`
`
`
`
`
`
`
`BIOEPIS EX. 1079
`
`Page 1
`
`BIOEPIS EX. 1079
`Page 1
`
`

`

`LEU(.99)
`
`GLU GLU Gll! GLU GLU GLU GlU GLU GLU GLU GLU GLU GLU GLU GUJ
`GLU GLU GLU GLU GLI
`ala
`VAL
`VAL
`VAL
`VAiL
`VAL
`VAL
`VAL
`VAL VAL
`VAL
`VAL
`VAL W<L
`VAL
`VAL
`Vfoi:L
`VAL
`VAl
`VAi.
`VAL
`VJI<L
`GtN GLN GLN GLN GLN GLI
`GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN GLN Gt.N GtN
`.. LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEl
`LEU
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VA!..
`VAl
`VAL
`VAL
`VAl
`leu
`leu
`leu
`leu
`~eu
`GLU GLU GLU GLU
`asp GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GLU GUJ GLX GLU GLU GLX GLI
`SER SER SER
`SER SER SER
`SER
`SER SER
`SER SER SER
`SER
`SER
`SER
`SER
`SER
`SER
`SER
`SER
`SEI
`thr
`GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GlY GLY GLY GLY GLY GLY GL'
`GLY GLY GLY GLY GLY GLY GlY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GLY GL'
`GLY GLY GLY GLY GLY GLY GLY GLY GLY
`GLY
`GlY GLY GLY GLY GLY GLY
`as;
`LEU
`LEI
`euF~u LEU
`LEU
`L
`VAL
`VAL
`VAL
`tte
`VAl
`LN ·
`lys
`GLN GLX GLI
`I \IS
`PRO PRO
`PRO PRO PAl
`LY GLY GLY GLY GLY GL'
`.
`LY GLY GLY GLY GLY
`Y
`<lf!
`SER SER SER SER
`SER SER
`SEI
`LEU
`LEU
`LEU
`LEU
`LEU
`LEI
`LEU
`
`P
`
`LEU
`
`LEU
`
`LEU
`
`LEU
`
`gly
`
`GL
`
`GL
`~
`
`.
`
`GL
`Y
`SER SER .
`LEU
`LEU
`
`S
`LEU
`
`R SE
`LEU
`LEU
`
`GLN
`
`L
`R
`L
`'! GLY
`l
`LY
`L
`L
`SER
`SER SER SER
`LEU
`LEU
`LEU
`LEU
`
`$EGUBN~u
`ARG P:Ril
`~~~a~ 01·~ ARG ARG ARG ARG AR!
`lliJI "DlDSI G
`.. ~ T'.: .. ~',s
`
`L.
`
`LEU
`SER
`Y
`CYS
`ALA
`A
`AL
`At
`ALA
`If.
`SER SER SER. SER SER SER
`
`U
`ER
`YS
`
`U
`R
`S
`_A
`LA
`
`H
`
`R
`s
`A AL
`-A
`AL/>l A
`SER SER SER
`E P
`R
`
`S
`
`T
`
`TH
`
`.
`.
`
`Ia
`s
`'A
`A
`SER SER
`H
`· KR. H
`
`EU
`
`LEI
`LEU
`LEU
`LEU
`LEU
`LEU
`SER
`SE!
`SEA
`SER
`SER
`gly
`CYS CYS CYS CYS CYS CY:
`LA ALA ALA
`ALA
`ALA
`ALA Au
`ALA
`ALA
`LA ALA
`ALA Au
`ALA
`SER
`SER SER
`SEI
`SER
`y
`GLY Gl..'
`GLY
`·IE
`PHE
`PHi
`E
`,R
`PH
`
`TYR
`SER
`ALA ASN
`VAL. MET
`TYR ASN
`
`ASX
`TYR
`MET
`
`TYR
`THR
`MET
`VAL
`
`HR
`
`PH
`
`..
`
`l
`
`. i)H
`
`p X.;
`
`.H
`
`;
`
`TYR
`
`GLY
`
`ASN. ASP
`
`TYR
`
`ASX
`
`SER
`
`VAL
`
`HI~
`
`TR
`LEI
`ARI
`GLI
`Gl
`PRI
`GL
`
`ARG
`GLN
`ALA
`PRO
`GLY
`
`•• o_m_,.,,_'-V~'~"-'
`
`TRP
`VAL
`
`TRP
`VAL
`ARG
`GLN
`VAL
`THR
`GLY
`
`TRP
`VAL
`PRO
`GLY
`ALA
`PRO
`GLY
`ARG
`GLY
`LEU
`
`VAL
`ARG
`GLN
`ALA
`PRO
`G'LY
`
`VAL
`V1\L
`VAL
`AfiG ARG ARG
`GLN GLN GLN
`ALA
`ALA
`ALA
`PRO
`PRO PRO
`GLY GLY GlY
`LYS
`GLY
`LEU
`
`VAL
`ARG
`GLN
`ALA
`PRO
`GLY
`
`VAL
`
`VAL
`ARG
`
`MET(.95)
`
`LYS
`ASN
`THR
`LEU
`TYR
`LEU
`LEU
`GLN ASN
`MET MET
`LEU ASN
`.SER SER
`LEU
`LEU
`GLIJ ARG
`PRO ALA
`GLU GLU
`ASP ASP
`THR
`
`LEU
`GLU
`ALA ALA
`GLU GLU
`ASP ASP
`
`.198$
`
`PHE
`#
`. GLY
`SER
`SER
`ALA
`. lf_A_!::. __ VA!:, ...
`TRP TRP
`GLY
`GLN
`GLY
`l'I4Jll
`LEU
`
`PKE
`A"s\J-~iJ>EPelRTMENT c:71 HEALTH
`. PHE
`ASP ~~J ~
`As
`·- -···--·····---~---~; ~~N~t"JMAN-SEJWIGES,.--~--'- ----~~~; - . ~~; --~~-- -· -----~-c-c-·-"-·-~·--'-~~
`gt
`gt~ ~t~aMic Health ~ice
`gt~ gt~ ~~
`r~~
`~~~ tflliomlllnstitutes~ Health
`·~~ ~~ ~~~
`~ ~
`L YS
`LEU!
`LEW
`LEW
`LEU
`PRIG wE0
`LE''
`VAL
`\1$i!L
`SER
`THf!t
`
`T~
`VAL
`THR
`VAL
`SER
`SER
`
`BIOEPIS EX. 1079
`Page 2
`
`

`

`SEQUENCES OF PROTEINS OF
`IMMUNOLOGICAL INTEREST
`
`Elvin A. Kabat, Tai Te Wu, Howard Bilofsky,
`Margaret Reid-~liller, and Harold Perry
`
`( 1983)
`
`Page;
`
`If
`
`6; 20 Position -1 of 145'CL (precursor heavy chains) should be Phe.
`
`15;
`
`31 Pau and Paul are the same protein.
`35
`
`54; 204
`205
`
`and 10K26-12A1
`The antibody specificities for 10K44-7A1
`light chains) should by anti-p-azobenzene arsenate.
`
`(mouse kappa
`
`65;
`
`65;
`
`65;
`
`65;
`
`66;
`
`67;
`
`13 SAPC178 and SAPC176 (mouse lambda light chains) should be named as S178
`16
`and S176.
`
`light
`lambda
`4 References for HOPC1, J698, H2061, S176, and H2020 (mouse
`should be Weigert, M., Cesari, I.M., Yankovich, S.J. & Cohn, M.
`5 chains)
`6
`(1970) Nature, 228, 1045-1047.
`16
`17
`
`should be
`7 References for W3159 and MOPC511 (mouse lambda light chains)
`I.M. & Weigert, M.
`12 Cesari,
`(1973) Proc. Natl. Acad. Sci. U.S.A., 70,
`2112-2116.
`
`2
`3
`13
`
`26
`27
`
`sequenced
`light chains) were
`lambda
`(mouse
`and S178
`J558, XS104,
`completely, while HOPC1,
`J698, H2061, S176, H2020, W3159, and MOPC511
`(mouse lambda
`light chains) were analyzed by
`amino acid
`sequence
`compositions.
`
`and MA8-13
`There is an additional reference to TEPC952
`light chains)
`i.e., Elliott, B.W., Jr., Steiner, L.A.
`(1981) Fed. Proc., 40, 1098.
`
`lambda
`(mouse
`& Eisen, H.N.
`
`The statement in the notes of mouse lambda light chains, "The order of
`the genes has been determined as V1-J3-C3-J1-C1-V2-J2-C2-J4-C4," should
`be
`replaced by
`"There are
`two
`linkage groups:
`J3-C3-J1-C1
`and
`J2-C2-J4-C4."
`
`111;
`
`23 Positions 13 and 14 of CAM (human heavy chain subgroup III)
`Gln and Lys respectively.
`
`should be
`
`168; 30 Position 171 of S43'CL (light constant chain) should be Asn.
`
`should be Ser
`168; 35 Positions 142 and 143 of MOPC315 (light constant chain)
`and Gly respectively, based on the translation from nucleotide sequences
`(Bothwell, A.L.M., Paskind; M., Roth, M., Imanishi-Kari, T., Rajewsky,
`K. & Baltimore, D.
`(1982) Nature, 298, 380-382; Wu, G.E., Govindi, N.,
`Hozumi, N. & Murialdo, H.
`(1982) Nucl. Acids Res., 10, 3831-3843).
`
`(heavy constant chain) have been
`185; 52 Positions 258 and 263 of MOPC173
`revised by the authors to Pro and Val respectively.
`
`246;
`
`The position numbering for the codons of
`light chain variable
`should read as 95, 95A, 95B, 95C, 95D, 95E, 95F, 96, and 97.
`
`region
`
`The human kappa J-segments (Hieter, P.A., Maizel, J.V., Jr. & Leder, P.
`(1982) J. Biol. Chem., 257, 1516-1522) are as follows:
`
`,u
`
`.J2
`
`E
`
`.ll
`
`_,)5_
`
`TGG TRP
`96
`THR
`97 ACG
`98 TTC
`PHE
`99 GGC GLY
`100 GAA GLN
`101 GGG GLY
`THR
`102 ACC
`103 AAG LYS
`104 GTG VAL
`105 GAA GLU
`106 ATC
`ILE
`107 AAA LYS
`108 CGT ARG
`
`TYR
`TAC
`THR
`ACT
`PHE
`TTT
`GGC GLY
`CAG GLN
`GGG GLY
`ACC
`THR
`AAG
`LYS
`CTG LEU
`GAG GLU
`ATC
`ILE
`AAA LYS
`CGT ARG
`
`PHE
`TTC
`ACT THR
`TTC
`PHE
`GGC GLY
`CCT
`PRO
`GGG GLY
`ACC
`THR
`AAA LYS
`GTG VAL
`GAT ASP
`ATC
`ILE
`AAA LYS
`CGT ARG
`
`CTC LEU
`ACT THR
`TTC
`PHE
`GGC GLY
`GGA GLY
`GGG GLY
`ACC
`THR
`AAG
`LYS
`GTG VAL
`GAG GLU
`ATC
`ILE
`AAA LYS
`CGT ARG
`
`ILE
`ATC
`THR
`ACC
`PHE
`TTC
`GGC GLY
`CAA GLN
`GGG GLY
`ACA
`THR
`CGA ARG
`CTG LEU
`GAG GLU
`ATT
`ILE
`AAA LYS
`CGT ARG
`
`*D
`In
`Yt
`2(
`to,
`AI
`N'
`:f: B<
`The
`by·
`
`BIOEPIS EX. 1079
`Page 3
`
`

`

`SEQUENCES OF
`J PROTEINS OF
`IMMUNOLOGICAL
`INTEREST
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of
`Precursors, V-Regions, C-Regions, J-Chain,
`!32-Microglobulins, Major Histocompatibility Antigens,
`Thy-1, Complement, C-Reactive Protein, Thymopoietin,
`Post-gamma Globulin, and a 2-Macroglobulin
`
`1983
`
`Elvin A. Kabat*, TaiTe Wu t, Howard Bilofsky t.,
`Margaret Reid-Miller"t, and Harold Perry"t
`
`* Depts. of Microbiology, Human Genetics and Development, and Neurology, Cancer Center/
`Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New
`York, NY 10032 and the National Institute of Allergy and Infectious Diseases, Bethesda, MD
`20205
`t Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics, Northwestern University, Evanston, IL 60201 and the Cancer Center,
`Northwestern University Medical School, Chicago, IL 60611
`+Bolt Beranek and Newman Inc., Cambridge, MA 02238
`
`The collection and maintenance of this data base is sponsored through Contract N01-RR-8-2118
`by the following components of the National Institutes of Health, Bethesda, MD 20205:
`
`Division of Research Resources
`National Cancer Institute
`National Institute of Allergy and infectious Diseases
`National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`
`U.S. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`Public Health Service
`National Institutes of Health
`(1983)
`
`BIOEPIS EX. 1079
`Page 4
`
`

`

`)\J
`
`Our listing ,of se_quenc,es will be kept up to date. Investigators are invited to send additional
`sequence data when accepted for publication. Send two copies of the manuscript together with
`a letter of acceptance from a journal to:
`Dr. E.A. Kabat
`National ln.stitutes of Health
`Building 4, Room 337
`9000 Rockville Pike
`Bethe.sda, Maryland 20205
`If a computer tape is available, please send it to facilitate entering sequences.
`-when published, three reprints should be provided.
`If any published sequences have been overlooked or if any errors are found, please bring them to
`our attention.
`
`BIOEPIS EX. 1079
`Page 5
`
`

`

`xxi.
`
`TABlE OF CONTENTS
`
`PRECURSOR
`PRECURSORS OF KAPPA LIGHT CHAINS ................................................................................... 1
`PRECURSORS OF LAMBDA LIGHT CHAINS ................................................................................. 4
`PRECURSORS OF HEAVY CHAINS .......................................................................................... 6
`PRECURSOR OF BETA-2-MICROGLOBULIN ................................................................................. 10
`PRECURSORS OF MAJOR HISTOCOMPATIBILITY ANTIGENS ............................................................... 12
`
`VARIABLE REGION LIGHT CHAIN SEQUENCES
`HUMAN KAPPA LIGHT CHAINS SUBGROUP I .............................................................................. 14
`HUMAN KAPPA LIGHT CHAINS SUBGROUP II ............................................................................. 20
`HUMAN KAPPA LIGHT CHAINS SUBGROUP Ill ............................................................................. 23
`HUMAN KAPPA LIGHT CHAINS SUBGROUP IV ............................................................................. 28
`
`HUMAN LAMBDA LIGHT CHAINS SUBGROUP I ............................................................................ 30
`HUMAN LAMBDA LIGHT CHAINS SUBGROUP II ............................................................................ 33
`HUMAN LAMBDA LIGHT CHAINS SUBGROUP Ill ........................................................................... 36
`HUMAN LAMBDA LIGHT CHAINS SUBGROUP IV ........................................................................... 39
`HUMAN LAMBDA LIGHT CHAINS SUBGROUP V ........................................................................... 41
`HUMAN LAMBDA LIGHT CHAINS SUBGROUP VI ........................................................................... 43
`MOUSE KAPPA LIGHT CHAINS ............................................................................................ 45
`MOUSE LAMBDA LIGHT CHAINS .......................................................................................... 65
`
`RAT KAPPA LIGHT CHAINS ................................................................................................ 68
`
`RABBIT KAPPA LIGHT CHAINS ............................................................................................ 70
`RABBIT LAMBDA LIGHT CHAINS .......................................................................................... 82
`
`GUINEA PIG KAPPA LIGHT CHAINS ........................................................................................ 84
`GUINEA PIG LAMBDA LIGHT CHAINS ...................................................................................... 86
`
`DOG LIGHT CHAINS ....................................................................................................... 88
`
`PIG KAPPA LIGHT CHAINS ................................................................................................ 90
`PIG LAMBDA LIGHT CHAINS .............................................................................................. 92
`HORSE KAPPA LIGHT CHAINS ............................................................................................. 94
`CHICKEN LAMBDA LIGHT CHAINS ............................................................... : ......................... 96
`TURKEY LAMBDA LIGHT CHAINS .......................................................................................... 98
`SHARK KAPPA LIGHT CHAINS ............................................................................................ 100
`MISCELLANEOUS LIGHT CHAINS ......................................................................................... 102
`
`VARIABLE REGIONS HEAVY CHAIN SEQUENCES
`HUMAN HEAVY CHAINS SUBGROUP I .................................................................................... 105
`HUMAN HEAVY CHAINS SUBGROUP II ................................................................................... 109
`HUMAN HEAVY CHAINS SUBGROUP Ill ................................................................................... 111
`MOUSE HEAVY CHAINS SUBGROUP I .................................................................................... 118
`MOUSE HEAVY CHAINS SUBGROUP II ................................................................................... 121
`MOUSE HEAVY CHAINS SUBGROUP Ill ................................................................................... 128
`MOUSE HEAVY CHAINS SUBGROUP IV ................................................................................... 138
`MOUSE HEAVY CHAINS SUBGROUP V ................................................................................... 140
`RAT HEAVY CHAINS ...................................................................................................... 144
`
`RABBIT HEAVY CHAINS .................................................................................................. 146
`
`GUINEA PIG HEAVY CHAINS ............................................................................................. 150
`CAT HEAVY CHAINS ............................................................................................ , ......... 152
`DOG HEAVY CHAINS ..................................................................................................... 154
`PIG HEAVY CHAINS ...................................................................................................... 156
`HORSE HEAVY CHAINS ................................................................................................... 158
`CHICKEN HEAVY CHAINS ................................................................................................. 160
`SHARK HEAVY CHAINS .................................................................................................... 162
`MISCELLANEOUS HEAVY CHAINS ........................................................................................ 164
`
`CONSTANT REGION SEQUENCES
`LIGHT CONSTANT CHAINS ............................................................................................... 167
`
`HEAVY CONSTANT CHAINS CH1. REGION ................................................................................. 173
`HEAVY CONSTANT CHAINS HINGE REGION ............................................................................. 178
`HEAVY CONSTANT CHAINS CH2 REGION ................................................................................. 183
`HEAVY CONSTANT CHAINS CH3 REGION ................................................................................. 188
`HEAVY CONSTANT CHAINS EXTRA LONG CH3 REGION .................................................................. 193
`HEAVY CONSTANT CHAINS CH4 REGION ................................................................................. 194
`HEAVY CONSTANT CHAINS EXTRA LONG CH4 AND MEMBRANE BOUND REGIONS ...................................... 196
`
`SEQUENCES OF RELATED PROTEINS
`J CHAIN .................................................................................................................. 202
`BETA-2-MICROGLOBULINS ................................................................................................. 204
`MAJOR HISTOCOMPATIBILITY ANTIGENS N REGION ..................................................................... 206
`MAJOR HISTOCOMPATIBILITY ANTIGENS C1 REGION .................................................................... 208
`MAJOR HISTOCOMPATIBILITY ANTIGENS C2 REGION .................................................................... 210
`MAJOR HISTOCOMPATIBILITY ANTIGENS MEMBRANE REGION ........................................................... 212
`MAJOR HISTOCOMPATIBILITY ANTIGENS CYTOPLASMIC REGION ........................................................ 214
`I REGION GENE PRODUCTS A-CHAIN A1 REGION ........................................................................ 217
`I REGION GENE PRODUCTS A-CHAIN A2 REGION ........................................................................ 219
`I REGION GENE PRODUCTS A-CHAIN MEMBRANE BOUND REGION ...................................................... 221
`I REGION GENE PRODUCTS B-CHAIN B1 REGION ....................................................................... 224
`I REGION GENE PRODUCTS B-CHAIN B2 REGION ....................................................................... 226
`I REGION GENE PRODUCTS 8-CHAIN MEMBRANE BOUND REGION ...................................................... 228
`
`THY-1 ANTIGENS ......................................................................................................... 231
`COMPLEMENT COMPONENTS ............................................................................................ 233
`MISCELLANEOUS RELATED PROTEINS ................................................................................... 238
`
`CODONS OF NUCLEIC ACID SEQUENCES
`
`COD9NS OF PRECURSOR REGION LIGHT CHAIN ........................................................................ 241
`CODONS OF PRECURSOR REGION HEAVY CHAINS ...................................................................... 243
`CO DONS OF VARIABLE REGION LIGHT CHAINS .......................................................................... 246
`CODONS OF VARIABLE REGION HEAVY CHAINS ......................................................................... 248
`
`CODONS OF LIGHT CONSTANT CHAINS ......................................................•........................... 251
`
`CO DONS OF HEAVY CONSTANT CHAINS CH1 REGION ................................................................... 253
`CODONS OF HEAVY CONSTANT CHAINS HINGE REGION ................................................................ 254
`CODONS OF HEAVY CONSTANT CHAINS CH2 REGION ................................................................... 255
`CODONS OF HEAVY CONSTANT CHAINS CH3 REGION ................................................................... 256
`CODONS OF HEAVY CONSTANT EXTRA LONG CH3 REGION ............................................................. 257
`CODONS OF HEAVY CONSTANT CHAINS CH4 REGION ................................................................... 258
`
`BIOEPIS EX. 1079
`Page 6
`
`

`

`xxii
`
`PREC
`
`(continued)
`
`CODONS OF HEAVY CONSTANT EXTRA LONG CH4 AND MEMBRANE BOUND REGIONS ................................. 259
`CODONS OF MAJOR HISTOCOMPATIBILITY ANTIGENS N REGION ........................................................ 261
`CODONS OF MAJOR HISTOCOMPATIBILITY ANTIGENS C1 REGION ....................................................... 262
`CODONS OF MAJOR HISTOCOMPATIBILITY ANTIGENS C2 REGION ....................................................... 263
`CODONS OF MAJOR HISTOCOMPATIBILITY ANTIGENS MEMBRANE REGION ............................................. 264
`CODONS OF MAJOR HISTOCOMPATIBILITY ANTIGENS CYTOPLASMIC REGION ........................................... 265
`
`CODONS OF HUMAN D SEGMENT ....................................................................................... 267
`CODONS OF MOUSE D SEGMENT . , ..................................................................................... 269
`CO DONS OF MOUSE KAPPA J SEGMENT ................................................................................ 272
`CO DONS OF MOUSE LAMBDA J SEGMENT .............................................................................. 273
`CODONS OF RAT KAPPA J SEGMENT ................................................................................... 274
`
`CODONS OF HUMAN HEAVY J SEGMENT ................................................................................ 275
`CODONS OF MOUSE HEAVY J SEGMENT ................................................................................ 276
`PSEUDOGENES ........................................................................................................... 277
`
`SUMMARY TABLES
`
`AMINO ACID DISTRIBUTION IN ALL VARIABLE REGION LIGHT CHAINS .................................................. 281
`AMINO ACID DISTRIBUTION IN ALL VARIABLE REGION HEAVY CHAINS .................................................. 283
`CODON DISTRIBUTION IN ALL VARIABLE REGION LIGHT CHAINS ........................................................ 285
`CODON DISTRIBUTION IN ALL VARIABLE REGION HEAVY CHAINS ....................................................... 288
`
`VARIABILITY PLOTS
`
`ALL LIGHT CHAINS ....................................................................................................... 292
`ALL HEAVY CHAINS ...................................................................................................... 292
`ALL KAPPA LIGHT CHAINS ............................................................................................... 293
`ALL LAMBDA LIGHT CHAINS ............................................................................................. 293
`ALL HUMAN LIGHT CHAINS .............................................................................................. 294
`ALL HUMAN HEAVY CHAINS ............................................................................................. 294
`ALL HUMAN KAPPA LIGHT CHAINS ...................................................................................... 295
`ALL HUMAN LAMBDA LIGHT CHAINS .................................................................................... 295
`ALL MOUSE KAPPA LIGHT CHAINS ...................................................................................... 296
`ALL RABBIT KAPPA LIGHT CHAINS ...................................................................................... 296
`ALL HUMAN KAPPA LIGHT CHAINS SUBGROUP I ........................................................................ 297
`ALL HUMAN HEAVY CHAINS SUBGROUP Ill .............................................................................. 297
`CYTOCHROMES C .......................................................... , ............................................. 298
`
`INDICES
`INDEX OF PROTEINS ..................................................................................................... 299
`INDEX OF ANTIBODY SPECIFICITIES ..................................................................................... 318
`
`BIOEPIS EX. 1079
`Page 7
`
`