
`Small intestine radius: 1 cm
`
`Colon volume:
`
`1200 mL
`
`Qh:
`
`
`
`1.5 mL/min
`
`Opt logD Model
`C1Alpha:
`
`C2Alpha:
`
`C3Alpha:
`
`C4Alpha:
`
`Stom
`ASF's:
`0.
`
`
`
`0.18148
`1.0944
`0.0734
`0.31836
`Duod
`
`1.304
`
`
`
`Permeabilities: Stom
`
`Colon
`
`0.
`
`0.51
`
`
`
`J1
`
`1.376
`
`
`
`J2
`
`1.545
`
`
`
`I1
`
`1.76
`
`
`
`I2
`
`2.035
`
`
`I3
`
`2.421
`
`
`I4
`
`0.016
`
`
`Colon
`0.023
`
`
`Duod
`
`J1
`
`J2
`
`I1
`
`I2
`
`I3
`
`I4
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`
`0.51
`
`
`0.51
`
`
`pH's:
`
`Stom
`1.3
`
`Solubilities:
`Colon
`
`2.30E+00
`
`2.81E+01
`
`
`Duod
`6.
`
`Stom
`
`J1
`
`6.2
`
`
`
`J2
`
`6.4
`
`
`
`Duod
`
`J1
`
`I1
`
`6.6
`
`
`
`J2
`
`I2
`
`6.9
`
`
`
`I1
`
`I3
`
`7.4
`
`
`
`I2
`
`I4
`
`6.4
`
`
`
`I3
`
`Colon
`6.8
`
`
`I4
`
`2.31E+00
`
`2.30E+00
`
`
`2.31E+00
`
`
`2.30E+00
`2.31E+00
`
`
`2.31E+00
`
`
`2.30E+00
`
`Pharmacokinetic parameters:
`FPE = 
`0
`
`
`Clearance = 
`
`
`
`
`183.7709
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0001
`
`

`

`76.8
`
`
`
`
`0.41
`2.11E‐1 Pred TMax = 
`
`
`
`
`1.12E+0 Pred AUC = 
`
`
`
`5.29E+2
`
`
`
`24 h
`
`0.0755
`Vc/Vd = 
`
`Subject weight = 
`
`K12 = 
`27.8514
`
`K21 = 
`3.2778
`
`Fp = 
`99
`
`Half life = 
`Pred CMax = 
`
`
`
`
`
`
`
`
` 
`Total simulation time:
` 
` 
`J1UnRel J2UnRel I1UnRel I2UnRel I3UnRel I4UnRel CUnRel
`Time(h) StUnRel DUnRel
`
`
`
`
`
`
`
`
`
`
`SUndiss DUndiss J1Undiss
`J2Undiss
`ExUnRel Total Unrel. (mg)
`
`
`
`
`
`
`I1Undiss
`I3Undiss
`I4Undiss
`CUndiss ExUndiss
`I2Undiss
`
`
`
`
`
`Total. Undiss. (mg)
`SDiss
`J1Diss
`I1Diss
`DDiss
`J2Diss
`I2Diss
`I3Diss
`
`
`
`
`
`
`
`
`ExDiss
`Total. Diss. (mg)
`SDegrad DDegrad J1Degrad
`I4Diss
`CDiss
`
`
`
`
`
`
`
`J2Degrad
`I3Degrad
`I4Degrad
`I1Degrad
`I2Degrad
`
`
`
`
`
`CDegrad TotalDegrad
`SAbs
`J1Abs
`I1Abs
`I3Abs
`DAbs
`J2Abs
`I2Abs
`
`
`
`
`
`
`
`
`
`Abs Rate
`Net Ka Total Absorbed
`I4Abs
`CAbs
`
`
`
`
`
`
`First Pass %
`Fa %
`TotalExcreted
`Central Periph
`Cp (mg/L)
`CLiver 
`Time (h)
`
`
`
`
`
`
`StomEnt (mg)
`DuodEnt (mg)
`Juj1Ent (mg)
`Juj2Ent (mg)
`(mg/L)
`
`
`
`
`
`
`Ile1Ent (mg)
`Ile2Ent (mg)
`Ile3Ent (mg)
`Ile4Ent (mg)
`ColnEnt (mg)
`
`
`
`
`GB Amount (mg)
`(ng‐h/mL)
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`4.00E+2 0.E+0
`0.E+0
`4.00E+2 0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`4.00E+2 0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.e+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`0.E+0
`0.e+0
`0.e+0
`0.E+0
`0.e+0
`0.e+0
`0.e+0
`0.e+0
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`8.E‐2
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`‐3.047E‐7
`0.E+0
`3.783E‐1
`0.E+0
`0.E+0
`0.E+0
`‐3.047E‐7
`
`
`
`
`
`
`0.E+0
`9.079E‐2
`3.506E‐3
`4.762E‐1
`3.783E‐1
`9.079E‐2
`
`
`
`
`
`1.487E+1
`4.393E‐1
`1.204E‐2
`2.771E+2
`8.846E+1
`
`
`
`
`
`3.332E‐4
`
`
`
`
`
`4.428E‐7
`2.32E‐9 2.046E‐12
`4.182E+2
`1.085E‐5
`3.772E‐3
`7.816E‐5
`1.665E‐6
`1.77E+0 1.814E‐1
`1.569E+1
`
`
`
`
`
`9.644E‐12
`1.764E+1
`0.E+0
`8.971E‐1
`6.837E‐8
`1.868E‐9
`
`
`
`
`
`1.129E‐6
`‐3.464E‐7
`6.224E‐5
`1.026E‐1
`2.528E‐3
`
`
`
`
`
`6.52E‐3 5.875E‐2
`1.002E+0
`2.506E‐1
`‐5.824E‐10
`‐1.245E‐9
`
`
`
`
`
`0.E+0
`4.178E‐2
`2.065E‐12
`3.932E‐2
`2.127E‐2
`
`
`
`
`
`
`0.e+0
`7.41e‐1 9.157e‐2
`8.E‐2
`6.781E‐3
`5.661E‐2
`
`
`
`
`
`
`
`2.362e‐3
`9.059e‐5
`2.974e‐5
`2.459e‐5
`7.628e‐7
`
`
`
`
`
`1.133e‐6
`1.386E‐1
`0.E+0
`
`
`1.6E‐1 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`6.414E‐2
`‐1.29E‐8
`‐1.29E‐8
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`1.171E‐3
`1.906E‐2
`6.414E‐2
`1.906E‐2
`0.E+0
`
`
`
`
`1.522E‐1
`1.917E+2
`1.231E+2
`4.49E+1 2.741E+0
`
`
`
`
`5.316E‐4
`2.566E‐7
`4.062E‐10
`4.455E‐5
`
`
`
`
`2.696E+1
`5.708E+0
`1.196E+0
`5.019E‐2
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`F %
`
`AUC
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.e+0
`
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.e+0
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`
`0.E+0
`
`
`8.563E‐2
`
`8.429E‐3
`
`4.373E+2
`
`2.083E‐3
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0002
`
`

`

`1.915E‐9
`3.391E+1
`3.891E‐7
`6.982E‐6
`8.812E‐5
`
`
`
`
`
`1.631E‐3
`7.379E‐5
`6.56E‐1 3.287E‐2
`2.784E+0
`0.E+0
`
`
`
`
`
`
`1.029E‐2
`9.266E‐2
`‐1.347E‐8
`‐4.627E‐6
`‐3.387E‐8
`
`
`
`
`
`1.957E‐1
`4.068E‐10
`3.475E+0
`8.686E‐1
`0.E+0
`2.631E‐1
`
`
`
`
`
`2.177E‐1
`0.e+0
`2.396E‐1
`1.6E‐1
`3.374E‐2
`
`
`
`
`
`
`1.789e‐3
`3.851e‐4
`1.872e+0
`5.195e‐1
`2.813e‐2
`
`
`
`
`
`1.662E+0
`0.E+0
`2.751e‐4
`1.349e‐5
`9.106e‐6
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.4E‐1
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`1.333E‐2
`0.E+0
`1.435E‐7
`1.435E‐7
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`2.733E‐4
`1.796E‐2
`1.333E‐2
`4.056E‐3
`0.E+0
`4.056E‐3
`
`
`
`
`
`7.187E+0
`6.054E‐1
`1.326E+2
`1.281E+2
`7.616E+1
`
`
`
`
`
`4.777E‐6
`1.11E‐8 4.553E+2
`4.637E‐3
`5.981E‐4
`5.017E‐2
`
`
`
`
`
`1.298E‐2
`8.172E‐4
`1.03E+1 3.297E+0
`2.088E‐1
`3.475E+1
`
`
`
`
`
`9.454E‐5
`8.049E‐6
`5.23E‐8 4.857E+1
`4.87E+0 1.76E+0
`0.E+0
`
`
`
`
`
`
`
`1.339E‐1
`1.002E‐2
`7.307E‐4
`2.192E‐5
`‐3.391E‐8
`
`
`
`
`
`‐1.896E‐7
`1.241E‐2
`1.117E‐1
`6.774E+0
`1.693E+0
`
`
`
`
`
`1.11E‐8 3.947E‐1
`2.4E‐1
`0.E+0
`6.953E‐1
`7.701E‐1
`
`
`
`
`
`
`6.807E‐2
`3.941E‐1
`0.e+0
`2.643e+0
`1.232e+0
`
`
`
`
`
`1.047e‐1
`9.372e‐3
`1.639e‐3
`9.142e‐4
`3.124e‐5
`
`
`
`
`
`4.612e‐5
`5.726E+0
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`3.2E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`2.672E‐3
`‐2.402E‐7
`0.E+0
`0.E+0
`0.E+0
`‐2.402E‐7
`0.E+0
`
`
`
`
`
`
`6.16E‐5 3.694E‐3
`2.672E‐3
`8.935E‐4
`0.E+0
`8.935E‐4
`
`
`
`
`
`
`1.66E‐1
`1.506E+0
`9.17E+1 1.185E+2
`1.024E+2
`1.327E+1
`
`
`
`
`
`4.724E+2
`2.005E‐2
`3.541E‐3
`3.761E‐5
`1.174E‐7
`
`
`
`
`
`4.497E‐2
`4.014E+1
`1.478E+1
`6.403E+0
`5.432E‐1
`
`
`
`
`
`6.192E+1
`3.742E‐3
`5.641E‐4
`6.524E‐5
`5.531E‐7
`
`
`
`
`
`3.424E‐2
`3.426E‐3
`6.811E+0
`3.337E+0
`3.418E‐1
`0.E+0
`
`
`
`
`
`1.218E‐1
`1.053E+1
`2.928E‐4
`1.82E‐7 ‐5.823E‐7
`1.353E‐2
`
`
`
`
`5.843E‐1
`1.564E+0
`2.632E+0
`1.174E‐7
`0.E+0
`1.306E+0
`
`
`
`
`
`2.961e+0
`0.e+0
`3.2E‐1
`1.008E‐1
`5.436E‐1
`
`
`
`
`
`
`2.062e+0
`4.83e‐3 2.063e‐3
`6.815e‐5
`2.441e‐1
`2.862e‐2
`
`
`
`
`
`9.988e‐5
`1.251E+1
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`4.E‐1
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐2.162E‐8
`‐2.162E‐8
`‐7.147E‐26
`0.E+0
`0.E+0
`4.626E‐4
`
`
`
`
`
`1.856E‐4
`1.326E‐25
`7.515E‐25
`4.626E‐4
`1.856E‐4
`
`
`
`
`
`1.215E+2
`1.028E+2
`6.766E‐4
`6.343E+1
`1.359E‐5
`
`
`
`
`
`1.803E‐4
`1.339E‐2
`2.025E+1
`3.982E‐1
`5.908E‐2
`2.9E+0
`
`
`
`
`
`1.029E+1
`1.878E+1
`4.887E+2
`4.387E+1
`7.147E‐7
`
`
`
`
`
`3.168E‐4
`2.151E‐3
`1.096E+0
`1.131E‐1
`1.166E‐2
`
`
`
`
`
`6.775E‐1
`7.417E+1
`8.48E+0 5.255E+0
`3.368E‐6
`0.E+0
`
`
`
`
`
`
`1.404E‐2
`1.075E‐2
`1.364E‐3
`1.612E‐6
`‐1.302E‐6
`8.5E‐2
`
`
`
`
`
`1.264E‐1
`1.451E+1
`3.627E+0
`0.E+0
`2.05E+0 7.147E‐7
`
`
`
`
`
`
`7.466E‐1
`2.519E+0
`4.E‐1
`1.288E‐1
`6.571E‐1
`
`
`
`
`
`
`2.932e+0
`2.856e+0
`6.48e‐2 1.159e‐2
`0.e+0
`4.415e‐1
`
`
`
`
`
`
`4.04e‐3 1.19e‐4 1.719e‐4
`2.172E+1
`0.E+0
`
`
`
`
`0.E+0
`0.E+0
`4.8E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`3.644E‐8
`‐5.554E‐26
`3.644E‐8
`0.E+0
`0.E+0
`
`
`
`
`
`4.091E‐25
`6.634E‐5
`3.415E‐5
`‐2.749E‐26
`
`
`
`1.064E‐4
`4.387E+1
`2.788E‐6
`8.563E+1
`
`
`
`
`
`0.E+0
`0.E+0
`
`
`6.634E‐5
`
`3.415E‐5
`
`1.333E+2
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0003
`
`

`

`1.366E‐1
`
`4.645E+1
`
`2.849E‐2
`
`9.852E+0
`
`4.245E‐3
`
`1.858E+1
`
`3.541E+0
`
`0.e+0
`2.689e+0
`
`7.459e‐3
`
`
`3.817E‐2
`
`2.218E+1
`
`6.182E‐3
`
`7.377E+0
`
`6.702E‐6
`
`4.644E+0
`
`
`
`3.521e+0
`
`1.839e‐4
`
`
`7.805E‐1
`
`5.041E+2
`
`2.326E‐1
`
`8.55E+1 0.E+0
`
`
`2.627E‐2
`
`1.275E‐1
`
`8.786E‐1
`
`
`
`2.389e‐2
`
`0.E+0
`0.E+0
`0.E+0
`
`
`8.265E‐26
`
`5.454E‐6
`
`3.034E+1
`
`1.331E+0
`
`5.187E+2
`
`4.165E‐1
`
`0.E+0
`
`
`5.415E‐2
`
`1.265E‐1
`
`9.826E‐1
`
`
`
`4.365e‐2
`
`
`4.752E+0
`2.741E+1
`
`
`3.046E‐6
`6.281E‐4
`
`
`1.883E+0
`1.472E+1
`
`
`1.436E‐5
`1.113E‐3
`
`
`1.726E‐1
`1.146E+0
`
`
`1.417E‐2
`‐2.376E‐6
`
`
`3.046E‐6
`0.E+0
`2.883E+0
`
`
`4.8E‐1
`1.515E‐1
`7.373E‐1
`
`
`1.211e‐1
`6.812e‐1
`
`
`2.585e‐4
`3.297E+1
`
`
`0.E+0
`0.E+0
`5.6E‐1
`0.E+0
`
`
`‐7.543E‐9
`0.E+0
`0.E+0
`
`
`3.833E‐23
`7.844E‐6
`
`
`5.137E‐7
`1.437E‐5
`
`
`3.419E+1
`6.971E+0
`
`
`1.754E‐3
`1.013E‐5
`
`
`1.944E+1
`2.903E+0
`
`
`3.13E‐3 4.775E‐5
`9.604E+1
`
`
`1.742E+0
`3.056E‐1
`
`
`‐3.718E‐6
`1.406E‐2
`
`
`1.013E‐5
`0.E+0
`3.774E+0
`
`
`5.6E‐1
`1.695E‐1
`7.905E‐1
`
`
`1.981e‐1
`9.428e‐1
`
`
`4.584E+1
`0.E+0
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`6.4E‐1
`0.E+0
`
`
`
`
`
`
`
`
`‐3.604E‐8
`‐5.409E‐24
`0.E+0
`0.E+0
`‐3.604E‐8
`8.257E‐7
`
`
`
`
`
`7.721E‐7
`1.826E‐22
`7.721E‐7
`2.345E‐19
`8.257E‐7
`
`
`
`
`
`1.391E+2
`5.506E+1
`2.099E+1
`1.742E‐6
`8.496E‐8
`
`
`
`
`
`4.167E‐3
`1.821E‐1
`2.05E+0 4.625E‐1
`4.018E+1
`9.434E+0
`
`
`
`
`
`2.425E+1
`2.721E+1
`4.947E+1
`2.808E‐5
`5.325E+2
`
`
`
`
`
`7.481E‐3
`3.002E‐2
`1.079E‐1
`4.134E+0
`6.745E‐1
`
`
`
`
`
`1.18E+1 2.449E+0
`1.181E+1
`0.E+0
`1.059E+2
`1.324E‐4
`
`
`
`
`
`
`2.174E‐2
`5.005E‐5
`‐5.063E‐6
`4.894E‐1
`9.865E‐2
`
`
`
`
`6.665E+0
`0.E+0
`1.38E‐2 1.242E‐1
`2.666E+1
`4.695E+0
`
`
`
`
`
`
`2.808E‐5
`1.063E+0
`5.517E+0
`6.4E‐1
`1.833E‐1
`
`
`
`
`
`
`1.968e+0
`4.317e+0
`2.94e‐1
`8.23E‐1
`0.e+0
`1.206e+0
`
`
`
`
`
`7.231e‐2
`2.224e‐2
`3.68e‐4 4.62e‐4 5.997E+1
`0.E+0
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`7.2E‐1
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`‐2.081E‐9
`‐1.343E‐25
`‐2.081E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`9.367E‐8
`3.158E‐19
`9.367E‐8
`1.029E‐7
`1.459E‐21
`1.029E‐7
`
`
`
`
`
`2.22E‐7 1.452E+1
`4.303E+1
`1.356E+2
`1.292E‐8
`4.517E+1
`
`
`
`
`
`1.201E+1
`2.922E+0
`7.296E‐1
`3.323E‐1
`8.746E‐3
`
`
`
`
`
`5.457E+2
`5.032E+1
`2.898E+1
`6.774E‐5
`2.901E+1
`
`
`
`
`
`5.547E+0
`1.012E+0
`1.58E‐2 3.192E‐4
`1.802E‐1
`5.532E‐2
`
`
`
`
`
`1.151E+2
`1.247E+1
`1.394E+1
`3.247E+0
`0.E+0
`7.27E‐1
`
`
`
`
`
`
`4.037E‐2
`1.077E‐4
`‐5.884E‐6
`1.345E‐2
`1.637E‐1
`
`
`
`
`
`1.21E‐1 3.059E+1
`7.646E+0
`0.E+0
`6.774E‐5
`5.628E+0
`
`
`
`
`
`
`1.123E+0
`6.392E+0
`7.2E‐1
`1.936E‐1
`8.399E‐1
`
`
`
`
`
`1.61e+0 4.457e+0
`1.455e+0
`0.e+0
`4.049e‐1
`1.106e‐1
`
`
`
`
`
`
`3.559e‐2
`5.022e‐4
`5.737e‐4
`7.507E+1
`0.E+0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`
`
`‐7.543E‐9
`
`
`1.84E‐25
`6.937E+1
`
`2.671E‐1
`
`4.824E+1
`
`5.892E‐2
`
`1.095E+1
`
`1.041E‐2
`
`2.265E+1
`
`4.557E+0
`
`0.e+0
`2.343e+0
`
`1.319e‐2
`
`
`0.E+0
`0.E+0
`
`
`7.844E‐6
`
`5.454E‐6
`
`1.387E+2
`
`8.951E‐2
`
`2.497E+1
`
`1.463E‐2
`
`9.587E+0
`
`2.022E‐5
`
`5.662E+0
`
`
`
`4.01e+0
`
`
`2.65e‐4 3.562e‐4
`
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0004
`
`

`

`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`8.E‐1
`
`
`
`
`
`
`
`
`7.044E‐25
`1.983E‐8
`7.607E‐9
`7.607E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`1.604E‐8
`1.604E‐8
`‐2.208E‐20
`1.983E‐8
`‐1.222E‐17
`
`
`
`
`1.004E+1
`1.294E+2
`3.322E+1
`4.777E‐8
`2.004E‐9
`
`
`
`
`
`3.921E+0
`1.07E+0 5.57E‐1 1.665E‐2
`1.457E+1
`4.903E+1
`
`
`
`
`
`
`5.092E+1
`3.035E+1
`3.359E+1
`5.582E+2
`1.464E‐4
`
`
`
`
`
`9.366E‐2
`2.8E‐1
`3.026E‐2
`6.901E‐4
`1.431E+0
`7.106E+0
`
`
`
`
`
`1.597E+1
`4.116E+0
`1.018E+0
`1.297E+1
`0.E+0
`1.238E+2
`
`
`
`
`
`6.849E‐2
`2.087E‐4
`‐5.306E‐6
`1.304E‐2
`2.526E‐1
`
`
`
`
`
`3.44E+1 8.6E+0
`6.56E+0 1.464E‐4
`1.166E+0
`0.E+0
`1.174E‐1
`
`
`
`
`
`
`
`2.011E‐1
`0.e+0
`8.E‐1
`8.453E‐1
`7.164E+0
`
`
`
`
`
`
`4.457e+0
`1.676e+0
`1.586e‐1
`5.259e‐1
`1.289e+0
`
`
`
`
`
`9.087E+1
`6.812e‐4
`6.902e‐4
`0.E+0
`5.404e‐2
`
`
`
`
`8.8E‐1 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`0.E+0
`
`0.E+0
`
`0.E+0
`0.E+0
`
`0.E+0
`
`5.886E‐9
`5.007E‐24
`5.886E‐9
`2.781E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`‐1.799E‐19
`2.781E‐9
`3.365E‐9
`3.365E‐9
`‐1.928E‐16
`
`
`
`
`1.289E‐8
`6.946E+0
`2.539E+1
`1.214E+2
`4.048E‐10
`
`
`
`
`
`1.702E+1
`5.01E+0 1.48E+0 8.716E‐1
`2.931E‐2
`5.176E+1
`
`
`
`
`
`
`5.701E+2
`5.132E+1
`3.14E+1 3.793E+1
`8.774E+0
`2.897E‐4
`
`
`
`
`
`1.481E‐1
`5.36E‐2 1.365E‐3
`1.32E+2 0.E+0
`1.93E+0 4.103E‐1
`
`
`
`
`
`
`
`1.787E+1
`5.033E+0
`1.36E+0 3.676E‐1
`1.082E‐1
`1.336E+1
`
`
`
`
`
`‐2.021E‐6
`1.134E‐1
`3.81E+1 9.524E+0
`1.261E‐2
`3.722E‐4
`
`
`
`
`
`1.195E+0
`7.829E+0
`7.481E+0
`0.E+0
`2.897E‐4
`
`
`
`
`
`
`8.8E‐1
`0.e+0
`4.347e+0
`2.061E‐1
`8.422E‐1
`1.016e+0
`
`
`
`
`
`7.813e‐2
`1.86e+0 6.516e‐1
`2.155e‐1
`9.222e‐4
`8.108e‐4
`
`
`
`
`
`1.072E+2
`0.E+0
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`9.6E‐1
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`0.E+0
`
`
`
`
`
`1.188E‐7
`‐3.64E‐7
`‐3.196E‐22
`0.E+0
`‐3.64E‐7
`1.151E‐8
`4.776E‐17
`1.151E‐8
`3.231E‐14
`1.188E‐7
`
`
`
`
`1.125E+2
`1.924E+1
`4.804E+0
`2.154E‐10
`‐2.333E‐7
`
`
`
`
`4.837E‐2
`1.289E+0
`6.15E+0 1.949E+0
`5.342E+1
`1.925E+1
`
`
`
`
`
`3.22E+1 4.198E+1
`1.051E+1
`5.33E‐4 5.813E+2
`5.161E+1
`
`
`
`
`
`
`2.502E+0
`5.733E‐1
`2.214E‐1
`2.512E‐3
`1.397E+2
`8.9E‐2
`
`
`
`
`
`1.364E+1
`1.962E+1
`5.979E+0
`1.748E+0
`0.E+0
`5.1E‐1
`
`
`
`
`
`
`1.614E‐1
`6.207E‐4
`5.793E‐6
`1.215E‐2
`1.093E‐1
`
`
`
`
`
`4.166E+1
`1.042E+1
`8.385E+0
`5.33E‐4 1.213E+0
`0.E+0
`
`
`
`
`
`
`8.385E+0
`9.6E‐1
`2.092E‐1
`8.328E‐1
`0.e+0
`
`
`
`
`
`
`
`4.157e+0
`7.767e‐1
`2.797e‐1
`7.9e‐1
`2.005e+0
`1.08e‐1
`
`
`
`
`
`1.246e‐3
`9.359e‐4
`1.238E+2
`0.E+0
`
`
`
`0.E+0
`0.E+0
`0.E+0
`1.04E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐2.647E‐8
`0.E+0
`0.E+0
`
`
`
`
`
`
`6.762E‐28
`‐2.647E‐8
`8.513E‐8
`2.435E‐8
`5.793E‐17
`‐1.498E‐18
`8.513E‐8
`2.435E‐8
`
`
`
`
`1.031E+2
`8.642E‐10
`8.477E‐8
`3.323E+0
`1.449E+1
`
`
`
`
`
`1.819E+0
`2.122E+1
`7.299E+0
`2.466E+0
`5.412E+1
`
`
`
`
`
`5.921E+2
`5.18E+1 3.28E+1 4.57E+1 1.229E+1
`7.561E‐2
`9.226E‐4
`
`
`
`
`
`
`3.14E+0 7.699E‐1
`3.16E‐1 1.4E‐1
`4.348E‐3
`1.47E+2 0.E+0
`1.386E+1
`
`
`
`
`
`
`
`2.121E+1
`6.935E+0
`2.177E+0
`6.802E‐1
`2.294E‐1
`
`
`
`
`
`4.509E+1
`9.794E‐4
`2.052E‐5
`1.168E‐2
`1.051E‐1
`
`
`
`
`
`1.127E+1
`9.267E+0
`9.226E‐4
`1.221E+0
`8.838E+0
`0.E+0
`
`
`
`
`
`1.04E+0 2.106E‐1
`8.188E‐1
`6.08e‐1 3.913e+0
`0.e+0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0005
`
`

`

`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`7.161E‐9
`‐1.175E‐8
`
`
`4.017E‐9
`7.572E‐20
`
`
`9.374E+1
`1.084E+1
`
`
`2.466E+0
`3.014E+0
`
`
`3.326E+1
`5.194E+1
`
`
`4.334E‐1
`9.997E‐1
`
`
`2.265E+1
`1.402E+1
`0.E+0
`
`
`3.133E‐1
`1.475E‐3
`
`
`4.839E+1
`1.21E+1 0.E+0
`
`
`
`9.194E+0
`1.12E+0
`
`
`
`3.637e+0
`4.638e‐1
`
`
`1.839e‐1
`2.232e‐3
`
`
`
`3.495e‐1
`8.964e‐1
`2.109e+0
`
`
`0.E+0
`1.406E+2
`1.067e‐3
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.12E+0 0.E+0
`
`
`
`
`
`
`9.315E‐27
`‐1.175E‐8
`0.E+0
`0.E+0
`
`
`
`
`4.017E‐9
`7.161E‐9
`1.096E‐18
`
`
`
`2.299E+0
`8.952E‐11
`3.165E‐10
`
`
`8.421E+0
`2.287E+1
`5.398E+1
`
`
`
`6.023E+2
`1.517E‐3
`1.129E‐1
`
`
`
`3.836E+0
`1.408E+1
`4.911E+1
`
`
`
`1.539E+2
`7.147E‐3
`2.105E‐1
`
`
`
`8.774E‐1
`2.639E+0
`7.886E+0
`
`
`
`1.009E‐1
`1.121E‐2
`4.516E‐5
`
`
`
`1.221E+0
`1.517E‐3
`1.012E+1
`
`
`
`0.e+0
`8.013E‐1
`2.106E‐1
`
`
`
`4.225e‐1
`1.007e+0
`2.173e+0
`
`
`
`1.205e‐3
`
`
`0.E+0
`1.575E+2
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.2E+0
`
`
`
`
`
`
`
`
`5.018E‐9
`4.116E‐8
`‐5.71E‐26
`4.116E‐8
`0.E+0
`0.E+0
`
`
`
`
`1.036E‐9
`‐6.039E‐19
`1.036E‐9
`5.018E‐9
`‐9.982E‐18
`
`
`
`
`1.59E+0 8.072E+0
`8.463E+1
`4.736E‐8
`6.522E‐11
`
`
`
`
`
`3.577E+0
`3.23E+0 1.621E‐1
`9.481E+0
`2.418E+1
`
`
`
`
`
`3.36E+1 5.219E+1
`1.585E+1
`5.203E+1
`6.119E+2
`
`
`
`
`
`3.043E‐1
`1.124E‐2
`1.604E+2
`5.747E‐1
`1.261E+0
`
`
`
`
`8.82E+0 3.128E+0
`2.395E+1
`1.1E+0
`1.413E+1
`0.E+0
`
`
`
`
`
`
`8.33E‐5 1.074E‐2
`9.662E‐2
`5.155E+1
`2.134E‐3
`
`
`
`
`
`9.461E+0
`1.095E+1
`0.E+0
`2.385E‐3
`1.214E+0
`
`
`
`
`
`1.2E+0
`0.e+0
`2.094E‐1
`7.812E‐1
`3.513e‐1
`
`
`
`
`
`
`1.104e+0
`4.966e‐1
`2.944e‐3
`2.201e+0
`2.285e‐1
`
`
`
`
`1.743E+2
`1.353e‐3
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.28E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐7.219E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐7.219E‐9
`6.608E‐26
`5.564E‐9
`1.839E‐9
`1.762E‐19
`3.095E‐18
`5.564E‐9
`1.839E‐9
`
`
`
`
`
`7.597E+1
`5.815E‐11
`3.057E‐10
`5.984E+0
`1.1E+0
`5.17E+1
`
`
`
`
`
`4.139E+0
`4.107E+0
`2.249E‐1
`2.516E+1
`1.045E+1
`
`
`
`
`
`6.212E+2
`5.209E+1
`3.385E+1
`3.608E‐3
`5.496E+1
`
`
`
`
`
`1.759E+1
`5.356E+0
`1.553E+0
`7.402E‐1
`4.252E‐1
`
`
`
`
`
`1.666E+2
`0.E+0
`1.422E+1
`2.511E+1
`9.727E+0
`1.7E‐2
`
`
`
`
`
`3.637E+0
`1.346E+0
`5.299E‐1
`2.984E‐3
`1.391E‐4
`
`
`
`
`
`5.457E+1
`1.364E+1
`1.176E+1
`1.026E‐2
`9.235E‐2
`0.E+0
`
`
`
`
`
`1.202E+0
`9.646E+0
`1.28E+0 2.072E‐1
`3.608E‐3
`
`
`
`
`
`
`0.e+0
`3.05e+0 2.196e+0
`1.188e+0
`7.591E‐1
`2.645e‐1
`
`
`
`
`
`5.694e‐1
`2.761e‐1
`3.832e‐3
`1.514e‐3
`1.909E+2
`
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`1.36E+0 0.E+0
`
`
`
`
`‐7.169E‐10
`0.E+0
`0.E+0
`
`
`
`
`
`‐6.237E‐10
`2.98E‐18
`1.14E‐9 7.606E‐1
`7.207E‐11
`
`1.131E+1
`2.581E+1
`
`
`5.214E+1
`6.299E+2
`
`
`9.295E‐1
`6.16E+0 1.871E+0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1.434e‐1
`
`
`
`1.674e‐3
`
`
`
`
`
`0.E+0
`
`
`
`5.313E+1
`2.385E‐3
`4.578E+0
`
`4.135E‐1
`1.289E+1
`
`3.345e+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐6.237E‐10
`‐7.169E‐10
`‐5.727E‐27
`
`
`
`2.331E‐9
`4.858E‐20
`2.331E‐9
`
`
`
`4.982E+1
`6.788E+1
`4.419E+0
`
`
`
`4.684E+0
`5.09E+0 3.029E‐1
`5.279E‐3
`
`
`
`3.403E+1
`5.745E+1
`1.926E+1
`
`
`
`5.768E‐1
`2.488E‐2
`1.724E+2
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0006
`
`

`

`2.614E+1
`0.E+0
`1.428E+1
`1.06E+1 4.157E+0
`1.612E+0
`
`
`
`
`
`
`4.05E‐3 2.173E‐4
`6.621E‐1
`9.787E‐3
`8.809E‐2
`5.746E+1
`
`
`
`
`
`1.253E+1
`0.E+0
`1.436E+1
`5.279E‐3
`1.184E+0
`9.759E+0
`
`
`
`
`
`1.36E+0 2.042E‐1
`7.355E‐1
`1.982e‐1
`0.e+0
`
`
`
`
`
`
`
`2.761e+0
`2.164e+0
`1.255e+0
`6.389e‐1
`3.255e‐1
`
`
`
`
`
`4.92e‐3 1.692e‐3
`2.074E+2
`0.E+0
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.44E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`2.529E‐9
`4.188E‐10
`4.188E‐10
`1.61E‐26
`0.E+0
`0.E+0
`
`
`
`
`
`
`5.126E‐11
`1.404E‐19
`‐1.221E‐18
`5.126E‐11
`2.529E‐9
`
`
`
`6.043E+1
`3.252E+0
`3.069E‐9
`3.229E‐11
`5.261E‐1
`
`
`
`
`
`6.165E+0
`5.198E+0
`2.615E+1
`1.205E+1
`4.761E+1
`
`
`
`
`
`3.417E+1
`5.217E+1
`6.382E+2
`3.974E‐1
`7.498E‐3
`
`
`
`
`
`7.625E‐1
`1.142E+0
`5.966E+1
`2.088E+1
`6.98E+0 2.213E+0
`
`
`
`
`
`1.78E+2 0.E+0
`1.433E+1
`2.706E+1
`1.143E+1
`3.534E‐2
`
`
`
`
`
`
`4.684E+0
`1.896E+0
`8.09E‐1 5.354E‐3
`3.23E‐4 9.317E‐3
`
`
`
`
`
`
`6.021E+1
`1.505E+1
`0.E+0
`1.327E+1
`7.498E‐3
`8.385E‐2
`
`
`
`
`
`
`
`1.44E+0 2.004E‐1
`7.108E‐1
`1.162E+0
`9.806E+0
`
`
`
`
`1.479e‐1
`2.485e+0
`2.109e+0
`1.306e+0
`7.034e‐1
`0.e+0
`
`
`
`
`
`3.754e‐1
`6.226e‐3
`1.891e‐3
`2.236E+2
`0.E+0
`
`
`
`
`0.E+0
`1.52E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`1.019E‐10
`‐2.578E‐27
`1.019E‐10
`‐1.308E‐11
`0.E+0
`0.E+0
`
`
`
`
`
`
`8.911E‐20
`‐1.308E‐11
`‐1.426E‐20
`5.286E‐10
`5.286E‐10
`
`
`
`5.525E‐11
`7.326E‐10
`3.639E‐1
`2.386E+0
`5.362E+1
`
`
`
`
`
`1.265E+1
`5.668E+0
`7.318E+0
`4.516E+1
`2.619E+1
`
`
`
`
`
`6.461E+2
`5.219E+1
`3.427E+1
`5.094E‐1
`1.037E‐2
`
`
`
`
`
`6.163E+1
`2.241E+1
`7.805E+0
`2.574E+0
`1.375E+0
`
`
`
`
`
`1.833E+2
`1.437E+1
`2.787E+1
`9.851E‐1
`4.889E‐2
`0.E+0
`
`
`
`
`
`1.221E+1
`5.211E+0
`2.193E+0
`9.693E‐1
`6.916E‐3
`
`
`
`
`
`8.85E‐3 7.965E‐2
`6.283E+1
`1.571E+1
`0.E+0
`4.618E‐4
`
`
`
`
`
`
`1.398E+1
`1.037E‐2
`1.136E+0
`9.796E+0
`1.52E+0
`
`
`
`
`
`
`1.96E‐1 6.851E‐1
`1.1e‐1 2.226e+0
`0.e+0
`
`
`
`
`
`
`
`2.036e+0
`1.341e+0
`7.614e‐1
`4.245e‐1
`7.765e‐3
`2.115e‐3
`
`
`
`
`
`2.394E+2
`0.E+0
`
`0.E+0
`0.E+0
`1.6E+0
`0.E+0
`
`
`
`0.E+0
`0.E+0
`‐6.702E‐10
`
`
`‐4.952E‐19
`‐2.927E‐10
`
`
`‐2.479E‐11
`‐9.58E‐10
`
`
`4.256E+1
`2.599E+1
`
`
`6.396E‐1
`1.402E‐2
`
`
`6.338E+1
`2.386E+1
`
`
`1.247E+0
`6.607E‐2
`
`
`5.733E+0
`1.295E+1
`
`
`6.395E‐4
`8.388E‐3
`
`
`1.466E+1
`1.402E‐2
`0.E+0
`
`
`1.6E+0
`1.911E‐1
`6.588E‐1
`
`
`1.361e+0
`1.949e+0
`
`
`2.549E+2
`2.371e‐3
`
`
`1.68E+0 0.E+0
`0.E+0
`0.E+0
`
`
`
`
`0.E+0
`1.708E‐9
`0.E+0
`
`
`
`6.107E‐18
`‐1.835E‐10
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`‐2.927E‐10
`‐6.702E‐10
`
`
`4.826E‐11
`1.258E‐19
`
`
`4.746E+1
`1.746E+0
`
`
`8.533E+0
`6.086E+0
`
`
`3.435E+1
`5.221E+1
`
`
`1.627E+0
`2.951E+0
`
`
`2.858E+1
`1.439E+1
`0.E+0
`
`
`1.141E+0
`8.751E‐3
`
`
`6.531E+1
`1.633E+1
`
`
`9.735E+0
`
`
`
`0.e+0
`1.986e+0
`8.169e‐2
`
`
`4.716e‐1
`
`
`9.549e‐3
`
`0.E+0
`0.E+0
`
`
`1.708E‐9
`
`‐1.814E‐18
`
`
`
`0.E+0
`0.E+0
`
`
`‐1.835E‐10
`
`4.173E‐10
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`0.E+0
`0.E+0
`
`
`1.27E‐26
`
`4.826E‐11
`2.517E‐1
`
`1.311E+1
`
`6.536E+2
`
`8.628E+0
`
`1.883E+2
`
`2.501E+0
`
`7.549E‐2
`
`1.108E+0
`
`
`
`8.119e‐1
`
`0.E+0
`0.E+0
`0.E+0
`
`
`‐1.257E‐25
`
`4.173E‐10
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0007
`
`

`

`
`
`
`
`
`
`
`
`
`
`4.192E+1
`1.275E+0
`1.741E‐1
`2.023E‐9
`3.784E‐11
`
`
`
`
`9.79E+0 7.883E‐1
`6.444E+0
`1.343E+1
`2.556E+1
`3.988E+1
`
`
`
`
`
`2.522E+1
`3.44E+1 6.492E+1
`5.222E+1
`6.607E+2
`1.855E‐2
`
`
`
`
`
`1.549E+0
`8.744E‐2
`1.896E+0
`3.339E+0
`9.441E+0
`
`
`
`
`
`1.364E+1
`6.245E+0
`2.921E+1
`1.441E+1
`0.E+0
`1.931E+2
`
`
`
`
`
`1.324E+0
`1.087E‐2
`8.618E‐4
`7.933E‐3
`2.816E+0
`
`
`
`
`
`1.691E+1
`0.E+0
`1.531E+1
`7.14E‐2 6.766E+1
`1.855E‐2
`
`
`
`
`
`
`1.077E+0
`9.629E+0
`1.68E+0 1.857E‐1
`6.321E‐1
`
`
`
`
`
`
`6.056e‐2
`1.766e+0
`1.852e+0
`1.366e+0
`8.54e‐1
`0.e+0
`
`
`
`
`
`5.156e‐1
`1.158e‐2
`2.661e‐3
`2.7E+2
`0.E+0
`
`
`
`0.E+0
`0.E+0
`1.76E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`2.231E‐9
`9.441E‐9
`‐8.756E‐25
`9.441E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`
`7.02E‐10
`4.387E‐17
`‐1.323E‐17
`2.231E‐9
`7.02E‐10
`
`
`
`
`3.695E+1
`4.027E‐11
`1.246E‐8
`1.204E‐1
`9.284E‐1
`
`
`
`
`
`1.107E+1
`2.494E+1
`1.362E+1
`6.739E+0
`3.717E+1
`
`
`
`
`
`3.444E+1
`6.675E+2
`5.222E+1
`9.555E‐1
`2.409E‐2
`
`
`
`
`
`6.628E+1
`
`
`
`
`
`2.179E+0
`1.024E+1
`3.735E+0
`2.649E+1
`2.977E+1
`1.442E+1
`1.894E+0
`1.135E‐1
`1.976E+2
`0.E+0
`
`
`
`
`
`6.743E+0
`3.135E+0
`1.514E+0
`1.328E‐2
`1.428E+1
`
`
`
`
`
`6.988E+1
`1.747E+1
`1.135E‐3
`7.486E‐3
`6.738E‐2
`
`
`
`
`
`1.593E+1
`2.409E‐2
`1.043E+0
`9.484E+0
`0.E+0
`
`
`
`
`
`
`1.76E+0 1.799E‐1
`4.487e‐2
`1.566e+0
`6.05E‐1
`0.e+0
`
`
`
`
`
`
`1.749e+0
`1.358e+0
`8.875e‐1
`5.557e‐1
`1.387e‐2
`
`
`
`
`
`2.846E+2
`2.992e‐3
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.84E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`3.691E‐8
`‐1.098E‐7
`‐1.098E‐7
`2.124E‐23
`0.E+0
`0.E+0
`
`
`
`
`
`
`2.611E‐9
`5.002E‐16
`‐1.222E‐15
`3.691E‐8
`2.611E‐9
`
`
`
`
`
`3.449E+1
`3.253E+1
`8.33E‐2 6.749E‐1
`1.375E‐10
`‐7.E‐8
`
`
`
`
`
`
`1.141E+0
`1.236E+1
`1.368E+1
`6.968E+0
`2.417E+1
`
`
`
`
`
`6.748E+1
`3.447E+1
`6.739E+2
`5.223E+1
`3.075E‐2
`
`
`
`
`
`2.281E+0
`2.473E+0
`2.768E+1
`1.101E+1
`4.134E+0
`
`
`
`
`
`1.488E+1
`3.025E+1
`2.019E+2
`1.443E+1
`1.449E‐1
`0.E+0
`
`
`
`
`
`7.225E+0
`3.455E+0
`1.711E+0
`1.598E‐2
`1.464E‐3
`
`
`
`
`
`
`
`
`
`1.651E+1
`6.344E‐2
`7.197E+1
`1.799E+1
`0.E+0
`7.049E‐3
`
`1.84E+0 1.739E‐1
`3.075E‐2
`1.008E+0
`9.306E+0
`
`
`
`
`
`
`0.e+0
`1.385e+0
`1.642e+0
`5.778E‐1
`3.327e‐2
`
`
`
`
`
`1.339e+0
`9.121e‐1
`5.911e‐1
`1.642e‐2
`3.367e‐3
`
`
`
`
`
`2.988E+2
`0.E+0
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`1.92E+0 0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`2.538E‐7
`‐9.317E‐7
`2.163E‐22
`‐9.317E‐7
`0.E+0
`0.E+0
`
`
`
`
`
`
`1.759E‐8
`5.312E‐15
`1.759E‐8
`‐1.266E‐14
`2.538E‐7
`
`
`
`
`
`2.86E+1 3.188E+1
`4.897E‐1
`5.762E‐2
`‐6.586E‐7
`8.43E‐10
`
`
`
`
`1.343E+0
`1.363E+1
`7.131E+0
`2.327E+1
`1.363E+1
`
`
`
`
`
`2.877E+1
`6.854E+1
`3.449E+1
`5.223E+1
`3.865E‐2
`6.8E+2
`
`
`
`
`
`1.176E+1
`4.533E+0
`2.776E+0
`2.711E+0
`1.821E‐1
`
`
`
`
`
`2.06E+2 0.E+0
`1.444E+1
`3.068E+1
`1.543E+1
`7.688E+0
`
`
`
`
`
`
`3.773E+0
`1.912E+0
`1.898E‐2
`1.856E‐3
`6.622E‐3
`
`
`
`
`
`5.96E‐2 7.394E+1
`1.848E+1
`0.E+0
`1.707E+1
`3.865E‐2
`
`
`
`
`
`
`9.718E‐1
`9.098E+0
`1.92E+0 1.676E‐1
`
`
`
`
`
`
`5.506E‐1
`2.471e‐2
`1.223e+0
`1.533e+0
`1.309e+0
`9.281e‐1
`0.e+0
`
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0008
`
`

`

`
`
`
`
`
`
`0.E+0
`3.124E+2
`3.792e‐3
`1.921e‐2
`6.212e‐1
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.E+0
`
`
`
`
`
`
`
`
`
`7.99E‐8 1.472E‐19
`‐4.766E‐9
`‐1.292E‐26
`‐4.766E‐9
`0.E+0
`0.E+0
`
`
`
`
`
`
`1.048E‐7
`1.464E‐9
`2.669E‐8
`3.839E‐19
`7.99E‐8 2.669E‐8
`
`
`
`
`
`2.227E+1
`3.985E‐2
`3.548E‐1
`2.512E+1
`2.935E+1
`
`
`
`
`
`4.788E‐2
`1.347E+1
`7.229E+0
`1.488E+1
`1.562E+0
`
`
`
`
`
`1.248E+1
`5.223E+1
`3.45E+1 6.946E+1
`2.978E+1
`6.857E+2
`
`
`
`
`
`3.084E+0
`3.182E+0
`2.257E‐1
`2.099E+2
`4.929E+0
`
`
`
`
`
`1.444E+1
`3.106E+1
`1.593E+1
`8.13E+0 4.087E+0
`0.E+0
`
`
`
`
`
`
`2.115E+0
`2.226E‐2
`2.315E‐3
`6.207E‐3
`5.587E‐2
`
`
`
`
`
`7.579E+1
`1.895E+1
`1.76E+1 4.788E‐2
`0.E+0
`9.343E‐1
`
`
`
`
`
`
`2.E+0
`1.611E‐1
`0.e+0
`8.866E+0
`5.236E‐1
`
`
`
`
`
`1.078e+0
`1.425e+0
`1.272e+0
`9.357e‐1
`1.842e‐2
`
`
`
`
`
`6.459e‐1
`4.27e‐3 3.256E+2
`0.E+0
`2.224e‐2
`
`
`
`
`0.E+0
`0.E+0
`2.08E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`1.404E‐9
`‐1.731E‐26
`0.E+0
`0.E+0
`
`
`
`
`
`
`4.16E‐9 ‐1.574E‐20
`1.404E‐9
`4.16E‐9 2.741E‐9
`3.294E‐20
`2.741E‐9
`2.859E‐10
`8.906E‐9
`
`
`
`
`
`2.756E‐2
`2.567E‐1
`2.205E+1
`2.694E+1
`2.12E+1 1.323E+1
`
`
`
`
`
`7.267E+0
`1.607E+1
`1.796E+0
`6.912E+2
`5.856E‐2
`
`
`
`
`
`3.452E+1
`7.028E+1
`3.071E+1
`1.316E+1
`5.224E+1
`
`
`
`
`
`5.32E+0 3.395E+0
`3.693E+0
`2.76E‐1 2.136E+2
`1.444E+1
`0.E+0
`
`
`
`
`
`
`3.139E+1
`1.639E+1
`8.551E+0
`4.395E+0
`2.319E+0
`
`
`
`
`
`7.752E+1
`2.582E‐2
`2.847E‐3
`5.806E‐3
`5.225E‐2
`
`
`
`
`
`1.938E+1
`1.809E+1
`5.856E‐2
`8.96E‐1 8.613E+0
`0.E+0
`
`
`
`
`
`
`2.08E+0 1.545E‐1
`0.e+0
`1.379e‐2
`9.494e‐1
`4.967E‐1
`
`
`
`
`
`
`1.319e+0
`1.227e+0
`9.356e‐1
`2.549e‐2
`6.648e‐1
`
`
`
`
`
`3.382E+2
`4.804e‐3
`0.E+0
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.16E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐6.661E‐11
`‐1.962E‐10
`‐1.962E‐10
`‐1.431E‐27
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`2.408E‐10
`4.106E‐22
`‐3.41E‐23
`‐6.661E‐11
`2.408E‐10
`
`
`
`
`1.934E+1
`1.855E‐1
`4.19E‐11
`7.073E‐11
`1.907E‐2
`
`
`
`
`
`2.044E+0
`1.721E+1
`2.464E+1
`1.29E+1 7.247E+0
`2.009E+1
`
`
`
`
`
`6.963E+2
`5.224E+1
`3.452E+1
`7.099E+1
`7.077E‐2
`
`
`
`
`
`3.157E+1
`1.381E+1
`5.702E+0
`3.706E+0
`4.243E+0
`
`
`
`
`
`2.171E+2
`1.445E+1
`3.168E+1
`1.681E+1
`3.335E‐1
`0.E+0
`
`
`
`
`
`8.948E+0
`4.694E+0
`2.521E+0
`2.964E‐2
`3.455E‐3
`
`
`
`
`
`7.913E+1
`1.978E+1
`1.856E+1
`5.419E‐3
`4.877E‐2
`0.E+0
`
`
`
`
`
`8.343E+0
`2.16E+0 1.479E‐1
`7.077E‐2
`8.573E‐1
`
`
`
`
`
`
`0.e+0
`8.35e‐1 1.217e+0
`1.178e+0
`4.703E‐1
`1.039e‐2
`
`
`
`
`
`
`9.284e‐1
`6.78e‐1 2.894e‐2
`5.399e‐3
`3.503E+2
`0.E+0
`
`
`
`
`
`2.24E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐5.291E‐10
`‐1.576E‐28
`‐5.291E‐10
`6.832E‐10
`0.E+0
`0.E+0
`
`
`
`
`
`
`1.729E‐22
`6.832E‐10
`2.376E‐10
`
`
`
`
`
`2.376E‐10
`8.834E‐22
`1.437E‐11
`4.245E‐10
`1.319E‐2
`1.339E‐1
`1.695E+1
`
`
`
`
`
`1.25E+1 7.175E+0
`1.828E+1
`2.303E+0
`2.249E+1
`1.895E+1
`
`
`
`
`
`7.012E+2
`5.224E+1
`3.453E+1
`7.162E+1
`8.459E‐2
`
`
`
`
`
`3.234E+1
`1.443E+1
`6.073E+0
`4.016E+0
`4.83E+0 3.987E‐1
`
`
`
`
`
`1.445E+1
`3.193E+1
`1.72E+1 9.322E+0
`2.205E+2
`0.E+0
`
`
`
`
`
`
`2.722E+0
`3.371E‐2
`4.144E‐3
`4.983E+0
`5.047E‐3
`
`
`
`
`
`8.064E+1
`2.016E+1
`1.9E+1
`4.542E‐2
`0.E+0
`8.459E‐2
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0009
`
`

`

`
`
`
`
`
`9.147e‐1
`
`4.443E‐1
`2.24E+0 1.411E‐1
`8.059E+0
`8.184E‐1
`
`
`
`
`
`1.124e+0
`1.118e+0
`7.338e‐1
`0.e+0
`7.902e‐3
`
`
`
`
`
`0.E+0
`3.619E+2
`6.056e‐3
`3.259e‐2
`6.856e‐1
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.32E+0 0.E+0
`
`
`
`
`
`
`
`
`
`
`‐8.732E‐13
`5.583E‐10
`1.421E‐28
`‐8.732E‐13
`0.E+0
`0.E+0
`
`
`
`
`
`
`8.851E‐11
`8.851E‐11
`6.799E‐23
`5.583E‐10
`‐8.544E‐26
`
`
`
`
`
`9.122E‐3
`9.658E‐2
`1.485E+1
`6.734E‐10
`1.123E‐11
`
`
`
`
`
`7.057E+0
`1.927E+1
`2.572E+0
`1.78E+1 1.206E+1
`2.047E+1
`
`
`
`
`
`7.058E+2
`5.224E+1
`3.453E+1
`7.217E+1
`1.001E‐1
`
`
`
`
`
`1.501E+1
`6.432E+0
`4.321E+0
`5.45E+0 4.718E‐1
`3.305E+1
`
`
`
`
`
`1.445E+1
`3.215E+1
`1.755E+1
`0.E+0
`9.673E+0
`2.237E+2
`
`
`
`
`
`2.918E+0
`3.8E‐2
`4.917E‐3
`4.691E‐3
`4.222E‐2
`5.261E+0
`
`
`
`
`2.051E+1
`1.942E+1
`0.E+0
`1.001E‐1
`7.795E‐1
`8.204E+1
`
`
`
`
`
`2.32E+0 1.344E‐1
`4.189E‐1
`0.e+0
`7.764E+0
`
`
`
`
`
`
`
`6.443e‐1
`6.071e‐3
`
`
`
`
`
`8.954e‐1
`1.067e+0
`1.025e+0
`6.88e‐1 3.64e‐2 6.777e‐3
`3.729E+2
`0.E+0
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.4E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐1.583E‐10
`2.596E‐11
`‐1.789E‐28
`2.596E‐11
`0.E+0
`0.E+0
`
`
`
`
`
`
`4.561E‐11
`3.858E‐25
`‐1.583E‐10
`4.561E‐11
`‐4.47E‐23
`
`
`
`
`1.301E+1
`4.886E‐12
`‐7.44E‐11
`6.309E‐3
`6.962E‐2
`
`
`
`
`
`2.017E+1
`1.157E+1
`6.898E+0
`1.859E+1
`1.666E+1
`
`
`
`
`
`7.265E+1
`2.85E+0 1.173E‐1
`7.102E+2
`5.224E+1
`3.454E+1
`
`
`
`
`
`3.37E+1 1.555E+1
`6.777E+0
`4.62E+0 6.102E+0
`5.531E‐1
`
`
`
`
`
`
`2.267E+2
`0.E+0
`1.445E+1
`3.234E+1
`1.786E+1
`1.E+1
`
`
`
`
`
`
`3.11E+0 4.251E‐2
`3.916E‐2
`5.528E+0
`5.777E‐3
`4.351E‐3
`
`
`
`
`
`8.334E+1
`2.084E+1
`0.E+0
`1.981E+1
`1.173E‐1
`7.409E‐1
`
`
`
`
`
`7.462E+0
`2.4E+0
`1.278E‐1
`3.941E‐1
`0.e+0
`
`
`
`
`
`
`5.655e‐1
`8.713e‐1
`4.724e‐3
`9.363e‐1
`1.009e+0
`
`
`
`
`
`6.853e‐1
`
`
`
`
`7.564e‐3
`3.834E+2
`0.E+0
`4.035e‐2
`0.E+0
`2.48E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐2.186E‐12
`‐2.93E‐29
`‐2.186E‐12
`‐8.041E‐11
`0.E+0
`0.E+0
`
`
`
`
`
`
`2.419E‐26
`‐8.041E‐11
`3.898E‐11
`‐2.945E‐24
`3.898E‐11
`
`
`
`
`
`7.547E‐12
`‐2.564E‐11
`4.364E‐3
`5.017E‐2
`1.139E+1
`
`
`
`
`
`1.104E+1
`6.704E+0
`2.098E+1
`1.684E+1
`1.554E+1
`
`
`
`
`
`5.224E+1
`3.454E+1
`3.133E+0
`1.364E‐1
`7.143E+2
`
`
`
`
`
`3.428E+1
`1.606E+1
`7.108E+0
`4.912E+0
`7.307E+1
`
`
`
`
`
`1.445E+1
`3.251E+1
`6.783E+0
`6.427E‐1
`2.296E+2
`0.E+0
`
`
`
`
`
`1.031E+1
`5.782E+0
`3.296E+0
`4.72E‐2 6.724E‐3
`1.815E+1
`
`
`
`
`
`8.455E+1
`2.114E+1
`4.029E‐3
`3.626E‐2
`0.E+0
`2.017E+1
`
`
`
`
`
`7.153E+0
`2.48E+0 1.212E‐1
`1.364E‐1
`7.027E‐1
`
`
`
`
`
`
`0.e+0
`3.73e‐3 4.96e‐1 8.533e‐1
`8.431e‐1
`3.701E‐1
`9.5e‐1
`
`
`
`
`
`
`6.781e‐1
`
`
`
`
`4.443e‐2
`8.416e‐3
`3.933E+2
`0.E+0
`0.E+0
`2.56E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`‐4.576E‐13
`‐1.236E‐29
`‐4.576E‐13
`2.417E‐11
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐1.097E‐27
`‐4.425E‐25
`2.113E‐11
`2.417E‐11
`2.113E‐11
`
`
`
`
`
`5.059E‐11
`8.701E‐13
`3.019E‐3
`3.616E‐2
`9.969E+0
`
`
`
`
`
`1.05E+1 6.481E+0
`2.169E+1
`3.42E+0
`1.523E+1
`1.444E+1
`
`
`
`
`
`
`7.182E+2
`5.224E+1
`3.454E+1
`7.344E+1
`1.572E‐1
`
`
`
`
`
`3.481E+1
`1.653E+1
`7.423E+0
`5.195E+0
`7.488E+0
`
`
`
`
`
`7.41E‐1 2.324E+2
`0.E+0
`1.445E+1
`3.266E+1
`1.841E+1
`
`
`
`
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0010
`
`

`

`7.762E‐3
`5.205E‐2
`3.475E+0
`
`
`
`0.E+0
`2.142E+1
`8.566E+1
`2.051E+1
`
`
`
`2.56E+0 1.147E‐1
`6.842E+0
`
`
`
`
`4.349e‐1
`7.759e‐1
`2.993e‐3
`
`
`
`4.86e‐2 9.334e‐3
`4.028E+2
`
`
`
`
`
`1.059E+1
`6.022E+0
`
`
`3.723E‐3
`3.351E‐2
`
`
`1.572E‐1
`6.651E‐1
`
`
`3.468E‐1
`0.e+0
`
`
`
`8.91e‐1 8.117e‐1
`6.668e‐1
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.64E+0 0.E+0
`
`
`
`
`
`
`
`
`
`
`‐1.169E‐10
`‐3.767E‐12
`2.679E‐29
`‐3.767E‐12
`0.E+0
`0.E+0
`
`
`
`
`
`
`5.952E‐11
`5.319E‐25
`5.952E‐11
`‐1.169E‐10
`8.17E‐28
`
`
`
`
`
`8.724E+0
`2.607E‐2
`2.088E‐3
`‐3.168E‐11
`1.253E‐11
`
`
`
`
`2.23E+1 3.709E+0
`6.234E+0
`9.938E+0
`1.339E+1
`1.375E+1
`
`
`
`
`
`7.376E+1
`3.454E+1
`5.224E+1
`7.219E+2
`1.799E‐1
`
`
`
`
`
`8.215E+0
`5.468E+0
`7.721E+0
`1.697E+1
`3.529E+1
`
`
`
`
`
`1.864E+1
`3.279E+1
`1.445E+1
`0.E+0
`2.351E+2
`8.479E‐1
`
`
`
`
`
`6.25E+0 3.646E+0
`5.704E‐2
`1.085E+1
`
`
`
`
`
`
`8.89E‐3 3.434E‐3
`8.669E+1
`2.167E+1
`0.E+0
`2.082E+1
`1.799E‐1
`3.091E‐2
`
`
`
`
`
`2.64E+0 1.084E‐1
`6.53E+0
`3.244E‐1
`6.283E‐1
`
`
`
`
`
`
`3.812e‐1
`7.04e‐1 8.327e‐1
`7.777e‐1
`2.444e‐3
`0.e+0
`
`
`
`
`
`
`5.283e‐2
`1.032e‐2
`4.117E+2
`0.E+0
`6.518e‐1
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.72E+0 0.E+0
`
`
`
`
`
`
`
`
`
`
`1.588E‐12
`‐2.078E‐29
`1.588E‐12
`5.728E‐11
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐1.632E‐11
`5.728E‐11
`‐1.632E‐11
`1.892E‐25
`3.513E‐29
`
`
`
`
`4.407E‐11
`1.444E‐3
`1.881E‐2
`7.633E+0
`‐8.616E‐13
`
`
`
`
`
`9.373E+0
`5.97E+0 2.281E+1
`3.999E+0
`1.24E+1 1.237E+1
`
`
`
`
`
`
`2.044E‐1
`7.254E+2
`5.224E+1
`3.454E+1
`7.404E+1
`
`
`
`
`
`3.572E+1
`1.737E+1
`8.003E+0
`5.73E+0 8.96E+0 9.635E‐1
`
`
`
`
`
`
`1.445E+1
`3.29E+1 1.885E+1
`1.109E+1
`2.376E+2
`0.E+0
`
`
`
`
`
`
`3.81E+0 6.214E‐2
`1.011E‐2
`3.162E‐3
`2.846E‐2
`6.464E+0
`
`
`
`
`
`
`
`2.191E+1
`0.E+0
`8.764E+1
`2.111E+1
`2.044E‐1
`5.924E‐1
`
`
`
`2.72E+0 1.022E‐1
`3.029E‐1
`6.218E+0
`0.e+0
`
`
`
`
`
`
`
`2.03e‐3 3.341e‐1
`6.375e‐1
`7.756e‐1
`7.418e‐1
`6.338e‐1
`
`
`
`
`
`5.712e‐2
`1.136e‐2
`4.201E+2
`0.E+0
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.8E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`‐7.46E‐11
`‐7.905E‐13
`3.586E‐30
`‐7.905E‐13
`0.E+0
`0.E+0
`
`
`
`
`
`5.62E‐11
`‐4.359E‐29
`‐7.46E‐11
`5.62E‐11
`6.351E‐26
`
`
`
`
`
`6.678E+0
`‐3.197E‐12
`9.992E‐4
`5.715E‐12
`1.359E‐2
`
`
`
`
`
`4.286E+0
`5.692E+0
`2.322E+1
`1.116E+1
`1.14E+1 8.809E+0
`
`
`
`
`
`7.287E+2
`5.224E+1
`3.454E+1
`7.429E+1
`2.308E‐1
`
`
`
`
`
`3.611E+1
`1.775E+1
`8.269E+0
`5.98E+0 9.721E+0
`1.088E+0
`
`
`
`
`
`0.E+0
`1.445E+1
`1.904E+1
`1.131E+1
`2.4E+2
`3.3E+1
`6.665E+0
`
`
`
`
`
`3.966E+0
`1.142E‐2
`2.907E‐3
`2.616E‐2
`6.734E‐2
`
`
`
`
`
`8.852E+1
`2.213E+1
`2.138E+1
`2.308E‐1
`0.E+0
`
`
`
`
`
`5.576E‐1
`2.8E+0
`9.616E‐2
`2.823E‐1
`5.909E+0
`0.e+0
`
`
`
`
`
`
`2.927e‐1
`7.046e‐1
`1.715e‐3
`5.762e‐1
`7.202e‐1
`
`
`
`
`
`6.131e‐1
`6.142e‐2
`1.247e‐2
`4.28E+2 0.E+0
`
`
`
`
`0.E+0
`0.E+0
`2.88E+0 0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`
`
`
`
`
`
`
`
`
`
`1.769E‐11
`6.533E‐13
`5.683E‐31
`6.533E‐13
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐1.258E‐11
`1.276E‐28
`‐1.258E‐11
`‐6.573E‐26
`1.769E‐11
`
`
`
`
`1.138E‐11
`1.11E‐12
`6.911E‐4
`9.84E‐3 5.841E+0
`1.003E+1
`
`
`
`
`
`1.049E+1
`5.405E+0
`2.353E+1
`4.57E+0 2.59E‐1
`8.252E+0
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Azacitidine 400mg All Data.TXT
`
`Apotex v. Cellgene - IPR2023-00512
`Petitioner Apotex Exhibit 1059-0011
`
`

`

`3.646E+1
`7.451E+1
`3.454E+1
`5.224E+1
`7.319E+2
`
`
`
`
`
`1.221E+0
`1.049E+1
`6.218E+0
`8.518E+0
`1.809E+1
`
`
`
`
`
`1.152E+1
`1.921E+1
`3.309E+1
`1.445E+1
`0.E+0
`2.423E+2
`
`
`
`
`
`4.114E+0
`7.261E‐2
`1.281E‐2
`2.668E‐3
`6.852E+0
`
`
`
`
`
`8.932E+1
`2.233E+1
`2.163E+1
`2.59E‐1
`0.E+0
`2.401E‐2
`
`
`
`
`
`5.604E+0
`2.88E+0 9.033E‐2
`2.626E‐1
`5.238E‐1
`
`
`
`
`
`
`2.565e‐1
`5.2e‐1
`6.668e‐1
`6.667e‐1
`0.e+0
`1.472e‐3
`
`
`
`
`
`
`6.572e‐2
`1.364e‐2
`4.355E+2
`0.E+0
`5.903e‐1
`
`
`
`
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`0.E+0
`2.96E+0 0.E+0
`
`
`
`
`
`
`
`
`
`
`‐9.935E‐13
`2.847E‐30
`‐9.935E‐13
`‐2.827E‐11
`0.E+0
`0.E+0
`
`
`
`
`
`
`‐2.827E‐11
`2.931E‐11
`1.083E‐25
`2.931E‐11
`‐1.623E‐28
`
`
`
`
`
`8.776E‐12
`4.781E‐4
`7.14