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`Celltrion, Inc., Exhib
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`778 of 778
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`NANCY MAHONEY, CCRIRPR
`Date:
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`(2 c.
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`EXHIBIT
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`. .R ......SS. .............. ...... N ...... F ... D. . .P. . .G. .F... .....P .....KOL
`
`... V. .
`
`Q.
`
`EVQLVESGGGLVQPGGSLRLSCAAS WVRQAPGKGLEWVA RFTISRDDSKNTLYLQNNSLRAEDTAVYYCAR WGQGTLVTVSS consensus
`1
`FRi
`
`FR4
`
`FR3
`
`FR2
`
`90 94 105 110
`
`80 abc
`
`49 66 70
`
`20 25 36 40
`
`10
`
`sequences.
`1987 that however were grafted as part of structural Hi loop (Chothia et al. 1987) in patent '21 3): 70 out of 82 FR residues are identical in the two FR
`Heavy chain VH (residue and FR are labeled according to Kabat etal. 1987 except for FR1, which includes additional residues 26 to 30 in Kabat etal.
`
`CAMPATH-IH
`
`............
`
`.....
`
`F .........I
`
`GVPSRFSGSGSGTDFTLTISS Q5DFATYYC FGQGTKVEIKRT consensus
`
`109
`
`88 100
`FR4
`
`70
`
`57 60
`
`FR3
`
`DI QMTQS PSSLSASVGDRVTI TC WYQQKPGKAPKLLIY
`49
`1
`FRi
`
`40
`
`35
`
`20
`
`10
`
`FR2
`
`Light chain VL (residue and FR are labeled according to Kabat et al. 1987): 80 out of 82 residues are identical in the two FR sequences.
`
`identical to the corresponding residue in the consensus sequences.
`and the heavy chain of the human antibody KOL (Riechmann Exhibit E). The residues of CAMPATH-11 and KOL are shown as dots where they are
`Comparison of FRs consensus sequences of Patent '213 (top lines) with those (bottom lines) in the CAMPATH- 1 H light chain (Riechmann et al. 1998)
`
`RIECHMANN EXHIBIT P
`
`Celltrion v. Genentech
`IPR2017-01374
`Genentech Exhibit 2063
`
`
`
`Celltrion, Inc., Exhibit 10030
`
`
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`J 100
`
`
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`80
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`
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`113
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`110
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`
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`I
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`95
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`4FA B
`2HFL
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`_____
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`_____
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`_____
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`_____
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`_____
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`_____
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`_____
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`_____
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`
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`90
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`2 seqs
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`
`
`3 seqs
`
`3 seqs
`
`
`
`
`____
`
`75
`
`60
`
`I
`
`I
`
`I55
`
`I°
`
`I
`
`120
`
`I
`
`I
`
`I
`
`I
`
`1'
`
`_____
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`_____
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`_____
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`_____
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`
`
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`
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`I
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`1
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`70
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`
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`50
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`I
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`130
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`777 of 778
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`_____
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`5 seqs
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`____
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`I
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`105
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`I
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`
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`85
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`
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`65
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`45
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`25
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`iri111II,
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`-r-
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`r
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`i-
`
`VH Contacts
`
`V1V11
`Contact
`CDR (Cho)
`CDR (Kab)
`Kabat#
`
`V1 -V11
`
`Contact
`CDR (Cho)
`
`(Kab)
`
`CDR
`
`Kabat#
`
`YL-Vil
`
`Contact
`CDR (Cho)
`CDR (Kab)
`Kabat #
`
`VL-VII
`Contact
`CDR (Cho)
`CDR (Kab)
`Kabat#
`
`VL-VII
`Contact
`CDR (Cho)
`CDR (Kab)
`
`#
`
`Kabat
`
`Contact
`CDR (Cho)
`CDR (Kab)
`Kabat #
`
`