Curriculum vitae
`
`Adrian Williams
`
`Research Dean fer Health and
`
`Professor of Pharmaceutics
`
`February 2013
`
`Maven Pharmaceuticals, inc.
`EK2U02
`
`0001
`
`Mylan Tech" Inc. v. Maven Fhanna.. Ins.
`IPREEllB-Elflli's
`
`

`

`Personal Details
`
`Name:
`
`Adrian Christopher Williams
`
`Present appointment:
`
`Professor of Pharmaceutics and
`Research Dean for Health
`
`University of Reading
`
`Date of birth:
`
`39th November 1953
`
`Qualifications:
`
`2913: FAPS: Fellow of the UK Academy of Pharmaceutical Sciences.
`
`299?: FHEA; Fellow of The Higher Education Academy {23322}.
`
`1992: C.Chem. F.R.S.C. — Chartered Chemist. Fellow of the Royal Society of
`Chemistry.
`
`1999: PhD. in Pharmaceutical Technology. University of Bradford. “Terpenes and
`Urea Analogues as Penetration Enhancers for Human Skin"
`
`199?: B.Sc. {Honours} in Combined Sciences. Biology and Chemistry. {C.N.A.A.l.
`
`Previous appointments:
`
`2911 to 2915: Head. School of Chemistry, Food and Pharmacy, University of
`Reading
`
`2999 to 2911: Head. School of Pharmacy. University of Reading.
`
`2994 to 2999: Professor of Pharmaceutics. School of Pharmacy. University of
`Reading.
`
`2992 to 2994: Professor of Biophysical Pharmaceutics. School of Pharmacy.
`University of Bradford.
`
`1999 to 2992: Reader in Pharmaceutical Technology. School of Pharmacy.
`University of Bradford.
`
`199? to 1999: Senior Lecturer in Pharmaceutical Technology. School of Pharmacy.
`University of Bradford.
`
`1995 to 199?: Lecturer B in the Department of Pharmaceutical Technology. School
`of Pharmacy. University of Bradford.
`
`1999 to 1995: Lecturer A in the Department of Pharmaceutical TechnoioEil". Sohool
`of Pharmacy. University of Bradford.
`
`9992
`
`

`

`RESERI’CH and scholarship
`
`Research outputs
`
`DRCID ID: encompassed-rem;
`h-index: 52; i1fl-index QB; 11,0fi4 total citations. (Google Scholar}
`
`HIEfEfEEd research EEEEI’S Eublf'ShEd fn [oumafsl'
`
`Bold indicates principal author
`
`1. Mansfield, Elli-1., Pandya, Y.,
`|_,
`I'vlun, 5a., Rogers, S.E., Abuthui—lonita,
`Danino.
`[J.. Williams, A3.
`and ifthutoryanslrtiyl UM.
`"Structure
`and
`characterisation of hydroxyethylcellulose-decorated silica nanoparticles". REC
`Advances, DUI: 1fl_1fl39lc?raflti?1fik
`
`Hademoglou. PL, Williams, AC. and Collins, CD. "Bioaocessipility of F'BDEs
`present in indoor dust: A novel dialysis membrane method with a TBI'IEI Tea
`absorption sink". Science of the Total Environment tSTDTEN}. 2MB, 621: 1—8.
`DUI: 1El.1El1Efj.scitotenv.2fll?.1 1.09?
`
`Lenn. J.. Neil, J.. Donahue,
`
`(3., Democlr, K., Tibbetts, C-'v'., Cote-Sierra, J..
`
`Smith. S.H.. Rubenstein, l1. Thern‘en. J.—F'., Fendergrast. 5.. Killough. J.. Brown.
`MB, and WilliamsI AC.
`”RNA aptarner delivery through intact human skin", .J.
`Invest. Dermatol, 2013, 138, ESE-ESE. DDl: 1D.1D1Blj.jid.2fl1101351.
`
`Kat-ova, E.A., Cole, J.C., Kerb, 0., Williams, AC. and Shankland, K. “improved
`crystal
`structure
`solution from powder diffraction data
`by
`the use of
`conformational
`information".
`J. Appl. Cryst, 2fl1'f. 5|}:
`1421—1421“.
`DOI:
`10.11UTIS1BUUEFET1TD12596
`
`lvl., Williams, AC. and
`.J.C., Kore, 0., Lopez-lbanez,
`Kat-ova, E.A., Cote,
`Shankland, K. "Improved performance of crystal structure solution from powder
`diffraction data through parameter tuning of a simulated annealing algorithm". J.
`Appl. Cryst, 201?, 5d: 1411-1420. DDl: 10.11fler1BUUfif’BF1TU126fl2
`
`"Design, synthesis
`lvl.B.
`. Arezki, NR, Williams. 31.0., Coho, A.J.A. and Brown,
`and characterisation of linear unnatural amino acids for skin moisturisation." Int.
`
`J. Cosmet. Sci, 2D1E, 39: 'r'2—32. DDI:1EI.1111lics.12351
`
`Mun, E-A., Williams, AC. and Khutoryanslrly, V.V., "Adhesion of thiolated silica
`nanoparticles to urinary bladder mucosa: Effects of PEGylation,
`thiol content
`and
`particle
`size",
`Int.
`J.
`Pharm.,
`2016, E 32-38.
`Dfll:
`1:11U16rj.ijpharm.2l2llfi.flt3.026
`
`Mansfield, E.E.'I.H, de la Rosa, U.R., Kowalczyk, R.M., Grilto, I. Hoogenboom. R.,
`Sillence, K., Hole, P., Williams, AL. and Khutoryansltiy, V.'v'., "Side chain
`variations radically alter the diffusion of polytE-alkyi-E-oxazolineis functionalised
`nanoparticles through a mucosal barrier"- Etiomaterials Science, 21318, 5, 1318-
`1321 DDE:1U.1039rcfimel33?5c.
`
`_ Spillman, l'vl.J.. Shankland, K, Williams, AC. and |Cole, JL‘. "CDASH: a cloud-
`enabled program for structure Sfllutiflfl from PDWUEI' difil‘flfitifll‘l data". J. Appl.
`Cryst. 2015. fl. 2033-2033. DOI.‘ 10.11D?!S1EDU§?E?1502049X.
`
`DUDE
`
`

`

`10.Mansfieid. E.D.H. Sillence. K.. Hole. Ft. Williams. KC. and Khutoryanskiy. Vii“
`“PDZyIation: a new approach to enhance nanoparticie diffusion through mucosal
`barriers". Nahosbale. 21315.1. TEET‘I—‘IBETB. DUI: 1D.1UBQI’C5NRD31?BH
`
`11.Ng. K.W.. Lau. WM. and Williams. AD. "Towards pain-free diagnosis of sltin
`diseases through multiplexed microneedles: biomarlter extraction and detection
`using a highly sensitive blotting method”. Drug Delivery and Translational
`Research. 2015. 5. BET—305. DDI: 10.100i'rs133454015—0231—5
`
`“Thermodynamic and
`12.Etizley. 8.13.. Williams. AC. and Khutoryanskiy. UM.
`kinetic properties of Interpolymer complexes assessed by isothermal
`titration
`calorimetry and surface plasmon resonance". Soft Matter. 2014. fl. 0254-0250.
`DUI: 10.1039rc4sm011330
`
`13.Mun. E.A.. Morrison, P.W..l.. Williams. AB. and Khutoryanskiy. 1.1.1.1.. “Do the
`harder properties of the cornea: a microscopy study of the penetration of
`fluoresceMJy-labeiled nanoparticies. polymers and sodium fluorescein". Moi.
`Pharm.. 2014. u {10}. 3555-3554. DDI: 10.1021rmp500332m
`
`P.. Williams. AD and
`t1. Rogers. S.E.. Hole.
`14.Mun. EA. Hanneli.
`Khutoryanskiy. UM. "On the role of specific interactions in the diffusion of
`nanoparticles in aqueous polymer solutions". Langmuir, 2014. E. 300-312.
`DOI: 10.10210a4029035
`
`15.Aravindan. L. Bickneil. KA. Brooks. G.. Khutoryanskiy. 'vW. and Williams AD.
`"A comparison of
`thioiated and disulphidecrosslinked polyethylenimine for
`nonviral gene
`delivery". Macromol. Biosci..
`2013. fl. 1153-11?3. DUI:
`10.1002rmabi201300103
`
`(3.. Rawiinson-l'vlaione. 13.. Williams. AC. Spillman.
`1S.Mejurnder. M. Buckton.
`Ivl..l.. Pidock. E.. Shankland. K. “Application of hydrogen-bond propensity
`calculations to an indomethscin-nicotinamide {1:1} co-crystal". Cryst. Eng.
`Comm. 2013. fl. 4041-4044. DDI: 10.1030rc3ce40ssi'j
`
`1T.Williams AC... “Brian Barry: Innovative Contributions to Trensdermai and Topics]
`Drug Delivery".
`In Special Issue "Developments in Skin Delivery: To Scheuplein
`and Beyond”. Skin Pharmacology and Physiology. 2013. E. 234-242. DDI:
`10.1150r000351045.
`
`10.Arif. I.S.. Hooper. G.I.. Greco. F.. Williams. A.0.. Boateng. 5.1“. “Increasing
`doxorubicin activity against breast cancer cells using PPARy—ligands and by
`exploiting circadian rhythms“. British Journal of Pharmacology. 2013. E. 11?0-
`1138. DUI: 10.1111rbhp.12202.
`
`10.Niemczyk. Al. Williams. AD. Ftavvlinson. C.F.. Hayes. W.. Greenland. B.W..
`Chappeil. D.. Khutoryanskaya. D.
`"Novel polyvinylpyrrolidones to improve
`delivery of poorly—water soluble drugs; from design to synthesis and evaluation”.
`Moi. Pharm.. 2012. 3. 223212241 DUI: 10.1021I'mp30002'01t.
`
`La... Williams. All. Khutoryanskiy.
`20.Sogias.
`mucoadhesive tablets for oral delivery of ibuprofen".
`502-510. DUI: 10.1015i].ijphann.2012.0?.00i"
`
`“Chitosan—based
`'v'.'v'.
`Int. J. Pharm.. 2012. E.
`
`0004
`
`

`

`“Uptimizing layer-
`21.Bizley. 8.0.. Williams. AU. Kemp. F.. Khutoryanskiy. my.
`by-layer deposition of interpolymer complexes on solid substrates using Biacore“.
`Soft Matter. 2012. E. SEE—0100?. DUI: 10.1039lU25M25052E
`
`22_Rizl. H... Green. R.J_. Donaldson. M. Williams. A.C.. “Using pH abnormalities in
`diseased skin to trigger and target topical therapy". Pharm. Res. 2011 . g. 2539-
`2500. DUI: 10.100rls11095—011-0400—4
`
`(3.. Rawiinson-Malone. C... Williams. A.U.. Spillman.
`23.Majumder. M. Duel-don.
`M.J.. Shankland. N. Shankland. K.
`“A carbamazepine-indometnacin [1:1]
`oocrystal produced by milling". Uryst. Eng. Comm. New. 2011. EESET—ESZB.
`DUI: 1 0.1 0391031 ce 05050f
`
`PL. Green. R.J.. Khutoryanskaya. U.. Donaldson. M. Williams. A.U..
`24.Rizi.
`"Mechanisms of burst
`release from polymeric microparticles”.
`J. Phami.
`Pharmacol. 2011:§§. 1141-1155. DUI: 10.1111lj.2042-?150_201101322}
`
`it. Green. R.J.. Donaldson. M. Williams. All. “Production of pH-
`25_Rizi.
`responsiye microparlicles by spray drying:
`Investigation of experimental
`parameter effects on morphological and release properties". J. Pharm. Sci.
`2011. 100. 505-5203. DUI: 10.1002ljps22291
`
`26.nli. W. Williams. All. and Rawiinson. U.F_. “Stochiometrically governed
`molecular interactions in drugzPoloxamer solid dispersions". Int. J. Pharm. 2010,
`E. 1152—158. DUI: 10.101fifj.ijpharrrl.2010.03.014
`
`2?.8ogias. La... Khutoryanskiy. 0.0. and Williams. A.C.. “Exploring the factors
`affecting the solubility of chitosan in water". Macromol. Chem. Phys. 2o1o. m.
`426—433. DUI: 10.1002fmaop200000305
`
`EBArayindan. L. Bicknell. Ks... Brooks. (3.. Khutoryanskiy. 0.0. and Williams AU.
`"Effect of
`acyl
`chain
`length on
`transfection efficiency and toxicity or
`poiyethylenimlne".
`Int.
`J.
`Pharm..
`2000. E.
`201—210.
`DUI:
`10.101Erj.ijpnarm.2009.05.052
`
`“Why is chitosan
`In... Williams, FLU. and Khutoryanslciy. VAL.
`20.8ogias.
`mucosadhesiye?". Eliomacromolecules. 2000. Q m. 103-1042.
`
`30_Khutoryanskaya. U.‘i.f.. Williams. AU. and Khutoryanskiy. 0.0.. “pH-Mediated
`interactions between polylacrylic acid} and methylcellulose in the formation of
`ultrathin multilayered hydrogeis and spherical nanoparlicles". Macromolecules.
`200?. 40l21l T?0?-TT13_
`
`I_. “Polymer-
`31_Rawlinson. UF.. Williams. AD... Timmins. RT. and Grimsey.
`mediated disruption of drug crystallinity". int. J_ Pnann. 200?. 33B 42-43.
`
`32.DeMatos. L.L.. Williams. All. Booth. S.W.. Felts DR. and Blagden. N. 'Solyent
`influences on metastable poiymorph lifetimes: Real—time interconversions using
`energy dispersive X-ray dittractometry". J. Pharm. Sci. 200?. E. 1069-10T8_
`
`33.El Maghraby. G.M.M.. Williams. AU. and Barry. B.W. “Can drug-bearing
`liposomes penetrate intact skin?" J. Pharm. Pharmacol. 2000. g. 415-420.
`
`DUDE
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`

`(t
`
`34.Tekko, La, Bonner Mil, Bowen, FLU. and Williams 11.0., “Permeation of
`bioactive constituents from Arnr'ca montana preparations through human Skin in
`vitro." J. Pharm. Fhannaccl., 2000, fl. 116?—11?5.
`
`35.Tekito, IA, Bonner MC. and Williams A0, "An optimised reverse-phase high
`performance
`liquid
`chromatographic method for evaluating percutaneous
`absorption of glucosamine hydrochloride", J. Pharm. Biomed. Anal, 2000, fl,
`305-392.
`
`30Williams, Ml, Edwards, H.G.M., Lawson, EB and Barry, B.W., “Molecular
`interactions between the penetration enhancer 1,8-cineole and human skin"., J.
`Raman Spectrosc, 2000, E, 301-300.
`
`3T.El Maghraby, G.M.l'vl., Williams, AC. and Barry, B.W., “Drug interaction and
`location in llpcsomes: correlation with polar surface area",
`Int. J. Pharm. 2005,
`202 1?0-105.
`
`38.Lu, M., Williams, AR, Timmins, P and Forbes, R.T.. "Disorder and dissolution
`enhancement: deposition of ibuprofen onto insoluble carriers", Eur. J- F'narrn.
`Sci, 2005, E, EBB—294.
`
`39.Ahmed. A. Barry, B.W., Williams, AC. and Davis, A.F., “Penciclovir solubility in
`Eudragit films: a comparison of X—ray,
`thennai, microscopic and release rate
`techniques", J. Pharrn. Biomed. Anal, 2004, 33, 045-050.
`
`40.Williams, A.C., Cooper, 0.3., Thomas, L., Griffith, L.J., Petts, CR. and Booth,
`SW, “Evaluation of drug physical
`form during granulation,
`tablettlng and
`storage", Int. J. Pharm.. 2004. 2235, 20—30.
`
`41.EI Maghraby, G.M.M., Williams, AC. and Barry, B.W., “Interactions of
`surfactants (edge activators} and skin penetration enhancers with liposomes", Int.
`J. Pharm. 2004, 2105 143-151.
`
`42.0'Brien, L.E., Timmins, P, Williams, AC. and York, F'., "Use of in situ FT—Raman
`spectroscopy to study the kinetics of the transformation of carbamazepine
`polymorphs", J. Pharm. Biomed. Anal, 2004, E, 335-340.
`
`43.52nitowslta, M, Janiclti, 8., Williams, A, Lau, S. and Stolthc A., “pH-induced
`modifications to stratum comeum lipids investigated using thermal, spectroscopic
`and chromatographic techniques", J. F'harm. Sci., 2003, g2, 1'r"3-1?El.
`
`44.Caspers, P.J., Williams, a.c., Caner, as... Edwards, H.G.lvl., Barry, 0W,
`Bruining, HA. and Puppies, G.J., "Monitoring the penetration enhancer dimethyl
`suifcxide in human stratum corneum in vivo by confocal Raman spectroscopy".
`Pharm. Res, 2002,fi, 15?T—1500.
`
`IM. and Booth, 300..
`45.Campbell Roberts. S.N.C., Williams, All, Grimsey,
`"Quantitative analysis of mannitol polymorphs.
`l. Fr-Raman spectroscopy“, J.
`Phann. Biomed.Anal., 20012; 1135-1141
`
`IM. and Booth. S,W..
`46.Campbell Roberts. 8.N.C., Williams, ac, Grimsey,
`”Quantitative analysis of mannitol polymorphs.
`ll. X—ray powder diffractometry -
`
`DUDE
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`

`

`exploring preferred orientation effects”. J. Phaml. Biomed. Anal, 2992, 29,1149—
`1159
`
`4?.El Maghraby, G.M.M., Williams. AC. and Barry, B.W., "Skin hydration and
`possible shunt route penetration in controlled estradiol delivery from deformable
`and standard liposomas", J. Pharm. Pharmacol, 2991, fl, 1311-1322.
`
`43.Mackay, it_ll.il_a_, Williams. ac. and Barry, a.vv_, “Effect of melting point of chiral
`terpenes on human stratum corneum uptake", Int. J. Pharm, 2991, 229, 999?.
`
`49.El Maghraby, G.l‘vl.l'vt., Williams, AC. and Barry, B.W., “Skin delivery of 5—
`fluorouracil from ultradefcrmable and standard liposcmes in vitrc", J. Pharm.
`Pharmacol. 2991. fl, 1959—1977.
`
`59.5tott, F.W., Williams, AC. and Barry, E.W., "Mechanistic study into the
`
`enhanced transdermal permeation of a model fl-blocker, propranolol, by fatty
`acids: a melting point depression effect", Int. J. Pharm., 2991,,2_1;9_, 191—1199.
`
`51_E| Maghraby, G.M.M., WilliamsI AC- and Barry, El.W., “Uestradiol skin delivery
`from ultradeformable liposcmes: refinement of surfactant concentration“, Int. J.
`Pharrn, 2ooo, fl, sis—M.
`
`52.E| Maghraby, G.M.M., Williams, All. and Barry. B.W., “Skin delivery of
`oestradiol from lipid vesicles: Importance of Iiposome structure", Int. J. Pharm.
`2090, 2&1, 159—139.
`
`l'v'l.J., McKenzie, L. and
`53.0uinn, Ea... Forbes. R.T.. Williams, 9.0., Oliver,
`the hydrofluoroalkane
`in
`Purevval, T.S.,
`"Protein conformational
`stability
`propellants
`tetraiiuoroethane and heptatiuoropropane analysed by Fourier
`transform Raman spectroscopy“, int. J. Phan'n, 1999, E, 31-41.
`
`“Solubility
`54.Greenhatgh, D.J., Williams, All, Timmins, P. and York, P.,
`parameters as predictors of miscibility in solid dispersions", J. Pharm. Sci, 1999,
`fl, 1192-1199.
`
`"Skin delivery of
`59E! Magnraby, G.M.M_, Williams, AC. and Barry, EI.W.,
`oestradiol from deformable and traditional Iipcsomes: mechanistic studies", J.
`Pharm. Pharmacol., 1999, fl, 1123-1134.
`
`59_Lavvson, E_E_, Edwards, H_G.fvi_, Eiarry, SW. and Williams. AG, “Interaction of
`salicylic acid with verrucae assessed by FT-Raman spectroscopy", J. Drug
`Targetting, 19993343951.
`
`5?.Stott, P.W., Williams, AC. and Etarry, B.W., “Transdem'ial delivery from eutectic
`systems; enhanced permeation of a model drug,
`ibuprofen", J. Control. Rel,
`1asa, flZ9?-399.
`
`53.Williams. RC” Shatri, SR5. and Barry, E.W_, “Transdermal permeation
`modulation by cyclodel-ttrins: a mechanistic study”, Fharm. Elev. Tech. 1999. a,
`283—296.
`
`DDUT
`
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`

`59.Lawscn. E.E.. Anigoogu. AME... Williams, A.C.. Barry. E.W.. and Edwards.
`H.G.M.. "TI'IItEtl'TFIEli}:r induced molecular diSUI‘dEI‘ in human stratum corneum lipids
`compared with a model phospholipid system; FF—Raman
`spectroscopy".
`Spectrochim. Acta. 1393. E. 543—558.
`
`fifl.Tavlor. L.S.. Williams, AC. and York P.. "Particle size dependent molecular re—
`
`arrangements during the dehydration of trehalose dihydrate - in situ Fr-Raman
`spectroscopy". Pharm. Res... 1993. E. ism-1214.
`
`scanning
`"Differential
`and Williams A.C..
`ELAI—Saidan. S.M.. Barry. B.W.
`calorimetry of human and animal stratum comeum membranes". Int. J. Pharm.
`1993. E. 17-22.
`
`62.Moghimi. H.R.. Williams. AC. and Ean‘y. E.W.. “Enhancement by terpenes of 5—
`fluorouracil permeation through the stratum corneum: Model solvent approach."
`J.Phan11.Phannacol.. 1998. 3. 955-984.
`
`intercellular
`lvl.. Janicki. S. and Williams. AC. “Intracellular or
`53.52nitowska.
`localization of the polar pathway of penetration across stratum corneum". J.
`Pharm. Sci.. 1sss.fl.11oe1114.
`
`E4.Tayior. L.S.. York, P.. Williams. AB. and Mehta. V.. “Characterisation of frozen
`glucose solutions". Pharm. Dev. Tech.. 199?. $31. 395-4132.
`
`65_Edwards. H.G.M.. Farweil. D.W.. Turner. JCM. and Williams, A.C_. “Novel
`environmental chamber for Fr-Raman spectroscopy: study of in situ phase
`change of sulfur". Applied Spectroscopy. 199?. Q. 1D1—1DT.
`
`l-I.G.l'vl.. "Biomedical
`fidtawson. E.E.. Barry. B.W.. Williams1 AC. and Edwards.
`applications of Ramah spectroscopy”. J. Raman Spectrosc. 195mg. 111-111
`
`6?.Moghimi. HR. Williams. AC. and Barry. B.W.. “A lamellar matrix model for
`stratum corneum intercellular lipids.
`‘v’. Effects of terpene penetration enhancers
`on the structure and thermal behaviour of the matrix". Int. J. Pharm. 199?. 145.
`41-54.
`
`fidMoghimi. HR. Williams. AC. and Barry, B.W.. "A lamellar matrix model for
`stratum corneum intercellular lipids.
`|. Characterisation and comparison with
`stratum corneum intercellular stnicture". Int. J. Pharm. 1995. m. 103—115.
`
`EQMoghimi. H.Ft.. Williams. ac. and Barry. aw. "in. lamellar matrix model for
`stratum corneum intercellular
`lipids.
`ll. Effect of geometry of the stratum
`corneum on permeation of model drugs 5-fluorouracil and oestradiol".
`Int. J.
`PharTn.. 1995. m. 11?—129.
`
`TDAnigbogu. A.N.C.. WilliamsI AB. and Barry. El.W.. "Permeation characteristics
`of El-methoxvpsoralen through human skin; relevance to clinical treatment". J.
`Pharm. Pharmacol.. 1996. id. 351366.
`
`?1_Armstrong. CL. Edwards. H.G.lvl_. Farwell. D.W. and Williams. AC... Fr'-
`Raman microscopic study of drug distribution in a transden'nal drug delivery
`device". ‘v'itirational Spectroscopy. 1996. u. 1135—113.
`
`DUDE
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`

`r2_Edwards. H.G.M.. Williams, AC. and Barry. 999.. "Human skin: A Fourier
`transform Raman spectroscopic study of the lceman". Spectroscopy Europe.
`1996. g {1}. 19-13.
`
`F3.McMahon. L.E.. Tirnmins. P.. 1li'liilliams. AC. and York. P.. “Characterisation of
`dihydrates prepared from carcamazepine polymorphs". J. Phann. Sci. 1996. _a_s_.
`1964-1999.
`
`r4.lyloghimi. H_R.. 1ir'irilliraims. AC. and Barry. 3.19.. “A Iamellar matrix model for
`stratum corneum interceilular lipids.
`lll. Effects of terpene penetration enhancers
`on the release of 5—fluorouracil and oestradio] from the matrix". Int. J. Phan'n..
`
`199s. flour.
`
`?5_Mflgl'lin‘li. HR... Williams. KC. and Barry. B.W.. “A lameliar matrix model for
`stratum comeum intercellular lipids.
`l‘y'. Effects of terpene penetration enhancers
`on the permeation of 5—fluorouracil and oestradiol through the matrix".
`Int. J.
`Phann. 1999. 145. 49-59.
`
`reatott. P.W.. Williams. AC. and Barry. B.W.. “Characterization of complex
`coaceryates at some tricyclic antidepressants and evaluation of their potential for
`enhancing transdermal flux". J. Control. Release. 1999. 4_1. 215-221
`
`??.Eclwarcls, H.G.M_. Williams. AC. and Fannrell. D.W.. "F’alaeodental studies using
`FT—Raman spectroscopy". Biospectroscopy.1995. 1. 29-313.
`
`?9.Edwards. H.G.M.. Williams. ac. and Barry. B.W.. "Potential applications of FT—
`Raman spectroscopy for dermatological diagnostics“. J. Mol. Structure. 1995.
`E. are-sea
`
`?9_Megrao. Ma... 1I.r'irilliams. AC. and Barry. B.W.. "Oestradiol permeation across
`human skin. silastic and snake skin membranes: the effects of ethanolrwater co-
`
`solyent systems". Int. J. Pharm. 1995. m. 191-112.
`
`eeYamane. MA. Williams. RC. and Barry. E.W.. "Effects of terpenes and oleic
`acid as skin penetration enhancers towards 5-fluorouracil as assessed with time;
`permeation. partitioning and differential scanning calorimetry".
`Int. J. Phann.
`1995. m. ear-251.
`
`91.Williams. so. Edwards. HEM. and Barry. B.W.. "The 'lceman*: molecular
`structure of 5299 year old skin characterised by Raman spectroscopy and
`electron microscopy". Biochim. Biophys. Acta. 1995. 1249. 93—195.
`
`92_Anigoogu. A.N.C.. Williams, no. Bany. SW. and Edwards. H.G.M_. “Fourier
`transform Raman spectroscopy 9f interactions oehyeen the penetration enhancer
`dimethyl sulphoxide and human stratum corneum”.
`Int. J. Pharm. 1995. E.
`419-426.
`
`ss.Yamane. Min... Williams. ac. and Barry. B.W.. "Terpene penetration enhancers
`in propylene giycolrwater co—solyent systems: effectiveness and mechanisms of
`action". J. Pharm. Pharmacol.. 1995. 4_?_. 9719-989.
`
`9999
`
`

`

`HI
`
`B4.Megrab. NA. Williams. A.C. and Barry, B.W.. "Cestradiol permeation through
`human skin
`and silastic membrane:
`effects
`of propylene
`glycol
`and
`supersaturation". J. Control. Release. 1995. E. arr-294.
`
`35.Edwards, H.G.M.. Williams. A.C.. Fanyeil. Ei.W.. Barry. BW. and Ruli. F.. "Noyel
`spectroscopic
`deconyoiution
`procedure
`for
`complex
`biological
`systems:
`yibrationai components in the Ff-Raman spectra of ice-man and contemporary
`skin". J. Chem. Soc. Faraday Trans. 1995. 9_1. 3993-3891
`
`BIS-Taylor. L5,. York. P.. Williams. AG. Edwards. H.G.M.. Mehta. 9.. Jackson.
`(3.3.. Badcoe. LG. and Clarke. AR. “Sucrose reduces the efficiency of protein
`denaturation by a chaotropic agent". Biochim. Biophys. Acta. 1995. 1253. 39—49.
`
`9?.Williams. A.C_. Edwards. H.G.M. and Barry. B.W-. ”Raman spectra of human
`keratotjc biopolymers; skin. callus. hair and nail". J. Raman Spectrosc. 1994. g.
`95—93.
`
`98.Edwards. H.G.M.. Fanyeil. DW. and Williams. A.C.. "FT-Raman spectrum of
`cotton; A polymeric biomolecular analysis". Spectroshim. Acta. 1994. E. 99?-
`31 1.
`
`B9Williams. AG. Edwards. H.G.M. and Barry. 9.99.. “A comparison of FT—Raman
`spectra of mammalian and reptilian skin“. Analyst. 1994. _1_19_. 563-599.
`
`99.Williams. A.C. and Edwards. H.G.iir'l.. “Fourier transform Raman spectroscopy of
`bacterial cell walls". J. Raman Spectrosc. 1994. a. 9?3«9?T.
`
`"A critical
`91.Williams. AIL, Barry. Et.W.. Edwards. H.G.l'yi. and Falwell. D.W..
`comparison of some Raman spectroscopic techniques for studies of human
`stratum corneom". Pharm. Res. 1993. fl. 1642—1941
`
`92.Barry. Ei.W.. Edwards. H.G.M. and Williams. A.C.. "Fourier Transform Raman
`and infrared spectra of snake skin". Spectrochim. Acta . 1993. 49A. 991-991
`
`93.Edwards. H.G_M_. Fame-ii. EJ_W_. WilliamsI A.C. and Barry. e.w.. “Raman
`spectroscopic studies of the skins of the Sahara sand yiper. the carpet python
`and the American black rat snake". Spectrochim. Acta. 1993 fl. 913—919.
`
`"On the non-Gaussian
`94.Williams. AC. Cornwall. PA. and Barry. Ei.W..
`distribution of human skin penneabilities". int. J. Phamr. 1992. fig. 993?.
`
`95_Williams. A.C_. Edwards. HEM. and Barry. B-W.. “Fourier Transform Raman
`Spectroscopy: a noyel application for examining human stratum comeum". Int. J.
`Pharn'i.. 1992. Q. R11-R14.
`
`9E.Eiarry. Ei.W.. Edwards. H.G.M. and Williams. A.C.. "Fourier Transform Raman
`and infrared vibrational study of human skin: assignment of spectral bands". J.
`Raman Spectrosc. 1992. g. 941-945.
`
`9?.Williams. A13. and Barry. B.W.. "Tarpenes and the lipid—protein—partitioning
`theory of skin penetration enhancers“. Pharm. Res. 1991. a. 1?-24.
`
`0010
`
`

`

`1|
`
`ea.Williams. A.C. and Barry, e.w., "The enhancement index concept applied to
`terpene penetration enhancers ffll' human skin and ITIDElBl liprhlllC (oestradion
`and hydrophilic (E—fluorouracil} drugs“. Int. J. Pharm, 1991, a, 15?—153.
`
`99.Wi|liams, A13. and Barry. B.W., "Urea analogues in propylene glycol as
`penetration enhancers in human skin“, Int. J. F'narm., 1939, E, 43—511
`
`1oo. WilliamsI A.C. ancl Barry. B.W., "Essential oils as novel skin penetration
`enhancers", Int. J. Phann, 1939, E, R?-R9.
`
`Review articles guolisned in ioornals
`
`. El Maghrapy, G.M.M., and Williams, AJB. “Vesicular systems for delivering
`conventional small organic molecules and larger macromolecules to and through
`human skin", Expert Opinion on Dmg Delivery, 2009, E [2}, 149-164.
`
`. El Maghraoy. G.M.M., Barry, B.W.. and 1v‘v‘illiams, AC. "Liposomes and skin:
`From drug deiiyery to model membranes". Eur. J. Pharm. Sci. EDGE, E. 233—222.
`
`. El Maghraby, G.M.M., Williams, AC. and Barry. B.W., "Can drug-bearing
`liposomes penetrate intact skin?” J. Pharm. Pharmacol, EEDE, fifi, 415—429.
`
`_ Williams, A.C., “Taking the transdennal route; technological advances point to a
`new star
`in drug delivery”, Pharmaceutical Manufacturing and Packaging
`Sourcer, Winter 2004, 84-31
`
`. Williams, Act, “Recent advances in transdermal drug delivery", Eur. J. Hosp.
`Pharm., 2flfl4. 1D: 53.
`
`. Williams, A.C. and Sony, El.W., “Penetration enhancers", Advanced Drug
`Delivery Reviews. 2on4, fl soc—er e.
`
`. Williams, All. and Barry, S.W., “Skin absorption enhancers". l_n Critical Reviews
`in Therapeutic Drug Carrier Systems iBruck, S.D., Ed], CRC Press Inc. Boca
`Raton, Florida, USA, 1991;! {3,4}, 3fi5-353.
`
`4
`
`El
`
`B. Williams, AC and Barry aw, "Raman Spectroscopy", J. Toxicol. - Cutaneous
`and Ocular Toxicol.. 2oo1. E, 431511.
`{Reprinted from Percutaneous
`Absorption iBronaugh, R.L. and Maioach, H.l., Eds}, 3'” Edition, Marcel Dekker,
`New York and Basel, 1999, pp 433-514}.
`
`_ Lawson, E_E_, Edwards, H.G.lll|_, Williams, AC. and Barry, B.W., "Applications of
`Raman spectroscopy to sl-cin research“, Skin Research and Technology, 199?. s:
`mil-154.
`
`Authored book
`
`1. Williams, A.C.
`"Transdermal and Topical Drug Deliyery; from theory to clinical
`practice”. Pharmaceutical Press, London. 2003.
`
`0011
`
`

`

`12
`
`W
`
`in: Aulton's
`delivery".
`drug
`and transdermal
`“Topical
`1. Williams A.C.
`Pharmaceutics; The design and manufacture of medicines {Aulton M. E. and
`Taylor. H.l'vlC- Eds}. Elsevier. Chapter 40. 201?.
`
`2. Mg. K.W.. Lau. W.M. and Williams. A.C. “Synergy between chemical
`penetration enhancers".
`In: Percutaneous Penetration Enhancers; Chemical
`Methods in Penetration Enhancement (Dragioevic—Curic. N and Maibach. H.l.
`Eds). Springer. Berlin. STS—305 [Chapter 25]. 2015.
`
`3. Williams A.C. "Urea and derivatives".
`
`in: Percutaneous Penetration Enhancers
`
`{Dragicevio—Curic. N and lvlaibach. H.l. Eds}. Springer. Berlin. 301—305 {Chapter
`20}. 2015
`
`In: Aulton's
`delivery".
`and transdermai drug
`“Topical
`4. Williams A.C.
`Pharmaceutics; The design and manufacture of medicines {Aulton M. E. and
`Taylor. K.M.G. Eds}. Churchill Livingstone. London. Chapter 30. 2013.
`
`"Chemical penetration enhancement;
`and Walters K.A..
`5. Williams. A.C.
`possibilities and problems".
`In: Dermatologic. Cosmeceutic and Cosmetic
`Development; Therapeutic and novel approaches (Walters. K.A. and Roberts.
`lvl.S. Eds}. Informa Healthcare. USA. Chapter 30 {pp 4073—505}. 2003.
`
`E. Williams A.C. “Pharmaceutical solvents as vehicles for topical dosage forms” in:
`Solvent Systems and their Selection in Pharmaceutics and Biopharmaceutics
`(Augustijns. P and Brewster. ME. Eds}. Springer 8. AAPS Press. USA. Chapter
`13 {Pp 403 - 425}. 200?.
`
`T. Williams. A13. and Barry. B.W.. "Chemical penetration enhancement" in:
`Enhancement in Dmg Delivery tTouitou. E. and Barry ELW. Eds}. CRC Press.
`Boca Raton. USA. Chapter 12 [pp 233 — 254]. 200?-
`
`"Improving the
`a. Ahmed. A.. Williams. no. early. aw. and Davis. A.F..
`dissolution rate of
`ibuprofen: does this enhance permeation from aqueous
`polymer film formulation?” In Perspectives in Percutaneous Penetration. {Brain.
`KR. and 1I.r‘l.lalters. K.A.. Eds). STS Publishing Ltd.. Cardiff. Uol. 0a. 31. 2004.
`
`0. Ahmed. A. Williams. AC. Barry. SW. and Davis. A.F.. "Formulation of
`ibuprofen in aqueous latex films: drug delivery through silastic membranes" In
`Perspectives in Percutaneous Penetration. (Brain. KR. and Walters.K.A.. Eds].
`STS Publishing Ltd.. Cardiff. 1|v'ol. Ba. 32. 2004.
`
`10.Williams, A.C.. "Deformable liposomes?” In Perspectives in Percutaneous
`Penetration. (Brain. KR. and Walters. K.A.. Eds]. STS Publishing Ltd.. Cardiff.
`Vol. Eta. 15. 2004.
`
`0012
`
`

`

`13-
`
`11.52nitowska. M.. Janicl-ti. 9.. Williams. A.. Stoltho. A. and Lau. 9.. “fire effects
`of pH 1-12 on stratum comeum structure and permeation" In Perspectives in
`Percutaneous Penetration. (Brain. KR. and Walters.K.A.. Eds]. STE Publishing
`Ltd.. Cardiff. ‘v'ol. Ba. 33. 2994.
`
`12.EI Maghraby. C.M.M.. Williams. AC. and Barry. B.W.. "In vitro skin delivery of 5—
`fluorourecil
`from ultradefonnabie vesicles“ In: Perspectives in Percutaneous
`Penetration (Brain. KR. and Walters.K.A.. Eds}. STE Publishing Ltd. Cardiff.
`'v'ol. ?a. 58. 2002.
`
`13.El Maghraby. G.M.M.. Williams. AC. and Barry. B.W.. "Penetration enhancers in
`llposomes for skin delivery of oestradiol. Can they replace surfactants?" ln:
`Perspectives in Percutaneous Penetration (Brain. KR. and Walters.l<.A.. Eds}.
`STS Publishing Ltd.. Cardiff. lv'ol. Ta. 59. 2992.
`
`14.Mackay. K.M.B.. Williams. A.C. and Barry. B.W.. "Effect of melting point of chiral
`terpenes on stratum corneum uptake"
`ln: Perspectives
`in Percutaneous
`Penetration. (Brain. KR. and Walters.K.A.. Eds]. STS Publishing Ltd.. Cardiff.
`'v'ol. Ta. 55. 2992.
`
`15.Patel. L.. Williams, AC. and Barry. El.W.. "A comparative study of transdermal
`permeation from 5-aminolevulinic
`acid formulations"
`In: Perspectives
`in
`Percutaneous Penetration. (Brain. KR. and Walters.K.A.. Eds]. 5T8 Publishing
`Ltd. Cardiff. Vol. Ta. ED. 2092.
`
`1E.Williams, A.C.. "Some pharmaceutical applications of Raman spectroscopy" in
`Handbook of Raman Spectroscopy“:
`from the Research Laboratory to the
`Process Line (I. Lewis and H.G.M. Edwards. Eds.) Marcel Dekker inc. New York.
`2991. 535—591.
`
`1?.El Maghraby. G.M.M.. Williams. AC. and Barry. B.W.. “Mechanistic studies of
`improved oestradiol skin delivery from different lipid vesicles". in: Perspectives in
`Percutaneous Penetration. 1|v'ol. 9b (Brain. KR. and Walters.K.A.. Eds}. STS
`Publishing Ltd. Cardiff. 2999.
`
`ln: Percutaneous
`19.Williams, AC. and Barry. B.W.. “Raman spectroscopy".
`Absorption tBronaugh. EL. and Maibach. H.l.. Eds}. 3rd Edition. Marcel Dekker.
`New York and Basel. 1999. pp 498-514.
`
`19.Moghimi. HR.. Barry, 3.99. and Williams. A.C.. “Stratum corneum and bam‘er
`performance — a model
`lamellar approach.
`In: Percutaneous Absorption
`{Elronaugh. EL. and Maibach. H.l.. Eds]. 3"13 Edition. Marcel Dekker. New York
`and Basel. 1999. pp 515-553.
`
`“Chemical penetration enhancement:
`and Barry. B.W..
`29.Williams, AC.
`Possibilities and problems" ifl Dermal Absorption and Toxicity Assessment
`(Roberts. M..l. and Walters. K.A.. Eds.). Marcel Dekker Inc.. New York. 1999.
`Chapter 13. pp. 29?-312.
`
`0013
`
`

`

`14
`
`21.Williams. AIL. Lawson. E.E.. Barry. B.W. and Edwards. H.G.M.. "Probing the
`stratum corneum barrier using FT-Raman spectroscopy".
`I_n Prediction of
`Percutaneous Penetration. Vol.5b (Brain. KR. James. V.J. and Walters. HA.
`{Eds}. STS Publishing Ltd.. Cardiff. 1993. poi-9.
`
`22.Williams. AS. Megrab. NA. and Barry. B.W.. "Permeation of oestradiol through
`human epidermal and silastic membranes from saturated transcutolfwater
`systems". jg Prediction of Percutaneous Penetration. Vol.4b (Brain. KR. James.
`V.J. and Walters. K.A.. Eds}. STS Publishing Ltd.. Cardiff. 1999. 139-138.
`
`I_n Physical
`spectroscopy".
`"Vibrational
`23.9ugay. DE. and Williams. A.C..
`Characterization of Pharmaceutical Solids iElrittain. H.G. Ed}. Marcel Dekker
`lnc.. New York. 1995. 59—91.
`
`In
`"Urea and its derivatives as penetration enhanCers".
`24.1Nilliams, A.C..
`Percutaneous Penetration Enhancers tMaibach. H1. and Smith. E.W.. Eds—l.
`CRC Press. Boca Raton. Florida. 1995. 239—299.
`
`lg Percutaneous
`25.Williams. AC. and Barry. B.V‘u'.. "Raman spectroscopy".
`Penetration Enhancers tMaibach. Hi. and Smith. E.VV.. Eds}. CR8 Press. Boca
`Raton. Florida. 1995. 419-429.
`
`In:
`29.Etarry. SW. and Williams. 19.0.. "Permeation enhancement through skin".
`Encyclopedia of Pharmaceutical Technology. Vol.11 {Swarbrick. J. and Eloylan.
`J.C.. Ede]. Marcel Dekker Inc.. New York. 1995. 449—493.
`
`2?.Barry. SW. and Williams. A.C.. "Terpenes as skin penetration enhancers". I_n
`Pharmaceutical Skin Penetration Enhancement (Walters. KA. and Hadgraft. J..
`Eds}. Marcel Dekker. New York and Basel. 1993. pp_95-111.
`
`29.Anigbogu. AND. Williams, AG. Barry. 9.9V. and Edwards. H.G.M.. “Fourier
`Transform Raman spectroscopy in the study of interactions between terpene
`penetration enhancers and human skin".
`I_n Prediction of Percutaneous
`Penetration; Methods. Measurements. Modelling. Vol.3 (Brain. KR. James. V.J.
`and 1I.I"il'alters. Kit... Eds). STS Publishing. Cardiff. 1993. Ell-36.
`
`29_Williams. AC. and Barry. 9.9V- “Transdermal oestredioi permeation: the effects
`of terpene penetration enhancers“.
`I_n Prediction of Percutaneous Penetration:
`Methods. Measurements. Modelling. Vol.9 (Scott. Rt}. |Guy. R.H.. Hadgraft. J.
`and Bodde. H.E.. Eds) IBC Technical Services. London. 1991. 399-393.
`
`39.Williams. AC. and Barry. B.W.. "The use of terpenes as skin penetration
`enhancers". I_n Prediction of Percutaneous Penetration; Methods. Measurements.
`Modelling" (Scott. R.C.. Guy. RH. and l-ladgraft. J.. Eds} IEC Technical Services.
`London. 1999. 224-239.
`
`Pu