New Orfieans,
`Louisiana
`August 30—
`September 4, 1987
`
`Mylan Exhibit 1009, Page 1
`
`20 38988
`08/95 XL102-013-01 ea-r
`
`1
`
`Mylan Exhibit 1009, Page 1
`
`

`
` eefiingg Parewinfis
`
`Division
`
`Where to send inquliries and orders
`
`ENVIRONMENTAL
`CHEMISTRY
`
`FUEL CHEMISTRY
`
`POLYMERIC MATERIALS
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`ENGINEERING, INC.
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`PETROLEUM
`CHEMISTRY, INC.
`
`POLYMER
`CHEMISTRY, INC.
`
`“ Payment with order
`
`C. Ellen Gonter
`National Sanitation Foundation
`PO. Box 1468
`
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`
`Karl S. Vorres
`Director of Publications
`Chemistry Div. Bldg. .211
`Argonne National Lab
`Argonne, Illinois 60439
`(312) 972-2000
`
`American Chemical Society
`Distribution Office
`1155-16th St., N.W.
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`(202-872-4364)
`
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`Ventures R&D Div.
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`
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`
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`* '1. For members of the Division, no cha
`rge except dues for divisional membership ($10.00 member; $12.00
`affiliate member; $5.00 student member).
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`, prices are as follows: (a) Vols. 38-43, $8.00 in
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`Standing orders are available. Prepaid orders do not incur handling charges. Individuals must submit
`payment with order. (Note: Vol. 48 out of print.)
`
`Mylan Exhibit 1009, Page 2
`
`
`
`Mylan Exhibit 1009, Page 2
`
`

`
`RUBBER DIVISION, INC. Rubber Division, lnc.
`Rubber Division Library and
`Information Services
`The University of Akron
`Akron, Ohio» 44325
`
`ATTN: Mrs. Ruth Murray, Literature Chemist
`(216-375-7197)
`
`Technology.
`
`Texts of papers presented at all Rubber Division, lnc. national meetings and many of the
`local group meetings are available for sale as single papers or full sets.
`
`Cost of meeting papers:
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`Single papers
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`three times meeting price
`twice meeting price
`members, affiliates and subscribers—$6.00 per item
`all others-——$8.00 per item
`
`Mylan Exhibit 1009, Page 3
`
`Mylan Exhibit 1009, Page 3
`
`

`
`Kant, J.
`Kanmr, S. W.
`
`ORGN
`COLL
`COLL
`MBTD
`Kan, P. M.
`ORGN
`Kaplzm, J. K.
`Kapuscinslci, R. B.
`ENVR
`ENVR
`
`Karaman, I1. M.
`
`Karaini, J. H.
`l(nras7.,
`I". E.
`
`POLY
`CELL
`PMSE
`PMSE
`POLY
`Knraynnnis, N. M.
`INOR
`FU EL
`CELL
`PMSE
`AGFD
`MB'I‘D
`MBTD
`B IOL
`I(arikO, K.
`INOR
`Karim, K.
`PHYS
`Karim, O. A.
`COLL
`Karis, '1‘.
`K:.1rl(are, S. B. MBTD
`Karl, D. W.
`MBTD
`K.fn'liel<, S. J.
`ENVR
`Kurlin, K. D.
`INOR
`INOR
`AGRO
`FUEL
`APQYL
`ORCN
`CHAS
`CHAS
`I(arunasena, A. PMSE
`Kzishmzm, Y.
`ORGN
`Kashyap, R. P.
`INOR
`Kasiewski, C.
`MEDI
`Kassler, P.
`F UE L
`Kaszns, G.
`PMSE
`Krmiyamzi, M.
`ACRO
`I(z1thardek;1r, V.
`BIOL
`MED]
`Knllinwzila, G. MEDI
`Kato, K.
`FLUO
`KaI.re, N.
`MBTD
`Katz, D. A.
`HIST
`K2112, E.
`MBTD
`Kat.’/., H. E.
`COLL
`I& EC
`CMEC
`I.
`Ka1'/.,
`MEDI
`Katz, L.
`Kznzenberg, C. CELL
`Kai.’/.enl)erger, C.
`CELL
`KnLzenellenbogen, J. A.
`MEDI
`INOR
`K2iu1'f'mann, 'I‘.
`MBTD
`Kaufman, C.
`I(:1uImnn, J. A. CHAS
`CHAS
`CHAS
`PH YS
`PHYS
`Kaufman, R. J. MBTD
`Keiusch, H. H.
`POLY
`Kawni, J.
`CARB
`Kawusumi, Masaya
`MACR
`ORGN
`IN OR
`
`Knrcli, J. A.
`Kzirchesy, J. J.
`Kzirdos, J. L.
`Karel, M.
`Kzirgi, F.
`
`I(:n:ns, J. S.
`Karm, S. B.
`Karraker, D. G.
`
`Karri('.l<, G. L.
`Kz1rsLadt., M. L.
`
`I(aLlmwzil:;1, 1"‘. G.
`
`Kauiimun, J. J.
`
`Kay, A. J.
`Kaynli, W.
`1(z1zakofT, C. W.
`
`‘ N UCL
`Kazlauskas, R. J.‘
`ORGN
`
`0105
`0141
`0142
`0068
`0273
`
`0016
`0044
`
`0103
`0085
`0093
`0094
`0167
`
`0341
`0098
`0078
`0111
`0098
`0055
`0175
`0018
`0372
`0142
`0190
`0067
`0151
`0052
`0001
`0015
`0176
`0027
`0175
`0261
`
`0023
`0028
`0132
`0276
`0328
`0059
`0033
`0017
`0072
`
`0016
`
`0079
`0080
`0020
`0029
`0035
`0101
`0080
`0016
`0014
`0003
`0064
`
`0063
`
`0012
`0104
`0092
`0040
`0041
`0011
`0041
`0042
`0095
`0209
`0008
`
`001.0
`0047
`0372
`
`00.13
`
`0193
`
`Kazmierczalc, R.
`
`Keasling, J.
`Kebarle, P.
`Keck, G. E.
`Keefer, L. K.
`
`Keegs1.r:1, P. B.
`Keeney, 17‘. N.
`Keeney, M.
`Keesee, R. G.
`lKeil, D. G.
`Keimig, T. 1..
`Keister, J. B.
`Keiter, E. A.
`Keiter, R. L,
`
`Keith, L. H.
`
`Kellar, D. E.
`Keller, A.
`Keller, 0. L.
`Keller, S. W.
`
`KdbyJ.
`Kelley, R. D.
`Kellogg, G. L.
`Kelly, D. A.
`Kelly, H. C.
`Kelly, J.
`Kelly, M. B.
`Kelly, M. T.
`KdwJLNL
`Kelly, R. N.
`Kelly, W. R.
`Kelly, K. C.
`Kemal, C.
`
`Kempf, D. J.
`Kendall, R. A.
`Kendrick, K. L.
`
`Kennedy, J. P.
`Kennedy, R. C.
`Kennicutt, M. C.
`
`Kerns, O. S.
`Kerr, L.
`Kerry, H.
`Kerschner, J. L.
`
`Kersey, M. T.
`Keskliula, H.
`
`AGRO
`Kearney, P. C. AGRO
`ENVR
`ORG N
`ORGN
`MBTD
`PHYS
`ORGN
`INORORGN
`ORGN
`PHYS.
`AGRO
`BIO L
`PHYS
`FUEL
`ANYL
`INOR
`INOR
`C1-IED
`I N O R
`CHAS
`CHAS
`PETR
`PMSE
`NUCL
`INOR.
`P MSE
`1&EC
`COLL
`COLL
`FERT
`INOR
`A NYL
`PHYS
`CMEC
`1&EC
`ANYL
`ENVR
`ENVR
`B IOL
`B IOL
`MEDI
`PHYS
`PHYS
`C HAS
`Kendurski, S.
`AGRO
`Kenlield, .1).
`ORGN
`Kenion, G. B.
`Kennedy, C. H. BIOL
`Kennedy, H. M.
`CELL
`PMSE
`FLUO
`GEOC
`KennicuL1., M. C., II
`ENVR
`GEOC
`G EOC
`Kennieutl, M. C., III
`EN VR
`Kenyon, M. M. AGFD
`Keogh, R.
`FU EL
`Kerby, M. C.
`INOR
`Kerley, E. L.
`IN OR
`Kern, R. D.
`FUEL
`PHYS
`FERT
`A N YL
`ENVR
`IN OR
`ANYL
`PMSE
`PMSE
`PMSE
`Kesler, D. J.
`Kessissoglou, D. P.
`INOR
`INOR
`Keweshan, C.
`Khalecli, M. G. ANYL
`ANYL
`
`0007
`0024
`0277
`0036
`0038
`0019
`0010
`0144
`0186
`0286
`0287
`0042
`0060
`0057
`0005
`0069
`0143
`0319
`0265
`0083
`0265
`0010
`0013
`0006
`0002
`0063
`0330
`0188
`0059
`0016
`0015
`0037
`0337
`0137
`0107
`0003
`0032
`0127
`0093
`0086
`0026
`0058
`0085
`0077
`
`0147
`0032
`0053
`001.8
`0069
`
`0055
`0017
`0003
`0035
`
`0028
`0024
`0025
`
`0114
`0045
`0016
`0323
`0482
`0053
`0111
`0042
`0157
`0066
`0041
`0091
`0135
`0141
`0086
`
`0235
`0088
`0155
`0156
`
`Khaledi, M. G.
`Khan, I7. R.
`Klmn, R.
`1(hanapurL~., S. P.
`
`ANYL
`MBTD
`AG FD
`
`0157
`0143
`0138
`
`ORGN
`ORGN
`COLL
`ORGN
`
`0048
`0054
`0077
`0262
`
`C E L L
`ORGN"
`ENVR
`BIOL
`PMSE
`[NOR
`INOR
`GEOC
`FUEL
`ENVR
`ACFD
`ENVR
`CHAS
`(‘.1-{AS
`POLY
`POLY
`POLY
`INOR
`
`0026
`0126
`0256
`0036
`0110
`0368
`0369
`0033
`0055
`0181
`
`0031
`0071
`0015
`0047
`0071
`0072
`0144
`0366
`
`MEDI
`
`0016
`
`Klmnarian, C.
`Klmnnz), IL K.
`l(l1zn'z17.ipOur, A.
`Kl1ai.vli, L. A.
`Klielmi.-m, C.
`KhOj.'i, S. M.
`Kia, H. G.
`Kiliala, I’. A.
`
`Kieber, D. J.
`Kiefer, J.
`l-I.
`Kiene, R. P.
`Kilhourne, E. M.
`
`Kilby, J. A.
`Kilie, S.
`
`Killough, P. M.
`Kilp:.il,rick, B.
`1*‘.
`
`Kilpntrick, M. P.
`Kim, 13. H.
`Kim, C. H.
`Kim, C.—l'I.
`Kim, C. J.
`Kim, I).
`Kim, D. W.
`Kim, D. Y.
`Kim, H.
`
`ENVR
`ORGN
`M 13'1" D
`MEDI
`INOR
`ORGN
`ORGN
`COLL
`PMSE
`POLY
`POLY
`ORCN
`MED!
`PHYS
`PMSE
`INOR
`COLL
`POLY
`CELL
`ORGN
`PMSE
`POLY
`COLL
`INOR
`CARB
`POLY
`MBTD
`INOR
`rmnw
`
`0066
`0209
`0066
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`0332
`0141
`0151
`0115
`0135
`0201
`0086
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`0066
`0051
`0171
`0019
`0087
`0008
`0071
`0211
`0174
`0040
`0233
`0295
`0006
`0036
`0051
`0401
`0028
`
`ANYL
`COLL
`ACFD
`ANYL
`INOR
`ACFD
`INOR
`INOR
`COLL
`CELL
`
`0082
`0211
`0078
`0016
`0422
`0056
`0088
`0233
`0054
`0083
`
`AG R0
`
`0154
`
`l\/1.1.!‘.DI
`ORGN
`PHYS
`ITLUO
`FLUO
`PMSE
`
`0056
`0232
`0187
`0003
`0005
`0066
`
`1N O R.
`() RG N
`
`0387
`0231
`
`Kim, H. C.
`Kim, H. J.
`Kim, H. P.
`Kim, H. S.
`Kim, J. H.
`Kim, J. M.
`Kim, K.
`
`Kim, M. S.
`Kim, O. K.
`
`KmLY.H
`Kim, Y. K.
`Kimbrell, S. M.
`
`Kinium, Y.
`King, A. H.
`King, B. C.
`King, C.
`King, C. J.
`King, H.
`King, K. A.
`King, '1‘. S.
`Knm,W.D
`Kingslmry, I”. D.
`Kingsbury, W. D.
`Kini, A. M.
`
`Kinkead, S. A.
`
`Kinlock, A. J.
`Kinnaird, M. G.
`
`Kinneary, J. F.
`
`Mylan Exhibit 1009, Page 4
`
`Mylan Exhibit 1009, Page 4
`
`

`
`é
`{
`,
`;
`
`E
`
`I
`"
`5
`
`
`
`.
`
`' le 17 u.s. code)
`-
`ted by Copvrlsht ‘aw ”'t
`
`This material m3V be protec
`,
`XU 62-320, AN HMG—COA REDUCTASE INHI
`COMPACTIN
`F. G. Kathawalal, T. Scallenz, R. G. Encstroml, D. B
`_
`,
`H. Scliif§tErT, R. St—a—:Bler1, J. Kratunisl, J. R.J wareing‘, C. F. Jewell‘,
`L. widier‘, s. wattanasin‘
`‘Sandoz Research Insti
`New Jersey 07936, U.S.I-\.
`'
`icine, University of New
`7
`s a high level of interest in the development
`COA reductase inhibitor . Efforts at Sandoz
`inhibitors have led to XU 62—320-
`[R*,S*—(E)l—(i)—
`_
`design and synthesis of novel HMG—CoA reductasc
`. —methylethyl) —lH-inclol—2
`compactin in ll'1I1l.b]tlIlg HM(:—CoA reductcise in
`—yl] —hept—6—enotite
`vitro and cholesterol biosynthesis in vivo
`Desicrn, synthesis and struc-
`Lure &1CLlVJ.t_‘y relationships with the <;erie'
`Xd-62-32
`will be presented .
`
`SYNTHESIS OF THE 3R, SSIENANTIOMER OF XU 62Y320
`80.
`Charles F. Jewell, Jr.
`,
`James R. wareing ,
`Stabler’, E‘afzu.lla G. KaT:hawa.l.al, and Terry Scallenz
`1
`East Hanover, NJ 07936
`‘Saiidoz Research Institute,
`University of
`9
`New Mexico, School of Medicine, Dept. of
`Albuquerque,
`NM 87131.
`
`AND ITS ANALOGS
`Leo widlerl, Russell
`
`Biochemistry,
`
`and effective HMG—CoA reductase inhibitors have led to XU 62-320,
`lR*,S*—-
`.li Institute Lo develop safe
`.
`(l:7)](i)—SodiLini—3,5—dihydroxy—7—[3—(4—fI.uorophonyl)—l(—ineLhyletliyl)——lll—
`in(lol—2—yl]—hept:—6—enoate, which is more potent
`th
`'
`.
`an compactin in inhibi«
`._______._
`‘-
`.‘
`the synthesis of
`the single enantionier of XU 62—
`'
`biosynthesis in ViVO.'I‘hI.S
`320 which has the same absolute configuration as coiupactin.
`
`,
`
`81.
`TR/\NS-6-[2-(SUBSTITUTED—PYRROL—l—YL)
`HMG-CO/\ REDUCTASE INHIBITORS.
`B. D. Roth, M. L. Hoefle, D. R. Sllskovic, C. D.
`HEW CL/~\SS OF
`Stratton, M. H. Wilson, and R. S. Newt'o7iTD§p'a'FE'ments of Cheniistry and Pharmacology,
`Warner—Lanibert/Parke—Davis P
`2800 Plymouth Road.
`harmaceuti'cal Research, Ann Arbor, Michigan
`48lO5.
`‘Il’lhl'b'ltlOn of HMG—CoA Reductase,
`thesis, has proved to be an effective
`'
`'
`both animals and man.
`The in vitro te
`‘ing serum cholesterol
`(substi'tuted»pyrr0l—-l
`series of potent inhibitors
`The synthesis and structure/acti'vi'ty
`,hown them to be a new
`relationships of these novel
`inliibitors will be ciscussed.
`
`0
`
`levels in
`"9
`
`DH
`
`ANTIHYPERTENSIVE 3—(1—SUBSTITUTE
`82.
`Strugczewski, B. L. Schmid, E. W. Long,
`Pharmacology Departments, Hocclist—Roussel Ph
`Route 202—20(i North.
`
`D-l+—PIPEiRlDINYL)—1,2—BENZISOTHIAZOLl3S. J. T.
`J. Kitzen, and R. Ress, Chemical Research and
`armaceuticals Inc., Somerville, New Jersey 08876.
`
`
`
`Mylan Exhibit 1009, Page 5