(Print Clearly -— Use permanent ink pen)
`
`Related work continued from notebook no.
`
`Notebook No. L/(O é I
`
`
`
`WasmAS/uéméfioioowLQJ/Md W
`
`Signature
`
`Why We Bloom
`{AW
` 2: a u
`' E
`
`(Print)
`
`Name
`
`on
`
`(Upon completion, fill in the following information)
`No further entries after:
`/i >’ lg Z Z O
`M I? D y
`e r
`Received for storage on:
`f i
`0
`Mon
`ay
`Received by W A.
`
` git) Name
`Signature
`
`1
`
`Related work continued in notebook no.
`
`Merck Exhibit 2226, Page 1
`Mylan v. Merck,
`|PR2020-00040
`
`
`
`
`
`mm“mmMMEWW*‘«mmwwwwmnnmiwnAMmwwfimmzwmmmnuwm
`
`
`
`Merck Exhibit 2226, Page 1
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No.L 1
`Continued From Page
`
`
`
`
`7 who» Val/M
`
`‘
`
`“J93017LE”&, 1/6 1"
`
`(Diwhngfimkk [/31 (I g
`L
`
`C Fa} 4“"..‘9;
`
`
`
`.1
`
`L
`T‘
`
`
`
`.13.,“
`
`nk‘q‘han
`
`
`I
`J
`
`
`
`1
`
`1
`o
`T
`.
`J
`J
`r
`
`LL dx ()qfid’qy
`V
`i
`
`
`{
`
`r
`
`T
`
`.
`
`
`f
`r
`
`
`
`«ottwvfwa 4;!qu
`
`[
`
`r
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`k
`y
`L
`
`
`gin/«qfi'Jc
`
`”A Nhlf'H‘i
`
`L
`
`
`
`
`
`
`[
`
`T
`F
`
`J
`1
`A
`
`
`
`
`
`
`I
`L
`Y
`
`
`
`I
`
`4
`L_
`
`l
`I.
`4
`1.“;
`[
`J
`
`7
`2
`
`L T
`[
`L’
`
`1
`
`T'
`
`I
`
`
`“Y
`I
`
`l
`J
`r
`1
`I2
`
`f
`*
`J
`L
`
`
`Li
`
`f
`[
`f
`ContinuedonPage
`
`Jig W LUNA/(es
`gflh flgafl
`7/lé/aolo
`
`
`J
`Signed
`Date
`Signed
`Date
`Merck Exhibit 2226, Page 2
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 2
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. .3211”;
`~16 “”4”
`~
`2
`Continued From Page
`{mp}
`h
`qu
`53RQJECTELLO { Cm”! ‘
`
`
`__..__ _ Mflmfiflm
`____._____..
`
`
`$JAKCV¢ B
`F
`L
`
`4
`r
`h { UV Mexsurewdz rm (39(wa échFF‘l
`
`
`v‘ eq
`rs
`F
`L
`I
`“inn—314’ Am a £393.?” 13>“). {its 47”}? m was WP“ Lpd-m‘im
`
`1 {fir fink 3‘} “,H‘M)
`P'Vj'l‘s
`[Pfiw‘L U ('mei“ C {(Kgfi
`r Mr”) i6 w “W’s 1/9on MM! a»; 9 WE)
`
`téui “Y“ i r WWW nmm Mir PM
`
`J
`L
`“$£3C+l‘v~\ Qafirc}
`1.10—7.30“. Lfii‘g‘ptzi 0+“ (,[Kwfi
`[2’1 9 (,ufixf‘
`i
`
`‘SAA—ffv
`“‘ ("V‘ZL‘W bst \’}F ”“7 “Sr
`1
`Y
`i
`
`r
`“hart/“J
`r
`L
`‘
`Ci05i~vL‘o7~ rwigg‘m} g3
`55 * LIMA LH‘IW m {f (yigwg
`“W“ (Lady ”aim! H‘-
`i
`
`
`{M
`,1
`1”?" 9V3 +Mhr
`:14!» 2mm, w«;~fly< fikslx
`L
`I
`
`r
`-IA}.§P,\ L'D),‘0I—I’
`rho «9N54ws
`4
`r
`
`
`
`L
`
`L
`1
`
`k
`o
`
`J
`F
`
`r
`L
`
`“L
`
`J
`
`i
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`i
`4
`MW“,
`1
`4
`[‘sz u<r5§\
`a03l‘p143 1*“ 3M} £13153”
`[,st 11199.“! “a“?
`d’nedi‘ A554}
`)V‘L}
`
`a
`90“
`f-J'§
`+rxxs meX'ffi
`(09ml.
`\mf—wq-{x 4Q [PIKSK
`[
`
`., V533”
`1.](03i‘nl‘txlT +0 «ziisayg
`r
`J
`
`,k
`o
`L
`I.
`L
`J
`1
`i
`
`{5.9
`cloWfiquq‘f $619“.
`“of LIL“
`n‘i’cnk? Lax» \Nym Lam?) qu {wJL (“WA
`
`l_
`fifi}_fl‘f¢5¥‘ff€\r
`T0
`(MVP. “Jawpilud.
`.Fizx (K
`L
`T
`‘
`
`" 55%
`93 (“0 “o! 4': WQN$CV5
`r
`r
`[
`
`,___‘
`i
`L
`
`qul’pl‘bS umpyflflj-L m3
`LIPS um I
`n 69“” if<r5qudjufihd luk (NM T
`#
`
`
`9A erwaMy («my «Lemma, M ,
`A
`F
`
`1mg}
`$131-4 «1/
`’(‘MW‘QNiLJ/S
`T
`o
`r
`
`
`J
`1
`J
`1
`
`4
`
`[
`
`
`r 4
`F
`
`I
`1
`r
`J
`T
`
`
`
`1
`L
`
`
`
`L
`l
`
`o
`r
`J
`
`1
`J
`L
`
`Continued on Page
`
`
`Read and Understood By
`
`% 4/
`
`CifiLflg
`
`{fin WWW
`
`Signed
`
`“Wis/Mm
`
`Date
`W
`Mylan v. Merck,
`|PR2020-00040
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 3
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. £3151.— >
`
`Continued From Page
`
`3
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Continued on Page 0 (I
`
`“ms/awe
`
`Date
`
`
`
`
`
`Mylan v. Merck,
`
`|PR202b-00040
`
`Merck Exhibit 2226, Page 4
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. ALA
`Continued From Page ._..___,._.._..__o._.
`PfiQJECT ELLQMOQH
`CMF) (89
`
`
`WWWfl
`
`Y
`
`
`
`
`BquL g2
`r
`h
`
`
`
`L
`3%3/3032e/ Mi v 9449/1“ I‘M“) ”a" “Fr #1 WM, +me~r 11"" r T
`+
`
`r Mg) 9'“
`L
`*
`r
`I
`*
`*
`*
`“
`
`a
`_.
`ffmrv‘ Vr/
`(4‘
`[PA‘I‘MF’
`“
`’Rp MSMNMS,F¢V OGSWJ—i‘ur qurhi
`i
`r
`
`S4?” Frank?
`r
`W
`h
`4
`P
`
`JIMWEE «It-Ayfir
`$4 34“, alkyd [PM 3'”;
`+Rrac/«3M
`L
`2A. vmx
`M
`
`
`FUN 1M4 ”if We‘ll m+~¢® r5444»
`(M vie.
`
`numb/ob
`93%“, RE My“ 33% fiwrflfium‘,‘ V‘r’wb‘)
`a
`+
`‘
`T
`1
`J
`L
`_
`
`e
`T
`1% S (V’rxLI‘mquJrW- HIM;
`(«\wh “WVWTJ 1
`r
`4
`
`T
`L
`J
`1
`4
`w
`4
`L
`
`gimme/1n WW}
`$313- «19%
`3F
`90%».
`4
`
`ram) 463.2%.“ +2 {My} 4 CM «(Lu {ragga
`r
`J
`T
`
`
`
`o
`
`
`L
`r
`L
`ii {3‘5 1:123“: / LCw‘hmfi
`9],?) M”)
`.4
`J
`F
`4
`F
`j
`
`
`4
`T
`1
`F
`fi
`*
`J
`
`r
`1
`r
`L
`1
`F
`l
`L
`?
`W1
`
`f
`h
`A
`r
`T
`T
`l
`J
`‘
`fl
`
`Jr
`T
`L
`*1
`
`
`
`L
`r
`r
`T
`L
`f
`T
`+
`r
`*
`
`
`
`r
`T
`1
`J
`J
`o
`.J
`L
`7
`L
`4
`L
`J
`r_—_J
`fl
`L
`-
`
`T
`4
`o
`r
`L
`j
`r
`4
`r
`-
`
`
`l
`T
`J
`1
`r
`T“
`
`
`
`
`
`
`r
`‘
`F
`I T
`"
`L
`T
`T
`T
`r
`L
`4
`I
`r
`4
`4
`l
`4
`fl
`
`1
`4
`T
`L
`‘
`L
`L
`
`J
`_T
`v
`I
`T
`J
`T
`J
`
`A
`r
`t
`
`
`
`
`L
`
`L
`
`T
`
`V
`
`r
`
`r
`
`I
`
`F
`
`1
`T
`L
`L
`7“
`J
`P
`#
`
`
`F
`fl
`r
`o
`L
`1
`Continue?! on Page
`5 ’
`A.
`R)
`“‘H
`
`t
`
`Read and Understood By
`
`
`9/1 ‘3‘ro
`380m wail
`7//b[3“°‘ D e
`
`
`Date
`Signed
`'
`.
`.
`Date
`Mylan v. Merck,
`|PR202b-00040
`
`
`
`
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 5
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`
`Natebook No.L.
`Continued From Page AL“
`
`5
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Sn“? S’I/AS ff(g,«>{ (as
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`l
`
`J
`
`MA
`
`111
`
`
`
`
`
`
`Continued on Page 0 6
`
`
`
`
`
`fife/low
`Date .
`age
`,
`|
`|PR2020-00040
`
`x |
`Mylan v. Merck,
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 6
`Mylan v. Merck, IPR2020-00040
`
`

`

`gfiGJECT E1349“) 0" d
`6“"!§ (8“
`
`
`Notebook No. flfi
`Continued From Page ,Q‘é—w»
`
`«4319
`
`.
`4
`L
`L
`,
`k
`P
`4
`
`
`
`
`
`A H EBab-(L i=5 ‘2 L
`
`
`
`
`
`Mn.)
`L
`
`i
`L
`1
`
`r4
`
`T
`r
`T
`
`1
`
`.L
`4
`i
`
`J
`
`
`
`
`i
`
`i
`1
`
`i
`+
`4
`
`
`
`
`f
`
`
`i
`i
`
`L
`i
`i
`
`‘¥
`1
`
`J
`+-—
`4
`
`“
`i
`
`1
`L
`1
`
`o
`,
`if
`4
`J
`
`T
`
`+
`
`i
`F
`T
`J
`
`o
`T +
`
`i
`~1
`
`Continued on Page Q
`L
`—-
`”1
`
`Read and Understood By
`
`i
`
`
`
`
`
`
`
`
` F
`
`
`
`my“)
`
`afiwmw
`
`v/zeIMu
`
`Date
`.
`.
`Signed
`ate
`
`Mylan v. Merck, IPR202b-00040
`
`W,
`
`Merck Exhibit 2226, Page 7
`Mylan v. Merck, IPR2020-00040
`
`

`

` *
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`x |
`rc
`Mylan v. Merck,
`
`age
`,
`|
`|PR2020-00040
`
`PRDJECT 6" 10,00 Ml
`
`(”PX ( g V
`
`Notebook No. LI“!
`Continued From Page __.___Q_é_~.___
`
`
`7
`
`
`
`
`
`
`
`
`
`
`
`
`
`77W
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`l
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 8
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. “EL—L
`8
`._
`,
`Continued From Page __._._T__....
`PRQJECT C L10 I 0 On! /
`("l”) I 2 9
`
`
`
`__-
`
`o
`L
`r
`L
`r
`
`
`L
`
`w
`
`L
`
`r
`
`H
`
`
`
`V
`
`J
`
`{)H’CT\Q\HV1‘
`\Ile’
`J L
`1
`L
`,
`
`
`
`
`o
`I
`I
`I
`L
`T
`“
`1
`
`i
`r
`4
`j;
`T
`i
`J
`
`l
`I
`L.
`L
`
`I
`L
`L.
`r
`
`F
`'
`T
`T
`i
`T
`[L
`J.
`4
`
`
`J
`J
`r
`[
`I
`,
`
`
`L
`I,
`I,
`J.
`T
`
`
`1
`L
`I
`
`L
`r
`L
`.1
`
`L
`1
`L
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`J
`
`
`
`
`
`
`
`
`
`W
`i
`r
`F
`*
`
`1
`
`.I
`
`L
`
`l
`T»
`r
`_ 4
`
`
`J
`r
`
`
`
`L
`T
`«I
`A
`
`
`..
`5
`fl
`{
`
`1
`o
`L
`I
`r
`
`
`*
`
`+
`T
`I
`L
`
`
`l
`4
`I
`w
`1
`J
`
`4
`L
`f
`
`
`
`I
`‘l
`L'
`1
`T
`J
`I
`1
`I
`L
`1
`J
`
`
`
`7
`T
`1
`.1
`[
`.1
`.4
`J
`§,
`1,
`4
`I
`
`1
`L
`r
`L
`1
`j
`J
`4
`
`
`F
`I
`T
`
`
`
`1
`[
`1
`.L
`7
`1
`L
`T
`J
`
`r
`1
`
`1
`1
`Continued on Page
`
`Read and Understood By
`
`Date
`Signed
`
`,
`age
`'
`'
`|PR2020-00040
`Mylan v. Merck,
`
`29% wk
`
`7/25sz
`
`
`
`
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 9
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No.L 9
`Continued From Page
`
`
`
`
`
`""Lwflw'a
`
`
`
`
`
`w‘ilfi‘éiéé‘iéFél‘z
`
`J
`
`r
`
`if
`
`
`
`L
`
`L
`
`1
`
`4
`
`{
`
`
`
`
`1
`
`
`
`
`
`1
`
`1
`
`1
`
`T
`
`
`
`L
`
`L
`
`
`Swffi“‘4\'fh
`1 (1.1-,
`
`r
`4
`J
`'1
`
`[
`
`
`
`
`L
`
`T
`”I
`
`MM win Mr.
`
`
`*
`1
`$19.?“ DJ Dr! 9
`”TL”?
`
`(Mar ziwsg i
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`l l
`
`
`
`
`
`
`
`I
`
`*
`
`[
`
`
`i
`J
`
`
`i
`J
`r
`
`J
`j
`
`l
`
`
`
`[
`I
`
`1
`J
`
`l
`L
`{
`
`Y
`
`L
`#*
`l
`
`
`J
`
`
`r
`
`
`*
`l
`
`J
`
`Continued on Page
`
`
`Read and Understood By
`
`fix 601306251
`
`Signed
`
`7/1700
`
`Date
`Xhlbit 2226, Page 10
`erc
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 10
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. EL.“
`19
`PROJECT ELZJMDO ‘I(
`CV5 ’34
`Continued From Page
`
`
`
`
`
`
`40; wufv ‘m‘l‘x' #061.
`
`km.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`+511”
`CL,
`.hfi 1M1, uJ
`_
`
`
`
`
`
`
`
`
`
`
`
`
`
`We) film ["3501 +1 $.15»wa
`‘
`«in 4”}
`(5 \IYIJ PAWS}
`+9 tag“?
`W i
`i
`i
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`’
`I
`A
`
`
`
`
`fl
`
`*
`:1
`i Mi
`*“*
`i
`rwifl
`j
`
`
`L? Q/
`§/3/w
`33:)» WW
`:7[(7[(0
`
`
`
`
`j
`
`i
`
`me
`i
`
`r
`
`Em v“) (19¢)
`
`
`
`i
`
`“i
`
`€133
`
`
`
`+9 lML V41, 1.”) 9+» CV
`‘1‘) {a
`Swim,“
`n w WL‘
`
`L
`
`[
`
`[
`
`L
`
`(2.0]; ~19 9.4}qu
`
`712 C \Ntd‘xl‘ QM?“
`
`1
`
`I
`
`-
`
`”£11. “f urn 6w 1“
`
`Zfoh‘L—V—JJ
`
`
`
`
`
`
`
`1
`
`
`
`
`
`
`
`‘1
`4
`Continued on Page 1
`
`
`Read and Understood By
`_
`
`Signed
`
`Date
`
`
`Signed
`
`Date
`
`Mylan v. Merck, IPR2d20-00040
`
`Merck Exhibit 2226, Page 11
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No.
`3 0 5 /
`
`PROJECT ELL” 100“”
`(MP) If 9
`Continued From Page
`
`
`
`'1
`wmlflk CMLNW)
`infilfljlimwfi
`>q0i~$P\ 3%? 111% $9 ZS”<~
`
`Mew/*1 quo
`
` g.
`(“#129”ny grief}?! .
`(4041;! A) (o 4H WNW)
`F'w (2W5 F4}
`~
`cum VALQfiPA Emmi)
`m mm “WW“
`k
`r
`
`«L (3%”:
`(unfinFixQ ffdix
`I
`J
`~J‘Pb 404,“ $145; )
`(N \‘F
`C40} H‘ (q‘“/ J14”! (7‘71“ ‘1 1!
`
`
`
`A
`
`L
`L
`l
`
`1
`
`11
`
`
`
`by) WM? 5m) «1'9“ /
`
`«,1
`
`[p “TMQ JAK y?“
`
`7
`
`3a m 4: WM {5;
`
`j
`
`.
`
`1» «4% e M M3
`
`I
`
`L
`
`l
`
`.
`
`Y
`
`L
`
`I
`
`T
`
`F
`
`L
`
`I
`
`4
`
`
`
`
`
`
`
`
`
`
`
`
`1
`4
`T
`
`2
`
`3
`
`I
`
`
`V
`g
`r
`,
`r
`J
`
`
`
`r
`l
`
`
`FILr % STIR
`I
`
`
`L
`T
`r
`r
`
`.1-
`’CF
`
`J
`JAM“WJT
`(LIAqF(in)#11101 '11!“
`rl\
`*
`I
`S Ffvmh aqrue Edwl’firof (“saw wd
`u
`l Cflfi
`
`'
`*
`”T1“?
`T
`1
`9w
`4
`4
`(7031-1 ~94 Culwl‘fivg SPF (:fiyl—w “a?
`M
`«Fa,» (ofiuqu/O/fi [$qu
`}
`
`
`(«H ”7 “Fl avg} 314““
`51L Oilfifl’In'aL/
`gx'l“ “TI
`5%
`fly) ~I "0 wawk}; 14 «F 61'»
`(-(Fv‘fr
`J‘Tp {ch-«MG [AF #PM
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`iDL‘Lb QML SJJ)
`
`J
`
`I
`
`J
`
`4
`
`
`5
`4
`T
`_Continued on Page
`
`
`M sin/w
`
`.
`
`(732» 62%”
`
`7/‘7/’ 0
`
`
`
`
`Signed
`Signed
`Date
`Merch-Exhibit 2226, Page 12
`Mylan v. Merck,
`|PR2020-00040
`
`Date
`
`Read and Understood By
`
`{Sf FwiNFbJjfi"
`7.;ng
`(vim Fe)
`?
`77
`(5?"
`P) 2
`
`kaSvL‘P\{kt4-f Cd! ”#1)le OFWQ) m}wi'f’xl‘ #0397
`I
`[
`T
`I
`I
`j
`
`L
`
`1
`
`l
`
`I
`
`_
`
`J
`
`J.
`
`L
`
`»
`
`T
`
`
`Lido
`(13m me
`r
`i
`L
`
`W
`I
`i
`J
`l
`y
`r
`T
`y
`
`
`Merck Exhibit 2226, Page 12
`Mylan v. Merck, IPR2020-00040
`
`

`

`Nfiiebfiflk N6, ilfpwz’iwfi
`
`‘32
`, cw) (:9
`Continued From Page W
`. “,7,”
`V
`PRQJECTQLLWM _
`
`g
`i
`I
`t
`'
`X
`'
`i
`i
`’
`’
`z
`e
`i
`f
`,
`
`q
`r
`.
`w.
`I }
`g
`x,
`g
`I
`V
`4 -‘
`g
`.1»,
`‘r
`-0 v-
`
`
`
`
`
`
`
`Cfnifwwwiyl:4 .quFw (LWEJ TM‘hm, x.:»1\f
`.
`,0
`ifjf‘g‘figm j“ numunxalmm mummy :ummW w— ~
`”— 4 a I
`, _ ,,
`
`.
`
`
`
`
`'-
`
`}
`
`E
`
`“
`
`"
`
`
`'
`I
`I
`ignmmh ’
`I
`I
`$230M -
`‘
`I
`flPPPPP28:5,? M
`,
`,
`“mm
`A
`.1
`
`t
`‘1
`“
`"J“ j
`
`r»
`~——'
`L“
`H
`J
`1
`~‘
`,
`”f
`
`a
`V
`m R u
`A
`—~
`-0
`__
`m A
`
`
`;
`i
`.
`|
`1
`1
`’
`i
`I
`
`
`«
`
`T
`
`
`
`
`*
`N
`
`
`
`
`
`
`-
`w
`m
`_
`,
`”1
`«J
`
`J
`
`i
`
`F
`V7
`—
`r
`7
`I
`A
`‘
`7k
`‘7
`
`
`
`F»
`A
`'
`F
`_
`A
`0
`—
`V
`
`
`
`_
`_
`E
`'r
`'
`a
`T
`
`
`_
`I
`4,. I
`_
`“M
`«_
`,
`J
`E
`L
`w
`1,”.
`
`M
`_L
`,.
`H
`J
`._
`-_
`I
`I“! ,,,,,
`'
`I
`is
`
`
`
`
`
`.4
`L._
`A
`M
`a
`
`
`
`f
`M
`—
`M
`
`
`
`,j'-
`,0
`.1
`
`
`
`L
`w
`,
`
`
`
`F
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`a
`
`J
`J
`
`
`
`\
`4
`,
`1
`A
`
`Coniinued on Page
`
`Read and Understood By
`
`
`Date
`Signed
`MerckE
`Mylan v. Merck |PR2020-00040
`
`£25 QMM ,
`
`7/1703
`
`Date
`
`
`
`
`
`hawtmtmhlmWMmMimNM.“u.4“We”».4,W,Au‘.20,0,.”H0VH‘.,0wmy,“‘
`
`
`
`MWig-I‘mmWNNMBWJMmth4‘J-Arul“mm;umzwamawmméa
`
`Merck Exhibit 2226, Page 13
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`
`j 87 (71
`
`Notebook No. #QLL—
`
`Continued From Page
`
`13
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 14
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 14
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`
`
`
`Notebook No.W
`Continued From Page ”IA—w
`
`
`9mm (m /g,
`lflr’a’r
`
`
`4
`
`J
`
`Y‘J“5E:b;
`
`g‘y’flf?
`
`
`'
`r
`1
`1
`
`
`
`
`$5112 Snip/x
`«‘5
`
`[$0
`4
`“Ll!
`
`97¢ I
`L
`
`H43
`{
`
`
`
`1
`
`j
`
`j
`
`’t (id?
`H
`r
`4
`1
`
`212—,
`J
`
`
`
`$
`
`
`
`
`
`
`I
`
`+
`
`_
`
`
`i
`
`I
`4
`
`
`
`L
`
`l
`
`7
`
`l
`
`
`_¢
`F
`J
`2
`L
`T
`
`
`
`
`j
`
`1
`
`L
`
`
`
`l
`
`[
`
`1
`
`T
`
`J
`L
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`I
`r
`{
`[
`
`L
`Y
`1
`I.
`T
`I
`r
`
`4
`1
`.
`F
`
`r
`r
`
`
`1
`E
`
`*
`
`[
`
`4
`
`i J
`
`
`
`i
`
`l
`
`
`T
`A
`f
`i
`
`1
`L
`Continued on Page
`
`Read and Understood By
`T
`ium @3091
`
`
`
`9/L/(o
`
`Date
`
`Signed
`
`7/!71113
`
`Date
`“’"MercR Exfilfilt 2226, Page 15
`Mylan v. Merck,
`|PR2020-00040
`
`T
`L
`
`Merck Exhibit 2226, Page 15
`Mylan v. Merck, IPR2020-00040
`
`

`

` i 9.191171: Rn Mr F 49% ] Msmk) 1 i o L
`
`
`
`PROJECT-ELL 9’ ‘3 9" l I
`
`Notebook No. Aim
`Continued From Pagem
`
`15
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`J
`
`i
`
`i
`
`L
`
`,
`
`
`
`
`
`r
`i
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1
`
`
`
`1
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`iii
`
`J
`J
`“
`Continued on Page
`
`
`
`
`
`9/3,
`02% €11an
`W0
`
`Signed
`Signed
`Date
`Merck Exh‘ibif’Z’ZZB, Page 1'6
`|PR2020-00040
`Mylan v. Merck,
`
`__J
`
`
`
`Read and Understood By
`
`
`1
`4
`
`
`‘ i i i r ‘
`
`Merck Exhibit 2226, Page 16
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`
`
`Notebook No. 5321.
`Continued From Page
`
`
`
`
`
`
`
`j
`i
`r
`r
`”ll/V'LQKNQ
`
`J
`
`
`
`1
`
`
`L
`t
`
`
`
`
`
`
`
`
`J
`
`a
`d
`
`T
`7
`
`j
`[
`
`
`
`
`
`]
`‘
`
`E“ Wow 9% M
`+9 W NW how 0
`+HWJFA)(3 l?”\:“L51
`UVUJV ,chh BRIT (“LA
`L
`L91»
`L ’12,” +5 {KS/{r
`31
`
`I
`L
`
`1
`
`T
`
`1
`.l
`
`J
`L
`
`j
`
`
`
`
`
`
`$914 @515 (
`L’q—Lk
`j
`
`
`1
`
`
`
`
`T
`
`
`cqfijgwfifirfiwlmh ROMLLA
`
`“.1
`
`f
`
`[
`
`J
`
`i—~
`
`
`L
`J
`[
`
`1
`1
`
`
`
`i
`
`J
`
`7
`
`a
`
`‘
`
`r
`
`1
`
`1
`
`L
`
`r
`
`1
`
`;
`
`
`
`
`
`T
`
`T
`
`J
`
`l
`J
`
`I
`H
`
`j
`
`
`
`
`
`A
`1
`X
`
`L
`[
`
`I
`l
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`r
`
`L
`
`;
`
`L
`
`1
`
`I
`
`I
`
`J
`l
`
`I
`
`”
`
`[
`k
`1
`*
`I
`‘
`a
`j
`[
`r
`1
`Y
`J
`L
`L
`7 Continued on Lage L L 1
`
`
`
`
`T
`L
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`x |
`erc
`Mylan v. Merck,
`
`|
`
`age
`,
`|PR2020-00040
`
`J
`J
`j
`
`Merck Exhibit 2226, Page 17
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`
`
`
`17
`
`
`
`
`
`Notebook No. iii};
`
`Continued From Pagem
`PRQJECT Ell—0 ./O 90 /(
`
`.
`———-——w
`W—WTW‘W‘i—"W
`
`i i [
`.
`W ~
`i
`»
`J‘“‘L“l‘§§‘i
`Juigigiigig 2
`2
`1
`J
`w w m w w s, m ow
`W
`
`1L
`I
`/ I
`1‘1742—1Amblenlr
`’
`1
`,
`gmetv)
`Sdgm‘Hcg
`{Dr
`L45 MS 45/;
`T
`< 2) ‘j
`
`Q'Qvg (QA
`P {qukfh
`wwé‘r
`MQPJ r1121
`i
`i
`i
`
`
`
`
`I
`7
`
`l
`L
`J
`7
`L
`J
`7
`L
`
`
`I
`4
`L
`+
`L
`
`l
`J
`1
`l
`
`i
`i
`T“
`
`L
`r
`,
`1
`2
`
`i
`i
`W
`I
`”J
`
`,1
`i
`i
`L
`
`i
`r
`L
`
`J
`f
`J
`i
`I
`i
`i
`
`
`,2
`
`J
`
`i”
`
`i
`
`i
`
`i
`
`J
`
`'
`
`T
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`‘
`
`i
`
`L
`
`W
`
`
`
`
`
`
`
`
`
`
`
`
`
`r
`
`F
`
`l
`
`[
`
`1
`
`I
`l
`L
`L
`
`L
`i
`J
`T
`F ,_
`
`1
`r
`1 T
`
`r
`i
`i
`L
`
`
`
`‘
`.3
`‘T
`4
`i
`L
`[
`L
`
`l
`1
`J
`1
`T
`[
`
`
`J
`4
`J
`
`
`
`
`
`
`
`
`l
`T
`1
`1
`
`
`
`
`
`
`
`
`
`
`
`
`
`1
`
`r
`
`J
`
`T
`
`j
`
`J
`i
`
`
`
`{
`
`i
`
`
`
`
`
`
`i
`i
`i
`i
`’
`i
`r
`i
`H
`
`1
`[
`i
`‘W
`T
`*
`i
`
`1
`Continued on Page
`1
`h
`i
`
`—
`L
`Read and Understood By
`
`1,“
`i
`
`J-
`r-
`r
`F
`i
`L
`
`i
`i
`T
`
`
`
`
`Signed
`Date
`Signed
`Date
`erck Exhibit 2226, Page 18
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 18
`Mylan v. Merck, IPR2020-00040
`
`

`

`Natebock No.Mg
`18
`
`Continued From Page
`PROJECT Eleblnnn/ l
`(-3ng 3 KW,
`,
`
`h“:
`r
`W
`,
`H
`T
`
`‘
`M
`n
`,
`_
`R,
`M
`i
`I
`343/ r Wyn/F0 ~ mg .17) n1,
`» 09% $4/95 $345+ [‘15 7?}.
`W
`
`L <
`
`_
`
`
`
`\
`
`
`C133l~q!“nl"é?§+tmb0
`y
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`4
`
`
`
`m
`_
`f
`r"
`
`
`
`
`
`
`
`
`
`
`
`
`
`—
`k
`-
`AM
`.4
`
`
`,m
`_
`_
`1
`_.
`7
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`r.
`k
`w
`1
`P
`L
`fl
`,
`
`
`
`
`
`
`
`
`
`
`
`j
`_.
`L—
`
`
`
`
`m
`I
`Contin
`d on Page
`
`Read and Understood By
`
`
`
`
`
`w among/l
`
`
`
`”7/M(9~o(o
`
`%0
`
`WWII/(‘1
`
`
`
`
`
`5 Date Signed . .Signed Date
`
`
`Mylan v. Merck, IPR2d20-00040
`
`Merck Exhibit 2226, Page 19
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`31m
`Notebook No.
` ,pnoJECT ELM/ma 5w" I???
`
`Continued From Page
`
`
`___._
`~7—
`T-__
`
`
`
`
`
`Obfl 519;“; 1/07 to ((31%)
`{erg‘HF W‘mr; Nay
`
`[
`(W‘s, ye/Ig
`A J
`
`4‘3! (I
`+
`F
`
`7
`J
`L
`
`
`
`19
`
`
`
`76 (Jamie) (,1; L5, J1 ‘15
`
`J
`
`J
`
`h
`
`
`,
`J
`.1
`
`
`
`
`
`fkslwk
`x073 (43,21th Karo
`J
`t
`L
`I
`1
`
`049m quxri
`‘Fp 'F/r-yrq
`L
`r
`J
`J
`I
`[
`
`I
`J'
`
`1
`
`
`r
`J
`
`
`
`
`
`1
`
`J
`
`
`
`__]
`
`F
`
`[J’LJer/r-J WM 1" (wt KL.»
`K, 2:” $216”PNZI/(o/rn
`
`
`J
`J
`J
`
`
`
`J
`
`J
`
`L
`
`J
`
`r
`
`J
`
`J
`L
`J
`
`{
`
`J
`
`[
`
`
`1
`L
`r
`w
`1
`r
`
`J
`
`r
`L
`
`r
`r
`*
`1
`
`
`j
`
`r
`
`L
`
`r
`
`J 1
`
`J
`
`L
`
`
`J
`"J
`J
`J
`
`
`o
`
`J
`
`J
`
`L
`
`
`
`
`
`L
`J
`
`J
`
`J
`
`J
`
`1
`
`1
`
`1L
`
`J
`
`J.
`
`
`
`
`
`J—J
`J
`I
`
`
`
`
`J
`J
`1
`
`
`L
`J
`‘
`J
`J
`J
`Continued on Page Q 9
`h
`Read and Understood By
`
`
`
`[
`
`J
`
`
`
`
`
`J
`
`
`
`
`
`J
`
`
`
`1
`J
`
`
`
`
`
`J
`
`J
`
`
`
`
`
`J
`
`J
`
`
`
`J
`
`
`
`J
`
`
`
`
`
`
`
`
`
`
`
`”J
`
`
`
`
`
`J
`
`
`
`
`
`
`
`
`
`J
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`.J
`
`
`
`
`
`
`
`J
`J
`J
`r
`
`J
`
`¢ 7/
`
`gay“,
`
`
`
`56%“ mam
`
`Merck Exhibit 2226, Page 20
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. 5202/
`Continued From Page
`
`
`
`
`
`
`
`
`
`
`
`
`f
`
`[
`
`T
`L
`i
`
`j
`
`J
`1
`
`L
`
`[
`i L
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`r
`
`J
`
`L
`
`I
`
`[
`
`J
`
`J
`
`7
`
`L
`
`r
`
`
`
`
`
`Am“ {A 03’
`(450$ (A
`$~A.blv>
`Pftfi’é'
`(A H‘
`?(""f°)
`gun};
`eigevl‘? LVLLQK 977.. M9 71(23'1/{0
`L
`T_
`1
`1
`x
`
`}
`r
`414~31(5fm L
`4
`[
`
`F
`I
`
`
`e
`I
`4
`L
`L
`T
`
`1L
`i
`1
`
`0
`F
`I 4
`L
`r
`[
`l
`
`
`
`L
`1
`j
`
`1
`r“—J
`
`l
`‘
`r"—!
`
`
`1
`I
`T
`
`J
`l
`,,,,,,
`L
`
`
`
`
`
`
`20
`» PROJECT é'qu In NV (
`(MIA I X?
`DJ} ~ 133%?
`9401+ — Lula).
`.
`,
`L
`
`
`39 («Mega fwaAAA]
`FA Tum 9v amp/F
`fl
`L
`j
`r
`t
`
`Eu
`1 =44;
`“L M)
`h a w r
`M
`A
`M1
`a
`1317 V
`fin a?
`A; S
`tr
`‘2
`f 4]
`
`(fluvznv-«l
`Hfil'llefl— r
`""
`L
`Ll‘lé
`“#75 lrngow'L
`#01 {-7.0qu
`J Cf)? (’1?»a(
`I If
`aim-mm
`qfi‘WUMT
`} New
`[9 ‘g
`Ejfitwoi‘!
`L~
`1
`”we
`(235
`Harp“
`(N MM
`{1 0‘!
`L
`WIN—M
`m M e
`u 9
`7
`L3 )kan
`993/” I94’L
`6‘03
`
`dopmr W
`1'0!“ fi‘r‘k
`7.0L
`1
`i
`J
`1
`gowkr ’1
`L cps-Vi mint
`(.1?
`n
`I
`
`9413p)..- [6T 1 Ckfi‘fl'li cl
`fffifl' ’wfl,
`9.5
`
`6
`
`J
`
`X
`
`T
`
`r
`
`j
`
`‘fi‘f C: r‘jl'M“ lei-”3*“
`
`j
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`+
`
`J
`
`L
`
`L
`
`L J
`i-
`
`T
`
`L
`
`I
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`r
`
`F
`
`l
`
`L
`r
`
`i
`L
`
`l
`
`j
`
`¥
`
`r
`
`i
`
`1
`
`
`4
`1
`F f
`'
`j
`1
`
`Continued on Page L]
`
`Read and Understood By
`
`
`
`4
`T
`r
`
`
`
`
`
`
`
`
`
`
`“41°
`0435?” mum
`9/"Im
`g 14/“
`
`Signed Signed Date Date
`
`
`Mylan v. Merck |PR2020-00040
`
`Merck Exhibit 2226, Page 21
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`PROJECT ELL—L“ (q M”
`(MI)
`’89
`
`21
`
`2 0'
`
`
`Notebook No. file—m
`Continued From Page
`_""‘""—‘T“‘“‘
`“*1
`
`
`
`
`
`
`
`
`
`
`
`
`
`l
`L
`f
`
`
`
`
`i
`
`t
`
`F
`
`f
`
`
`Y
`r
`
`
`{
`1
`j
`
`T
`J
`
`
`L
`1
`L
`
`
`
`
`L
`
`y
`
`F F
`
`
`
`
`f
`
`
`
`
`
`
`T
`r
`W
`
`
`
`,
`j
`[
`
`
`
`
`
`1
`"T
`
`*
`
`
`1
`I
`
`
`
`
`
`r
`L
`i
`1
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`3
`
`1
`
`?
`
`1
`
`J
`
`1
`
`4
`
`f
`
`l
`
`J
`
`‘
`
`F
`
`J
`
`1L
`I
`
`L
`
`T
`
`I
`7
`
`L
`
`
`[
`I
`J
`Continued on Page 2L
`
`Read and Understood By
`
`
`
`,9 fg/
`
`' ned
`I
`Date
`
`
`em 5% 669an
`
`Signed
`
`7mm
`
`Date
`
`mM
`
`ylan v. Merck,
`
`|PR2020-00040
`
`
`
`
`
` i
`
`
`
`1
`
`1L 4
`
`1
`‘
`
`T
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`r
`
`I
`
`I
`
`,
`
`L
`
`1
`
`’1
`1
`
`‘
`
`f
`
`L
`
`.
`
`
`
`Merck Exhibit 2226, Page 22
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`4
`1
`A
`
`r
`L
`F
`T
`4
`r
`
`
`Notebook No.L
`22
`Continued From Page __L_L__._—~
`PROJECTQ l‘V‘flWd
`C‘V‘EA ( g q
`
`
`(0/9
`WM
`‘L 61
`r
`3&9 A;
`L
`*
`IN ohm WW7 Mam, t/aV/m
`
`rah-Q50? “AW“ ($7( figfigccwh
`{ V; 7, m? {lg-{3
`4
`L
`
`rfjmpr! Ad 93073 wm‘l'flo
`A
`
`
`
`
`1
`‘45“
`kg“)
`RflMIKQg
`-Q: K \“M M «1‘
`[£31
`«6&5»!
`“336M
`MJ‘PNJ “\‘3‘x
`ngmgfi fl
`“(*SY‘FA4 ’1“
`i.
`I”-
`W 1
`Qfilklm'w
`5411" L
`~
`(‘9
`Lum- en»!
`Lynn
`LEL
`
`F
`1
`F
`N I
`A
`L541
`Ly'ql
`L
`\[
`
`L '99 ,
`{Ii-7L
`JALNJN"
`w
`1127} f
`lpm5 I
`11.19
`WWI“! [ALL
`" *
`”.7
`um i
`1sz
`flux-M
`r‘
`LL?
`
`“'35
`7F3Yr‘
`“
`. T
`7
`n‘
`‘T
`K
`
`w"? r
`741%
`any ”Mr
`“2 0?
`” r
`r
`H4
`L
`T
`
`IL '97
`w
`J» x
`\
`(“firi’dl‘d
`.__L
`94$!“
`sré;
`
`KM! W‘"
`L
`I
`K
`t "
`QM“: WM ‘5
`
`r
`
`L
`
`I
`
`L
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`[
`
`I
`
`
`J
`J
`J
`
`1
`‘
`1
`C1932”). “12;? cups -é‘ymisfl
`r
`f
`
`Lamb 37“,};c’u 04*») firm)
`I
`L
`L
`l
`
`
`a»:
`r
`r
`L
`
`r
`T
`T
`4
`4
`+
`
`1
`L
`i
`a
`
`r
`
`
`L
`r
`P
`r
`I
`r
`y
`1
`L
`r.
`1
`L
`J
`
`
`
`r‘
`4—“4
`‘
`1
`T
`
`
`
`
`
`i9“ Wald
`7(1‘41010
`/ 42/
`
`94(1/(9
`
`Date
`
`Signed
`
`
`
`Date
`
`Mylan v. Merck, IPR2d20-00040
`
`.1
`
`
`
`
`
`
`
`
`J
`
`4
`
`r
`
`L
`
`L
`
`4
`
`o&5¢“?“‘
`
`T
`
`T
`
`T
`
`b
`
`1
`
`‘
`
`
`
`‘J
`
`+
`
`*
`
`i
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`f
`4
`
`L
`L
`1
`L
`u,
`I
`
`
`i
`4
`r
`
`
`
`4
`.7
`1
`
`J.
`4
`r
`4
`J
`.1
`4L
`I
`
`4
`[
`1
`r
`F
`‘
`l
`
`
`I
`4
`Continued on Page 7.3
`
`Read and Understood By
`
`
`
`Merck Exhibit 2226, Page 23
`Mylan v. Merck, IPR2020-00040
`
`

`

` Notebook No. ill.“
`Continued From Page 7’1 '
`
`
`
`23
`
`
`L1?
`
`
`”watt 1 o‘ELHdA my“ will”)
`
`{
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`11
`
`J
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`M
`r
`4
`r
`[
`if 4')
`a‘)
`
`I
`I
`[395(43 i I
`phhsk
`
`+ I 4 }I1 l
`
`
`
`
`
`
`
`
`
`
` m'vtfmsz‘mflw-Tm,
`
`
`
`
`
` Y
`
`
`
`
`W *{1
`
`
`Read and Understood By
`
`|
`Mylan v. Merck,
`
`|
`
`age
`,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 24
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No.,_LL§1.‘__
`-
`242
`
`PRCJECT ELLv/q 9‘)” Continued From Page (“EA 1 E Q
`
`WfiWM—fl—Wwmefi—Wj
`
`51¢.quM f
`r
`F
`L
`A
`
`T
`4“?
`*
`
`
`"
`
`
`
`
`T
`*
`*‘
`
`
`
`1
`‘1
`T
`L
`L
`
`¥
`r
`1
`’l
`
`4
`a J
`
`
`
`r
`r
`1
`’
`1
`”J
`
`
`
`r
`r
`L
`
`[
`1
`L
`F
`;
`L
`L
`
`F
`T
`
`1
`
`”I
`fi_____1
`+
`
`
`r
`4
`1
`1
`r
`L
`
`l
`L
`
`
`r
`I
`l
`L
`r
`
`
`1
`1
`r
`L
`J
`*
`
`1
`r
`4
`
`r
`r
`i
`“I
`
`
`*1
`
`1
`+
`
`
`
`I
`i,
`T
`A.
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`4
`
`L
`
`J
`L
`
`1.
`1
`r
`
`T 1
`
`J
`I
`“I
`
`L
`V1
`1
`
`
`
`*‘—’l
`V
`L
`r
`r
`“I
`J
`I
`l
`.1
`.I
`
`J
`r
`
`J
`1
`r
`1
`1
`J
`
`L
`I
`
`F
`4
`1
`r
`J
`
`
`4
`L
`L
`r
`r
`4
`
`Continued on Page
`J
`
`
`Read and Understood By
`
`
`7% W
`
`ate
`Signed
`Date
`
`Mylan v. Merck, IPR2d20-00040
`
`$434“?
`
`(Ba/“wail
`
`“7114,1010
`
`
`
`Merck Exhibit 2226, Page 25
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. “Emiw
`3 q
`3
`a
`'
`I
`(A,
`Continued From Page
`PROJECT ELI“ (O M ‘
`
`
`25
`
`
`
`
`
`
`
`r M”"§ 7") (J ‘
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`5/(3/071§
`
`fin mow
`
`Date
`
`
`Signed
`
`
`l
`r
`L
`L
`F
`Continued on Page
`j
`
`Read and Understood By
`
`7/9‘6/ 9‘0“)
`
`Date
`WMerCKEXTTrUITZZZBTPaTg-e‘ZES‘“
`Mylan v. Merck,
`|PR2020-00040
`
`
`
`
`
`
`
`
`
`Merck Exhibit 2226, Page 26
`Mylan v. Merck, IPR2020-00040
`
`

`

`ggQJECT E LL“ (0m“
`(MK)
`I 89
`
`
`
`Notebook No.L
`Continued From Page _3,~_§.._4_.‘”1..“
`
`
`
`r
`l
`L
`
`J
`
`r
`J
`
`
`J
`L
`*_J
`
`l
`
`L
`J
`
`L
`L
`
`i
`
`J
`
`_J
`
`
`
`k
`
`L 4
`
`1
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`J
`
`J J
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`'} ”Zak Qf/v-«l A}: a
`L
`r
`
`@rvyx My Fwy! ’44 41M *3 Sal/5L
`J
`
`r
`f
`T
`x”?
`
`, "me fur-4
`4
`
`
`—« mummy“:
`_..,_._
`w W
`1031—25—01
`l ,
`*‘T‘Compnund ‘84
`'
`.
`Ambler“
`_
`F b
`
`'4031 — 25- 03
`
`JIINILIQIIIIIHJfi‘MM’
`T :campound184
`qlmmmmflw
`4626
`
`L8 i
`1:21:35-“
`"
`
`J mi
`,
`”
`
`T
`’1
`
`qCflrfi V “3 Jf (AL—L; M‘
`I
`
`.4
`J
`j
`r
`””‘f
`
`[r
`_J
`
`L
`
`54*
`&f
`
`25
`
`
`
`1—-——-]
`__—-—.~
`
`fir”
`
`4.
`
`‘
`
`234627
`campoundim
`“1|!“
`
`II
`
`J
`
`J
`
`J
`
`L
`7
`T
`T
`r
`A
`J
`
`T
`L—
`r 4
`r
`f
`k
`T
`r
`L
`I
`J
`
`r
`J
`J
`J
`1
`1
`
`T
`1
`L
`k
`F
`r
`J
`r
`L
`l
`
`
`T
`r
`r
`L
`1’
`
`J
`r
`J
`r L r
`
`4
`J
`r
`L
`r
`[
`l
`f
`F
`I
`J
`
`A
`'Y
`
`J
`J
`{
`Continued on Page
`7-7
`
`Read and Understood By
`
`g 8/
`
`3/ (‘L/c»
`
`Date
`
`616/“ @3491
`
`film/W"
`
`SignedW
`Mylan v. Merck, IPR2d20-00040
`
`Merck Exhibit 2226, Page 27
`Mylan v. Merck, IPR2020-00040
`
`

`

`
`
`27
`03 /
`Notebook No.
`2 é
`Continued From Page
`
`
`
`
`l 1
`
`4
`Compound 184
`I
`U'
`
`
`
`
`} i
`*WWT
`
`
`
`
`
`{mnggyhg5
`”L‘ES'Qz‘v—m] ”(W—ix”
`—«-» \nnlglgxmlhu
`*
`‘
`1
`
`ymlyyygwg
`W”
`
`
` 1
`
`!
`
`
`
`[
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`4561
`Zcompound 181
`1031—27 ~03
`
`.._,.__
`gmuygmg W ~
`1
`..__..,.
`w
`1 H
`J
`‘031 - 27 —- M
`
`'icllllflllélgglflla
`
`
`
`
`
`[
`
`
`I
`
`——r——~»—~~—
`
`
`,
`,
`I
`1;...L I,
`l
`mefifkwiA-fw qul [904 gn/fi
`
`
`
`W
`,
`(mfiLV
`+
`T
`
`
`j
`
`
`
`
`W
`*i
`
`
`f
`w
`l
`
`
`I'“ {
`r
`r
`r
`j
`
`1
`{
`a
`7.
`
`l
`,_._
`f
`T
`
`T T
`
`*
`
`i
`
`1
`
`1
`
`J
`
`
`
`
`J
`
`I
`
`J
`
`*
`
`
`
`
`L
`Continued on Page
`J
`
`
`Read and Understood By
`
`%
`
`Signed
`
`5/ {flp V
`
`Date
`
`_ 662A flagufl
`
`Signed
`
`7&0 61010
`
`x |
`erc
`Mylan v. Merck,
`
`|
`
`Date
`age
`,
`|PR2020-00040
`
`
`r
`’r
`
`
`Merck Exhibit 2226, Page 28
`Mylan v. Merck, IPR2020-00040
`
`

`

`28
`Notebook No.L
`
`___._
`PROJECT ELLD ‘“ m) I (
`Continued From Page
`(“30> ( 3 LI
`
`Ff—fl—“T—‘fi—W—L
`?> “L «“1 a Q
`I
`1
`4
`L
`
`
`
`L“
`
`
`
`o
`
`?
`
`4
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`a¢5‘~1$‘0( ~VE’§VQ)‘
`"‘ WN'PV)
`
`I
`
`i‘I Q‘mp'fif VH5! £- “3 ‘1‘ Mil A,“ iyrg}
`QJL‘
`Sr» 307“,” W M" ~34qu
`45" SM’DX kg 91*)
`L
`I
`
`J
`
`»
`
`
`
`
`1
`4
`F‘
`T
`T
`F
`I
`
`I
`
`F
`
`r
`L.
`r
`L
`L
`I
`
`
`
`
`k
`
`L
`r
`
`I
`
`L
`
`I
`
`I
`
`L
`
`I
`L
`
`.1
`[
`[
`1—
`I
`,
`J
`L
`
`1
`r
`‘I
`L
`J
`J
`L
`
`
`
`
`I
`L
`I
`J
`
`L
`
`T
`I
`
`.
`I
`
`I
`
`L
`
`{ i L
`1
`
`L
`
`L
`
`
`
`
`r
`1
`I
`L
`
`I
`I
`I
`I
`I
`I
`I
`L
`L
`L
`
`T
`*—‘“‘I
`I
`I.
`L
`L
`
`I
`I
`L
`l
`
`i
`L
`T
`I
`J
`I
`L
`r
`L
`I
`J
`
`
`I
`L
`I
`I‘
`
`1
`l
`r
`.1
`I
`I
`Y
`
`W
`L
`r
`L
`I
`f
`r
`
`l
`.T
`.I
`T
`I
`7
`J
`I
`I
`I
`‘L
`I
`I
`
`
`{
`T
`L
`J
`J
`.i
`L
`r
`..
`
`L
`.1
`I
`l
`1
`
`L
`L
`LLL
`I
`I
`I
`I
`l
`.I
`1
`4
`.l
`J
`1
`.J
`I‘
`l
`1
`_J
`
`J
`7
`I
`1
`l
`g
`l
`1
`
`I
`‘
`I
`I
`
`V
`4
`r
`A
`I
`a
`L
`Continued on Page
`
`Read and Understood By
`
`I
`
`L
`
`L
`
`L
`
`l
`
`1
`
`J
`
`J
`
`a
`
`\
`
`I
`
`
`Signed
`’
`Date
`Signed
`.
`Date
`,
`e
`
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 29
`Mylan v. Merck, IPR2020-00040
`
`

`

` Notebook No. 42%;)”
`
`Continued From Page
`
`29
`
`
`
`
`
` UZLFSMFM {MO {5 w grub Mm. Hindu!» {M
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`(if (D}7_,JL¢K my
`
`T 4‘
`
`L
`
`
`
`(fawn «3
`k
`
`*
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1
`
`1“
`I
`[
`
`4
`L
`L,
`1
`”l
`
`[
`Continued on Page
`
`L
`Read and Understood By
`fl”
`dfl
`€aggned
`
`
`
`
`
`i
`*
`.J
`
`L
`r
`
`L
`A
`
`4
`
`7
`
`J
`
`o
`
`i
`
`i
`
`
`
`
`7
`L
`F
`T
`
`l
`
`J
`
`
`
`“—r
`M
`
`1
`
`L
`
`+
`
`r
`
`'1
`
`L
`
`T
`
`
`
`i
`
`+
`
`L
`
`I
`
`'«-
`4X7
`
`”Signed
`
`é (5 9
`/ Date
`
`7/90 ska/0
`l/Date
`
`
`erc
`x |
`|
`,
`age 0
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 30
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. $.52:
`30
`PRQJECT ELIMOGOM
`,
`(fix ( 8 4
`Continued From Page ”L._#
`
`m " :34377 [meckrfit’ U3 {4”
`
`
`
`
`
`
`‘ 414‘? (Berra a J“
`4
`
`
`
`J
`
`JJ (am UJL
`
`
`
`T
`J
`r
`
`
`F
`
`J
`j
`
`T
`
`
`,
`L
`T
`1
`J
`QJ‘JWJJOJOR ~im «L [Lg o 5—4,
`cm (459—0).
`
`J
`L
`I
`
`J
`J—“T
`r
`”.1
`43140 girl-190% a”) 05% C/oith-JO}
`1
`J
`
`
`T
`
`T
`
`J
`
`
`J
`J
`J
`J
`
`
`
`k
`L
`.1
`
`
`# r
`,
`J
`,
`J
`
`r
`J
`L
`,
`J
`r
`L
`J
`T
`J
`
`J
`J
`J
`J
`
`J
`J
`J
`[
`J
`J
`L
`T
`
`J
`J
`1
`
`.1
`1__._l
`J
`J
`I
`l
`J
`J
`.J
`J
`
`
`J
`r
`l
`J
`
`
`J
`
`J
`
`,
`
`1
`
`T
`
`L
`
`L
`
`[
`
`J
`
`r
`l.
`J
`J._.._r
`1
`J
`J
`
`J
`L
`J
`r
`
`J
`
`*
`L
`l
`
`J
`
`r
`r
`
`l
`
`[
`
`Ff; m‘dxr -' 0‘9?
`J
`1
`‘d‘éflg}‘f) if
`i
`L
`i
`L
`p
`
`1% J9;w LP"
`+14% A ,L Jrgaymnfln) “mums NJ; fiH-gfi
`gan kw,“
`(d: “ff F1
`”PILL
`$.13“ Chip/H
`J
`(”hr-1T9!
`49
`I394»!
`7%1
`I
`
`g (“1742.
`J (LB/'N‘ql 4
`ltLJL
`J
`[
`1
`
`£554le
`5193“” *9
`V WL
`J
`1
`_,
`V
`f
`
`Eb (— 0— LI air!) ~tL H10, 0374‘ Qa51'3?“0/
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`J
`L
`L
`J
`1
`J
`1
`L
`1
`L
`
`
`J
`
`J
`
`J
`
`1
`
`T
`
`J
`r
`.J
`J
`L
`r
`J
`I
`J
`
`Continued on Page
`*5]
`
`Head and Understood By
`
`[
`
`W
`
`Ll
`
`Signed
`
`
`Date
`Date
`Signed
`Mylan v. Merck, JPR2d20-00040
`
`
`.
`.
`
`fiwmwl
`
`WW
`
`Merck Exhibit 2226, Page 31
`Mylan v. Merck, IPR2020-00040
`
`

`

`4/ ‘75 /
`Notebook No.
`
`Continued From Page __.3_£____
`*PRQJECT ELL” I 090”
`CM?)
`[24
`
`
`31
`
`:
`
`
`
`
`4414* ii iii.
`447
`4
`4
`
`“444494442 — 441144444443
`:li'ilsi'ii‘i
`*
`*
`
`
`
`
`
`J
`i
`
`
`J
`
`
`——~-——~_—J
`
`
`4
`4
`i
`
`
`i
`
`
`
`A
`L
`T
`L
`[
`
`
`y
`
`
`T
`
`i
`
`J
`
`i
`
`
`
`
`
`i
`
`4
`
`
`1
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`i
`i
`4
`J
`
`i
`
`r
`
`i
`
`i
`
`i
`l
`l
`j
`
`i
`J
`j
`i
`i
`f
`T
`1
`i
`L
`L
`i
`L
`
`i
`4
`l
`i
`
`
`
`iT Continued on Page
`Read and Understood By
`
`i
`
`i
`
`T
`
`1
`
`// 1%
`
`MHz/(o
`
`»
`
`56m 6&ij
`
`
`Signed
`Date
`Signed
`
`7/30/3010
`
`Date
`Merck Exhibit 2226, Page 32
`Mylan v. Merck,
`|PR2020-00040
`
`Merck Exhibit 2226, Page 32
`Mylan v. Merck, IPR2020-00040
`
`

`

`Notebook No. 403‘
`n
`,
`32
`Continued From PageM
`IPQGJ ECT EL°LO{OOO\\
`CbYKfioU“ é l 3
`
`
`q
`
`
`
`
`‘L
`A
`'
`L
`L
`a
`No ewhges‘
`{387/00th h ){WS‘L page,
`L
`F
`#
`4
`
`
`_
`L
`L
`..
`i
`.4
`L
`L
`
`1
`a
`
`I
`”*
`I
`F
`
`r
`T
`n
`+
`”
`L
`
`
`#
`r
`r
`L
`7
`T’
`L
`F
`
`l’
`L
`L
`A
`4
`L
`l
`4
`_.
`
`Z
`§§
`i
`i
`i;
`l,
`
`r
`k
`
`J
`‘
`
`r
`
`T
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`
`1
`J
`L
`L
`L
`L
`r
`1
`L
`4
`
`
`L
`L
`T
`L
`}
`A
`L
`L
`T
`L.
`
`
`L
`L
`L
`1
`L
`A
`f
`T
`J
`J
`; T
`r“
`T
`F
`1
`L
`a
`+
`i
`
`r
`A!
`47
`L
`l
`L
`1
`L
`T
`
`L
`L
`L
`F
`3
`T
`A}
`4
`J
`L gka T
`]L
`r
`T
`
`
`J
`*
`L
`*
`4
`r
`n
`4
`4
`7*
`‘r
`+
`F
`L
`
`f
`T
`l,
`f
`n
`.Y
`J
`r
`L
`L
`
`I—
`F
`T
`-—r
`i
`7-
`f
`*
`7L
`‘
`1
`L
`
`L
`l
`J
`4
`L
`L
`L
`1..
`
`J
`F
`J
`+
`L
`o
`4
`4
`
`
`1
`L
`.Lfi
`L
`J
`L
`“i
`L
`L
`l
`r
`L
`T
`L
`f
`I
`J
`
`L
`I
`L
`L
`L
`,
`i
`,-
`L
`“T
`._J
`
`
`r
`I
`L
`J
`L
`+ 4»
`.r
`L
`grfi
`L,
`r
`’
`T
`r
`1
`‘1
`r
`n
`L
`r
`—r
`1L
`Jr
`
`r
`T
`o
`'*
`T
`4
`1
`f
`"—
`x
`n
`
`L
`I
`r
`+
`f
`r
`T -1
`r
`L
`r
`4
`
`f +
`r
`1
`J
`n
`1
`t
`
`F
`i
`L
`T
`r
`[
`*7
`1 T
`J
`
`
`L
`P
`r
`+
`,
`L
`w
`L
`1
`
`L
`j.
`;
`L
`1
`..L
`i
`A
`i
`L
`L
`J
`1
`
`}
`r
`k
`%
`r
`r
`Continued on Page
`
`L
`mfg
`4
`Read and Understood By
`IE 3% 2 “5h“
`(O~ (mach:
`,
`‘
`x"
`J13/ 32%(0
`\BQ/k W W“ ,Q/L pg/
`Date h Signed . .Signed Date Mylan v. Merck, IPR2d20-00040
`
`
`
`r
`L
`
`L
`
`L
`
`n
`L
`
`i
`
`‘
`
`
`
`
`
`
`
`
`
`
`
`
`‘
`
`Merck Exhibit 2226, Page 33
`Mylan v. Merck, IPR2020-00040
`
`