GI
`e'L'u
`dfu
`GLU
`V;
`VAL
`VAL
`VAL
`em can
`GLN
`GLN
`LEU
`LE
`LEU
`LEU
`VAL w
`VAL
`VAL
`eLx
`at
`GLU
`GLU
`sen
`SE
`thr
`sen
`GLY
`en
`GLV
`GLY
`GLY
`GI
`GLY
`GLY
`LEU
`LE
`LEU
`LEU
`GLY
`GLY
`as
`GLY
`VAL W
`1
`VAL
`GLX
`G'LeN
`an
`Rys
`PRO PRO PF
`PRO
`GLY
`GLY
`G!
`GLY
`GLY
`GLY
`a.
`GLV
`sen
`ssn
`se
`sen
`Leu
`La)
`La
`LEU
`Am Am; ARG M
`LEU
`LEU
`LEU
`LE
`sea
`sen
`gly
`sz
`ALA
`ALA
`ALA
`AL
`cvs
`CYS
`CYS
`cx
`ALA
`ALA
`ALA
`AL
`sen
`sen
`sea
`32
`Van
`GLY
`GLY
`at
`we we we
`pr
`PHE
`Val
`P?
`THR me
`as
`pne
`SE-ZF1
`h«
`‘ff-‘Fl
`Asx
`Gl
`TYR
`Hts
`1”\
`MET MET
`MI
`VAL
`sea
`5
`_.
`Asx
`H
`TF
`LE
`Ar
`I
`8:
`PF
`GI
`LV
`GI
`PFGI
`Tf
`VI
`SET»
`4%T:
`
`sen
`TRP
`VAL
`
`
`
`A:
`GI
`<3»
`3:
`V.L!
`T‘
`:
`5!V4
`L‘
`G!
`Pl
`M
`A4
`ll
`SI
`Ar
`A:
`As
`Al
`
`NA
`
`E1Tl
`Ll
`T‘
`L!
`G
`Ll
`MET
`A:
`ASN
`u
`GLV
`Ll
`LEU
`ARG Al
`ALA
`Pl
`GLX
`G
`As):
`A:
`GLY
`AV
`ALA
`GLY
`Tl
`THR
`VAL
`pa
`VAL
`TYR
`T‘
`TYR
`TYR
`T‘
`TYR
`cvs
`:2‘
`CYS
`VAL
`A:
`ALA
`sen
`L‘
`ARG
`ASP Asx
`es
`LEU
`VAL
`T‘
`ALA
`u
`ALA
`Tl
`ALA
`A‘
`Am;
`6
`LEU
`A:
`T:
`9:
`—
`.
`
`.
`
`LYS
`GLY
`‘mm
`G”
`THE
`VAL
`'
`gen
`:2?
`
`T:
`e
`G
`TL
`9‘
`L;
`V
`3
`‘J
`
`GL1:
`GLU dfu
`GLU
`VAL
`VAL
`VAL
`VAL
`GLN
`em GLN
`GLN
`LEU
`LEU
`LEU
`LEU
`Ieu
`VAL
`VAL
`leu
`GLU
`GLU
`asp
`GLU
`sea
`sea
`sea
`sen
`GLY
`GLY
`GLY
`GLY
`GLV
`GLY
`(aw GLY
`
`GLY an GLY
`
`GLY
`
`GLY
`
`GLU
`8-CU
`efu
`VAL
`VAL
`VAL
`GLN
`GLN
`GLN
`LEU
`LEL!
`LEU
`VAL
`VAL
`VAL
`GLU mu GLU
`sen
`sea
`sen
`GLY
`GLY
`GLY
`GLY
`GLY
`GLV
`U
`I
`ELY
`ELY
`VAL
`cm LN
`PRO
`GLY
`LY
`GLY
`5
`sen
`LEU
`LEU
`MG A99
`LEU
`LEU
`sen
`am
`(A23
`rig
`ALA
`ALA
`seen
`SER
`Y
`LY
`E
`E
`2:
`R
`R
`sen
`
`éfu
`VAL
`GLN
`LEU
`VAL
`GLU
`size
`GLY
`GLY
`
`ala
`
`asp
`VAL
`GLN
`LEU
`VAL
`GLU
`see
`GLY
`GLV
`
`GLY
`
`all;
`VAL
`GLN
`LEU
`leu
`GLU
`sea
`GLY
`GLY
`
`GLY
`
`efu
`VAL
`GLN
`LEU
`VAL
`GLX
`sen
`GLY
`GLV
`
`SLY
`
`GLY
`
`GLY
`
`GLY
`
`GLV
`
`GLY
`
`éfu éfu GLU
`GL1;
`GLU
`efu GLU
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`VAL
`GLN
`GLN
`GLN
`GLN
`GLN em GLN
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`LEU
`VAL
`VAL
`VAL
`lav
`VAL
`VAL
`Ieu
`GLU
`GLU
`GLU
`GLU
`GLU
`GLU
`GLU
`sea
`sen
`sea
`sen
`sen
`sen
`sen
`GLY
`GLY
`GLY
`GLY an GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`GLY
`EU
`u
`GLY
`GLY
`Le
`L
`GL
`R
`PRO
`L
`G
`L
`EH
`LEU
`G
`U
`A
`s
`A
`sen
`‘E
`E
`I
`n
`
`ASN
`
`_
`
`1
`
`Law 99)
`
`'
`
`sea: 96)
`emse)
`'GLY( 99)
`
`PRO:.96)
`GLV
`SEFV 951
`LEU( 93:
`APGL 96»
`
`V
`
`1 cvs
`MM 95)
`saw 973
`GLY( 953
`PHE( 971
`
`I
`‘T
`[__
`map
`AAGL951
`(ELM 95)
`gmaog 95»
`GLY
`LVs(.95;
`-
`LEUL 95:
`nap
`VAL( 953
`[_
`
`:
`
`V
`E_
`one
`§.ARG
`
`\lLE
`SEF.
`Ans
`
`.
`Tn-A
`
`I>fiET( 95;
`
`
`
`»
`:
`I
`i
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`»’
`
`LY
`L‘
`VAL
`EFR
`
`T
`TYR
`
`Avg:
`_.
`ASN
`TYR
`~»
`TRP mp
`VAL
`VAL
`
`ALA
`Tun
`VAL
`TYR
`TYR
`CYS
`ALA
`ARB
`VAL
`THR
`mac)
`ALA
`ALA
`ALA
`sea
`LEU
`ma
`-—
`
`ALA
`THE‘!
`VAL
`TYR
`TYR
`cvs
`ALA
`Ar_‘-Lt;
`sen
`PRO
`VAL
`sen
`LEU
`VAL
`ASP
`GLY
`TRP
`LEU
`TVR
`TYR
`was
`as
`ALA
`sen
`38“ 9”
`V"_L_ _fl
`mp mp
`GLN
`GLN
`GLV
`BLY
`wen we
`G” W
`LEU
`LEU
`VAL
`ma
`
`
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`VAL
`
`
`
`1
`
`VAL
`TYR
`TYR
`cvs
`ALA
`ARG
`
`ALA
`ALA
`ALA
`ALA
`THE
`THE
`THE
`THE
`VAL
`LEU
`LEU
`VAL
`Tvn
`TYR
`TYR
`We
`TYR we
`TVR
`TYR
`cvs
`cvs‘
`cvs
`cvs
`ALA
`ALA
`ALA
`ALA
`ARG ARG ARG
`LYS
`ASP
`GLV
`ALA
`LYS
`GLY
`VAL
`mo
`sen
`TYR
`ALA
`VAL
`TYR
`sea
`T‘/R
`Mo was
`THR
`P1-IE
`
`.
`
`..
`
`M
`pm:
`P
`$*:pEgAnTMENT cw HEALTH
`NEMNVNI IIIAPJ Q|;flU|C‘C¢
`T‘Fh"7fi¥3"""""‘ """'3'$'$s;'“"""'“"
`aw
`GLYP®Iic Health Wice
`,
`Nfiiofifil lnstitutesw Health
`LEL»
`LEU!
`LEU
`VAL
`VAL
`VAL
`VAL
`awn
`THFI ma
`THR
`
`
`
`THR
`
`ALA
`ALA
`ALA
`THR
`sea
`THR
`VAL
`1LE
`VAL
`TYF1
`TYR
`TYR
`TYR
`TYR
`TYH
`cvs
`cvs
`cvs
`ALA
`ALA
`ALA
`ARG
`AFIG Am;
`VAL
`ASP Asx
`VAL
`ALA
`ARG
`VAL
`GLY
`LEU
`sea
`PRO GLY
`THE
`TYR
`PRO
`sea
`VAL ma
`sen
`ALA
`mo (:15
`THR
`sea
`PHE
`VAL
`—
`—
`ASP ASP
`ALA
`T
`“U ‘*5
`___WVL“L
`""*_L
`“'5
`TRP
`TRP
`TRP
`GLN
`GLN
`GLN
`(SLY Gl.Y
`GLY
`mm TMR ma
`W G” G"-"
`LE-U me
`Luau
`VAL
`VAL
`VAL
`sea
`THR
`THR
`
`.
`——
`
`Sanofi/Regeneron Ex. 1029, pg 902
`
`Mylan Ex. 1029, pg 902
`
`

`
`SEQUENCES OF PROTEINS OF
`JMMUNOLOGICAL INTEREST
`
`Elvin A. Kabat, Tai Te Wu, Howard Bilofsky.
`Margaret Reid-I-filler, and Harold Perry
`(1983)
`
`Epcatg
`
`6;
`15;
`
`20 Position -1 of 1145'CL (precursor heavy chains) should be Phe.
`31
`Pan and Paul are the same protein.
`
`514; 201!
`205
`
`1OI(26-12A1
`and
`The antibody speoificities for ‘£0101-14-7A1
`light chains) should by anti-p-azobenzene at-senate.
`
`{mouse
`
`kappa
`
`light:
`lambda
`References for HOPC1, J698, H2061. S176, and H2020 (mouse
`chains)
`should be Weigert, M., Cesari. I.M., Yonkovlch, S.J. & (John, M.
`(1970) Nature, 228, 10145-1031?.
`
`65;
`
`be
`should
`(mouse lambda light; chains)
`7 References for W3159 and MOPC511
`2112-2116.
`12 Cesari;
`LM.
`8: Weigert,
`.
`(1973) Proc. Natl. Aoad. Sci. U.S.A., 70.
`
`2
`3
`3
`
`sequenced
`chains) were
`light
`lambda
`(mouse
`S178
`and
`5558. X81015.
`completely. while HOPC1.
`J698, H2061. S176. H2020. W3159. and HOPC511
`composi tions .
`(mouse lambda
`light
`chains) were
`analyzed by
`amim acid sequence
`
`‘
`
`66;
`
`67;
`
`lambda
`(mouse
`and HA8-13
`26 There is an additional reference to TEPC9S2
`J: Elsen, H.N.
`27
`light
`chains)
`i.e., Elliott, B.W., J12, Steiner, L.A,
`(1981) Fed. Pr-oc.. H0. 1098.
`The statement in the notes of mouse lambda light chains, "The order
`of‘
`the
`genes has been determined as V1~J3-C3-J1—C1-112-J2—C2~J!t—C-it.‘V should
`J2-\'.!2-J1l—CN."
`be
`replaced by
`"were
`are
`two
`linkage groups:
`J3—C3-J1—C1
`and
`
`
`
`
`
`‘:..1..4.n_-.~In.A'
`
`
`
`'
`
`ARG
`
`5: Leder-,
`
`P.
`
`The human kappa J-segments (flieter. P.i».., Maizel. J.V., Jr.
`(1982) J. Biol. Chem, 257. 1516-1522) are as follows:
`it
`:22
`B
`.:.L*L
`PHB
`TRP
`TYR
`LEU
`TGG
`TAC
`TTC
`OTC
`96
`THE
`THR
`THR
`TIER
`ACG
`ACT
`ACT
`ACT
`97
`PHE
`PHE
`PHE
`TTC
`TTT
`TTC
`TTC FEE
`98
`SLY
`GLY
`GGC
`GGC GLY
`GCC
`GGC GLY
`99
`PRO
`GAA GLN
`CAG
`GLN
`CCT
`GGA GLY
`100
`GL1’
`GGG GLY
`GGG
`SLY
`GGG
`GGG
`GL1’
`101
`THE
`ACC
`THE
`ACC
`THR
`ACC
`ACC
`T1-IR
`102
`LXS
`103 Am LYS
`AAG
`LES
`AAA
`RAG
`LYS
`VAL
`1011
`GTG
`VAL
`CTG
`LEU
`GTG
`GTG
`VAL
`105
`GAA GLU
`GAG
`GLU
`SAT ASP
`GAG GLU
`106
`ETC
`ILE
`ATC
`ILE
`ATC
`ILE
`ATC
`ILE
`107
`AAA
`LYS
`AAA
`LYS
`AAA
`LYS
`AAA
`LYS
`108
`C61!‘
`AHG
`CGT
`ARG
`CST ABS
`CGT
`ARG
`
`:15.
`ILE
`ATC‘
`THE
`ACC
`PI-IE
`TTC
`GGC GLY
`CM GLN
`GGG GLY
`ACA
`TR}?
`CGA
`A126
`CTG
`LEI}
`GAG
`GLU
`ATT
`ILE
`AAA
`LYS
`CGT
`
`Sanofi/Regeneron Ex. 1029, P9 903
`
`Mylan Ex. 1029, pg 903
`
`be
`
`should
`
`III)
`23 Positions 13 and 111 of CAM (human heavy chain subgroup
`G111 and Lys respectively.
`30 Position 171 of‘ S113'CL (light constant chain) should be Asn.
`59!‘
`be
`35 Positions 1132 and 143 of MOPC315 (light constant chain}
`Should
`and Gly respectively. based on the translation from nucleotide sequences
`(Bothwell. A.L.M., Paskind, M., Roth. M.,
`Imanishi-Kari. T.,
`Fajewsky.
`K.
`& Baltimore, D.
`(1982) Nature, 296. 380-382;
`‘yin, G.E., Govindi. 11.,
`Hozumi, N. & Murialdo. H.
`(1982) Nucl. Acids Res., 10. 3831-38513).
`52 Positions 258 and 263 of MOPC173
`(heavy
`constant
`chain}
`have
`been
`revised by the authors to Pro and Val respectively.
`The position numbering for the eodons of
`light
`chain variable region
`3h°U1d Wad 38 95: 955. 955. 95C, 95D. 9513',
`9517. 96, and 97.
`
`111;
`168;
`168;
`
`185;
`2316;
`
`_
`‘
`
`1FX I
`
`.5
`
`.22 3
`
`_-
`1
`
`

`
`SEQUENCES OF
`
`PROTEINS OF
`
`IMMUNOLOGICAL
`INTEREST ,\
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of
`Precursors, V-Regions, C-Regions, J-Chain,
`
`E2-Microglobulins, Major Histocompatibility Antigens,
`Thy-1, Complement, C-Reactive Protein, Thymopoietin,
`Post-gamma Globulin, and org-Macroglobulin
`
`1 983
`
`Elvin A. Kabat*, Tai Te wul , Howard Bilofsky 39,
`Margaret Reid-Miller-‘F, and Harold Perryi
`
`*Depts. of Microbiology, Human Genetics and Development, and Neurology, Cancer Center!
`Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New
`York, NY 10032 and the National Institute of Allergy and Infectious Diseases, Bethesda, MD
`20205
`
`T Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics, Northwestern University, Evanston, IL 60201 and the Cancer Center,
`Northwestern University Medical School, Chicago, IL 60611
`1 Bolt Beranek and Newman lnc., Cambridge, MA 02238
`
`The collection and maintenance of this data base is sponsored through Contract N01—RR-8-21 18
`by the following components of the National Institutes of Health, Bethesda, MD 20205:
`Division of Research Resources
`National Cancer Institute
`National Institute of Allergy and infectious Diseases
`National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`
`US. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`Public Health Service
`National Institutes of Health
`
`"
`
`(1983)
`
`run; 1-1EA!.:1‘1-i SCIENCES LIBRARY
`._....m.n.-~.-mv nu!
`run-.1-1:m'm.n'n nuns
`
`Sanofi/Regeneron Ex. 1029, pg 904
`
`Mylan Ex. 1029, pg 904
`
`

`
`Our listing of sequences will be kept up to date. Investigators are invited to send additional
`sequence data when accepted for publication. Send two copies of the manuscript together with
`a letter of acceptance from a journal to:
`Dr. E.A. Kabat
`National Institutes of Health
`Building 4, Room 337
`9000 Rockville Pike
`Bethesda, Maryland 20205
`
`If a computer tape is available, please send it to facilitate entering sequences.
`when published, three reprints should be provided.
`
`If any published sequences have been overlooked or if any errors are found, please bring them to
`our attention.
`'
`
`Sanofi/Regeneron Ex. 1029, pg 905
`
`Mylan Ex. 1029, pg 905
`
`

`
`21
`20
`19
`15
`‘I7
`16
`saa MOPG PLAI
`16306
`K313
`K399
`315
`-13
`LAMac:A LAMBDA LAMBDA
`___
`---
`———
`———
`___
`CAG GAG
`GAG
`GAG
`GAG
`<scT GOT
`GCT
`GOT
`GOT
`GTT GTY
`GTT
`GTT
`GTT
`am GT6
`GTG
`GTG
`me
`ACT ACT
`ACT
`AcT
`AcT
`CAG CA6
`CA6
`CA6
`GAG
`GAA GAA
`GAA
`GAA
`GAA
`TCT TcT
`Tm
`TCT
`TcT
`GCA GCA
`GCA
`GCA
`GOA
`-_-
`---
`-.— ---
`---
`OTC
`cm
`on:
`cTc cm
`ACC
`Acc
`ACO
`Acc we
`ACA
`AcA
`AcA
`AcA Am
`TcA
`TcA
`ToA
`TCA TcA
`em
`ccT
`ccT
`OCT cor
`GGT
`GGT
`GGT
`G61’ G61’
`GAA
`GGA
`GAA
`GAA GGA
`AcA
`ACA
`ACA
`AcA AcA
`GTO
`GTC
`me me em
`ACA
`ATA
`AcA
`AcA ATA
`cm
`cTc
`CTC
`cm on:
`AcT
`ACT
`ACT
`ACT AGT
`TGT
`TGT
`TGT
`TGT TGT
`(:60
`Geo
`cec
`cec sec
`TcA
`TcA
`TcA
`TcA TCA
`AGT
`AGT
`ACT
`AGT AGT
`ACT
`ACT
`ACT
`AcT Am
`:2: "'
`-,_
`W,
`--Y ‘VWVVV
`(566
`(-168
`GGG
`ease
`em
`as“:
`ecr GOT
`an
`GT1’
`GT1’ GTT
`AcA
`AcA
`AcA ACA
`ACT
`ACT
`ACT ACT
`AGT
`em AGT
`AGT
`AAC
`AAC
`AAC AAG
`TAT
`TAT
`TAT
`TAT
`ecc
`ecc
`am: act:
`AAc
`AAC
`AAC AAC
`TGG
`TGG
`TBG T60
`GTT
`GTG
`aTc ATC
`cAA
`CAA
`cAA BAA
`GAA
`GAA
`GAA GAA
`-
`AAA
`AAA
`AAA AAA
`_
`ccA
`GCA
`ccA cc».
`.
`GAT
`an an an
`7
`on
`on on CAT
`-
`TTA
`TTA
`TTA TTA
`TTC
`TTC
`TTc TTG _ -
`AcT
`AcT
`ACT ACT
`_
`V7
`am
`GGT
`ear GGT
`-
`-
`cm
`cm on an _ -
`ATA
`ATA
`ATA ATC -
`.
`GGT
`GGT
`GGT
`em
`Acc
`Acc
`AGC
`AAC
`AAc
`AAC
`CGA
`cm
`GOT
`G61’
`ccA
`.ocA
`am
`am
`GTT
`GTT
`ccT ccT — —
`ccr
`c;cT
`soc err:
`_ _
`GTC
`Gcc
`AGA AGA - -
`AGA
`A<3A
`TTC
`TTC we we - -
`TCA
`TcA
`TcA TCA _ -
`GGC
`sec
`TOO
`Tcc
`cm
`cm
`ATT
`ATT
`em
`GGA
`GAG
`em
`AAG
`AAG
`ecr
`GOT
`soc
`(ace
`cm
`cm
`Ace
`Acc
`no
`no
`ACA
`Am
`G66
`G66
`GCA
`GOA
`CA6
`CA6
`AcT
`AcT
`GAG
`ans
`em
`GAT
`an
`GAG
`am
`am
`ATG
`ATA
`TAT
`TAT
`TTc
`TTc
`TGT
`TGT
`GOT
`em
`cu
`CT).
`TGG
`T66
`no
`no
`A80
`A50
`AAC
`AAC
`CAT
`cAT
`W-
`TGG
`- -
`GT6
`- -
`___
`_ _
`- -
`_ _
`- _
`- -
`-
`_ -
`.
`-
`, _
`.
`-
`- -
`.
`-
`_ 7
`- -
`- -
`7 -
`___
`
`'
`31
`;
`'
`
`
`
`3
`T
`
`
`
`
`
`-
`—
`-
`V
`-
`-
`—
`-
`—
`—
`
`
`
`---
`TTG
`GGT
`GGA
`em.
`Aco
`AAA
`CTG
`ACT
`GTC
`on
`am
`_--
`
`___
`
`___
`
`___
`
`---
`
`246
`
`11
`T1
`
`12
`L6
`
`13
`T2
`
`14
`L7‘
`
`
`
`GAT
`GT6
`Am"
`AcT
`ACT
`em
`Goo
`T56
`TAT
`GAG
`GAG
`AAA
`ccA
`ass
`cAA
`TcT
`cor
`AAA
`OTA
`cm
`
`TOG
`GCA
`TAO
`CGG
`
`GGA
`eTc
`
`
`
`GTC
`ccA
`TcA
`Aea
`TTC
`AGT
`G80
`AGT
`GGA
`T61’
`GGG
`GAA
`an
`TTT
`TOT
`on:
`AGO
`ATS
`A650
`A60
`me
`GAG
`TAT
`GAA
`SAT
`Am
`GGA
`ATT
`TAT
`TAT
`TGT
`CTT
`GAG
`TAT
`GAT
`GAG
`TTT
`cos
`on:
`ACG
`___
`
`_
`_
`_
`-
`--- -
`TTc _
`GGT _
`(507 -
`GGG _
`ACO -
`AAG A
`cm -
`GAG _
`CTG -
`--- -
`AAA
`cm"
`
`
`
`TTC
`GGA
`see
`see
`Acc
`AAG
`cm
`GAA
`ATA
`‘W
`AAA
`"_
`
`Sanofi/Regeneron Ex. 1029, pg 906
`
`Mylan Ex. 1029, pg 906
`
`———
`._-
`
`_,_
`AAA
`CGT
`
`---
`
`CODONS OF VARIABLE REGION LIGHT CNMNS
`15
`10
`9
`8
`7'
`6
`1
`2
`3
`4
`5
`PKAPPA
`HK101
`umoz MOPC MOPC MOPC MOPC K2A MPG MOPC s1o7
`(11)24
`41
`21
`157
`11
`use
`a
`___
`GGA
`——— ——— ———
`_,_ W,
`_"
`-__ *""
`eAc
`GAG GAC GAO
`em:
`AAC
`GAT
`GM) GAG GAO
`Am ATC Am ATT
`ATE
`ATT
`ATT
`ATc ATC ATT
`
`AAG TTG TTG GTG
`CAG
`STA
`GTG
`GAG GAG GTG
`ATG cm cm ATG
`ATS
`ATG
`ATA
`ATG ATG cm
`ACO ACT AC‘! Acc
`AC6 Acc Acc
`ACT AcT Acc
`GAG GAG GAG
`CAG
`CAA
`GAG
`GAG GAG CAA
`GAG
`TCT
`TcT
`GAT
`TOT TCT TOT
`TOT TCT T01’
`T01’
`cca
`coo
`GAA
`cap.
`C-CA ace
`ccA CCA ccA cAc
`Tcc
`AAA
`cm cacc acc GOT
`TcT Goo ecc
`AAA
`Tcc
`TCC
`Tcc Tcc Tcc TcT
`Tcc ATC ATC
`TTc
`TTA Am AAT
`CTA cTA TTG
`ATG cm CTG
`ATG
`TcT
`Tcc
`ccT
`TcT TCT GCT
`TAT TcT TCT Tcc
`soc
`ATS
`GTO
`GCA GOA are
`GOA am am AcA
`TCT
`TcA ACT
`TcT TcT TcT
`TCT AGT AGT
`TcA
`cm GTA
`TOT
`am am cTA
`CTA ccA cm an
`em:
`GGA
`GGA
`GGT G61’ G66
`GSA GGA GGA
`GGA
`GAA
`ram GAA
`GAA GAA cm
`GAG GAA GAA
`GAO
`Am Ace
`TAc
`AcT AoT AGG
`AGA AGA AGA
`AGG
`me
`are
`GTT
`GTO GTG ecc
`are are arc
`GTC
`AGT Acc Tcc
`ACC Ace ACC
`AcT A61‘ A61’
`A60
`cTc
`TTG
`ATC
`ATc ATC ATA
`ATC TTc TTC
`ATC
`ACT Acc
`TOG
`ACA AcA Too
`ACT TCC Toc
`ACO
`TGT
`TGC Tsc
`TGT TGT T60
`‘T60 rec TGC
`TGC
`use
`AAG
`OGA CGA AGA
`AAG A66 A66
`AM;
`GCA
`ecc
`GOA eon Gcc
`ace ace ecc
`eco
`A61’
`A31‘
`AGT AGT AGT
`AGT AGT
`AGT
`GAG
`GGG GGG (BAA
`ma
`CA5
`‘"
`'
`
`---
`sac
`An:
`GAG
`Am
`Ace
`CAG
`TCT
`CCA
`Tcc
`TcA
`cm
`TcT
`GCA
`TOT
`GTA
`GGA
`am
`AGA
`are
`Acc
`ATC
`ACT
`TsT
`can
`GOG
`AGG
`cAa
`
`
`
`
`
`o
`1
`2
`3
`4
`5
`6
`7
`3
`s
`10
`11
`12
`'15
`14
`:5
`us.
`:7
`1a
`15
`20
`21
`22
`:3
`24
`25
`25
`ETA
`275
`270
`270
`275
`___
`27F
`GGT
`as
`ATT
`29
`AGO
`so
`AGO
`31
`1'86
`32
`TTA
`as
`Goo
`34
`T66
`as
`TAT
`36
`CAG
`37
`GAG
`as
`AAA
`39
`cm
`40
`GAG
`41
`AAA
`42
`600
`43
`cc‘:
`44
`AAG
`as
`Tcc
`as
`cm
`47
`ATC
`43
`TAT
`49
`601'
`so
`GcA
`51
`Tcc
`52
`AGT
`53
`TT6
`54
`CAA
`55
`M31’
`56
`see
`57
`are
`5a
`cm
`59
`TCA
`so
`Ass
`51
`Tu:
`52
`AGE;
`sa
`G60
`54
`AGT
`65
`GGA
`es
`T01’
`37
`GGG
`ea
`A<:A
`as
`GAT
`70
`71 We
`72
`AcT
`73
`cm
`74
`Ace
`75
`ATC
`79
`A60
`77
`AGO
`7::
`(376
`79
`cm;
`so
`coT
`91
`BAA
`a2
`GAT
`as
`TTT
`54
`eon
`(35
`ACT
`as
`TAT
`37
`TAC
`ea
`T60
`ea
`CAA
`90
`cm
`91
`TAT
`92
`AAT
`96
`AGT
`94
`TAC
`95
`ocT
`as
`97
`9'».
`976
`97c
`970
`975
`97F
`as
`99
`100
`101
`:02
`103
`104
`105
`:05
`106A
`107
`ma
`
`F
`R
`1
`
`C
`D
`H
`1
`
`p
`g
`2
`
`3
`R
`2
`
`F
`R
`3
`
`C
`0
`H
`3
`
`F
`R
`4
`
`

`
`247
`
`SOURCE:
`CODONS OF VARIABLE REGION LIGHT CHAINS
`1) HK101: HUMAN FOETAL LIVER
`2) HK1I|2: HUMAN FOETAL LIVER
`3) IOPOI1: MOUSE ADULT
`4) IOPC21: MOUSE MRNA FROM MOPCZI
`5) 8090167: MOUSE ADULT
`6) IIOFCHSIKZ): MOUSE EMBRYO & PLASIIOCYTOMA
`MOUSE EMBRYO
`1) I(2A:
`8) IIPC11: MOUSE PLASMACYTOMA
`9) IIOPCTISB: MOUSE PLASMACYTOMA
`10) 51073: MOUSE EMBHYO
`MOUSE ADULT
`11) 1'1:
`MOUSE ADULT LIVER
`12) LB:
`MOUSE ADULT, ABNORMAL J OMITTED
`13) T2:
`MOUSE ADULT LIVER
`14) L7:
`15) PKAPPMIHZA: MOUSE MRNA FROM MPC11
`16) IGSSLAHBDA: MOUSE EMBEVO
`17) IG13LAIdBDA: MOUSE EMBRYO
`18)
`IGSIWLAMIDA: MOUSE ADULT
`19) 343: MOUSE ADULT
`20) MOPCS15: MOUSE ADULT
`21) PLAI43: MOUSE ADULT
`REFERENCE: ODDONS OF VARIABLE REGION LIGHT CHAINS
`1) IIK101: BENTLEY.D.L. & RA6B|TTS,T.H. (1960) NATUfiE.266,730-733.
`2)
`I-IK102: BENTL.EY,D.L & FIABBlT|'S,T.H. (1960) NATUHE.28B,730-733.
`
`
`3) IOPC4 2
`SEIDMAN.J.
`MAX.E.E. & LEDER,P. (1979) NATURE,1B0.870-3754
`4) INPCR1:
`FONG.K.LEI.A. G S)\LSER,W. (1579) BIOCHEMBIOPHYS.FlES.COMMUN..90,8G2-8&1: HAMLYN.P.H..GAIT.M.J. & MILSTE!N.C. (1981) NUCLACIDS
`RES_,9.44B5-4494.
`5) IIOPCIOT:
`JOHO,R,.WE|SSMAN.1.L.,EARLY.P..OOLE.J. & HOOD.L.
`(19fi0) PfiOC,NAT.AOAD.SCLU$A,77,1Hm-1111].
`8) IlOPc149(K2): NISHIOKAN. Bx LEDEFU‘. (1980) J. BIOLCHEM..255.3691vG694.
`T) KZA:
`NISI-IlOKA,Y. & LEDEEP. (1930) J.B|OL.CHEM..,255,3S91-3894.
`B) MPC11:
`SE|flMAN.J,G. 3. LEDEFLP. (1980) NATURE.2B6.779-783.
`9) HOPG173B:
`MAX.E.E..SE|DMAN.J.G.,MILLER.l-I. & LEDEEP. (1980) CEI.l..21.793—799.
`10) $1073: KWAN,S.P..MAX.E.E..SElDMAN.J
`..LEDER,P. & SCMARFF.M.IJ. (1981) CELL2657-66.
`11) T1:
`ALTENBUFlGER,W.,STE1NMETZM. 8- ZAGHAU.|-LG. (1980) NATUHE,267,803-607,
`12) L3:
`PECH,M.,HOORTL,J..S(}HNELl.,H. 8. ZACHAUJ-LG. (1981) NATURE.291,86B-670.
`13) T2: ALTENBUHGEFLW-.STEINMETZM. & ZACHAUJ-IIG. (1960) NATURE.287.SD3-607.
`14) L7:
`PECH,M..HOCHTL,J..SCHNELL.H. A ZACHAUJ-I.G, (1981) NATURE.291,665-670.
`15) PI(APPA('I1)24: RABBI‘|'TS,T‘H.,HAMLYN,P.H. 5 MA1'I'HYSSENS.G.
`(19613) CAN.J.B|OCHEM.,56,175~I87,
`16) IGOILAIIIDA: BEFlNARD.O. OZUMI,N. & TONEGAWA.S. (1978) CELL.15.1133-11:34.
`17) IG13LAMBDA: TCINEGAWA.
`..IuIAXAM,A.M.,T|ZAHD.H..BEFlNARD,O. 8: GILBERIW. (1973) PFlOC.NAT.ACAD.SGI.USA.75.1485—148Q.
`18) I03fl$LAMIDA:
`BEFiNARD.0..HOZUM|.N. 3: TONEGAWAS. (1578) CELL.15,I133-1144.
`19) s43:
`BOTHWELL.A.LM,PASKIND,M..fiETH.MHIMANISHI-KARI.T.,RAJEWSKY.K. & BALTIMDFIED. (1962) NATUFI.E.%8.380-382‘
`20) IOPC315:
`BOTHWELLAL.M‘,PASKIND.M.,FIETH,MJMANISHl-KARI.T..F1AJEWSK‘I,K. & BALTIMORED, (1582) NATURE,29B.3B0-362.
`21) PLAI-13:
`EOTHWELL.A.LM.,Pa\SK|ND,M.,SCHWARTZ.HO..SONENSHElN.G.E.,GEFl'ER.M‘L E BALTIMOHED. (1981) NATUHE.290.35~67.
`
`
`
`993....-.¢.‘m..w...:-.,(-~,.
`
`Sanofi/Regeneron Ex. 1029, pg 907
`
`Mylan Ex. 1029, pg 907
`
`

`
`BODONS OF VARIABLE REGION HEAVY CHAINS
`5
`1
`2
`3
`4
`LAMBDA LAMBDA LAMEDA HG3 H11
`VH26
`VH52
`VH32
`..._
`GAG
`GTG
`GAG
`CTG
`TTG
`GAG
`TOT
`GGG
`GGA
`GGO
`TTG
`318
`OCT
`GGG
`(366
`TCC
`AG-A
`“G
`CTO
`T00
`
`o
`1
`2
`3
`It
`5
`6
`7
`8
`9
`10
`11
`1%
`14
`15
`16
`17’
`19
`‘3
`20
`21
`
`F
`F!
`1
`
`246
`
`12
`11
`10
`9
`5
`7
`6
`MOPC
`MCPC MOPC HPC MOPC
`8
`SP1
`608
`167
`76
`A6ttt’1LT EM1B-Eve
`1 07
`-HL
`___
`...-
`___
`___
`.-_
`-_.
`___
`CA6 GAG GAA GAG GAG
`GAG
`GAG
`GAG
`GTG GTG GTG GTG GTG
`GTG
`GTA
`GTA
`OAG GAG ATG AAG AAG
`AAG
`CAG
`GAG
`CTG CTG OTG CTG OTG
`GTG
`CTG
`CTG
`GTG GTG GTG GTG GTG
`GTG
`AAG
`AAG
`GAG GAG GAG GAA GAA
`GAA GAG GAG
`GAG
`TCT TCC TCT TCT
`TOT
`TCT TCT
`TCA
`TOA
`GGG GGG GGG GGA GGA
`GGA GGA
`GGA
`GGA
`GCT GGA GGA GGA GGA
`GGA GGA
`COT
`COT
`GAG GGC GGO GGC GOO G60 G90
`GOO
`GOO
`GTG TTA TTA TTG TTG
`TTG‘ TTG CTG
`CTG
`212 81% $13 $18 31% Elia‘ SK?
`852
`258
`OCT GOT OCT COT CCT
`COT COT OCC
`GOG
`GGG GGG G-GA (566 G66 G66 GGA
`TCA
`TCA
`GCC GOG GGG GOT GOT
`GGT GGA CAG
`CAG
`TCA TCC TCC TCT TCT
`TCT TCC
`AGO
`AGC
`212 $5? £1? 25? SE?
`ESE?
`‘RI?
`$23
`$53
`GTT OTC OTC CTO GTC
`CTC CTC
`ATO
`ATC
`TCC TOG TCC TCC TCC
`TCC TOG ACA
`ACA
`
`13
`J
`556
`
`19
`23
`
`20
`3
`
`21
`102
`
`22
`18
`17
`15
`15
`14
`PCH
`MPO EI1-8 S43 MOPC 186
`105
`1 1
`21
`-1
`___ ___
`———
`---
`.-— “V -—— ———
`GAG CAG GAG GAT
`CAG GAG GAG CAT DAG
`GTO GTC GTO GT6 GTG GTO GTC GTC GTC
`CAG CAA CAA OAG CAA OAA GAA CAA CA8
`OTG CTG CTA CTG CTG CTG CTG CTG OTG
`GAG CAG GAG GTG CA8 GAG GAG GAG CAKE
`OAG GAG GAG GAG GAG GAG GAG GAG CAA
`TCT OCT OCT TCT COT OCT CCT OCT TCT
`GSA GGG GGG G66 666 G662 G633 GGG GGA
`SGT GOT GOT GGA GOT ACT GOT GOT GOT
`GAG GAG GAG GGC GAG GAA GAG GAG GAG
`CTG CTT TTT
`TTA CTT CTG CTG CTG GT6
`2&2 ‘£13 218 212 $33 E18 $3 E12 21%
`COT CCT CCT OCT OCT GOT GOT OCT COT
`GGG GGG GGG BGA (366 G138 (3136 G66 GGS
`ACT GOT GOT GGG GOT GCT TCT GOT GCT
`TCA TCA TCA TCC TCA TCA TOA TCA TCA
`‘E18 E13 ‘.312 SE? 312 S13 E12 E18 E12
`ATG CTG CTG OTC CTG CTG CTG GTG )\TA
`TOG TCC TOO TCC TCC TCC TCC TCC TCC
`
`IE2 IE8 1&8 E51 IE8 I28 38 IE8 {E8
`GCT GCT GCT GOG GCT GOT G61’ GCT GOT
`GOT TOT TOT
`TCT TOT TCT TCT TCT TCT
`GSA GGC GGC GGA GGC GGC GGC GGC GGC
`TAG TAO TAO TTO TAO TAO TAG TAO TAT
`AOG AUG ACC ACT ACO ACO ACC A00 A00
`TTC TTC TTC TTC TTC TTC TTO TTC TTO
`ACT AGO ABC AGT ACC ACO ACC ACO AGA
`AAG AGO AGO AGO AGO AGO AGO AGO AGO
`TAG TAG TAC TTT
`TAO TAG TAO TAO TAO
`1?? ES H8 $53 {$3 {$8 $3 I??? 1%?
`GGT CAO CA6 CAC GAO CAO GAT CAO GAO
`__- —_— --— ———
`«—— —~— —-— --— --—
`—~— ——— ——A —--
`~—- ---
`--— --— --—
`TGG TGG TGG TGG TOG TGG TGG TGG TGG
`GTA GTC1’ GTG GTT GTG GTG GTG GTG GTG
`AAG AAG AAC CBT AAG AAG AAG AAG AN3
`GAG CAG GAG CAG GAG CAG CAG GAG CAG
`AGE AGG AGG G8;
`CAT CGA CGA AAG CGA CAA CAA CAA GAG
`881 881 5&3} 8»; am am am sec em.
`GGG GGC GGC GGG GGG G96 G89 G60 G96
`CTT CTT CTT CTG CTT CTT CTT CTT CTT
`GAG GAG GAG GAG GAG GAG GAA GAG GAG
`TGG TGG TGG TGG TGG TGG TGG TGG TGG
`ATT ATT ATT GTO ATT ATT ATT ATT ATT
`GSA GGA GGA GOA GGA GGA GGT GGA GGA
`TAC GAT GAT AGT GAT AAT TAO OAT TAT
`E4‘? 2?? 2?? 1?‘? £9? 2?‘? 2?? £$‘*?” 11$
`COT OCT COT AGT OCT OCT OCT OCT OCT
`--- --- ---
`--— ~—-- --- --— ——— --—
`——-
`--— --— --— ——— --— --— --- ---
`GGA AAT AAT
`GGG AAT GGC TCT TCT AGA
`GGT AGT AGT AGT A61’ AAT GAT GAT GAT
`GGC GGT GGT AGT GGT GGT AGT AGT GGT
`IE? 33$ E3? 2% ‘E3? ‘A33? E3128? 2%?
`AAC AAG AOG CAC AAG AAO CAC AAC AAT
`TAG TAO TAG TAT
`TAG TAC TAO TAO TAO
`AAT AAT AAT GCA AAT AAT AAT AAT AAT
`GAG GAG GAG GAG GAG GAG CAA CAA GAG
`AAT AAG CAC ACA AAG AAG AAG AAG AAG
`TTC TTC TTC GTG TTC TTG TTC TTC TTG
`AAG AAG AGG AAG AAG AAG AAG AAG AAG
`GGC AGO AGO GGC AGO AGO GAG GGC GGC
`AAG AAG AAG C-GA AAG AAG AAG AAG AAG
`GOO GOO GOO TTC GCC GTC GOO GOO GOO
`ACA AOA AOA ACC ACA ACA ACA ACA ACA
`CTG CTG OTG ATC OTG OTG TTG TTG CTG
`ACT ACT ACT
`TCA ACT ACT ACT ACT ACT
`GOA GTA ATA AGA GTA GTA GTA GTA GOA
`GAO GAO GAG GAO GAO GAC GAG GAO GAO
`ASA AAA AAA AAT ACA AAA AAA AAA ACA
`TCC COG COC COO TOO TOO TCC TCC TCC
`TOO TCC TCC AAG TCC TCC TCC TOO TCC
`AGO AGO AGO AAG
`AGO AGO AGO AGO AGO
`AOA ACA ACA ACC ACA ACA ADA ACA ACA
`GOO GOO GOO CTG GOO GOO GOO GOO GOO
`TAO TAG TAO TAG TTC TAG TAO TAO TAG TAO
`
`ATG ATG ATG ATG OTG ATG ACG ATG ATS AIS
`2?? 81% $18 8?? E13 E13 8?? 812 8458 E13
`AAC AGO AGO AGC ACC AGC AGC AGO AGO AGO
`AGO AGO AGC AGO AGT
`AGO AGO AGO AGO AGO
`CTG CTG CTG OTG CTA CTG OTG CTG OTG CTG
`AG-A AOA ADA ACA AGG ACA ACA ACA ACA A011.
`TCT TCT TCT TCT
`TCT TCT TCT TCT TCT TCT
`GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG
`GAO GAO GAG GAO GAO GAG GAO GAG GAG GAG
`TCT TOT TOT TCT AC6 TCC TOT TCT TOT TOT
`GOA GOG GOG G06 G60 GOG GOG GOG GOG GOA
`GTC ATO C-ETC GTO ATG GTC GTC GTO GTO GTC
`$22 E28 12? $2? RE $2? $2? 1'25 T25 T15
`TGT TGT TGT TGT
`TGT
`TGT TGT TGT TGT T61’
`GOA GOA GOA GOA GOA GOA GOA GOA GOA GOA
`AGA AGA AGA AGA AGA AGA AGA AGA ATA AGA
`GAT see TAG TAT
`1'66 4—— --— --— --— --—
`AGG ATT em’ GGA GGT
`--— —-— --— --— ---
`TAO TAO CTG AAC
`12$ 38? S22 E35?
`AGT AGT ---
`TAO
`AGO AGO ——-—
`TAT
`CGC
`TAU
`TTT
`———
`---
`
`
`
`§
`
`.1
`
`A
`—
`--—
`--— ———
`__-
`GAO GAG GAO GAO
`TOG TAO TAC TAO
`TGG TGG TGG TGG
`GGC GGC GGC GGT
`GAA CAA CAA CAA
`GGG GGC GGC GGO GGA
`A00 A00 ACC ACO A00
`AC-C ACA AOA ACA A00
`3?? 8% 3% 3% 3%
`GTC GTC GTC GTO GTC
`TCC TCC TCC TCC TCC
`
`TCA TOR TCA TCA TCA ——— --— --— --— ---
`
`Sanofi/Regeneron Ex. 1029, pg 908
`
`Mylan Ex. 1029, pg 908
`
`
`
`
`
`IE8
`231 $1 I38
`{$3 E31 E31 2581 ES}
`GTC
`ACT Gcc GTC
`GOA GCC GCC ACT ACT
`TCA
`TCT TOT
`TCA
`TCT TCT TCT TCT TCT
`GGG
`GGG GGA
`GGA
`GGA GSA GGA GGG GGG
`TTC
`TTO TTC TTC
`TAG TTC TTC TTC TTO
`TCA
`ACC ACT
`TOA
`ACC ACC ACT AOC ACC
`TTA
`TTG TTC TTA
`TTC TTC TTO TTG TTC
`AGO
`AGT AGT
`ACO
`AAC AGT AGT AG‘-T
`AGT
`GGC
`GAT AAC
`GGC
`AGO AGO AGO GAT GAT
`TAT
`TTC TAO TAT
`TAO TAO TAT TTC TTO
`ATG ATG
`GT
`ATG ATG ATS ATG ATG
`2?}
`W "5" 9°“ ”° ”° W’
`‘G6 “E
`AAC
`CAC CAC TCT GAG GAG
`GAG AAC
`AAC
`___
`___ ___ _. ___
`--— ___
`--— --—
`--—
`__- H- M- 4--
`--— --- —--
`--—
`TGG
`TGG TGG TGG TGG TGG
`TGG TGG TGG
`GT7
`GTG GTC GTT GTC (-370
`GT0 GTC GTT
`OGC
`CGA CGC CGC CGC CGO
`CGC CGC
`CGC
`OAG
`GAG OAA
`CAG GAG
`GAG CAG
`GAG
`COT
`GOO GOT
`OCT
`COT
`ACT TCT
`COT
`AAG
`CAA AAG
`AAG AAG
`AAG AAG
`AAG
`8%’;
`881 883
`‘$83 288
`8E8 823 E82
`GGT
`GGG GGG
`AGA AGA
`ABA GGG GGT
`CTG
`CTT CTG
`CTG CTG
`C16 GTT
`CTG
`GAG
`GAG GTO
`GAG GAG
`GAG GAG GAG
`TGG
`TGG TGG
`TGG TGG
`TGG TGG TGG
`CTG
`ATG GTO
`ATT ATT
`ATT GTT
`CTG
`GGA
`GGA TOA
`GOT GOT
`GOT GOT
`GGA
`ATC AT
`AAO AAT
`AGA AGA
`ABA AGA
`TGG
`TGG
`A” “*1
`E2?
`fig?
`E8? E1‘? 1??
`23
`AGT TTG --—
`COT AGT
`AAC AAO
`--— --—
`AAA AAG
`AAA AAA
`
`--—
`--—
`-...-
`,7-
`GOT GGT
`GOT
`---
`GGT
`GGT
`AGT GAT
`AAT AAT
`OAT
`TOT
`AAT
`GAT
`GGT G-GG
`GAT AAA
`GAT GGT
`GGT AGT
`TAT TAT
`TAT
`TAT
`GGA
`GGA
`282 23?
`R23 282
`232 E82
`28%
`23%
`AGO AOG
`GAG GAA
`GAA CAT
`GAG
`GAC
`TAG TAO
`TAO TAC
`TAO TAT
`TAT
`TAT
`GOA GOG
`AGT AGT
`AGT GOG AAT
`AAT
`GAG GAC
`GOA GOA
`GOA GAG
`TOA
`TCA
`AAG TCC
`TCT
`TCT
`TCT TCT ACT
`GOT
`TTC GTG
`GTG GTG
`GT6 GTG OTC
`OTC
`GAG AAG
`AAG AAG
`AAG AAA AAA
`AAA
`GGC GGC
`GGT GGT
`GGT GGG TCC
`TCC
`AGA CGA
`0813 G66
`CGG AGG
`AGA
`AGA
`GTO TTC
`TTC TTC
`TTC TTC
`CTG
`OTG
`AGO ACC
`ATC ATC
`ATO ACC
`ACO
`AGC
`ATG ATC
`GTC GTC
`GTC ATC ATC
`ATC
`ACO TCC
`TCC TCC
`TCC TCA A00
`A60
`AG-G AGA
`AGA AGA
`AGA AGA
`AAG
`AAG
`GAG GAO
`GAO GAC
`GAO GAT
`GAG
`GAO
`ACG AAC
`ACT ACT
`ACA GAT
`AAC
`AAC
`TCC GOG
`TCC TCC
`TCC TCC
`TCC
`TCC
`ACG AAG
`CAA GAA
`OAA
`AAG
`AAG
`AGO AAC
`AGO AGC
`AGT
`AGO
`AGO
`ACA ACG
`ATC ATC
`GTC
`CAA
`CAA
`GTO CTG
`OTC OTC
`OTC
`GTT
`GTT
`TAO TAT
`TAG TAO
`TAO
`TTC
`TTC
`
`E31
`GOG
`TOT
`GGA
`TTC
`ACC
`TTT
`AGO
`AGO
`TAT
`AT6
`‘3°°
`AGO
`--—
`-~—
`TGG
`GTC
`CGC
`GAG
`GOT
`AAG
`883
`GGG
`CTG
`GAG
`TGG
`GTO
`TBA
`ATT
`AGT
`G"
`GGT
`-A-—
`--—
`AGT
`GGT
`GGT
`iéii
`TAG
`TAC
`EBA
`GAO
`TCC
`GTG
`AAG
`GGC
`C68
`TTG
`ACC
`ATC
`TCA
`AGA
`GAC
`RAT
`TCC
`AAG
`AAG
`ACG
`CTG
`TAT
`
`CTG
`24%
`AAC
`A80
`CTG
`AGA
`GOO
`GAG
`GAC
`AC8
`(500
`GTA
`P25
`TGT
`GOG
`AAA
`___
`---
`
`TAT
`
`CTT
`fie
`AAO
`AGO
`CTG
`AGA
`GOO
`GAG
`GAO
`ATG
`GCT
`GTG
`$23
`TGT
`GCA
`ACA
`___
`---
`
`ATG CTG
`€12
`31$
`AGO AAC
`A130 AGT
`CTG GTG
`ABA AGA
`TCT GOG
`GAG GAG
`GAC GAG
`ACG ACG
`G-CC GOT
`GTG GTG
`$25 $25
`TGT TGT
`GOG GOA
`AGA AGA
`-_- ---
`___ ___
`
`AAG
`AGC
`CTG
`AGA
`GOO
`GAG
`GAO
`ACG
`GOT
`GTG
`$25
`TGT
`GTG
`AAA
`--_
`---
`
`
`
`OTT
`OTT CTT
`‘£12
`31% E12
`AAT
`AAT AAT
`GOO
`GOO GOO
`CTG
`CTG C-TS
`AGA
`AGA AGA
`GCT
`GOT GOT
`GAG
`GAG GAG
`GAO
`GAO GAC
`ACT
`ACT ACT
`GCC GCC G00
`ATT
`ATT
`ACT
`$25 $25
`$25
`TGT
`TGT
`TGT
`GOA GOA
`ACA
`AGA AGA
`AGA
`em’ AAT an
`___
`___
`ace
`TAO
`GAO
`£8?
`E2?
`AGT
`AAT
`AGO
`AGO
`——~
`r——
`TAG
`TAC
`--.
`___
`TTT
`TGG TGG
`GGG
`TAG TAO
`TAO 7——
`TTC TTC
`TTO
`
`
`
`TTA
`TTA
`212
`2’+‘8
`AAC
`AAO
`AGT
`AGT
`CTG
`OTG
`CAA
`CAA
`ACT
`ACT
`GAT
`GAT
`GAO
`GAO
`ACA
`ACA
`GOO
`GOO
`AGG
`AGG
`$23
`$28
`TGT
`TGT
`GOO
`GOO
`AGA
`AGO
`em ___
`TOA
`___
`ATT
`12$
`TAO
`GGT
`CGT
`AGO
`GAG
`AAA
`TAO
`TTO
`———
`$3
`,,_ W,
`GAG
`GAT GAO
`GAT GAT
`GTO TAO TAG
`GT0 GTC
`TGG TGG TG6
`“N36
`TOG
`GGC GGC
`GGT
`G60 G60
`GOA CAA CAA
`GBA GOA
`G66 G68 G66 GGG
`GGA
`ACC ACO
`ACO ACO
`ACO
`A00 ACO
`AGO ACA ACT
`3?? $93
`8?? 8% 2%
`GT6 GTC
`GTC GTO GTO
`TCC TCC
`TCC TCC TCC
`TCA TCA
`TCA TCA TCA
`
`
`--—
`---
`—-»
`——— ———
`
`———
`
`33
`24
`25
`26
`27
`28
`29
`30
`31
`32
`34
`33
`35
`35A
`3513
`36
`37
`38
`39
`40
`43
`2.4
`44
`45
`1&6
`47
`46
`49
`51
`52
`5°
`52A
`528
`52C
`53
`54
`55
`2?
`SB
`59
`60
`61
`62
`63
`34
`65
`66
`67
`38
`69
`70
`71
`72
`73
`?4
`75
`76
`77
`78
`79
`
`R1
`
`3
`
`2
`g
`
`3
`*1
`2
`
`F
`R
`3
`
`C
`D
`H
`S
`
`90
`3%
`82A
`328
`52C
`B3
`84
`85
`56
`S7
`68
`89
`3?
`92
`98
`94
`95
`95
`9?
`33
`100
`100A
`1808
`1000
`100D
`1005
`100F
`100G
`00.!
`$1‘
`100K
`101
`102
`103
`104
`105
`106
`10?
`F
`110
`5 133
`111
`112
`113
`
`11
`
`

`
`DODOHS OF VARIABLE REGION HEAVY CHAINS (confd)
`28
`24
`25
`26
`27
`28
`29
`30
`V11
`V13
`1 86-2
`145
`V10
`POH
`PCH
`V1
`108A 1068
`GAA(570
`CAGCTG
`GAGGAGTOA
`GGACOT
`GAGCTGGTG
`AAGCOT
`GGCGOTTCA
`GTGAAG
`ATAAGC
`TGCAAG
`GOT
`TCT
`GATTABTCA
`TTC
`ACT
`GGC
`TACATCATG
`AAC
`
`GAGGTG
`AAGCTG
`GTGGAGTOT
`GGAGGA
`GGCTTGGTA
`GAGOCT
`G66G61’TCT
`CTGAGA
`OTCTGCTGTGCAACT
`
`TCT
`GGG
`TTCADC
`TTC
`ACT
`GAY
`TAOTAGATG
`AGO
`
`GAG
`GTGAAGGT6
`ATGGAGTOT
`GSAGGA
`GGCTTG
`GTAGAGOCT
`GGGGCTTCT
`CTGAGA
`OTCTOOTGTGAAGOT
`
`TCT
`GGA
`TTCACO
`TTC
`ACT
`GAT
`TACTAGATG
`AGO
`
`CAG
`GTOCAA
`CTG
`GAGGAGOCT
`G66GCT
`GAGCTT
`GTG
`AAGOCT
`GGGGCTTCA
`GTGAAG
`CTGTOGTGCAAGGOT
`TOT
`GGGTAOADC
`TTC
`AGO
`AGC
`TAGTGGATG
`CAC
`
`TGG
`GTC
`CGCGAG
`GOTCGGAGG
`AAGGOAGOTGAG
`
`TGG
`GTG
`AAGGAG
`AGGCOTGSA
`CGAGGCCTTGAG
`
`
`
`wmuosuvawmao
`
`1112
`1314
`‘IS16
`171819
`20212223
`24
`25
`25272B
`29
`30
`31
`323334
`35SSAS56
`35
`37
`38
`394041
`44454847
`48
`49
`505152
`52A
`52B52C
`
`*1:-n
`
`—mUo
`
`Nam
`
`GAGGTOGAGCTT
`GAGGAGTGA
`GGACCT
`GAGCTGGTG
`AAAOCT
`GGGGGCTCA
`GT6AAG
`ATA
`TCCTGCAAG
`GOT
`TGT
`GSA
`TACACA
`TTC
`ACT
`GAC
`TAGAAOATG
`SAC
`TGGGTG
`AAGGAG
`AGCCAT
`GGA
`AAGAGOCTTGAG
`
`TGG
`ATT
`GGA
`TATATT
`TAT
`OCT
`TAGAAT
`GGTGGT
`ACTGGC
`
`Mmun
`
`01:91»
`
`area
`
`3333;
`
`
`
`GAG
`GTGAAG
`CTG
`GTGGAATOT
`GGAGGA
`GGGTTGGTA
`GAGOCT
`GGGGGTTCT
`OTGAGA
`GTOT00T61‘GSAACT
`
`TCT
`GGG
`TTCACO
`TTC
`AGT
`BAT
`TTCTAOATG
`GAG
`TGGGTO
`(260CAG
`OCTGCA
`GGG
`AAGASAGTG
`GAG
`TGG
`ATT
`GCT
`GOAAGT
`AGA
`AAC
`AAA
`GETAATGAT
`TATACA
`ACAGAGTAG
`AGT
`GOATCT
`GTGAAG
`GGT
`CGGTTC
`ATCGTC
`TCC1AGAGAGACTTOO
`CAA
`AGOATC
`CTCTAC
`CTTGAG
`ATGAAT
`GCC
`CTGAGAGOT
`GAGGAO
`ACTGCCATT
`TATTAC
`TGTGOA
`AGA
`GAY
`
`31
`V
`3207.1
`GAG
`GTGAAGCTG
`GTGGAATOT
`GGAGGA
`G60TTGGTA
`GAGCOT
`GGGGGTTCT
`CTGASA
`CTCTCCTGTGOA
`
`ACT
`TCT
`G6-G
`TTCACC
`TTC
`AGT
`GAT
`TTCTACATG
`GAG
`
`33
`M0
`101
`
`GAG
`GT6GAGCTG
`AAG
`GAGTCA
`GGACCT
`GGCCTGGT6
`GAGBOG
`TGAGAGAGC
`CTGTOG
`ATCAOCTGCACA
`GTO
`TCT
`GGTTTCTCA
`YTA
`ACT
`ACC
`TATGGTGTA
`
`82
`V3
`
`GAGGT6AAGGTG
`GT6GAGTC-T
`GGAGGA
`GGCTTGGTA
`GAGOCT
`G66GGTTCT
`CTGAGA
`OTC
`TOGTGTGCA
`TOT
`TOT
`GGG
`TTCACO
`TTC
`ACT
`GAT
`TAGTAOATG
`AAC
`
`TGG
`GTC
`CGCCAG
`OCTCCA(366
`AAGAGACTG
`GAG
`TGG
`ATT
`GCT
`GOAAGT
`AGA
`AAC
`AAAGOTAATGAT
`T AT
`ACAACA
`GAGTAO
`AGT
`GOATCT
`GT6AAG
`G-GT
`CGGTTC
`ATCGTO
`TCCAGASAC
`
`TGG
`GTC
`GAOC-GGOCT
`66A
`GE-G
`AAGGCACTT
`GAG
`TAG
`TTGGOT
`TTGATT
`AGA
`AAC
`AAAGOTAAT(SGT
`TAOATAACA
`GAGTAG
`AGT
`GOATCTATG
`AAG
`GGT
`CGGTTC
`ACGATC
`TOGAGAGATAATTOG
`CAA
`AGOATC
`OTCTAT
`CTTCAAATGAACACA
`CTGABC
`1*
`GAGGAO
`AGTGCCACTTAT
`TAC
`TGTGOA
`AGA
`GAT
`
`37
`VH4-$1
`
`33
`PMU3
`
`249
`
`35
`BCL1
`
`34
`SP
`T15
`
`GAG
`GTGAAGCTG
`GTGGAATOT
`GGAGGA
`GGOTTGGTA
`GAGOCT
`G66G61’
`‘TEST
`CTGASA
`OTC
`TCCTGTGCAACT
`TCT
`GGGTTCACG
`TTC
`AGT
`GAT
`TTCTAOATG
`GAG
`
`TGG
`GTO
`CBCCAGCCT
`OCAGGG
`AAGAGACTG
`GAG
`TGG
`ATT
`GOT
`GCAAGT
`ASA
`AAC
`AAA
`GOTAATGAT
`TATACAACA
`GAGTAC
`AGT
`GOATCT
`GTGAAG
`GGT
`CGGTTC
`ATCGTO
`TCCAGAGAGACT
`TOO
`CAA
`AGOATG
`OTCTAO
`CTTGAGATGAAT
`G60
`0TGAGA
`GOT
`GAGGAO
`ACT
`GCCATTTATTAO
`TGT
`GOAAGA
`GAT
`
`SS
`9367
`CR!-r
`GAGGTTGAG
`CTT
`GAGCAGTCT
`GGAGCT
`GAGCTGGTG
`AGGGUT
`GGGTCC
`TCA
`GTGAAG
`ATG
`TOGTGCAAG
`GOT
`TOT
`GGATATACA
`TTC
`ACA
`AGO
`TAOGGTATA
`AAC
`
`TGG
`GT6
`AAAGAGAGG
`CUT
`GGA
`GAG
`GGCCTGGAA
`TGG
`ATT
`GGA
`TATATT
`AAT
`OCT
`GGAAAT
`
`GGTTATAATAACTAO
`AAT
`GAGAAGTTC
`AAG
`EGO
`AAGACCACACTG
`ACTGTAGAC
`AAATCC
`TCC
`AGOACA
`GOGTAC»
`ATG
`CAGCTCAGAAGO
`CTGACATOT
`GAGGAG
`TOT
`GOAGTE:TATTTC
`TGT
`GOAAGA
`TOGCAT
`TAGTAT
`GGTGGTAGO
`TAC
`GAGTTT
`
`
`
`Sanofi/Regeneron Ex. 1029, pg 909
`
`Mylan Ex. 1029, pg 909
`
`AAT
`
`TCC
`
`TGG
`ATT
`GGA
`AGGATTGAT
`OCT
`AATAGT
`GGT
`GGTACTAAGTAO
`GAGAAGTTCAAG
`AGC
`AAGSCC
`ACACTG
`ACTGTAGACAAACOG
`AGOACAGCCTAG
`ATGGAGOTC
`AGCAGO
`GT6ACATGT
`GAGGAG
`TCTGOGGTOTATTAT
`TGTGOAAGA
`
`AGT
`
`TGG
`TTG
`GOT
`TTGATT
`AGA
`AACAAA
`GOTAATGGC
`TAT
`ACAACAGAGTAT
`AGTGOATOTGTEAAG
`GOATCTGTETAAG
`GGT
`GGT
`CGGTTCACO
`CGGTTCACC
`ATC
`ATO
`TOGAGAGAT
`TCOAGA
`GATAA‘?
`AATTOT
`TGC
`CAA
`CAA
`AACATGOTCTAT
`AGOATC
`CTCTAT
`CTTCAAATG
`GTTCAAATG
`AACAC0
`AACAC0
`CTGAGA
`CTG
`AGAGOTGAGGAO
`GOTGAGGOG
`AGTG00
`AGTG00ACTTATTAG
`ACTTATTAG
`TGTGOAAAA
`TGTGGA
`AGA
`GAT GAT
`
`TGG
`GTC
`CGCGAG
`OCTCCA
`GGA
`AAGGSACTT
`GAG
`TGG
`TTG
`GGT
`TTT
`ATT
`AGA
`AAC
`AAA
`GCTAATGGT
`TAG
`ACAACA
`GAGTAG
`
`TGG
`GTG
`AAGGAG
`AGOCATGGA
`AAGAGOGT1’GAA
`
`TGG
`ATT
`GGA
`GAAATT
`AAT
`COT
`TAOAAT
`GGT
`GGTACT
`AGOT A0
`AACGAGAAG
`TTCAAG
`GGC
`AAGGOOACA
`TTG
`ACTGTAGAO
`ACATCC
`TCC
`AGOACAGOGTAC
`ATGGAGOTC
`GAO
`AGO
`CTG
`
`ACATCTGAGGAO
`TCTTTGC-ETCTATTAO
`TGTGOA
`AGA
`
`l\l\I l\|1|
`
`4-:~:~4~adlmozavmmcnmmmmchmmmmm.2-«arc-o<ocn~:a>01bonmdo«ac:-uazmAt»
`
`
`
`
`
`§88$83$8898333Sfififig§:!§%98
` IVIII aI>|xIu
`:-:31:
`
`

`
`250
`
`SOURCE: CODONS OF VARIABLE REGION HEAVY CHAIN5
`1) LAHBDA VHZB: HUMAN FOETAL LIVER
`2) LAHIDA VH52: HUMAN FOETAL LIVEFI
`3) LAHIDA VH32: HUMAN FOETAL LIVER
`4) HG3: HUMAN FETAL LIVEQ
`5) H11: HUMAN PLACENTA
`6) SP1»!-IL: MOUSE CDNA
`7) S107: MOUSE CDNA 3: GERMLINE
`B) IICPCO03: MOUSE ADULT
`9) IAOPCIFI: MOUSE (IONA
`10) NPC73: MOUSE CDNA
`11) HOPC111 ADULT: MOUSE ADULT
`12)
`lIOPC141 EfiRYO: MOUSE EMBHYO
`13) .1558: MOUSE CDNA
`14) HPC11: MOUSE MRNA
`15) 81-5: MOUSE ADULT
`16) S43: MOUSE ADULT
`17) MOPOQ1: MOUSE ADULT
`1B) 1I6-1: MOUSE EMBFIYO
`19) 23: MOUSE EMBRYO
`E) 3: MOUSE EMBRYO
`21) 102: MOUSE EMBHYO
`2:2) PCH105: MOUSE EMBFIYO
`23) P6111001: MOUSE EMBHYO
`24) PCPIWBB: MOUSE £MBfiY0
`25) V1: MOUSE SPERM
`26) V11: MOUSE SPERM
`27) V13: MOUSE SPERM
`28) 130-2: MOUSE EMBHYO
`29) 145: MOUSE EMERYO
`30) V10: MOUSE SPERM
`31) \I32|)7.1: MOUSE SPERM
`32) V3: MOUSE SPERM
`33) M5101: NEWBOHN MOUSE
`34) SFT15: MOUSE SPERM
`353 ECL1: MOUSE B-OELL LYMPHOMA
`353 9367 CRI+: MOUSE LIVER
`37) VHM1: MOUSE EMBRYO
`38) PHIJS: RABBIT ADULT SPLENIC GDNA
`REFERENCE: CODONS OF VARIABLE REGION HEAVY CHAINS
`1) LAHBDA V1126: RABB|TT8,T.H.,BEN1'I.EV.D.L.DUNNlGK.W..FOHSTER.A..MATH-I‘YSSENS.G. B. MlLSTEIN.C. (1930) COLD SPRING I-IARB.SY|aIP.QUANTI.BlOI.,
`45.867-B18.
`(CHECKED BY AU?)-IOR 12109159); MATTHYSSENSB. A RABBlTfS,T.H. (1980) FFIOC.NAT.ACAD.SC|.USA,77,B561-6585.
`2) IAIIBDA W152: RABBWTS.T.H..BENTLEV.D.L,DUNNICK,W..FOHSTER,A.,MAT|'H‘YS3ENS,G. B. MILSTEIMC. (1960 COLD SPRING HAFIB.SYMP.QUANTI.BlOL,
`45.857-B78.
`(CHECKED B\" AUTHOR 170918)); MA1'1'H‘ISSEN3,G. 8. RABBl1‘TS,T.H. (1930) PRGCNATA AD.SGl.USA,77,65E1-6565.
`3) LAIBDA VHS2: RABBI1'l'S,1',H..BENTLEY.D.1_,DUNN|CK,W.,FOFISTER.A..MATTHYSSEN$.G. 8- MILSTEIMC. (1980) COLD SPRING HARB.SYMP.QIJANTI.BK)l...
`45,667-378.
`(CHECKED BY AUTHOR 12109153): MATl"HY5SENS,G. 8- RAB8ITTS.T.)-I. (1990) PHOC.NAT.ACAD.SCl.USA.77,$661-6565.
`4) mil: REG!-IAVI,G.,BAM..D..GLAZER.L,.ZAKUT.FL 8: GI‘/0L,D. (1963) PROC.NAT.ACAD.SCLUSA.
`IN PRESS.
`fiECHAV|,G.,BIENZB..RAM.D.,BEN~NEF|lAH.Y..COHEN.J.B.,2‘AKUT.fi. & GIVOLD. (1932) PROD.NAT.ACAD.SGl.USA,79,4405—44fl9.
`5) H11:
`6) SP1-OIL: RABB|1T5.T‘H.,MATT)-IYSSENS.G. 3; HAMLYN.F‘.H. (1960) NATURE.284.238-248.
`7) S107: EARLY.P..HUANG.H.,DAVlS.M..GN.AME.l(. & HOOD.L. (1980) CELL.19.9B1-892.
`8) IGFOM8:
`EARLY.P..HUANG.H..DAV|S.M,,CALAME.I<. & I-<l00D.L. (1980) CELL.19,981—Q52.
`9) MOP0181: EARLYJ’..HUA.NG,H..DAV|S.M.,CALAME.K. & HO0D.L. (1980) CEL|..19.9'S1-992: KIM.‘-3..DAV|S.M..SlNN.E..PATTEN.P. & HO0D,L. (1%1) CELL27.
`573-531.
`*
`10) HPC7G: BEHNARDD. S. GOUGH.N.M. (1950) PROC.NAT.ACAD.SCI.USA.77.3350-3634.
`17) KOPC‘I41 ADILT: SAKAND,H.,MAKl,Fl..KUROSAWA,V..fiOEDEH.W. & TONEGAWAS. (1980) NATURE.286,5?6«683.
`12) IOPC141 EIIBRYO:
`SAKANO.H..MAK|.F\..K.UHDSAWA.Y4.FIOEDEfl‘W. S TONEGAWA3‘ (I980) NATUHE.286.8T5-B83.
`13) .1558: NEWELL.N.(fi|CHAFIDS,J1E.,‘l'UCKER,F'.W. 5 B1J°«'lTNER,F.Fl, (I930) 5ClENCE.2D9.1126-1132,
`14-) HPCI1:
`ZA.KUT.R,COHEN,~L 8- GWOLJ3.
`[19flU‘) NUCLACID5 RE5..B,3551-3501.
`15) 31-I:
`5OTH‘NELL,A,L.M..F'ASK|ND,M..F|ETH.M.,EMANISHI-KAH|‘T._R»'4.JEWSKY,|1‘. & BALTIMORED. (1981) CELL2I.625-BS7.
`16) 513: BOTHWELL.A.LM..PASK|ND.M..FIETH,M.,IMANiSHI-KAF||.T..FlAJEWSK‘t',K. E EALT|MOFIE,D.
`[19-B1) GELL.24.6Z5~B37.
`17) IOPG21:
`BDTHWELL.A.L.M..FASKIND‘M.)HETH.M.)|MANlS’Hl—KAFII_T,RAJEWSK'V.K.
`:81 BALTIMOFIEI), (1331) GELL24.E25-B37
`18) ‘I31: BOTHWELLA.L.M ,PASKIND.M.‘FlETH,M_JMANlSHPKAH|,'f,,FI.-KJEWSKYJVV 3- B-ALTIMBHED.
`(19311 CELL.24,525~537-
`19) 23: BOTHWELL.A..LM..F'A5KlND.M,,fiETH.M1.IMANkSHi-KAFlI.T,.FIF.JEWSK"I.K. B: BALTIMOFIED. (1981) CELL2-1.625-B7.
`20) 3: BDTHWELLA L,M.,PASKlND_M,RETH‘M,,|MANIISHI-KAFII,'T,,FU\..|EW$K.Y.K 5 EIALT|MC>FIE,D, (1931) CELL?-1,825-637.
`21)
`IEI1: BOTHWELL.A.L.M..F'ASK|ND,M.,RETH.M..|MANlSHl~KAFII,T,.FIAJEWSKYK. & BALTIMDHED. (1581) CELLV2-1.625-H7.
`22) PCH105: C0HEN.J‘B.)EFFRONJL4HECHAVLG"BEN-NEH|AH‘Y.1Zo°<KUT.F). 5 GIVOLJJ. (1932) NUCLACIOS FIES..10.335S»337D.
`Z3) PIZHHIIA: GIVOLD..ZAI€UT.R‘.EFFfi.0N,K.,FIECHAV|.G1.F|AM.D. & C0HEN,.|.E1 (I981) MATlJF1E,292.426-430.
`24) PCHNIIB: GlVOLD..ZAKUT.FI.EFFHON.K..FIECHAVl.G,.RAMJJ. 81 CdHEN.J.B. (1381) NA1’L|F1E.29-2.426»-1301
`25) V1: CFIEWSS GFIIFFINA,HUANG,H.,CALAME.K‘ E HOOD.L,