E- ARCHIVE
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`l,l.J ; : :~
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`~ 1111
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` archive.org
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`DECLARATION OF NATHANIEL E FRANK-WHITE
`
`
`1. I am a Records Request Processor at the Internet Archive, located in San Francisco,
`California. I make this declaration of my own personal knowledge.
`
`
`2. The Internet Archive is a website that provides access to a digital library of Internet
`sites and other cultural artifacts in digital form. Like a paper library, we provide
`free access to researchers, historians, scholars, and the general public. The Internet
`Archive has partnered with and receives support from various institutions,
`including the Library of Congress.
`
`
`3. The Internet Archive has created a service known as the Wayback Machine. The
`Wayback Machine makes it possible to browse more than 450 billion pages stored
`in the Internet Archive's web archive. Visitors to the Wayback Machine can search
`archives by URL (i.e., a website address). If archived records for a URL are
`available, the visitor will be presented with a display of available dates. The visitor
`may select one of those dates, and begin browsing an archived version of the Web.
`Links on archived files in the Wayback Machine point to other archived files
`(whether HTML pages or other file types), if any are found for the URL indicated
`by a given link. For instance, the Wayback Machine is designed such that when a
`visitor clicks on a hyperlink on an archived page that points to another URL, the
`visitor will be served the archived file found for the hyperlink’s URL with the
`closest available date to the initial file containing the hyperlink.
`
`
`4. The archived data made viewable and browseable by the Wayback Machine is
`obtained by use of web archiving software that automatically stores copies of files
`available via the Internet, each file preserved as it existed at a particular point in
`time.
`
`
`5. The Internet Archive assigns a URL on its site to the archived files in the format
`http://web.archive.org/web/[Year in yyyy][Month in mm][Day in dd][Time code in
`hh:mm:ss]/[Archived URL] aka an “extended URL”. Thus, the extended URL
`http://web.archive.org/web/19970126045828/http://www.archive.org/ would be the
`URL for the record of the Internet Archive home page HTML file
`(http://www.archive.org/) archived on January 26, 1997 at 4:58 a.m. and 28
`seconds (1997/01/26 at 04:58:28). The date indicated by an extended URL applies
`to a preserved instance of a file for a given URL, but not necessarily to any other
`files linked therein. Thus, in the case of a page constituted by a primary HTML file
`and other separate files (e.g., files with images, audio, multimedia, design
`elements, or other embedded content) linked within that primary HTML file, the
`primary HTML file and the other files will each have their own respective extended
`URLs and may not have been archived on the same dates.
`
`6. Attached hereto as Exhibit A are true and accurate copies of screenshots of the
`Internet Archive's records of the archived files for the URLs and the dates specified
`in the attached coversheet of each printout.
`
`Miltenyi Ex. 1040 Page 1
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`

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`E- ARCHIVE
`l,l.J
`;z
`
`~ 1111
`
` archive.org
`
`
`
`
`
`
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`
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`7. I declare under penalty of perjury that the foregoing is true and correct.
`
`
`
`
`DATE: ________________________
`
`
`________________________
`Nathaniel E Frank-White
`
`March 24, 2022
`
`Miltenyi Ex. 1040 Page 2
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`

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`
`EXHIBIT A
`EXHIBIT A
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`Miltenyi Ex. 1040 Page 3
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`Miltenyi Ex. 1040 Page 3
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`

`

`https://web.archive.org/web/20120422111453/http://www.nejm.org/doi/full/10.1056/NEJMoa110384
`9
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`Miltenyi Ex. 1040 Page 4
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`~--~~-------------------------------~
`I~
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`lhttp://www.nejm.org/dollfull/10.1056/NEJMoa1103649
`
`314ca~tures
`23s.,,2011 ,1,1.,2022
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`ORIGINAL ARTICU:
`BRIEF REPORT
`
`Chimeric Antigen Receptor- Modified T Cells in Chronic
`Lymphoid Leukemia
`David L Portor, M.D .. llruco L. Levine, Ph,O .. Michael Katos, Ph D .• Adam llagg. MD .. and Cart H. Juno, M 0.
`N Engl J Med 2011: 365:715-733 August 25, 2011
`
`A bstract
`
`Article
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`References
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`Citing Articles (67)
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`Letter s
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`We designed a lentiviral vector expressing a chimeric antigen
`receptor with specificily for the 8-cell antigen CD19, couple<! with
`CD137 (a costimulatory receplor in T cells [4-188)) and CD3-zela (a
`signal-lransduct,on component ol the T-cell antigen receptor)
`signaling domains. I'. low dose (approximately 1.5• 1 o5 cells per
`kilogram of body weght) of autologous chimeric antigen receptor(cid:173)
`modified T cells reinfused into a palient wi th refractory chronic
`lymphocytic leukemi• (CLL) expanded to a level that was more than
`1000 times as high as the initial engraflment level in vivo. wilh
`delayed development of the tumor lysis syndrome and wi th complete
`remission. Apart from the tumor lysis syndrome, the only other grade
`3/4 toxic effect related to chimeric antigen receptor T cells was
`lymphopenia. Engineered cells persisted at nigh levels for 6 months in
`the blood and bone marrow and continued to express the chimeric
`antigen receptor. A specific immune response was detected in the
`bone marrow. accompanied by toss of normal 8 cells and leukemia
`cells that express CD19. Remission was ongoing 10 months after
`treatment, Hypogamrnaglobulinemia was an expected chronic toxic
`effect.
`
`Full Text of ...
`
`Read the Full Article . '
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`) l.E-01.A L"\ TlUS A1tt'ICL£
`
`FIG URE 1
`
`RELATED ARTICLES
`
`,
`
`I
`
`,..,,
`
`EDITORIAL
`Redirecting T Cells
`AUg,JSI 25, 2011 f W.J. Ul'Da and O.L Lori90
`
`Clinical Response in lhe
`Patioot.
`
`FIGURE 2
`
`Serum and Bone Marrow
`Cytokincs bofOf'e and attar
`Chimeric Antigco Receptor T(cid:173)
`Cetl Infusion.
`
`\RTICLE ACTT\lTY
`67 artk:les ll3ve cued lhls
`an~e
`
`COR~ESPONDENCE
`Chimeric Antigen Receptor-Modified T Cells
`inCLL
`Novernber 17, 20H
`
`Cancer
`LeukemiaJ
`Lymphoma
`
`MOR.F. ll'\
`
`Research
`August 25, 2011 •
`
`TREl\llS, MOST VIEWED (L8Sl Week)
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`Dengue
`Aprll 12 2012
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`A Reader"s Guide 10 200 Years of the No,v
`£nglnnd Journnl of J\ledicine
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`W histling in ihe Dark
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`Miltenyi Ex. 1040 Page 5
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