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`Inventors (pleaseprovide full names):
`"T. ATSYVIAMAR u4. Am f eh Q,
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`PTO-1590 (1-2000)
`Point af Contact
`Barb O'Bryen
`Technical Info, Specialist
`CM1 12014-Fet-seas29T
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`SAWAI EX. 1015
`Page 534 of 1092 PTO_00000535
`
`SAWAI EX. 1015
`Page 534 of 1092
`
`
`
`Point of Contact:
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`
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`
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`
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`Phone: 308-4740
`
`
`
`.
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`Phone: 308-4259
`
`
`
`
`SAWAI EX. 1015
`Page 535 of 1092 PTo_ov000536
`
`SAWAI EX. 1015
`Page 535 of 1092
`
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`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 536 of 1092
`
`PTO_00000537
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`SAWAI EX. 1015
`Page 536 of 1092
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`L6
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`172 SEA FILE#REGISTRY SSS FUL L6
`6 SEA FILE“CAPLUS ABB=O0N
`18
`
`=> d ibib abs hitste LO 167. f11 cao; a que nos 110
`
`BNSWER 1 OF 6.
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`ACCESSION NUMBER:
`DOCUMENT NUMBER:
`TITLE:
`INVENTOR(S):
`
`PATENT ASSIGNEE (S):
`SOURCE:
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`LANGUAGE :
`RPAMTLY ACC. NUM. COUNT:
`PATENT ENFORMATION:
`
`COPYRIGHT 2000 ACS
`CAPLUS
`1999:282201
`CAPLUS
`.
`“ 230:311793
`Preparation of amides as antidiabetics
`Maruyama, Tatsuya; Suzuki, Takayuki: Onda, Kenichi;
`Hayakawa, Magahiko; Moritomo, Hirayuki; Kimizuka,
`Tetsuya; Matsui, Tetsuo
`Yamanouchi Pharmaceutical Co., Ltd., Japan
`PCT Int. Appl., 45 pp.
`CODEN: PIXKT2
`Patent
`Japanese
`1
`
`PATENT NO.
`
`KIND DATE
`
`APPLICATION NO.
`
`DATE
`
`19981015
`WO 1998-c7P4671
`19990429
`AL
`wo 9920607
`Ww:
`AL, AM, AU, AZ, BA, BB, BG, BR, BY, CA, CN, CU, CZ, EE, GD, GE,
`GH, GM, HR, HU, TD,
`IL,
`IS, JP, KE, KG, KR, KZ, LC, LK, LR, LS,
`Lt, LV, MD, MG, MK, MN, MW, MX, NO, NZ, PL, RO, RU, SD, 8G, SI,
`SK, SL, Td, TM, TR, TT, UA, UG, US, UZ, VN, YU, ZW, AM, AZ, BY,
`KG, KZ, MD, RU, Td,
`TM
`RW: GH, GM, KE, LS, MW, SD, $2, UG, ZW, AT, BE, CH, CY, DB, DK, ES,
`PI, FR, GB, GR, If,
`IT, LU, MC, NL, PT, SE, BP, BJ, CF, CG, CI,
`cM, GA, GN, GW, ML, MR, NE, SN, TD, TG
`AU 9889288
`Al
`19990506
`AU 1998-89288
`19981013
`AY 9894621
`Al
`19990510
`AU 199894621
`19981015
`EP 1029111
`Al
`20000816
`BP 1998~947894
`19981015
`R:
`AT, BE, CH, DB. DK. ES. FR, GB. GR, IT. LI. LU. Nb. SB, PT, TH, FI
`Searched by Barh O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 537 of 1092 PTo_ov000538
`
`SAWAI EX. 1015
`Page 537 of 1092
`
`
`
`It
`
`cPNHoe
`HocN* SN
`ok Na!
`
`6 C
`
`L
`
`Z O
`
`H
`
`|
`Ph CH: CH2 ~ NH CH9 ~~ CHQ >
`
`tT
`
`The title compds. Iofring B=
`an optionally substituted heteroaryl
`ower alkylene ox Lower
`optionally fused with a benzene ring; X = a bond,
`alkenylene (optionally substituted by hydroxy or lower alkyl), carbonyl,
`or NH (further details related to X are given); A= a lower alkylene or a
`group represented by (lower alkylene)-O; Ria and Rib = hydrogen or lower
`I
`alkyl; R2 = hydrogen or halogeno; and Z = nitrogen or CH] are prepd.
`are useful as diabetes remedies which not only function to accelerate the
`secretion of insulin and enhance insulin sensitivity but also have an
`anti-obesity action and an antihyperlipemic action based on their
`imidazole
`selective
`stimulative action on
`-beta,3 receptor.
`For axample,
`deriv, II was prepd,
`of this invention significantly decreased
`compas .
`blood sugar in mice.
`B23672-14~5P
`223672-09“1P
`223672"10~4P
`223672~12-6P
`223672-13-7P
`223672-14-8P
`223672-15-9P
`223672-16~+0P
`223672“1741P
`223672~19—3P
`223672—20~6P
`223672~18~2P
`223672—22-8P
`223672-23~-9P
`223672-21~7P
`223672-26-2P
`223672-24-0P
`223672~-25-1P
`223672-29-5P
`223672-~30~-8P
`223672-27-3P
`223672™34~2P
`223672-31-9P
`223672-32-0P
`223672~36~4P
`223672-38-6P
`223672-40-0P
`223672-42-2P
`223672~-44-4P
`223672~46~-6P
`223672~47~7P
`223672~48-8P
`223672-49~9P
`223672~-50~2P
`223672~51~3P
`223672~52~-4P
`223672-58~0PR
`223672-55~-7P
`223678-S3-5P
`223672~63~7P
`223672-65~-9P
`223672-60-4P
`223672~871P
`223672~68"2P
`2a3672-G60P
`223672-69-4P
`223672~-70-6P
`223672-71-7P
`223672~74~0P
`223672—73~9P
`223672~972~-HP
`223672-77-3P
`3223672~75-1P
`223672-76-2P
`223672~80-8P:
`223672~79~4P
`223672-79-5P
`Searched by Bark O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 538 of 1092
`
`PTO_00000539
`
`SAWAI EX. 1015
`Page 538 of 1092
`
`
`
`223673~28+7P
`223673-31-2P
`223673~58~3P
`223673-61-8P
`223673-64-1P
`
`223673-29~-8P
`223673~32-3P
`223673~59-4P
`223673-62-9P
`223673~-65~2P
`
`" 223673-27-6P
`223673=30-1P
`223673—33~4P
`223673-60~-7P
`223673-63-0P
`223673~G6~3P
`RL: BAC (Biological activity or effector, except adverse); SPN (Synthetic
`preparation); THU (Therapeutic use); BIOL (Biological study); PREP
`USES (Uses)
`(Preparation);
`of amides as antidiabetics)
`(prepn.
`CAPLUS
`223672~0O—1
`3-Pyridinecarbomamide, N-[4~[2-[[ (2R)-2-hydroxy-2-
`phenylethyl}aminojethyl]phenyl]-, dihydrochloride (9CT)
`
`RN
`CN
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Pe,
`we Se ye"
`
`ale
`
`H
`ue Ny
`
`Ph
`
`on
`Sai Rs oH
`
`@2 Hcl
`
`RN
`CN
`
`CAPLUS
`223672-1L0—4
`8-Quinolinecarboxamide,
`Ne (4~[2-{{ (2R}-2-hydroxy~2-
`phenylethyljamino]ethyl]phenylj-, dihydrochloride (SCT)
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 539 of 1092
`
`PTO_00000540
`
`SAWAI EX. 1015
`Page 539 of 1092
`
`
`
`RN
`223672"1165.CAPLUS
`cn
`2~Propenamide, N-[4=[2-{[ (2R)-2=hydroxy~2-phenylethyl] amino] ethyl] phenyl) ~
`3—(2=pyridinyl)+, dihydrochloride,
`(28)-
`(901)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`Double bond geometry as shown.
`
`Ph
`
`HO”ana 0Ro eeot
`
`N SO en
`H
`
`| N
`
`A
`
`@2 Hel
`
`RN
`223678-1286>.CAPLUS
`CN
`2~-Beanzothiazeleacetamide, N-[4-[2-[[ (2R)-2-hydroxy-2=
`phenylethyl] amino]ethyl]phenyl]-, dihydrochloride (3CT)
`
`INDEX NAMB)
`
`(CA.
`
`Absolute stereochemistry.
`
`ou gee
`
`See
`
`N
`
`HN
`
`C | TOY
`COSNENyON on
`
`: P
`
`h
`
`H
`
`@2 Hel
`
`RN
`
`223672-13-7
`
`CAPLUS
`
`Searched by Barb o'Bryen, STIC 308+4291
`
`SAWAI EX. 1015
`Page 540 of 1092
`
`PTO_00000541
`
`SAWAI EX. 1015
`Page 540 of 1092
`
`
`
`@2 uel
`
`RN
`CN
`
`CAPLUS
`223672+14-8...
`4~Thiazoleacetamide, N-{4~[2-[[ (2R)-2-hydroxy-2-
`phenylethyllamino]ethyl]phenyl|]~2-methyl-, dihydrochloride (9CI}
`INDEX NAMB)
`
`(CA
`
`Absolute stereochemistry.
`
`MeCTnawe
`HN. pnNeaeoROH
`
`
`Bo
`Ph
`
`@2 HCL
`
`RN
`CN
`
`CAPLUS
`223672-15-9
`LH-Imidazole-~2-acetamide, N= [4-[2=[[ (2R)-2-hydroxy-2-
`phenylethyljaminolethyl]phenyl]~, dihydrochloride (9CT)
`
`{CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 541 of 1092
`
`PTO_00000542
`
`SAWAI EX. 1015
`Page 541 of 1092
`
`
`
`@2. He1
`
`BN 223672-16=0.CAPLUS
`
`CN
`lH-Tetrazole-~S-acetamide, N- [4-f{2—[[ (2R)-2-hydrexy~2-
`phenylethyljaminolethyl]phenyl]~-, monohydrochloride (9CI)
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`,
`
`N,
`:
`Ww Yo ee
`\\
`New
`
`HN ,oe
`
`LemoneBeOH
`
`q
`
`Ph
`
`.
`
`:
`
`@ rel
`
`RN
`cn
`
` CAPLUS
`-223672-17~"1
`LH-1,2,4-Triazole~3~-acetamide, 2, 5~dihydro-N~[d-[2—[[ (2R)-2-hydroxy-2=
`phenylethyl] amino]ethyl) phenyl]~-S-thioxo~, monehydrochleridea (9CI)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`aNweyor>
`,
`fis&
`
`@ Hel
`
`Searched by Barb O'Bryen, STIC 3088429]
`
`SAWAI EX. 1015
`Page 542 of 1092 PTo_o0000543
`
`SAWAI EX. 1015
`Page 542 of 1092
`
`
`
`weBOge L7Bye OH
`
`@2 HCL
`
`RN
`CN
`
`
`223672° 193 CAPLUS
`1,2,4-Thiadiazole-3-acetamide; S~amino-N~[4-[2-[[ (2R) -2-hydroxy-2-
`phenylethyllaminojethyl]phenyl}~, dihydrochloride (9CIT)
`(GA INDEX NAMB)
`
`Absolute stereochemistry.
`
`ees ee
`.
`=
`HN,
`, ms A
`
`\ =
`
`1
`Se Nua NoROH
`Ho
`Ph
`
`Z
`
`Hon
`
`@2 HL
`
`RN|223672-20-6 CAPLUS
`
`CN
`Carbamic acid,
`(3-f[2-[{4~[2-{[ (2R) -2~hydroxy~-2-
`phenylethyl] amino] ethyl] phenyl} amine) ~2-oxoethyi]-1,2, 4~thiadiazel-5-ylJ]-,
`ethyl ester, monohydrochloride (9CI}
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 543 of 1092 PTo_00000544
`
`SAWAI EX. 1015
`Page 543 of 1092
`
`
`
`@ Hel
`
`RN
`CN
`
`CAPLUS
`223672-21-7
`4-Thiazoleacetamide,. 2-[ (3-fluorophenyl) amino] -N=[d=[(2=({ (2R)-2-hydroxy~2=
`phenylethyl]aminojethyl]phenyl)~, dihydrochloride (9CT)
`(CA INDEX NAME)’
`
`Absolute stereochemistry.
`
`H
`
`N
`
`TyYX m, oe
`
`NA
`
`-_
`
`BASS
`
`@2 acl
`
`RN
`CN
`
`CAPLUS
`223672-22~8
`2~Pyridineacetamide, 6-chloro-N-[4-(2~{{ (2R)-2-hydroxy-2~
`phenylethyl] amino)ethyl]phenyl]~, monohydrochloride (9CT)
`
`(CA INDEX NAME)
`
`' Absolute stereochemistry.
`
`ph
`!
`
`H
`
`@ uel
`
`Searched by Barb O'Bryan, STIC 308-4291
`
`SAWAI EX. 1015
`Page 544 of 1092
`
`PTO_00000545
`
`SAWAI EX. 1015
`Page 544 of 1092
`
`
`
`
`
`@ Her
`
`RN
`CN
`
`CAPLLUS
`2236722460
`lH-Imidagole-2-acetamide,, N-[4~[2-[[ (2R)~2-hydroxy-2-
`phenylethyl] amino] ethyl] phanyl]<1~ (2<methyl-2-propenyl)~, dihydrochloride
`(902)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`aaa no
`\
`4—N
`HN,
`
`@2 wel
`
`RN
`CN
`
`CAPLUS
`223672-25—1
`LH-Imidazole-~4d-acetamide, N~(4~-{2-[[(2R)-2-hydroxy-2~
`phenylethyl] amino] ethyl] phenyl ]~1-(phenylmethyl)~-, dihydrochloride (9CT)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Baxb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 545 of 1092
`
`PTO_00000546
`
`SAWAI EX. 1015
`Page 545 of 1092
`
`
`
`@2° HCL
`
`RN
`CN
`
` CAPLUS
`223672~26-2
`LH-Imidazole-4-acetamide, 1«( (2-chlorophenyl) methyl] «N- [4-[2«[[(2R)-2~
`hydroxy-2~phenylethyl]aminolethyl)phenyl]-, dihydrochloride (9CT)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`!P
`
`h
`
`2.
`
`AO
`
`o
`
`oN OyeOy
`,~ ws,le oe
`NNyeH
`
`@e HCL
`
`RN
`cn
`
` CAPLUS
`223672-27~3
`l«[ (3-chlorophenyl) methyl ] -N- [4-(2-[[ (2R)-2-
`LH-Imidazole-~4d-acetamide,
`hydrosy-2-phenylethyl}amine]ethyl]phenyl]-, dihydrochloride (9CT)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`|OS
`oe aea Woesee OH
`H
`h
`
`:P
`
`ch a
`
`“
`
`@2 Hel
`Searched by Barb O'Bryen, STIC 3084291)
`
`SAWAI EX. 1015
`Page 546 of 1092 PTo_00000547
`
`SAWAI EX. 1015
`Page 546 of 1092
`
`
`
`ge,yooH
`Ph
`
`@2:> Hel
`
`RN =223672—30~8.CAPLUS
`
`CN
`LH-Imidazole2-acetamide, 1-[ (4-flucropheny] ) methyl] -N- [4-[2=[[ (2R) «2=
`hydroxy-2-phenylethyl]amiho]ethylj]phenyl}-, dihydrochloride (9CI)
`(CA
`INDEX NAME)
`
`Absolute, stereochemistry.
`
`a~
`
`F.
`
`)
`See ‘
`oneVy
`“TSDAN
`
`:P
`
`h
`
`H
`
`@2 Hcl
`
`RN
`CN
`
`CAPLUS
`223672-31-9
`LH-Imidazole-2-acetamide, 1-[ (4-bromophenyl) methyl] -N-[4-(2-{[ (2R)-2~
`hydroxy-2-phenylethyl] aminolethyl]phenyl]«, dihydrochloride (9CT)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 547 of 1092 PTO_00000548
`
`SAWAI EX. 1015
`Page 547 of 1092
`
`
`
`ANOSLA.yeeH
`
`Ph
`
`@2.-HC2
`
`RN=-.223672=32-0° CAPLUS
`
`CN
`1lH-Imidazole-2-acatamide, N-[4-[2-([ (2R})-2-hydrosy-2-
`phenylethy]] amino] ethyl] phenyl] ~1~[ (4-dodephenyl) methy2}~ , Aihydrochloride
`(92)
`(CA INDEX NAME)
`Absolute. stereochemistry.
`
`@2 uel
`
`RN 223672~—-34~2.CAPLUS
`
`CN
`LH-Imidazole-2-acetamide, Ne(4-[2=[[ (2R)-2=hydroxy-2=
`phenylethyl]amino]ethyl] phenyl] ~1-[(4- (trifluoromethyl) phenyl] methyl] ~,
`dihydrochloride (9CI)
`{CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STC 308-4291
`
`SAWAI EX. 1015
`Page 548 of 1092 PTO_00000549
`
`SAWAI EX. 1015
`Page 548 of 1092
`
`
`
`varwoot
`
`H
`
`Ph
`
`@2. uc1
`
`RN 223672+36-4>.CAPLUS
`
`CN
`lH-Imidazole-2-acetamide, N~[d=[2°[{{2R)-2-hydroxy-2=
`phenylethyl] amino] ethyl] phenyl] -1-(2-naphthalenyl)-, dihydrochloride (9CT)
`(CA,
`INDEX NAME)
`:
`
`Absolute stereochemistry.
`
`of~\
`
`
`
`mI
`
`NOONNyBOoH
`H
`h
`
`:P
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`223672-38-6
`1H-ImidazoLle~2-acetamide, 1-( (4-fluorophenyl) methyl] -N-[4~[2-[[ (2R) -2-
`hydroxy2-phernylethyl] amino) ethyl] phenyl)-S-methyl-, dihydrochloride (3CT)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 549 of 1092 Pro_oo000550
`
`SAWAI EX. 1015
`Page 549 of 1092
`
`
`
`@2 Hcl
`
`RN 223672~40=0.CAPLUS ‘
`
`
`CN
`LH-Imidazole-2~-acetamide, 1+{ (4~fluorophenyl) methyl] ~N~ (4-[2~[[ (2B) -2-
`hydroxy~2-phenylethyl]amino}ethyl]phenyl]~4-methyl~, dihydrochloride (9CT)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`a
`
`om we
`
`os
`
`“0
`we
`
`(OF
`
`Sa~~
`
`L
`Se ye weSB OH
`H
`h
`
`i P
`
`\
`
`N
`
`HN,
`
`Me
`
`@2 HeL
`
`RN
`cn
`
`CAPLUS
`223672~42~2
`1LH-Tetrazole~S-acetamide, 1+( (4-fiuorophenyl) methyl] -N=(4—[2-[[ (2R)-2=
`hydroxy~-2-phenylethyl] amino] ethyl} phenyl] -, monohydrochloride (9CT)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 3084291
`
`SAWAI EX. 1015
`Page 550 of 1092 PTO_00000551
`
`SAWAI EX. 1015
`Page 550 of 1092
`
`
`
`@ cl
`
`RN
`CN
`
`.
`CAPLUS
`223672-44+4..
`1HeTetrazole-5-acetamide, 1~[(3,4-dichlorophenyl) methyl] -N- [4~[2-[ 1 (28) -2-
`hydroxy~2-phenylethyl] amino]ethyl)phenyl]~, monohydrochloride (9CI)
`(CA
`INDEX NAME)
`
`Absolute stersochemiatry.
`
`
`
`@ Hel
`
`RN
`CN
`
`CAPLUS
`223672-46-6
`2H-Tetrazole-S-acetamide, 2-[ (4-fluorophenyl) methyl] -N~ [4~ [2-[[(2R) -2~
`hydroxy-2-phenylethyl] amino]ethyl)phenyl]-, monohydrochloride (9C1)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb o'Bryen,
`
`sTTc 308-4291
`
`SAWAI EX. 1015
`Page 551 of 1092 PrTo_ov000552
`
`SAWAI EX. 1015
`Page 551 of 1092
`
`
`
`@ Hcl
`
`RN-223672~47=7|CAPLUS
`CN
`LHe 1, 2,4Triazole~3“acetamide, N«(d=(2={{ (2R)=2-hydroxy~2~
`phenylethyl) aminojethyl)] phenyl)]-, dihydrochloride (9CI)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`223672—48-8.
`4h-1,2,4-Telazole-3-acetamide, N-[4d=[2-[[ (2) -2-hydroxy~2=
`phenylethyl]amino]ethyl] phenyl] ~-5~[ (phenylmethyl) thie]~, dihydrochloride
`(901)
`(CBR INDEX NAME)
`
`Absolute stereochemistry.
`
`N
`
`~
`
`0
`on
`
`‘ome
`
`woe ON HN.
`“S$
`B
`
`Ph
`
`oH
`
`SgRe
`me
`
`Ph
`
`@2 Hel
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015°
`Page 552 of 1092 PTO_00000553
`
`SAWAI EX. 1015
`Page 552 of 1092
`
`
`
`HNL. Roe,ldAH
`
`Ph
`
`@ Hel
`
`CAPLUS
`223672-50-+2
`RN
`CN.4-Thiazoleacetamide;: N~«(4—[2=[[ (2R) -2-hydroxy-2~
`phenylathyl] amino) ethyl] phenyl] -2-~-{ (methylsulfonyl) amino] ~-,
`monohydrochloride (9CT}
`(CA INDEX NAME}
`
`Absolute stereschemistry:
`
`Ha
`
`Me
`
`Na Ne amy
`
`@ nel
`
`RN
`CN
`
` CAPLUS
`2¢23672~31"3
`4-Thiazoleacetamide, Z~[ (aminoiminomethy1) amino)~N~[4-[2-[[(2R)-2-hydroxy-
`e-phenylethyl}]aminojethyl]phenyl]~, dihydrochloride (9CI)
`(CA INDEX NAME}
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 553 of 1092 PTO_00000554
`
`SAWAI EX. 1015
`Page 553 of 1092
`
`
`
`@2 wel
`
`RN
`CN.
`
`CAPLUS
`223672452<4°
`4-Thiazeoleacetamide, Ne [4-[2*[[ (2R)-2-hydroxy-2-
`phenylethyl] amino] ethyl] phenyl] -2- (phenylamino)-, monohydrochloride (9CI)
`(CR INDEX NAME)
`
`Absolute stereochemistry.
`
`N.
`
`?
`
`0
`
`PHNFerv
`\y
`s
`HNN alL OeWooBSOn
`
`@ nel
`
`RN
`CN
`
`CAPLUS
`223672—$3-5
`1H~Imidazole-Z-acetamide, N«(4=[2=[{ (2R)=2“hydroxy-2=
`phenylethyl] amino] ethyl] phenyl] -4-[(4-nitrophenyl) methyl] -,
`monohydrochloride (9CI)
`(CA INDEX NAMB)
`
`Absolute stereochemistry,
`
`Searched by Barb O'Bryen, STIC 308—4294
`
`SAWAI EX. 1015
`Page 554 of 1092 PTO_00000555
`
`SAWAI EX. 1015
`Page 554 of 1092
`
`
`
`@ Her
`
`RN=.223672~-55-7 CAPLUS
`
`CN
`4—Thiazolecarboxamide,
` 2~amino~N~ [4-[2-[([(2R)<«¢2-hydraxy-2-
`phenylethyl] aminolethyl]phenyl]~, monohydrochloride (9CI)
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Ph
`
`4poA
`f y
`
`on
`
`an
`
`" k
`NZ v 7
`
`8
`
`@ x1
`
`CAPLUS
`223672-56-0
`RN
`4-Thiazoleacetamide, 2-amino»N~(4~{2~[[ (2R)-2~hydroxy+2—
`CN
`phenylethyl] amino] ethyl] phenyl ]-S-methyl-, dihydrochloride (9CT)|(CA
`INDEX NAME)
`
`*
`
`Absolute stereochemistry,
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 555 of 1092 PTo_ooo00556
`
`SAWAI EX. 1015
`Page 555 of 1092
`
`
`
`@2. HCL
`
`RN 223672-60—4°°CAPLUS
`
`CN
`4-Thiazolepropanamide,. 2g~amino-N~ [4~[2~([ (2R}-2-hydroxy-2~
`phenylethyl]amino]ethyliphenylj]-, monohydrochloride (9CT)
`
`(CA TNDEX NAME)
`
`Absolute stereochemistry.
`
`@ Hcl
`
`RN
`CN
`
`CAPLUS
`223672~63-7
`4~Benzothiazolecarboxamide, 2-amino-4,5,6, 7-tetrahydro~N~ (4~[2=[(f (2R)-2=
`hydroxy~2-phenylethyl] amino]ethyl]phenyl]-, dihydrochloride (961)
`(cA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`HO. p
`
`@2 Hel
`Searched by Barb o'Bryen, STIC 308~4251
`
`SAWAI EX. 1015
`Page 556 of 1092 PTO_00000557
`
`SAWAI EX. 1015
`Page 556 of 1092
`
`
`
`CcleAyeN
`
`. P
`
`h
`
`@ Hcl
`
`RN 223672-66-0-.CAPLUS
`
`CN H-1,2,4-Triazole-3-acetamide, N-{4-[2-(( (2B) -2-hydroxy-2-
`phenylethyl] amino] ethyl] phenyl] -1-(phenylmethyl)-
`(9CT)
`(CX INDEX NAME)
`
`Absolute stereochemistry.
`
`20
`N
`neAy” ee
`
`= Nf
`
`BNA PS,
`go»OH
`-
`an
`|
`yl
`” Se SyNRH
`Ph
`
`RN
`CN
`
`CAPLUS
`§-223672~67~-1
`4-Thiazoleacetamide, 2, 3-dihydro-Nn-[4- (2-0 (128) -2-hydrosy-2-
`phenylethyl} amino] ethyl] phenyl] ~3- (phenylmethyl) -2-thioxe-,
`monohydrochloride (9CI)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIG 308-4291
`
`SAWAI EX. 1015
`Page 557 of 1092 PTo_ooo005s8
`
`SAWAI EX. 1015
`Page 557 of 1092
`
`
`
`@ Hcl
`
`RN
`CN
`
`,
`CAPLUS
`223672~-68~2.
`8-Quinolinecdarboxamide, 5,6, 7, S-tetrahydro-N= [4-[2=-[ { (2R)-2-hydroxy-2-
`phenylethyl]amino]ethyl]phenyl]-, dihydrochloride (9CI)
`(CA INDEX NAME)
`Absolute stereochemistry.
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`223672-69+3
`LH-Imidazola-2-acatamide, N«[4~(2=[[ (2R)-2-hydroxy=2—
`phenylethylj]amino] ethyl) phenyl]~i-phenyl-, dihydrochloride.
`INDEX NAME)
`:
`
`(9CT)
`
`(CA
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 558 of 1092 PTo_oo000559
`
`SAWAI EX. 1015
`Page 558 of 1092
`
`
`
`@2 HCL
`
`RN
`CN
`
`:
`CAPLUS
`223672" 70~6
`LH-Imidazole-2-acetaitide, N~[4-[2={[ (2R)-2—hydroxy-+2~
`phenylethyl] amino] ethyl] phenyl)-1-((4- (l-methylethyl) phenyl) methyl} ~,
`dihydrochloride (9CT)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`L-Pr.
`
`ue
`
`f é
`
`ws “yyA an n-OH
`
`H
`
`Ph
`
`.
`
`@2 HCL
`
`RN
`CN
`
`-
`
`CAPLUS
`223672-71-7
`LH~Imidazole-2-acetamide, 1~([1,1'~biphenyl]~—4-ylmethy1) -N-[4~[2-[[ (2R}~-2~
`hydroxy-2-phenylethyllaminolethyl)phenyl!~, dihydrechloride (9CT)
`(CA
`INDEX NAME)
`
`Absolute stereochemlatry,
`
`Searched by Barh O'Bryen, STIC 908-4291
`
`SAWAI EX. 1015
`Page 559 of 1092
`
`PTO_00000560
`
`SAWAI EX. 1015
`Page 559 of 1092
`
`
`
`-loEI eBq
`
`Ph
`
`@2 Hcl
`
`RN=223672~72—8 CAPLUS
`
`CN
`LH-Tmidazole-2~acetamide, 1+[(2~chlorophenyl} methyl) -N-(4-[(2-[[ (2R) -2-
`hydroxy~2-phenylethyl}amino]ethyl]phenyl]-, dihydrochloride (9¢I)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`No
`
`me
`N
`HN‘
`
`SNNNyOBE OH
`H
`h
`
`iP
`
`\_//
`
`@2 Hcl
`
`RN
`CN
`
`CAPLUS
`223672-73~9
`1H-Imidazele-2-acetamide, 1-[ (3-chlorophenyl) methyl] -N-[4-[2=[£ (2B) ~2-
`hydroxy~2~-phenylethyl}laminojethyl}phenylj-, dihydrochloride (9CT)
`(CA
`INRPEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, SYLC 308-4291
`
`SAWAI EX. 1015
`Page 560 of 1092 PTO_00000561
`
`SAWAI EX. 1015
`Page 560 of 1092
`
`
`
`@2 Hel
`
`RN.|2223672+-74-0- CAPLUS
`
`Cn
`LH~Imidazole=2-acetamide,. 1~{ (3, 4-dichlorophenyl } methyl] «N» (4=[2—[[ (2R) -2-
`hydroxy~2-phenylethyljaminojethyl)}phenyl]~, dihydrochloride (9CT)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`PAGE 1-A
`
`CL
`
`“ejl
`CreVe
`“TS
`
`LE voR 8
`Ho
`h
`
`|P
`
`ia
`
`
`
`@2 Hel
`
`PAGE 2-A
`
`RN
`CN
`
`CAPLUS
`223672-75=1'
`lH-Imidazole+2-acetamide, N-(4-(2-[[(2R)-2~-hydroxy-2-
`phenylethyl] amino] ethyl] phenyl] -1-(2-pyridinylmethyl)~, dihydrochloride
`(9CIT)
`(CA INDEX NAME}
`Searched by Barb o'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 561 of 1092
`
`PTO_00000562
`
`SAWAI EX. 1015
`Page 561 of 1092
`
`
`
`mhkLOBEOn
`
`Hq
`
`!P
`
`h
`
`@2 KCL
`
`RN
`ON
`
`CAPLUS
`223672~76—2.
`4-Thiagoleacatamide, 2-atuine«.alpha.~hydroxy-N~([4=[2=[[ (2R) ~2-hydroxy-2~
`phenylethyl] aminojethyl]phenylj-, monohydrochloride (9CI)
`(CA INDEX NAME)
`
`Absolute stereochemistry,
`
`OH
`
`HaNewleSANO°
`‘J
`
`@ uel
`
`RN
`CN
`
` CAPLUS
`223672+7763
`LH-Tmidazole-2-acetamide, N~[4-(2-0[ (2R)-2~-hydroxy-2-
`phenylethyl]aminojethyl] phenyl] 1+ (2~methylpropyl)+, dihydrochloride ($¢1)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 562 of 1092 PTO_00000563
`
`SAWAI EX. 1015
`Page 562 of 1092
`
`
`
`@2. Hel
`
`RN
`CN
`
`223672-784 “CAPLUS
`LH-Imidazole-2-acetamide, 1-1 (2-£luorophenyl) methyl |] ~N» [4-[2~[[ (2R)-2-
`hydroxy-2-phenylethyl] aminojethyl]phenyl]-, dihydeochloride (9CT)
`(CA
`INDBX NAME}
`
`BaOu
`
`; e
`
`h
`
`Absolute stereochemistry.
`
`CL
`TO.
`LT
`SeWokNn”
`
`H
`
`@2 nel
`
`RN
`CN
`
`CAPLUS
`223672-79-5
`LH-Imidazole-2-acetamidé, 1-( (3-fluaropheriy]) methyl] oN» [4-[2-[[ (2R)~2~
`hydroxy-2-phenylethyllaminolethyl]phenyl}~, dihydrechloride (9CI)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 563 of 1092 PTo_o0000564
`
`SAWAI EX. 1015
`Page 563 of 1092
`
`
`
`a SeNB
`Ho
`h
`
`|P
`
`@2.-HCL
`
`RN
`cn
`
`CAPLUS
`223672-80"-8°
`LH-Imidazole-zg-acetamide, 1~[(2, 4-difluorophenyl) methyl] -N-[4-(2=[[ (2R}-2=
`hydroxy-2-phenylethyl]amino]ethyl)]phenyl]-, dihydrochloride (9CT)
`(CA
`TNDEX NAME)
`
`Absolute stereochemistry.
`
`COaa
`
`
`
`|
`(|
`F a ee
`\
`
`oST |
`
`tt nN”ORH :
`
`Ph
`
`OH
`
`HN,
`
`4N
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`223672-8)-9
`1H-Imidazole-2-acetamide, 1-[(2, 6-diflucrophenyl) methyl ]-N= [4~[2-[1 (2B) -2=
`hydroxy“2-phenylethyl] amino) ethyl)phenyl]-, dihydrochloride (9€I)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-429]
`
`SAWAI EX. 1015
`Page 564 of 1092 PTo_ooo00s65
`
`SAWAI EX. 1015
`Page 564 of 1092
`
`
`
`@2 HCL
`
`RN
`CN
`
`223672820 CAPLUS
`LH-Imidazole-2~-acetamide, 1-[ (3, 5-difluerophenyl]) methyl) -N~ [4-[2-[[ (2R) -2-
`hydroxy~2~phenylethyl]aminolethyll]phenyl]-, dihydrochloride (9CI)
`(CA
`TNDEX NAME)
`
`Absolute stereochemistry.
`
`F
`
`PAGE 1-3
`
`EC
`aves )
`(yor°
`N
`K ~
`
`SO woee OH
`4H
`h
`
`;P
`
`@2 xe
`
`PAGE 2-A
`
`RN
`CN
`
`CAPLUS
`223672-83-1
`1H-Imidazole~2-acetamide, 1-[ (2, 5-difluorophenyl) methyl] -N- (4-[2-({ (2R)-2~
`hycroxy-2-phenylethyl]aminolethyl}phenyl]~, dihydrochloride (9CT)
`(CA
`INDEX NAME)
`‘
`.
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 565 of 1092 PTo_ovo00se6
`
`SAWAI EX. 1015
`Page 565 of 1092
`
`
`
`LRwoe
`
`bh
`
`@2 nel
`
`RN
`Cn
`
`'
`CAPLUS
`$223672-84~2.
`lef (3, 4-difluorophenyl) methyl] «N- [4[2«[[(2R) -2=
`LH~Imidazole-2-acatamide,
`hydroxy~2-phenylethyl] amino}ethyl]phenyl]-, dihydrechloride (9CI)
`(CA
`XNDEX NAME)
`
`Absolute stereochemistry.
`
`.
`
`F AU
`
`
`
`N,
`
`PAGE 1-A
`
`RpOH
`
`Ph
`
`PAGE 2-A
`
`rr
`Ne SSa
`
`V_x
`
`HN.
`
`vt
`
`@2
`
`neL
`
`RN
`cn
`
`CAPLUS
`223672-85-3
`1lH-Imidazole~-2-acetamide, Ne [4-[2=[f (2R) -2-hvdroxv~2-
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 566 of 1092 PTO_00000567
`
`SAWAI EX. 1015
`Page 566 of 1092
`
`
`
`@2. Hel
`
`RN
`CN
`
`CAPLUS
`223672-86-4
`LH-Imidazgole~2-acetamide, N«{[4-[2-[[ (2B) -2-hydroxy-2-
`phenylethyl]aminojethyl] phenyl) -1-((2, 4, 5-trifluorophenyl)methyl]-,
`dihydrochloride (SCI)
`(CA INDEX NAME)
`
`Absolute stereochamistry.
`
`PAGE 1-A
`
`
`
`PAGE 2-2),
`
`@2 Wel
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 567 of 1092 PTO_00000568
`
`SAWAI EX. 1015
`Page 567 of 1092
`
`
`
`FE
`
`Sting
`
`et
`
`N,
`
`.
`
`oO
`
`HN.
`
`~.A
`ak |
`yOna\=
`Tk
`
`oO Sa,aaWr OH .
`i
`Ph
`
`@2 el
`
`PAGE 2-A
`
`RN
`CN
`
`CAPLUS
`223672-88~6
`1H-Imidazole-2-acetamide, N-[4-(2-[[(2R)~2-hydroxy-2-
`phenylethyl}] amino] ethyl] phenyl}~1-[ (pentaflucrophenyl) methyl] ~<,
`dihydrochloride (9CI)
`(CA INDEX NAMB)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STTC 308-4291
`
`SAWAI EX. 1015
`Page 568 of 1092 PTo_oo000s69
`
`SAWAI EX. 1015
`Page 568 of 1092
`
`
`
`N |ASoZoWoo”OH
`
`Bo
`Ph
`
`@2 Hel
`
`PAGE 2-A
`
`RN
`CN
`
`CAPLUS
`223672 B96].
`1H-Imidazole-2-acetamide, N=[4~[2-[[ (2R) -2-hydroxy-2-
`phenylethyl] aminolethyl] phenyl]~1~{(3-iodephenyl)methyl]-, dihydrochloride
`(90T)
`(CR,
`INDEX NAME)
`
`Absolute stereochemistry.
`
`[ )
`m SE ~
`C ' a
`|]ee a wm ot
`
`— N
`
`H
`
`oa
`
`Sg 7 Bet
`Ph
`
`OH
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`223672-90—0
`LH~Imidazole-2-acetamida, 1-[(2,6-dichlorophenyl) methyl] -N-[4—[2-[{ (2R)-2-~
`hydrexy-2-phenylethyl]aminojethyljiphenyl]~, monohydrochloride (9CI)
`(CA
`INDEX NAME)
`‘
`.
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 569 of 1092 PTo_00000570
`
`SAWAI EX. 1015
`Page 569 of 1092
`
`
`
`Me NeyNR
`
`Ph
`
`@ uel
`
`RN|223672-91~1- CAPLUS
`
`CN
`1H~Imidazole+2-acetamide, 1-[ (4-cyanophenyl) methyl] -N-[4~[2~[((2R)~2=
`hydroxy-2-phenylethyl]aminojJethyl]phenylj~-, dihydrochloride (9CI)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`NEwOQ
`
`¢ir
`
`oo BT
`
`AN, oe
`
`ws,
`es
`"
`SE et BY
`me
`Ph
`
`OH
`
`@2 Hel
`
`RN=.223672~92-2 CAPLUS
`
`CN
`1H-Imidazole-2-acetamide, N-[4-[2-[[ (2R)-a-hydroxy-e-
`phenylethyl}] aminojethyljphenyl}-1-(2-quinolinyl)-,
`txrihydrechloride (S¢€T)
`(CA INDEX NAME)
`
`Ahsolute stereochamistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 570 of 1092 PTO_00000571
`
`SAWAI EX. 1015
`Page 570 of 1092
`
`
`
`@3° Hel
`
`RN 223672~93—3.CAPLUS
`
`CN
`lH-Imidazole-2-acetamide, 1-[ (2-chloro+-6-fluorophenyl) methyl ]~N-[4-[2-
`[i {2R})-2-hydroxy-2-phenylethyllaminolethyl}phenyl)]-
`(9CT)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Lo eyNF
`
`H
`
`:P
`
`h
`
`RN =223672-94~4|CAPLUS
`
`CN
`1H~Imidazole~-2-acetamide,
`Lm ( (2+chloro~4~£Luorophenyl) methyl] -N~ (4~(2~
`{CA INDEX NAME)
`(((2R)-2-hydroxy~2-phenylethyl] amino)]ethyljphenyl}-— (9C1)
`
`Absolute stereochemistry.
`
`Searched by Barb QO'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 571 of 1092
`
`PTO_00000572
`
`SAWAI EX. 1015
`Page 571 of 1092
`
`
`
`RN 223672=95-5.CAPLUS
`
`CN
`dH-Imidazole-~2-acetamide, 1-[(2,5-dichlorophenyl) methyl] -N+[4-[2-[[ (2k) -2-
`hydroxy-2-phenylethyljaminolethyl]phenyl]-, dihydrochloride (SCI)
`(CA
`INDEX NAME)
`
`Absolute stereochemistry.
`
`AL
`onC
`TCSeaettNvBewOR
`
`PO
`Ph
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`223672=96+6
`Benzoic acid, 4-([2[2-[{4«[2~[{ (2R)~2-hydroxy~2=
`. phenylethyl} amino] ethyl] phenyl] amino] ~2-oxoethyl] -1H-imidazol-1l-yl] methyl} -
`, Methyl aster, dihydrochloride (9CI)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 572 of 1092 PTO_00000573
`
`SAWAI EX. 1015
`Page 572 of 1092
`
`
`
`@2 Hel
`
`PAGE 2-A
`
`RN 22367297479°CARLUS
`
`CN
`LH-Imidazole-2-acetamide, N- (4~-[2-[][ (2R)-2-hydroxy~2-
`phenylethyl] amino} ethyl lphenyl]-1-([(4- (l-piperidinylcarbony1) phenyl] methyl
`Je, dihydrochloride (9CT)
`(CA INDEX NAME}
`
`Absolute stereochemistry.
`
`foie Ne
`
`HN.
`
`a
`
`rer
`Jd Loaw
`L
`te
`ann,
`‘,
`sn
`LOO Sy” Re
`(J
`iu
`h
`
`» OH
`
`: P
`
`ee
`
`Cr So
`
`Ne
`
`@2 uch
`
`RN
`cn
`
`CAPLUS
`223672-98-8
`1H-~Pyrazole«leacetamide, Ne {4-{2-[[ (2R)-2-hydroxy-2~
`phenylethyl] aminojethvllohenvill-, monohvdrochloride (9CI)
`Searched by Bark O'Bryen, STIC 308-4291
`
`(CA INDEX NAME}
`
`SAWAI EX. 1015
`Page 573 of 1092
`
`PTO_00000574
`
`SAWAI EX. 1015
`Page 573 of 1092
`
`
`
`@ucL
`
`
`RN 223672999°CAPLUS . .
`
`
`CN
`1H-1,2,4-Triazole-l-acetamide,. N~[4~[2~[[ (2R)-2-hydroxy-2~
`phenylethyllamino]ethyl)phenyl]-, dihydrochloride (9¢1)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`ONE
`\_/
`tT
`
`n—
`
`BML,
`
`SS
`aein
`
`oe
`a Be
`
`OH
`
`mz
`
`Ph
`
`@2 Hcl
`
`RN
`CN
`
`CAPLUS
`223673-~-00+-5
`LH-Benzimidazole-l-acetamide, 2-amino~N=[4~{2=[[ (2R)-2-hydroxy~2~
`phenylethyljamino]ethyl]phenyl)]-, dihydrochloride (9CT)
`(CA INDEX NAME}
`
`Absolute stereochemistry.
`
`N,
`
`NH2
`
`I.
`
`
`1
`Sr
`| y~ eRoH
`N‘1
`nal Aal
`
`K
`N.,
`
`.
`
`H
`
`@2 Hel
`
`Searched by Barb O'Bryen, STIC 308-4241
`
`SAWAI EX. 1015
`Page 574 of 1092 PrTo_o0000575
`
`SAWAI EX. 1015
`Page 574 of 1092
`
`
`
`1nowon
`
`a
`
`@ cr
`
`RN
`CN
`
`CAPLUS
`223673-0247
`4~Pyridineacetamide;.N~(4~{2=[[(2R)=~2—hydroxy~2-
`phenylethyl] amino)ethyl|phenyl)]-, monohydrochloride (9¢T}
`
`(CA. INDEX NAME)
`
`Absolute atereochemiatry.
`
`Ph
`
`an a
`HO” RO™
`
`oo
`
`fooa
`
`eo
`
`@ yc
`
`RN
`cN
`
`223673-03-8 CAPLUS
`2-Pyridinepropanamide, N-[4-[2-[[ (2R)-2-hydroxy-2-
`phenylethyl]aminojethyl] phenyl]~, monohydrochloride (9CI)
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 575 of 1092 PTO_00000576
`
`SAWAI EX. 1015
`Page 575 of 1092
`
`
`
`@ acl
`
`RN 223673-04=9..CAPLUS
`
`CN
`1H-Imidazole-2-acetamidé, N~[4-[2={[ (2B) -e-hydroxy-2-
`phenylethyl] amino] ethyl} phenyl) -1~(2-phenylethyl)-, dihydrochloride.
`(CA INDEX NAME)
`
`(SCT)
`
`Absolute stereochemistry:
`
`rt Ph
`
`wo, pon ge
`
`(Tyem
`
`Sy
`
`IE
`
`HN.
`
`@2 Hel
`
`B °
`H
`h
`
`: P
`
`RN
`oN
`
`223673050 CAPLUS
`LH-Benzimidazole-Z-acetamide, N-[4~(2~-[[ (2R)-2-hydroxy-2-
`phenylethyllaminolethyliphenyl]~ (9CT)
`(CA INDEX NAMB)
`
`Absolute stereochemistry.
`
`Searched by Barb O'fryen, STIC 306-4291
`
`SAWAI EX. 1015
`Page 576 of 1092 PTO_00000577
`
`SAWAI EX. 1015
`Page 576 of 1092
`
`
`
`phenylethyl] amino]ethyl]phenyl]~3-methyl-, monohydrochloride (9CT)
`INDEX NAME)
`
`(CA
`
`Absolute stereochemistry.
`
`
`
`@ cl
`
`RN
`CN
`
`CAPLUS
`223673"07-2..
`1H-Imidazole-2~acetamide, N~{4-(2-[[ (2R} =2-hydrory-2=
`phenylethyl] amino] ethyl] phenyl ]-1- (phenylmethyl)-, dihydrochloride (9CI)
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 577 of 1092 PTO_00000578
`
`SAWAI EX. 1015
`Page 577 of 1092
`
`
`
`@2 Hel
`
`RN
`CN
`
`CAPLUS
`2236734083
`2-Pyridineacetamide,. N-[4-[2-[[(2R) -2-hydroxy-2-
`phenylethyl]aminojethyl)]phenyl]~4-methyl-
`(9CT})
`
`,
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`PH
`i
`
`H
`
`aadnae
`SySg SSJe
`
`we
`on
`
`le
`~~
`
`Me
`
`RN
`CN
`
`CAPLUS
`223673-09-4°°
`2-Pyridineacetamide, N-[4-[(2-[[ (2R) -2«hydroxy-2<
`phenylethyl] amino) ethyl] phenyl )=S=methyl-
`(9CI)
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Ph
`:
`an
`
`H
`N
`
`HO— Re ae “NH woe
`|oO” we
`
`RN=223673-10-7 CAPLUS
`
`CN
`2-Pyridineacetamide, N-[4=[2-[[ (2R)-2-hydroxy-2~
`phenylethyl] amino] ethyl] phenyl]~6—-methyl~ (9c)
`
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 578 of 1092 PTo_o0000579
`
`SAWAI EX. 1015
`Page 578 of 1092
`
`
`
`NAME)
`
`Absolute stereochemistry.
`
`-
`Me
`BaNS
`
`LN
`3
`HoBN SeySy
`
`@ Hcl
`
`RN
`CN
`
`223673-12-9...CABLUS
`2-Pyridineacetamide, N-[4«[(23)“2«[[ (2R) -2-hydroxy~2—
`phenylethyl] aminolpropyl]phenyl)-, monehydrochleride (3CT).
`NAME)
`
`(CA INDEX
`
`Absolute stereochemistry.
`
`
`
`@ cl
`
`RN
`cn
`
`CAPLUS
`223673-13-0
`1H~Imidazole~2~acetamide, N~[4~[(28)-2-[[ (2R)-2-hydroxy-2~
`phenylethyl] amino] propyl] phenyl ]~-L- (phenylmethyl)~, monohydrochloride
`(9CI)}
`(CA INDEX NAME)
`
`Absolute stereochemistry.
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 579 of 1092 PTo_ov000580
`
`SAWAI EX. 1015
`Page 579 of 1092
`
`
`
`@ Hel
`
`RN 223673—14~1°°CAPLUS
`
`CN
`a~Pyxidineacetamide, Ne [4-[2=[[2~ (2~fluorophenyl) ~2-
`hydroxyethyljaminojethyl]phenyl)-, monohydrochloride (9C1)°
`NAME)
`
`(CA INDEX
`
`a
`
`Oe
`
`=\
`
`on
`|
`oN
`| yNH C> CHg—
`c )/77CHCHaNECHaCHa
`
`
`bt
`oe
`
`F
`
`@ Hcl
`
`RN
`CN
`
`.
`CAPLUE
`223673152
`2-Pyridineacetamide, N~(4-[2-[[2~ (3-fluoropheny] } -2-
`hydroxyethyl]aminojethyl]phenyl)]-, monohydfochloride (9CT)
`NAME)
`
`(CA INDEX
`
`Q
`
`Pe
`TL 7CH--CH2—NH—CH2—CH2
`
`\
`
`ff
`
`{
`
`~
`
`IaNH Co CHa--~i“
`
`i
`No
`ee
`
`Pe
`ce
`
`@ nel
`
`RN
`CN
`
` CAPLUS
`223673-169"3
`2-Pyridineacetamide, N-[4-[2-[[2- (4~fluorophenyl) -2~
`hydroxyethyllamino]ethyl] phenyl] ~-, monohydrochloride (9CT)
`NAME)
`
`(CA INDEX
`
`Searched by Barb O'Bryen, STIC 308-4291
`
`SAWAI EX. 1015
`Page 580 of 1092 PTo_oo000581
`
`SAWAI EX. 1015
`Page 580 of 1092
`
`
`
`Absolute stereochemistry.
`
`a “oewhe HN.COoewo Seae WYB.oe OW
`
`eo
`Ph
`
`@ HCL
`
`RN
`CN
`
`223673-185 “CAPLUS
`2~Pyridineacetamide,.N~[4~(2=[[(2R)-2@ (3-chloraphenyl ) «2—
`hydroxyethyljaminojethyl]phenylj-, monohydrochloride (9CT)
`NAME }
`
`{CK INDEX
`
`Absolute. stereochemistry:
`
`H
`
`‘oe cr
`eu SE B Nye LF TS
`:
`oH
`Na
`
`H
`
`@ nel
`
`RN
`CN
`
`CAPLUS
`223673-19~6
`2~-Pyridineacetamide, N-{4-[2~[[2-hydroxy~2- (3-
`pyridinyl) ethyl} amine] ethyl ]phenyl]-, monohydrochloride:
`NAME)
`"
`
`(9¢2)
`
`(CA INDEX
`
`Searched by Barb O'Bryen, SPIC 308-4291
`
`SAWAI EX. 1015
`Page 581 of 1092 PTO_00000582
`
`SAWAI EX. 1015
`Page 581 of 1092
`
`
`
`Absolute stereochemistry.
`
`cL
`
`@2 KCL
`
`RN
`CN
`
`CAPLUS
`223673-21-0
`e~Pyridineacetamide, Ne (4—(2«[[(2R) -2<hydrox
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