`
`Catalog Number: 101423, 101424, 153916
`Creatinine
`
`Structure (free base):
`
`Molecular Formula:
`Molecular Weight:
`CAS #
`
`Free Base
`C4H7N3O
`113.1
`60-27-5
`
`Hydrochloride
`C4H7N3O·HCl
`149.59
`19230-81-0
`
`Zinc Chloride
`(C4H7N3O)2·ZnCl2
`362.5
`362.5
`
`Synonyms: 2-Amino-1,5-dihydro-1-methyl-4H-imidazol-4-one; 2-Amino-1-methyl-4-
`imidazolidinone; 1-Methylhydantoin-2-imide; 1-Methylglycocyamidine; 2-Imino-N-
`methylhydantoin; 2-Imino-1-methylimidazolidin-4- one
`
`Physical Description: White powder
`
`Solubility:
`
`Free Base: Soluble in 12 parts water; slightly soluble in ethanol; practically insoluble in
`acetone, ether, chloroform.1
`Hydrochloride: Soluble in water (50 mg/ml - clear, colorless to faint yellow solution)
`Zinc Chloride: Soluble in 1 N Hydrochloric acid (50 mg/ml - clear, colorless solution)
`
`Description: The end product of creatine catabolism.1 Normal constituent of urine; daily output about
`25 mg/kg body weight.1 Increased amounts in the urine are typically associated with substantially
`impaired renal function. Also found together with creatine in muscle tissues and blood.1 Reacts with
`picric acid under alkaline conditions to form a Janovski complex. The rate of formation of the colored
`complex, measured at 480-520 nm is proportional to the creatinine concentration.
`
`Availability:
`
`Catalog Number
`101423
`
`Description
`Creatinine, free base
`
`Size
`10 g
`25 g
`100 g
`
`153916
`
`Creatinine Hydrochloride
`
`http://www.mpbio.com/detailed_info.php?family_key=02153916&country=223
`
`Vireo Systems, Inc. Ex. 2019 - 001
`
`
`Harvest Trading Group, Inc. v. Vireo Systems, Inc.
`IPR2016-00947
`
`
`
`101424
`
`Creatinine Zinc Chloride
`
`References:
`
`10 g
`25 g
`100 g
`1 g
`5 g
`
`1. Merck Index, 12th Ed., No. 2638.
`2. Butler, A.R. and Glidewell, C., "Creatinine: an examination of its structure and some of its
`reactions by synergistic use of MNDO calculations and nuclear magnetic resonance
`spectroscopy." J. Chem. Soc. Perkin Trans., v. 2, 1465-1468 (1985).
`3. Hirate, et al., "The effect of sacrificing method on the tissue concentration of exogeneous
`creatinine in rats." Chem. Pharm. Bull., v. 33(11), 5105-5107 (1985).
`4. Kim, et al., "Sarcosine oxidase involved in creatinine degradation in Alcaligenes denitrificans
`subsp. denitrificans J9 and Arthrobacter spp. J5 and J11." Agric. Biol. Chem., v. 50(11), 2811-
`2816 (1986).
`5. Nakamura, et al., "Creatones A and B. Revision of the structure for the product of oxidation of
`creatinine and creatine." Bull. Chem. Soc. Jpn., v. 63(5), 1540-1542 (1990).
`6. Valcour, A.A. and Woodworth, R.C., J. Magn. Reson., v. 66, 536 (1986).
`7. Welch, M.J., et al., "Determination of serum creatinine by isotope dilution mass spectrometry
`as a candidate definitive method." Anal. Chem., v. 58(8), 1681-1685 (1986)
`8. Winquist, et al., "Determination of creatinine by an ammonia-sensitive semiconductor structure
`and immobilized enzymes." Anal. Chem., v. 58(1), 145-148 (1986).
`9. Yokozawa, et al., "Changes in the urinary constituents in rats with chronic renal failure during
`oral administration of rhubarb extract." Chem. Pharm. Bull., v. 33(10), 4508-4514 (1985).
`
`http://www.mpbio.com/detailed_info.php?family_key=02153916&country=223
`
`Vireo Systems, Inc. Ex. 2019 - 002
`
`
`Harvest Trading Group, Inc. v. Vireo Systems, Inc.
`IPR2016-00947
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