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`""5
`T:
`AsU-$LfiEPsN?TMENTQ3§HEALTH
`
`__3AE
`=-"'“.""*'-".!."."..A.".'.°.E"“"'1‘E.°.
`TRP
`T7?!‘
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`FEE‘
`GLY
`-
`GLY
`-
`.
`.
`gt? GL~P@]|c Health fifivlce
`THE lmloflallnstltutesfim Health
`Lvs
`Lew
`Leu
`LEU
`VAL
`VAL
`VAL
`VAL
`V
`sen
`THH
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`THR
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`
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`
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`TIME
`THR
`
`,
`SFR
`
`Genzyme Ex. 1029, pg 905
`
`

`
`
`
`
`
`
`
`SEQUENCES OF PROTEINS OF
`IMMUNOLOGICAL INTEREST
`
`Elvin A. Kabst, Tai Te Wu, Howard Bilofsky.
`Margaret Reid-Miller, and Harold Perry
`(1983)
`
`Page;
`
`#
`
`Eggata
`
`6;
`15;
`
`20 Position -1 of 145'CL (precursor heavy chains) should be Phe.
`35
`31
`Pau and Paul are the same protein.
`
`54; 204
`205
`
`The antibody specificities for 10K44-7A1
`10K26-12A1
`and
`light chains) should by anti-p-azobenzene arsonate.
`
`65;
`
`References for HOPC1, J698, H2061, S176,
`chains)
`should be weigert, M., Cesari
`.
`(1970) Nature, 228. 1045-1047.
`
`light
`lambda
`and H2020 (mouse
`I.M., Yonkovich. S.J. & Cohn, M.
`
`References for H3159 and MOPC
`12 Cesari.
`I.M. & Weigert, M.
`2112-2116.
`
`be
`should
`511 (mouse lambda light chains)
`(1973) Proc. Natl. Acad. Sci. U.S.A., 70.
`
`2
`3
`13
`
`26
`27
`
`65;
`
`66;
`
`67;
`
`J558. XS104.
`completely.
`(mouse lambda
`compositions.
`
`(mouse
`S178
`and
`light
`lambda
`sequenced
`chains) were
`while HOPC1.
`J69B. H2061.
`light
`chains) were
`S176, H2020. W3159. and MOPCE11
`analyzed by
`amino
`acid sequence
`
`chains)
`light
`(1981) Fed. Proc., 40. 1098
`
`The statement in the notes of
`genes has been determined
`be
`replaced by
`“There
`are
`J2—C2—J4-C4."
`
`and MAB-13
`, E.w., Jr.. Steiner, L.A.
`
`lambda
`(mouse
`& Eisen, H.N.
`
`"The order of
`mouse lambda light chains,
`as V1—J3-C3—J1-C1-V2—J2-C2-J4-C4," should
`two
`linkage groups:
`J3-C3-J1-C1
`and
`
`111;
`
`168;
`168;
`
`185;
`
`246;
`
`23 Positions 13 and 14 of CAM (human heavy chain subgroup
`Gln and Lys respectively.
`
`III)
`
`should
`
`be
`
`30 Position 171 of S43'CL (light constant chain) should be Asn.
`35 Positions 142 and 143 of MOPC315 (light constant chain)
`ser
`be
`should
`and Gly respectively. based on the translation from nucleotide sequences
`(Bothwell. A.L.M., Paskind, M., Roth, M.,
`Imanishi-Kari. T., Rajewsky.
`K.
`& Baltimore, D.
`(1982) Nature, 298, 380w382; wu, G.E., Govindi. N.,
`Hozumi. N. & Murialdo, H.
`(1982) Nucl. Acids Res., 10. 3831-3843).
`of MOPC173
`52 Positions 258 and 263
`chain)
`have
`revised by the authors
`
`been
`
`The position numbering for the codens of
`chain variable
`light
`should read as 95. 95A, 95B, 95C,
`95D, 95E. 95F. 96. and 97.
`
`region
`
`The human kappa J-segments (Hieter. P.A., Maizel. J.V ., Jr. & Leder,
`(1982) J. Biol. Chem.. 257, 1516-1522) are as follows
`41
`12
`13
`ii
`
`J5
`
`P.
`
`
`
`
`
`Genzyme Ex. 1029,
`
`pg 906
`
`Genzyme Ex. 1029, pg 906
`
`

`
`SEQUENCES OF
`
`PROTEINS OF
`
`IMMUNOLOGICAL
`INTEREST
`
`Tabulation and Analysis of
`Amino Acid and Nucleic Acid Sequences of
`
`Precursors, V-Regions, C-Regions, J-Chain,
`
`B2—Microglobulins, Major Histocompatibility Antigens,
`Thy-1, Complement, C-Reactive Protein, Thymopoietin,
`Post-gamma Globulin, and a2-Macroglobulin
`
`1 983
`
`Elvin A. Kabat*, Tai Te WUT, Howard Bilofsky 1,
`Margaret Reid-Mi/Ieri, and Harold Perryi
`
`‘Depts. of Microbiology, Human Genetics and Development, and Neurology, Cancer Center]
`Institute of Cancer Research, College of Physicians and Surgeons, Columbia University, New
`York, NY 10032 and the National Institute of Allergy and Infectious Diseases, Bethesda, MD
`20205
`
`T Depts. of Biochemistry, Molecular Biology, and Cell Biology, and Engineering Sciences and
`Applied Mathematics, Northwestern University, Evanston, IL 60201 and the Cancer Center,
`Northwestern University Medical School, Chicago, IL 60611
`I Bolt Beranek and Newman |nc., Cambridge, MA 02238
`
`The collection and maintenance of this data base is sponsored through Contract N01-RR-8-2118
`by the following components of the National Institutes of Health, Bethesda, MD 20205:
`Division of Research Resources
`National Cancer Institute
`National Institute of Allergy and Infectious Diseases
`National Institute of Arthritis, Diabetes, Digestive and Kidney Diseases
`National Institute of General Medical Sciences
`
`U.S. DEPARTMENT OF HEALTH
`AND HUMAN SERVICES
`
`Public Health Service
`National Institutes of Health
`
`A
`
`(1 983)
`
`runs HEALTH scusmcms LIBRARY
`__-.....-..-..-u-nu: n1:I
`I1A1'T‘E'nD'MTA
`TIMITS
`
`Genzyme EX. 1029, pg 907
`
`Genzyme Ex. 1029, pg 907
`
`

`
`Our listing of sequences will be kept up to date. Investigators are invited to send additional
`sequence data when accepted for publication. Send two copies of the manuscript together with
`a letter of acceptance from a journal to:
`
`Dr. E.A. Ka_bat
`National Institutes of Health
`Building 4, Room 337
`9000 Rockville Pike
`Bethesda, Maryland 20205
`
`If a computer tape is available, please send it to facilitate entering sequences.
`
`when published, three reprints should be provided.
`
`If any published sequences have been overlooked or if any errors are found, please bring them to
`our attention.
`“
`
`Genzyme Ex. 1029, pg 908
`
`Genzyme Ex. 1029, pg 908
`
`

`
`246
`
`11
`11
`
`12
`L6
`
`13
`12
`
`14
`L7
`
`
`
`
`
`———
`
`———
`
`———
`
`———
`
`___
`---
`11c ___
`001 ,2-
`001 ___
`000 ___
`A00 ___
`AA0 5-,
`010 ___
`0A0 "2
`010 ___
`___ 5,.
`AAA ———
`CGT CGT ——— -A— -—-
`
`--_
`110
`00A
`000
`000
`Acc
`AA0
`010
`0AA
`A1A
`__
`AAA
`CGG
`
`F
`R
`'
`
`C
`D
`H
`1
`
`1:
`R
`2
`
`0
`3
`2
`
`F
`H
`3
`
`C
`D
`H
`3
`
`F
`R
`4
`
`
`
`___
`11c
`00A
`000
`000
`A00
`AA0
`010
`0AA
`A1A
`___
`AAA
`———
`
`
`
`CODONS OF VARIABLE REGION LIGHT CHAINS
`21
`20
`19
`13
`17
`16
`15
`10
`9
`B
`7
`6
`1
`2
`3
`4
`5
`543 MOPC PLAI
`10309
`1019
`1099
`PKAPPA
`HK101 HK102 MOPC MOPC MOPC MOPC K2A MPC MDPC s1o7
`315
`-19
`(11124 mMa1:1A LAMBDA LAMBDA
`41
`21
`107
`149
`11
`1735
`a
`(K2)
`---
`---
`00A
`_-_
`-——
`---
`___
`___
`___
`___
`___ ___
`.._-
`___ ___ ___ _-_ -——
`___
`___
`0
`0A0
`0A0
`0A0
`0A0
`0A0
`0A0
`0A0
`AA0
`GAT
`0A0
`0A0 0A0
`0A0
`0AA 0A0 0A0 0A0 0A0
`0A0
`0A0
`1
`001 001
`A11
`001
`001
`001
`A10 A11
`A11
`ATC A10 A11 ATC AA1 A10 A10 ATC A10
`A10
`A10
`2
`011 011
`010
`0A0
`01A 010
`0A0
`0A0 010 0A0
`010 AA0 AA0 110 110
`011
`011
`011
`0A0
`3 we
`010 010
`A10
`A10
`A1A A10 A10 010 A10
`010 A10 A10 010 010 A10
`010
`010
`010
`A10
`4
`A10
`ACT ACT
`AC5
`ACC
`ACC
`ACT ACT ACC ACC
`ACC ACC ACC ACT ACT
`ACC
`ACT
`ACT
`ACT
`ACC
`5
`ACC
`0A0
`0A0
`0A0
`0AA
`CAG
`0A0
`0A0 0AA cA0
`0A0 0A0 0A0 0A0 0A0
`0A0
`CAG
`CAG
`0A0
`0A0
`5
`CA6
`0AA 0AA
`101
`101
`0A1
`101 101 101
`101
`101 101 101 101 101
`101
`0AA
`0AA
`0AA
`101
`7
`101
`101 101 101
`ccA 000
`0AA
`00A 00A 000 00A 00A 00A 00A 00A 00A 0A0
`101
`101
`101
`001
`5
`c0A
`00A 00A 00A
`100
`AAA
`010
`00c 000 001 100
`00A 101 101 000 000
`AAA
`00A
`00A
`00A
`100
`9
`100
`—— ——— ——
`101:
`100
`1c0
`100 100 101
`100 A1A 100 100 A10 A10
`110
`___
`———
`___
`A00
`1o
`TCA
`010 010 010
`11A A10
`AA1
`01A CTA 110 11A A10 A10 A10 010 010 A10
`010
`010
`010
`010
`11
`010
`A00 ACC Acc
`101
`100
`001
`101 101 001
`101
`001 1A1 1A1 101 101
`100
`A00
`A00
`A00
`101
`12
`101
`A0A A0A AcA
`000
`A10
`010
`00A 00A 010 000 000 GCA 00A 010 010
`AcA
`A0A
`A0A
`AcA
`00A
`13
`00A
`10A 10A 10A
`101
`10A A01
`101 101 101 101
`101 101 101 A01 A01
`TCA
`10A
`10A
`10A
`101
`1.1
`101
`001 001
`001
`010
`01A 101
`010 010 01A 010 010 01A 01A ccA 00A 01A
`001
`001
`001
`15
`01A GTA
`001
`001 001
`15
`00A
`00A 00A 00A 00A 001
`001 000 00A 000 00A 00A 00A 00A 00A
`001
`001
`001
`0AA 00A 0AA
`11
`0.40
`011::
`0A4
`0A0
`0AA
`0AA 0AA 0A0
`0AA 0A0 0A0 0A0 0AA 0AA
`0Ac
`0AA
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`AcA A0A A0A
`15
`Am.
`A0A
`A0A
`A00
`TAC
`A01 A01 A00 AGA AA0 A0A A0A A0A A0A A00
`A0A
`A0A
`A0A
`010 010 010
`19
`011:
`01c
`511:
`010
`011
`01c 010 000 010 010 010 010 010 010
`010
`010
`010
`010
`A0A A1A A0A
`2a
`A00
`A00
`A01
`A00
`100
`A00 A00 ACC A01 A00 A01 A01 A01 A01 A00
`A0A
`A1A
`A0A
`010 010 010
`21
`A10
`A10
`010
`110
`A10
`A10 A10 A1A 010 A10 A10 A10 110 110 A10
`010
`010
`010
`A01 A01 A01
`22
`A01
`A01
`A01
`ACC
`100
`A0A A0A 100 A01 A00 101 A01 100 100 A00
`A01
`A01
`A01
`101 101 101
`23
`101
`100
`101
`100
`100
`101 101 100 100 100 100 100 100 100
`100
`101
`101
`101
`000 000 000
`24
`000
`000
`000
`AA0
`00A 00A A0A 000 A01 AA0 AA0 A00 A00
`AA0
`000
`000
`000
`10A 10A TCA
`25
`000
`000
`00A 000
`00A 00A 00:: GCA 000 000 000 000 000
`000
`TCA
`10A
`10A
`A01 A01 A01
`29
`A00
`A01
`A01 A01
`A01 A01 A01 A01 A00 A01 A01 A01 A01 A01
`A01
`A01
`A01
`———
`———
`——-
`———
`———
`———
`--—
`v——
`v—— AGT ———
`_-_ ___ ——— ——v ———
`———
`———
`———
`——-
`A01 A01 A01
`3% 0A0
`0A0
`0A0
`0A0
`000 000 0AA 0A0
`10A 0A0 0A0 0A0 0A0
`0A0
`ACT
`A01
`ACT
`___
`___
`___
`27B
`———
`_5_ W-
`-_,
`___
`___ 011 _-_
`___
`___ ___ ___ ___ —~
`———
`_--
`___
`___
`———
`___
`270
`———
`GAT
`___
`___
`___
`000 000 ___
`270
`--_
`A01
`000
`000
`000
`001 001 001
`2715
`,,,
`___
`001
`001
`001
`011 011 011
`___
`___
`___
`___
`27F
`___
`---
`011
`011
`011
`A0A A0A A0A
`AA1
`A01
`0A1
`0A0 A01 0A0 0A0 A00 A00
`29
`001
`AA1 AA1 1A1
`ACA
`A0A
`A0A
`A01 A01 A01
`010
`A11
`010
`29
`A11
`A11 A11 000 A11
`ACT
`A01
`A01
`01A A11 A11 A11 A11
`A01 A01
`-5-
`011
`A01
`AGT
`30
`A00
`cAc
`CAC AA1
`cA1 A01 AA1 AA1 000 000
`AGT
`A01
`001
`AA0 AA0
`___
`A01
`A00
`31
`A00
`AA1 AA1 A01 001 100 A00 AGC A0A AcA A01
`AA0
`AA0
`AA0
`1A1
`1A1 _"
`A00
`1A1
`100
`32
`100
`1A1
`1A1 111 1A1
`AGT 1A1 1A1 AGC A00
`A01
`1A1
`1A1
`1A1
`000 000 ___
`11A 011
`110
`:33
`11A
`11A 11A A10
`11A 1Ac 11A 11A A1A A1A
`010
`000
`000
`000
`AA0 AA0
`AA0
`10
`000
`34
`000
`00A 00A 0A0 AA0 110 A00 A00 0A0 0A0
`000
`AA0
`AA0
`AA0
`100 100
`100
`100
`100
`as
`100
`100 100 100 110 cAc 100 100 100 100
`100
`100
`100
`100
`010 A10
`011
`1A1
`1A1
`35
`1A1
`1A1
`1A1 1A0 111
`100 110 110 1A1 TAT
`1A1
`010
`011
`010
`0AA 0AA
`0A0
`cAA
`0A0
`37
`0A0
`0A0
`0A0 0A0
`0A0
`1A0 0A0 0A0 0A0 0A0
`0A0
`0AA
`0AA
`0AA
`0AA 0AA
`0A0
`0A0
`0A0
`35
`0A0
`CAG 0A0 0A0
`0A0
`0A0 0A0 0A0 0AA CAA
`CAG
`0AA
`0AA
`0AA
`AAA AAA _ _
`0AA
`AAA
`AAA
`99
`AAA
`AAA AAA AAA
`AAA
`0A0 AAA AAA A0A A0A
`AAA
`AAA
`AAA
`AAA
`00A 00A _ _
`00A 00A 00A
`40
`00A
`0A0
`0A0 00A 00A AA0 00A 00A A0A A0A
`00A
`00A
`00A
`00A
`0A1
`0A1
`-
`-
`000
`0A1
`0A0
`41
`0A0
`00A 00A 00A 001 10A 000 000 AA1 AA1
`000
`0A1
`0A1
`0A1
`0A1
`0A1
`_ _
`AAA
`00A 0AA
`42
`AAA
`AAA AAA 0A0
`0AA 000 AA0 AAA 001 001
`0AA
`0A1
`0A1
`0A1
`11A 11A - _
`00::
`A01
`101
`49
`00c
`101 101 00A A01
`001 101 101 101 101
`101
`11A
`11A
`11A
`110 110 - 2
`001
`A11
`001
`44
`001
`001 001 000 A11 100 001 cc1 00A 00A 001
`110
`110
`110
`A01 A01
`5 -
`AA0
`AAA
`AAA
`45
`AA0
`0A0
`0A0 AAA AAA
`ccc AA0 AA0 A00 A00
`AAA
`A01
`A01
`A01
`001
`001
`- _
`010
`000
`010
`45
`100
`010 010 010 0A0 AAA A00 A00 011 011
`01A
`001
`001
`001
`01A 01A 5 _
`010
`010
`11A
`47
`010
`010 010 010 010 00c cm 010 010 010
`010
`01A
`01A
`01A
`A1A A10
`-
`-
`A10
`A10
`A11
`43
`A10
`010 010 ATC A10 110 01c A10 A1A A1A A11
`A1A
`A1A
`A1A
`001
`001 _
`1A1
`1A0
`1A0
`49
`1A1
`1A1
`1A1 1A1
`1A1 A11 1A1 1A1 AA0 AA0
`1A1
`001
`001
`001
`001
`001
`0A1
`000
`000
`50
`001
`AA1 AA1 001 0AA 0A1 001 001 AA1 1A1
`100
`001
`001
`001
`Acc A00
`51
`00A 000
`A0A
`000
`00A 00A 00A A0A A00 00A 00A 001 001
`00A
`A00
`A00
`A00
`AA0 A00
`52
`100
`100
`100
`100
`AAA AAA 100 100 A0A AA0 AA0 101 101
`100
`AA0
`A00
`AA0
`AA0 AA0
`53
`A01
`A01
`A01
`AA0
`A00 A00 AA0 AA1
`100 A0A A0A 0A0 0A0
`1A0
`AAC
`AA0
`AA0
`00A 00A
`54
`110
`110
`11A 000
`11A 11A 01A 11A AA0 110 110 100 101
`000
`00A
`00A
`00A
`001 001
`55
`0AA
`0AA
`0A1
`1A0
`00A 00A 0AA 0A1
`010 01A 01A A10 A10
`1A0
`001
`001
`001
`00A 00A
`50
`A01
`A01
`101
`ACT
`0A1
`0A1 101 101
`001 0A1 0A1 101 101 A01
`00A
`00A
`.00A
`001 001
`57
`000
`000
`001
`000
`001
`001 000 001
`101 000 000 000 000
`00A
`001
`001
`001
`011 011
`5a
`010
`010
`010
`010
`010 010 A10 010 00A 010 010 A10 A10
`010
`011
`011
`011
`001 001
`59
`00A
`00A ccc
`ccc
`00A 00A 001 00A 010 00A 00A 001 001
`000
`001
`001
`001
`000 010
`so
`10A
`10A
`AAA
`0A1
`10A 10A 000 AAA CCA 10A 10A 100 100
`0A1
`000
`010
`000
`A0A A0A
`51
`A00
`A00
`A00
`c0c
`A00 A00 A00 A00
`001 A00 A00 A00 A00
`000
`A0A
`A0A
`A0A
`110 110
`52
`110
`110
`110
`110
`11c 110 110 110
`000 110 110 111 111
`110
`110
`110
`110
`10A 10A
`59
`A00
`A00
`A01
`AcA
`A01 A01 A01 A01
`110 A01 A01 A01 A01
`A0
`10A
`10A
`10A
`000 000
`54
`000
`000
`000
`001
`000 000 000 000 A01 000 000 000 000
`000
`000
`000
`000
`100 100
`55
`AGT
`A01
`A01
`A01
`A01 A01 A01 A01 000 A01 A01 A01 A01 A01
`10c
`100
`010 010
`55
`GGA
`00A
`A00
`00A
`00A 00A 000 A00 A01 00A 00A 00A 00A 00A
`010
`010
`A11 A11
`57
`101
`101
`101
`101
`1cA 1cA 101 101
`000 101 101 10A 10A 101
`A11
`A11
`513
`000
`000
`000
`00A
`00A 00A A00 000 101 000 000 000 000
`000
`00A
`00A 00A 00A
`59
`A0A
`AcA
`10A AcA
`A0A ACA A0A 10A 000 0AA cAA A0A A0A A00
`0A0
`0A0
`0A0
`0A0
`70
`0A1
`0AA
`0A1
`0AA
`0A1 0A1
`GAT
`AA0
`AA0
`AA0 AA0
`71
`110
`110
`1A1
`1A1
`111 1A1
`110
`001
`001
`001 001
`72
`A01
`A01
`101
`101
`101 101
`A01
`000
`000
`000 000
`73
`010
`010
`010
`010
`010 010
`110
`010
`010
`010 010
`74
`A00
`A00
`A00
`AA0
`A00 A00
`A00
`A00
`A00
`A00 A00
`75
`A10
`ATC
`A10
`A10
`A10 A10
`A10
`ATC
`A10
`A10 A10
`75
`A00
`A00
`A00
`AA0
`A00 A00
`A00
`AcA
`A0A
`A0A A0A
`77
`A00
`A00
`A00
`AGC
`A00 A00
`A01
`000
`000
`000 000
`7a
`010
`010
`011
`010
`010 010
`010
`00A
`00A
`A0A 00A
`79
`0A0
`0A0
`0A0
`0A0
`0A0 0A0
`0A0
`0A0
`0A0
`0A0
`0A0
`so
`001
`001
`101
`001
`001
`A01
`A01
`A01 A01
`a1
`0AA
`0A1
`0AA
`0AA
`0AA
`0A0
`0A0
`0A0
`0A0
`92
`0A1
`0A1
`0A1
`0A1
`0A0
`0A1
`0A1
`0A1
`0A1
`33
`111
`111
`111
`111
`01A
`GAG
`0A0
`0A0
`0A1
`54
`00A
`00A
`01A
`000
`00A
`00A
`00A
`00A 00A
`as
`A01
`A01
`0Ac
`A01
`011
`A1A
`A10 A10
`as
`1A1
`1A1
`1A1
`1A1
`1A1
`1A1
`1A1
`1A1
`57
`1A0
`1A0
`1A0
`1A0
`1A0
`110
`11c 110
`as
`100
`100
`101
`101
`101
`101
`101 101
`as
`0AA
`0AA
`01A
`0AA
`0A0
`001
`001 001
`9c
`cA0
`0A0
`0AA
`0A1
`0AA
`01A
`01A 01A
`91
`1A1
`1A1
`1A1
`111
`0A1
`100
`100 100
`92
`AA1
`AA1
`001
`100
`1A1
`1A0
`1A0 110
`99
`A01
`A01
`A01
`A01
`A01
`A00
`A00 A0A
`94
`1A0
`1A1
`101
`A01
`A01
`AA0
`AA0 AA0
`95
`001
`0A1
`0A1
`95
`___
`___
`111
`97
`- —
`~--
`011
`537A
`_ _
`___
`___
`973
`_
`-
`___
`970
`,
`,
`970
`_
`_
`___
`9715
`, 0
`-__
`975
`- _
`___
`915
`_ _
`99
`- -
`11:0
`- -
`101
`_
`-
`1o2
`___
`1oa
`104
`105
`105
`1osA
`107
`105
`
`_
`:3
`1
`
`*
`1
`
`
`
`
`
`~—-
`
`___
`_
`_
`_ _
`_ _
`- _
`- _
`_ 5
`-
`-
`_ _
`---
`W-
`-
`-
`_ -
`- -
`_ -
`— —
`—--
`
`———
`110
`001
`GGA
`00A
`A00
`AAA
`010
`A01
`010
`01A
`GGT
`———
`
`___
`———
`110 110
`001 000
`00A 001
`001
`00A
`A00 A00
`AAA AA0
`010 010
`A01 A01
`010 010
`01A 01A
`GGC GGT
`—-«- —--
`
`___
`———
`———
`
`--_
`———
`———
`
`Genzyme Ex. 1029, pg 909
`
`
`
`
`
`
`Genzyme Ex. 1029, pg 909
`
`

`
`247
`
`SOURCE: OODONS OF VARIABLE REGION LIGHT CHAINS
`1) HK10I: HUMAN FOETAL LIVER
`2) HI(1l)Z: HUMAN FOETAL LIVER
`3) MOPC41: MOUSE ADULT
`4) MOPC21: MOUSE MRNA FROM MOFCZ1
`5) IIOFC167: MOUSE ADULT
`6) MOPC149(K2): MOUSE EMBRYO E PLASMOCYTOMA
`7) K2A: MOUSE EMBRYO
`8) MPC11: MOUSE PLASMACYTOMA
`Q) Il0PC17SB: MOUSE PLASMACVTOMA
`10) S1073: MOUSE EMBRYO
`11) T1: MOUSE ADULT
`12) L6: MOUSE ADULT LIVER
`18) T2: MOUSE ADULT, ABNORMAL J OMITTED
`14) L7: MOUSE ADULT LIVER
`15) PKAPPA(11)2l: MOUSE MRNA FROM MPC11
`16)
`IGBBLAIBDA: MOUSE EMBRVO
`17) IG13LAHBDA: MOUSE EMBRYO
`18)
`IGSIIEILAIIBDA: MOUSE ADULT
`19) S43: MOUSE ADULT
`20) MOPC315: MOUSE ADULT
`21) PLAI-13: MOUSE ADULT
`
`REFERENCE: CODONS OF VARIABLE REGION LIGHT CHAINS
`1) HK1Il1: EENTLEY.D.L. G: HABB|TTS.T.H. (1980) NATURE.288.73D-733.
`2) HK102: EENTLEY,D.L 8 FIABBl'|'I'S,T.H. (1980) NATURE.288.730-733.
`3) MOPCI1:
`SEIDMAN.-J.G..MAX.E.E. 8: LEDER,P. (1979) NATURE,180.37'0-375.
`.,9.4485-4494.
`(1979) BIOCHEMBIOPHYS.RES.COMMUN..9D.832-8417 HAMLYN.P.H.,GA|T,M.J. 8: M|LSTElN,C. (1981) NUCLACIDS
`4) MOPC2'1:‘:EsFONG.K.LE|,A. E SALSEFLW.
`5) MOPC187:
`JOHO,R..WE|SSMAN.LL..EARLY.P..COLE.J. 8 HOOD.L.
`(1980) PROC.NAT.ACAD.SCI.USA.77,1106-1110.
`6) MDPC149(K2): NlSHlOKA.Y. Ex LEDER,P. (1980) J. Bl0L.CHEM..255.3691-3694.
`7) I(2A: NlSHl0KA.Y. & LEDER,P. (1980) J.B|DL.CHEM:,255.3691-8694.
`8) MPC11:
`SE|DMAN.J.G. E. LEDER,P. (1950) NATURE,285,779—783.
`9) MOFC17lB: MAX.E.E..SE|DMAN.J.G.,MILLER.H. 8 LEDER,P.
`(1980) CELL.21.793-799.
`10) 51073: KWAN,S.P.,MAX.E.E..SEIDMAN,J.G.,LEDER,P. 8 SCHARFF.M.D. (1981) CELL,2S,57-66.
`11) T1: ALTENBURGER.W.,STEINMETZ.M. 8- ZACHAU,H.G. (1980) NATURE.287.603-607,
`12) L8:
`PEOH.M..HOCHTL,J.,SCHNELLH. 8 ZACHAU,H.G.
`(1981) NATUFlE,291,86B-670.
`13) T2: ALTENBUFIGER,W.,STE|NME|'Z.M. 8: ZACHAU.H.G. (1980) NATURE.287,B03-607.
`14) L7:
`PECH,M..HOOHTL.J..SCHNELLH. 8 ZACHAU,H.G. (1981) NATURE,291,668-670.
`15) PKAPPA(11)2A:
`FIABBITTS,T.H.,HAMLYN,P.H.
`Eu MA'|'fHYSSENS.G.
`(1980) CAN.J.B|OCHEM..55.176-187.
`16) IGOBLAHBDA: BEFlNARD.O..HOZUM|,N. & TONEGAWA,S.
`(1978) CELL.15,1138-1144.
`17) IG13LAHBDA: TONEGAWA.S..MAXAM,A.M..T|ZARD.FL.BEFlNAHD,O. E G|LBERT.W.
`(1978) FFIOC.NAT.ACAD.SCl.U$A.75.1485-1489.
`18) IBIISLAHIDA: BEFlNARD,0..HOZUM|,N. 8 TONEGAWA.S.
`(1978) GELL.15,1139-1144.
`19) S48: BOTHWELL.A.LM.,PASK|ND.M..RETH,M..IMANISHI-KAR|,T..RAJEWSKY.K. Bu BALTlMORE,D. (1982) NATUR.E.298.380-382.
`20) HOPC315: EOTHWELLA.L.M..PASKlND.M.,RETH,M..|MAN|SHI-KAR|.T..RAJEWSKY,K. G: BALTIMORE.D. (1982) NATURE,2%.3B0-382.
`21) PLAI-13: BOTHWELL,A.L.M.,PASKlND,M.,SCHWARTZ,R.C..SONENSHE|N.G.E.,GEFI'ER.M.L. & BALTIMORE,D. (1981) NATUFIE,290.65-87.
`
`"
`
`Genzyme Ex. 1029, pg 910
`
`Genzyme Ex. 1029, pg 910
`
`

`
`GODONS OF VARIABLE REGION HEAVY CHAINS
`5
`1
`2
`3
`4
`LAMBDA LAMBDA LAMBDA HG3 H11
`v1-125
`VH52
`VH32
`_-.
`GAG
`GTG
`CAG
`GTG
`TTG
`GAG
`TCT
`GGG
`GGA
`GGG
`TTG
`GTA
`GAG
`GGT
`GGG
`GGG
`TGG
`GTG
`AGA
`TGG
`GTG
`TGT
`GGA
`GGG
`TGT
`GGA
`TTG
`AGG
`TTT
`AGG
`TAT
`AGG
`GGG
`ATG
`AGG
`2-2
`——A
`TGG
`GTG
`GAG
`GGG
`GGT
`GGA
`GGG
`AAG
`GGG
`GTG
`T
`G33
`GTG
`TGA
`GGT
`ATT
`AGT
`GGT
`2-2
`2..
`AGT
`GGT
`GGT
`AGG
`AGA
`TAG
`TAG
`GGA
`GAG
`TGG
`GTG
`AAG
`GGG
`GGG
`TTG
`AGG
`ATG
`AGA
`TGA
`GAG
`AAT
`TGG
`AAG
`AAG
`AGG
`GTG
`TAT
`
`F
`1
`Fl
`
`C
`R
`1
`
`E
`2
`
`S
`R
`2
`
`O
`1
`2
`3
`4
`5
`s
`7
`s
`9
`10
`11
`12
`13
`14
`15
`15
`17
`15
`10
`21
`20
`22
`2:4
`24
`25
`2e
`27
`2a
`29
`so
`32
`a1
`as
`34
`as
`35A
`3513
`as
`a7
`as
`aa
`40
`41
`42
`43
`44
`45
`47
`‘G
`46
`49
`so
`51
`52
`52A
`523
`520
`53
`54
`55
`56
`57
`50
`59
`so
`61
`s2
`63
`s4
`65
`es
`s7
`ea
`69
`71
`70
`72
`73
`7
`7s
`75
`77
`73
`79
`
`TAT
`
`246
`
`s
`s1=1
`-1-11.
`
`13
`J
`553
`
`15
`14
`MPC 31-3
`11
`
`19
`23
`
`20
`3-
`
`21
`102
`
`22
`1a
`17
`1e
`PCH
`18::
`s43 MOPC
`105
`-1
`21
`——— ——— ——— ———
`--— ——r
`___ ___
`GAG GAG GAG GAT GAG GAG GAG GAT GAG
`GTG GTG GTG GTG GTG GTG GTC GTG GTG
`GAG GAA GAA GAG GAA GAA GAA GAA CAG
`GTG GTG GTA GTG GTG GTG CTG CTG CTG
`GAG GAG GAG GTG GAG GAG GAG GAG GAG
`GAG GAG GAG GAG GAG GAG GAG GAG GAA
`TGT GGT GGT
`TGT
`GGT GGT GGT GGT TCT
`GGA GGG GGG GGG GGG GGG GGG GGG GGA
`GGT GGT GCT
`GGA GGT AGT GGT GGT GGT
`GAG GAG GAG GGG GAG GAA GAG GAG GAG
`GTG GTT TTT
`TTA GTT GTG GTG GTG GTG
`GTA GTG GTG GTG GTG GTG GTG GTG GTG
`AGA AAG AAG GAG AAG AAG AGG AAG AAG
`GGT GGT GGT GGT GGT GGT GGT GGT GGT
`AGT GGT GGT
`GGG GGG GGG
`TGA TGA TGA TGG TGA TGA TGA TGA TGA
`GTG GTG GTG GGG GTG GTG GTG GTG GTG
`AAG AAG AAG AAA
`AAG AAG AAG AAG AAG
`TGG TGG TC
`ATG GTG CTE
`Age
`TGG TGG TGC TGT
`TGG TGG TGG TGG TGG
`AAG AAG AAG
`GGA AAG AAG AAG AAG AAG
`GGT GGT GGT
`GGG GGT GGT GGT GGT GGT
`GGT TGT TGT
`TGT TGT TGT TGT TGT TGT
`GGA GGG GGG GGA GGG GGG GGG GGG GGG
`TAG TAG TAG TTG TAG TAG TAG TAG TAT
`AGG AGG AGG AGT
`AGG AGG AGG AGG AGG
`TTC TTG TTG TTG TTC TTG TTG TTG TTC
`AGT AGG AGG AGT
`AGG AGG AGG AGG AGA
`TAG TAG TAG TTT
`AAG AGG AGG AGG Afig Agg AGE AGG ITAcAag
`TGG TGG TTA GGA TGG TGG TGG TGG TAT
`ATA ATG ATG ATG ATG ATG ATG ATG ATA
`GGT GAG GAG GAG GAG GAG GAT GAG GAG
`-2-
`-2- 2-2
`-22
`222 222 2--
`--— ---
`222 222 222
`2-— 2--
`--— --— --— --—
`TGG TGG TGG TGG TGG -res TGG TGG TGG
`GTA GTG GTG GTT GTG GTG GTG GTG GTG
`GAG GAG GAG GAG GA
`A
`A
`AAG AAG AAG GGT AAS 6A2 3A2 322 32g
`AGG AGG AGG GGT AGG AGG AGG AGG AGG
`CCT GGT GGT GGA GGT GGT GGT GGT GGT
`GGA GGA GGA GAG GGA GGA GGA GGG GGA
`GAT GGA GGA AAG GGA GAA GAA GAA GAG
`GGG GGG GGG GGG GGG GGG GGG GGG GGG
`GTT GTT CTT CTG GTT GTT GTT CTT CTT
`
`G83 G33 G83 G83 G83 G83 $88 G83 G33
`ATT ATT ATT GTG ATT ATT ATT ATT ATT
`GGA GGA GGA GGA GGA GGA GGT GGA GGA
`GAT AGG AGG TAG AGG AAT AAG AGG TAT
`ATT ATT ATT ATT ATT ATT ATT ATT ATT
`TAG GAT GAT AGT GAT AAT TAG GAT TAT
`GGT GGT GGT AGT GGT GGT GGT GGT CCT
`_
`_ _ 2..
`.2.
`-2-
`-2- 22- 222 222
`22- 2--
`___
`222
`222 2-- 2-.
`-..- ___
`GGA AAT AAT GGG AAT GGG TGT TGT AGA
`GGT AGT AGT AGT AGT AAT GAT GAT GAT
`GGG GGT GGT AGT GGT GGT AGT AGT GGT
`TTT GGT GGT AGG GGT GGT GAA GAT AGT
`AGT AGT AGT GTG AGT AGT AGT AGT AGT
`AAG AAG AGG GAG AAG AAG GAG AAG AAT
`TAG TAG TAG TAT
`TAG TAG TAG TAG TAG
`AAT AAT AAT GGA AAT AAT AAT AAT AAT
`GAG GAG GAG GAG GAG GAG GAA GAA GAG
`AAT AAG GAG AGA AAG AAG AAG AAG AAG
`TTG TTC TTG GTG TTC TTG TTC TTG TTG
`AAG AAG AGG AAG AAG AAG AAG AAG AAG
`GGG AGG AGG GGG AGG AGG GAG GGG GGG
`AAG AAG AAG GGA AAG AAG AAG AAG AAG
`GGG GGG GGG TTG GGG GTG GGG GGG GCC
`AGA AGA AGA AGG AGA AGA AGA AGA AGA
`GTG GTG GTG ATG GTG GTG TTG TTG GTG
`GGA
`TA ATA
`3?} 3%: 811;);
`AGT 313T AGT TEA
`GAG GAG GAG GAG GAG GAG GAG GAG GAG
`AGA AAA AAA AAT AGA AAA AAA AAA AGA
`TGG GGG GGG GGG TGG TGG TGG TGG TGG
`AGG AGG AGG AAG A C A C
`TGG TGG TGG AAG Tgc Tgc
`AGA AGA AGA ACC AGA AGA AGA AGA AGA
`GGG GGG GGG GTG GGG GGG GGG GGG GGG
`TAG TAG TAG TAG TTG TAG TAG TAG TAG TAG
`
`
`
`TAT
`AAT
`TGA
`GGT
`GTG
`AAA
`TGG
`AGA
`GTG
`AGG
`ATG
`AAG
`AGG
`GAG
`AAC
`TCC
`AGG
`AAG
`GAA
`GTT
`TTG
`
`12
`11
`10
`9
`e
`7
`MOPC
`MCPC MOPC HFC MOPC
`s
`141
`503
`167
`75
`141
`107
`ADULT EMBRYO
`___
`___
`___
`___
`___
`___
`.1._
`GAG
`GAG
`GAG GAG GAA GAG GAG
`GAG
`GTG GTG GTG GTG GTG
`GTG
`GTA
`GTA
`GAG GAG ATG AAG AAG
`AAG
`GAG
`GAG
`GTG GTG GTG GTG GTG
`GTG
`GTG
`GTG
`GTG GTG GTG GTG GTG
`GTG
`AAG
`AAG
`GAG GAG GAG GAA GAA
`GAA GAG
`GAG
`GAG
`TGT TGG TCT TGT
`TGT
`TCT
`TCA
`TGA
`TGT
`GGG GGG GGG GGA GGA
`GGA GGA
`GGA
`GGA
`GGT GGA GGA GGA GGA
`GGA GGA
`GGT
`GGT
`GAG GGG GGG GGG
`GGG
`GGG GGG
`GGG
`GGG
`GTG TTA TTA TTG TTG
`TTG‘ TTG GTG
`GTG
`AAG GTT GTG GTA GTA
`GTA GTG GTG
`GTG
`AAG GAG AAG GAG GAG
`GAG GAA
`GGG
`GGG
`GGT GGT GGT GGT GGT
`GGT GGT
`GGG
`GGG
`GGG GGG GGG GGT GGT
`GGT GGA
`GAG
`GAG
`GGG GGG GGA GGG GGG
`GGG GGA
`TGA
`TGA
`TGA TGG TGG TGT
`TGT
`TCT
`TCC
`AGG
`AGG
`GTG GTG GTG GTG GTG
`GTG ATG GTG
`GTG
`AAG AGA AAA AGA AGA
`AGA AAA
`TGG
`TGG
`TGG TGG TGG TGG TGG
`TGG TGG AGA
`AGA
`GTT GTG GTG GTG GTG
`GTG GTG
`ATG
`ATG
`TGG TGT TGT TGT
`TGT
`TGT
`TGT
`TGG
`TGG
`AAG GGA GGA GGA GGA
`GGA GTT
`AGG
`AGG
`GGA GGG GGG AGT AGT
`AGT GGG
`GTG
`GTG
`TGT TGT TGT TGT TGT
`TGT TGT
`TGA
`TGA
`GGA GGA GGA GGG GGG
`GGG GGA
`GGA
`GGG
`TAG TTG TTG TTG TTG
`TTG TTG TTG
`TTG
`AGG AGG AGT AGG AGG
`AGG AGT
`TGA
`TGA
`TTG TTG TTG TTG TTG
`TTG TTG TTA
`TTA
`AAG AGT AGT AGT AGT
`AGT AGT
`AGG
`AGG
`TAG TAG TAT TTG TTG
`TTG TAG TAT
`TAT
`AGG AGG AGG GAT GAT
`GAT AAG
`GGG
`GGG
`TAT TGG GGG TAG TAG
`TAG TGG GGT
`GGT
`ATG ATG ATG ATG ATG
`ATG ATG GTG
`GTA
`GAG GAG TCT GAG GAG
`GAG AAG
`AAG
`AAG
`222 222 222 222
`222
`222
`22-
`2——
`2.-
`___ 2--
`.2- 22-
`———
`———
`»——
`~~-
`-22
`TGG TGG TGG TGG TGG
`TGG TGG TGG
`TGG
`GTG GTG GTT GTG GTG
`GTG GTG GTT
`GTT
`GAG GAA
`GAG GAG
`GAG GAG
`GAG
`GAG
`GGA GGG GGG GGG GGG
`GGG GGG
`CGC
`GGG
`GGG GGT
`GGT GGT
`AGT TCT
`GGT
`GGT
`CCT GGA
`GGA GGA
`GGA GGA
`GGA
`GGA
`GGA GGG
`GGG GGG
`GGG GAG
`GGA
`GGA
`GAA AAG
`AAG AAG
`AAG AAG
`AAG
`AAG
`GGG GGG
`AGA AGA
`AGA GGG GGT
`GGT
`GTT GTG
`GTG GTG
`GTG GTT GTG
`GTG
`TGG TGG
`TGG TGG
`TGG T
`T
`T
`GAG GTG
`GAG GAG
`GAG G33 G33
`G33
`ATG GTG
`ATT ATT
`ATT GTT
`GTG
`GGA TGA
`GGT GGT
`GGT GGT
`GGA
`ATA GGT
`GGA GGA
`GGA GAA
`AGG
`ATG ATT
`AGT AGT
`AGT ATT
`ATA
`AAG AAT
`AGA AGA
`AGA AGA
`TGG
`GGT AGT
`AAG AAG
`AGT
`TTG —
`222 .2.
`AAA AAG
`AAA AAA
`2-.
`222
`GGT GGT
`GGT
`.2.
`222
`AGT GAT
`AAT AAT
`GAT
`TGT
`GGT
`GGT GGG
`GAT AAA
`GAT GGT
`AAT
`GGT AGT
`TAT
`TAT
`TAT
`TAT
`GGA
`AGG AGG
`AGA AGA
`AGA GGA
`AGG
`AGA AGA
`AGA AGA
`AGA AGA
`AGA
`AGG ACG
`GAG GAA
`GAA GAT
`GAG
`TAG TAG
`TAG TAG
`TAG TAT
`TAT
`GGA GGG
`AGT AGT
`AGT GGG
`AAT
`GAG GAG
`GGA GGA
`GGA GAG
`TGA
`AAG TGG
`TGT
`TGT
`TGT
`TGT
`AGT
`TTG GTG
`GTG GTG
`GTG GTG GTG
`GAG AAG
`AAG AAG
`AAG AAA
`AAA
`GGG GGG
`GGT GGT
`GGT GGG
`TGG
`AGA GGA
`GGG GGG
`GGG AGG
`AGA
`GTG TTG
`TTG TTG
`TTG TTG
`GTG
`AGG AGG
`ATG ATG
`ATG AGG
`AGG
`ATG ATG
`GTG GTG
`GTG ATG
`ATG
`AGG AGA
`AGA AGA
`AGA AGA
`AAG
`AGG TCC
`TCC TCC
`TGG TGA AGG
`GAG GAG
`GAG GAG
`GAG GAT
`GAG
`AGG AAG
`AGT AGT
`AGA GAT
`AAG
`TGG GGG
`TGG TGG
`TGG TGG
`TGG
`AGG AAG
`AGG AGG
`AGT AGT
`AGG
`AGG AAG
`GAA GAA
`GAA AAA
`AAG
`AGA AGG
`ATG ATG
`GTG AGT
`GAA
`GTG GTG
`GTG GTG
`GTG GGT GTT
`TAG TAT
`TAG TAG
`TAG TAG TTG
`A
`A
`A
`A
`A
`STE EGG
`3T3 STE
`STE SIG II?
`AGG AAG
`AAT AAT
`AAT AAG
`AAG
`GTG ATG
`ATG ATG
`ATG ATG ATG
`AGG AGT
`GCC GGG
`GGG AAG AGT
`AGA AGA
`AGA AGA
`GAA
`GTG GTG
`GTG GTG
`GTG TTA GTG
`TGT GGG
`GGT GGT
`AGT
`GAG GAG
`GAG GAG
`GAT
`GAG GAG
`GAG GAG
`GAG
`GCC GGT
`GGG GGG
`GGG
`AGG AGG
`AGT AGT
`AGA
`GTG GTG
`ATT ATT
`AGG
`TAT TAT
`TAT
`TAT
`TAG
`TAG TAG
`TAG TAG
`TAG
`TGT TGT
`TGT
`TGT
`TGT
`GGG GGA
`GGA GGA
`GGG
`AGA AGA
`AGA AGA
`AGG
`2-2 2-2
`GAT AAT
`GTG
`.2.
`.22
`___
`.2.
`TCA
`ATT
`TAT
`TAG
`TAG
`GGT
`GGT
`AGG
`AAA
`GAG
`TAG
`TTG
`
`U11‘
`AAG
`ATG
`AGT
`GAA
`GTG
`AGT
`GAT
`GAG
`GGG
`AGA
`AGG
`TAG
`TAG
`TGT
`GGG
`AGA
`2-2
`22.
`222
`2--
`___
`22-
`___
`
`-2-
`2--
`___
`__
`-22
`222
`
`813
`AAG
`ATG
`AGG
`AGA
`GTG
`GGG
`GAG
`GAG
`GGG
`ACG
`GTA
`TAT
`TAG
`TGT
`GGG
`AAA
`--—
`___
`
`EU
`AAG
`ATG
`AGG
`AGA
`GTG
`GGG
`GAG
`GAG
`GGT
`ATG
`GTG
`TAT
`TAG
`TGT
`GGA
`AGA
`___
`___
`
`AAG
`AGG
`AGA
`GTG
`GGG
`GAG
`GAG
`GGT
`AGG
`GTG
`TAT
`TAG
`TGT
`GTG
`AAA
`___
`2.2
`
`F
`Q‘
`
`3?
`a2A
`32
`023
`53
`a2G
`04
`as
`as
`aa
`e7
`as
`90
`91
`92
`gs
`94
`95
`96
`97
`ea
`99
`100
`100A
`1003
`1000
`100F
`100G
`1
`100.1
`‘$.”
`100K
`101
`102
`103
`104
`105
`106
`107
`F
`105
`R
`4 we
`110
`111
`112
`11a
`
`C
`D
`H
`3
`
`€713 813
`813 313 E33 31% SIG 313 S38 €713
`AAG AGG AGG AGG
`AGG AGG AGG AGG AGG AGG
`GTG GTG GTG GTG ATG GTG CTC GTG GTG GTG
`AGG AGG AGG AGG AGT AGG AGG AGG AGG AGG
`AGA AGA AGA AGA AGG AGA AGA AGA
`A
`GTG GTG GTG GTG GTA GTG GTG GTG 23‘; C32
`TGT TGT TGT TGT
`TGT TGT TGT TGT TGT TCT
`GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG
`GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG
`GGA GGG
`G
`TGT TGT
`Ecg
`GTG ATG
`GTG GTG GTG GTG GTG
`TAT TAG
`GAT TAT TAT TAT TAT
`TAG GAG
`TAT TAT TAG TAG TTG
`TGT TGT
`TGT TGT TGT TGT TGT
`GGA GGA
`GGA GGA GGA GGA GGA
`AGA AGA
`AGA AGA AGA ATA AGA
`GAT GGG
`--— --— --— --— --—
`Ace ATT
`___ ___ ___ ___ ___
`TAG TAG
`TGG TAG
`TAG AAT
`TTC AGT
`222 AGG
`GGG
`TAG
`___
`TTT
`___ ___
`
`
`TCA TGA TGA TCA TCA 222 2-2 222 222 2-2
`
`222
`1:;
`222
`222
`222
`GAG
`GAG
`GAT
`GTG TAG TAG
`TGG TGG Tee
`GGG GGG GGT
`GGA GAA
`GAA
`GGG GGG
`GGA
`AGG AGG
`AGG
`AGG AGT
`TGA
`GTG GTG GTG
`AGG AGA
`AGT
`GTG GTG GTG
`TGG TGG TGG
`TCA TCA TcA
`
`.2.
`.2-
`___
`___
`___
`
`
`
`-2-
`222
`222
`
`-22
`-22
`.2.
`2-2 .2.
`GAT GAG GAG GAG GAG
`GTG TGG TAG TAG TAG
`TGG TGG TGG TGG TGG
`GGG GGG GGG GGG GGT
`GGA GAA GAA GAA GAA
`GGG GGG GGG GGG GGA
`AGG AGG AGG AGG AGG
`AGG AGT AGT AGT
`TGA
`GTG GTG GTG GTG GTG
`AGG AGA AGA AGA AGG
`GTG GTG GTG GTG GTG
`TGG TGG TGG TGG TGG
`
`- _
`2 _
`2 2
`— —
`— —
`— —
`— —
`— —
`
`
`
`Genzyme Ex. 1029, pg 911
`
`Genzyme Ex. 1029, pg 911
`
`

`
`D
`1
`2
`3
`4
`5
`8
`7
`B
`9
`10
`11
`12
`13
`14
`15
`16
`17
`18
`19
`20
`21
`22
`23
`24
`25
`
`28
`:9
`29
`30
`31
`32
`34
`33
`
`30
`
`32
`
`249
`
`35
`
`37
`
`33
`
`GAT
`$52
`TTT
`AGT
`AGA
`TAC
`ATG
`TGG
`
`CDDONS OF VARIABLE REGION HEAVV CHAINS (cDrIt'd)
`36
`34
`33
`31
`2.3
`24
`25
`26
`27
`28
`29
`CFII+
`T15
`101
`3207
`DBA
`06
`FMU3
`9SG7 VH441
`BCL1
`SP
`MC
`V3
`V
`V10
`145
`186-2
`V13
`V11
`V1
`“PCH
`1PCI-BI
`.1
`-
`———
`_-— _ _
`___ ___ -__ ———
`___ ___ ___
`___
`___ ..-_ _-_
`———
`———
`GAG GAA GAG GAG GAG CAG GAG GAG GAG GAG CAG GAG GAG GAG
`GAG
`———
`GTC GTC GTG GTG GTG GTC GTC GTG GTG GTG GTG GTG GTT GTT
`GTG
`CAG
`GAG CAG AAG AAG AAG CAA CAA AAG AAG AAG CAG AAG GAG GAG
`AAG
`TCA
`CTT GTG CTG CTG GTG GTG CTG CTG CTG CTG CTG CTG CTG CTT
`CTT
`GTG
`GAG GAG GTG GTG ATG GAG GAG GTG GTG GTG AAG GTG GAG GAG GTC
`AAG
`GAG CAG GAA GAG GAG GAG GAG GAA GAA GAG GAG GAA GAG GAG
`GAG
`GAG
`TCA TCA TCT TCT TGT GGT CGT TGT TGT TCT TCA TGT TGT
`TGT
`TGT
`TGG
`GGA GGA GGA GGA GGA GGG GGG GGA GGA GGA GGA GGA GGG GGA
`GGA
`GAG
`GGT CGT GGA GGA GGA GCT GCT GGA GGA GGA CGT GGA CGT GGT
`GGT
`GGA
`GAG GAG GGG GGC GGG GAG GAG GGG GGC GGG GGG GGG GAG GAG
`GGC
`GGT
`CTG CTG TTG TTG TTG CTT GTT TTG TTG TTG GTG TTG GTG CTG
`GTG
`CTC
`GTG GTG GTA GTA GTA GTG GTG GTA GTA GTA GTG GTA GTG GTG
`GTG
`TTC
`AAA AAG CAG GAG CAG AAG AAG GAG CAG CAG CAG GAG AGG AGG
`GAG
`AAG
`OCT GGT GCT GCT GCT GGT CGT GCT GGT CGT GGC GGT GGT GCT
`CGT
`GGA
`GGG GGG GGG GGG GGG GGG GGG GGG GGG GGG TGA GGG GGG GGG
`GGA
`ATG
`GGC GCT GGT GGT GCT GCT GGT GGT GGT GCT GAG GGT GTO TCC
`GGA
`GAT
`TCA TCA TCT TCT TCT TCA TCA TCT TCT TCT AGG ‘TCT TC-A TCA TCC
`A00
`GTG GTG CTG CTG CTG GTG GTG GTG CTG CTG CTG CTG GTG GTG
`CTG
`CTG
`AAG AAG AGA AGA AGA AAG AAG AGA AGA AGA TGC AGA AAG AAG
`AAA
`AGA
`ATA ATA CTC CTC CTC CTG CTG CTC CTC CTC ATG CTC ATT ATG
`CTC
`CTC
`TCC ACC TCC TCC TCC TCC TCC TGC TCC TCC ACC TCC TCC TCC
`TCC
`ACC
`TGC TGC TGT TGT TGT TGC AGG TGT TGT TGT TGC TGT TGC TGC
`TGT
`TGC
`AAG AAG GGA GGA GAA AAG AAG GGA GCA GGA AGA GGA AAG AAG
`GCA
`ACA
`GGT GCT ACT ACT GCT GCT GCT ACT ACT TCT GTG ACT GGT GCT
`GGC
`GTC
`TGT TCT TCT TCT TGT TGT TGT TCT TGT TCT TGT TCT TGG TCT
`TCA
`TOT
`TT
`TT
`G
`A
`A
`TTG
`ACA TCA ACC ACC ACC ACC ACC ACC ACC ACC TCA ACC AGA ACA
`TGC
`$23 $2; $5 $2 $$e
`$$s $$* $$2
`$64
`TTC TTC TTC TTC TTC TTC TTC TTC TTC TTC TTA TTG TTC TTG
`CTC
`ACT ACT AGT ACT ACT ACG ACG AGT AGT ACT ACT AGT ACT
`AGA
`AGT
`GAC GGC GAT GAT GAT AGC AGC GAT GAT GAT ACG GAT GAT AGC
`TOT
`TAC TAG TTC TAC TAC TAC TAC TTC TTC TAC TAT TTC TAT
`TAC
`TAT
`ATG ATG ATG ATG ATG ATG ATG ATG ATG ATG GTA ATG ATG ATA
`GTG
`AAG ATG TAG TAG TAG TGG TGG TAC TAG TAC GGT TAC GCT GGT
`GGC
`
`F
`H
`1
`
`6
`D
`
`R 1
`
`F
`R
`2
`
`8
`R
`2
`
`F
`R
`3
`
`3R
`3
`
`F
`R
`4
`
`
`
`52C
`53
`54
`55
`56
`57
`58
`59
`6!)
`61
`E2
`63
`64
`55
`
`AAC
`AGT
`GAC AAG GAG AGG AGC CAC GAC GAG GAG AAG AAG GAG GAC AAC
`32‘
`355 I: III
`III :2 :2: Z:
`:2: 2:: I: III II: III
`III I: III "-
`3B
`TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG TGG
`TGG
`37
`GTG GTG GTC GTC GTC GTG GTG GTC GTC GTC GTT GTC GTG GTG
`GTC
`38
`AAG AAG CGC CGC CGC AAG AAG CGC CGC GAC CGC CGC AAG AAA
`GGG
`39
`GAG GAG GAG GAG GAG GAG GAG GAG GAG GGG GAG CAG GAG CAG
`CAG
`40
`AGG AGG GCT GGT CGT AGG AGG GCT CGT GCT TGT GCT AGT
`AGG
`GGT
`41
`CAT GAT CGA GGA GGG GGT GCT GGA GGA GGA GGA GGA GAT
`CGT
`CGA
`42
`GGA GGA GGG GGA AGG GGA GGA GGG GGG GGG GGA GGG GGA GGA
`GGG
`43
`AAG AAG AAG AAG AAG CGA CGA AAG AAG AAG AAG AAG AAG GAG
`AAA
`44
`AGG AGG AGA GCA GGA GGC GGG AGA AGA GGA GGT AGA AGT
`GGC
`GGG
`45
`GTT GTT CTG CTT GCT CTT CTT CTG CTG CTT GTG CTG CTA CTG CTA
`46
`GAG GAA GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG GAG GAA
`GAA
`47
`TGG TGG TGG TGG TGG TGG TGG TGG TGG TAG TGG TGG TGG TGG
`TGG
`48
`ATT ATT ATT TTG TTG ATT ATT ATT ATT TTG CTG ATT ATT ATT
`ATT
`48
`GGA GGA GCT GGT GCT GGA GGA GCT GCT GCT GGA GCT GGA GGA
`GGA
`50
`TAT GAA GGA TTT TTG AGG AGG GGA GGA TTG GTG GGA GTT
`TAT
`GAA
`51
`ATT ATT AGT ATT ATT ATT ATT AGT AGT ATT ATA AGT ATT ATT
`ATT
`52
`TAT AAT AGA AGA AGA GAT GAT AGA AGA AGA TGG AGA AGT AAT
`AAT
`———
`———
`———
`——— A
`A
`._-
`“V-
`-——
`222
`222
`2:2
`———
`-—— ——— GCT GCT GCT GGA GGT
`——— GCT GCT GCT
`———
`———
`——~
`TAC TAC AAT AAT AAT AAT AAT AAT AAT AAT AGG AAT TAC GGA
`GAT
`AAT AAT GAT GGT GGC AGT AGT GAT GAT GGT ACG GAT AAT AAT
`AGC
`——~
`GGT GGT TAT TAC TAT GGT GGT TAT TAT TAG GAG TAT GGT GGT
`AGT
`AGT
`GGT GGT AGA AGA ACA GGT GGT ACA AGA ATA TAT ACA AAT
`TAT
`AGG
`GGT
`ACT ACT ACA AGA AGA ACT ACT ACA AGA AGA AAT AGA AGG AAT
`ATA
`AGA
`GGC AGG GAG GAG GAG AAG AAG GAG GAG GAG GGA GAG AGO
`AAG
`AAG
`TAT
`TAG TAG TAC TAG TAT TAC TAG TAG TAG TAC GGT TAC TAC TAC
`TAT
`CTT
`AAC AAC AGT AGT AGT AAT AAT AGT AGT AGT TTG AGT AAG AAT
`AGG
`GGG
`CAG GAG GGA GGA GCA GAG GAG GGA GOA GGA ATA GGA GAG GAG
`GCA
`AAC
`AAG AAG TCT TCT TCT AAG AAG TCT TCT TCT TGG TCT AAG AAG
`TCT
`TGG
`TTG TTG GTG GTG GT!T TTC TTC GTG GTG ATG AGA GTG TTT TTC
`CTA
`GGG
`AAG AAG AAG AAG AAG AAG AAG AAG AAG AAG CTG AAG AAG AAG
`AAG
`AAA
`AGG GGC GGT GGT GGT AGC AGC GGT GGT GGT AAC GGT GGC GGC
`GAT
`AGC
`TC
`TC
`232 4“ *2
`$:-=3 $3 $2 2:: £2
`$432 $92 $3
`as
`ACA ACA ATG ACC ACC ACA ACA ATG ATG ACC AAG ATG AGA ACA
`ATG
`AGC
`68
`TTG TTG GTC ATG ATG GTG GTG GTG GTC ATG GAC GTC ATG CTG
`ATG
`ATG
`69
`ACT ACT TCC TCC TCC ACT ACT TCC TCC TCC AAT TCC ACT ACT
`TCC
`ACC
`70
`GTA GTA AGA AGA AGA GTA GTA AG