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Displaying 54-68 of 80 results

1024 Exhibit: Kinoshita 07

Document IPR2015-00669, No. 1024 Exhibit - Kinoshita 07 (P.T.A.B. Feb. 2, 2015)
Unless appropriately restored at any early stage after the surgery, the destroyed chorionic structure in the damaged area tends to cause adhesion between organs, and may occasionally result in a loss of basic functions.
The use of a tissue-reconstructing material made from a freeze-dried amnion with an epithelium is especially preferred because it imparts strong binding force to the applied site without any possibility of causing a foreign body reaction against the adhesive components.
The use of a tissue- reconstructing material made with a dry amnion is especially preferred as it provides a high degree of bonding strength to the applied site without causing a foreign body reaction against the adhesive components.
cornea harvested from a six week old Japanese white rabbit was immersed in DMEM containing 10% fetal bovine serum (FBS), and then had the conjunctiva, corneal endothelium, and other unnecessary tissue excised.
In the present example, the desired relative position between liquid surface 5a of trypsin solution 5 and the amnion 10 can be achieved by placing the fluorocarbon resin frame 3 on protrusions 7 inside the container 6.
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1008 Exhibit: Jones Expert Declaration

Document IPR2015-00669, No. 1008 Exhibit - Jones Expert Declaration (P.T.A.B. Feb. 2, 2015)
I have been retained by counsel for the Petitioner, Musculoskeletal Transplant Foundation, (i.e., Greenberg Traurig, LLP) to offer technical opinions in connection with a Petition for inter partes review (“the Petition”) on U.S. Patent No. 8,323,701 B1 (“the ‘701 Patent”).
In order to provide background for my analysis of the ‘701 Patent, reference is made to Parry et al., Premature Rupture of the Fetal Membranes, The New England Journal of Medicine 338(10), 663-670 (March 5, 1998) (“Parry”).
However, the concept of removing an epithelial layer from its associated amnion so as to expose the underlying basement membrane was well known in the art at the time of the claimed invention (see e.g., Kinoshita-06 or -07, Shenaq, Wei, Shimazaki, Wang, etc.).
While the epithelial layer is removed in Kinoshita-06 to facilitate culturing of cells on the basement membrane, a POSA would have recognized that the same advantages discussed above are equally applicable to amnion grafts MTF Ex. 1008, p. 81
wherein at least one of the membranes is selected from the group consisting of a naturally occurring growth factor, a platelet concentrate, a bone marrow aspirate, stem cells, or an antibiotic.
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1040 Exhibit: Lee

Document IPR2015-00669, No. 1040 Exhibit - Lee (P.T.A.B. Feb. 2, 2015)
Surface epithelial breakdown can be caused by such exogenous insults as infection, xerosis, trauma, or chemicals and can be aggravated by such endoge­ nous conditions as paralytic or neurotrophic exposure, keratomalacia, or recurrent corneal erosions.
When associated with excessive inflammation or failure of normal healing responses, such epithelial breakdown may eventually progress to persistent sterile corneal ulcers.1'3 Therefore, early diagnosis and institution of appropriate medical therapies to correct the underly­ ing cause, to suppress the untoward inflammation, or to augment tissue healing are often curative in the management of corneal epithelial defects and ulcers.1,2 However, for reasons that remain unclear, the established ulceration can persist and predispose to imminent perforation even after the application of these therapies.
Amniotic membranes have been used for other indications15: as a graft for burned skin,16 artificial vagina, and conjunctival symblepharon 17; as a dress­ ing for skin wounds18 and for repairing omphalo­ celes19; or as a substrate to prevent tissue adhesion in surgeries of the head, abdomen, 20 and pelvis.
In conclusion, amniotic membrane transplantation may be considered an alternative substrate for treating persistent corneal epithelial defects with sterile ulcer- ation that are refractory to conventional medical treatment.
The authors wish to express their deep gratitude to Dr Juan Batle of Santo Domingo for introducing us, at the Annual Meeting for Residents and Alumni of the Bascom Palmer Eye Institute in 1992, to the use of amniotic membranes, and to Dr Gene Burkett for obtaining donor placentas.
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1002 Exhibit: 701 Patent File Wrapper

Document IPR2015-00669, No. 1002 Exhibit - 701 Patent File Wrapper (P.T.A.B. Feb. 2, 2015)
Patent and Trademark Office; US, DEPARTMENT OF COMMERCE Under the Papenivork Reduction Act of 1995, no persons are required to respond to a collection of information unless it displays a valid OMB control number Also Form PTO-1050
ether than the applicant; a registered axiomey or agent; or {he assigns: at other party in interest as shawl: b I the rte-cows ofiha United Strum Patent and Tradem'ark Office” Anfiwrizad Signature Typed or minted name SEEN“: $Wi$§m Ragisatratim No. mewmww
Fer gene and vainahie censidereiinn, the receipt anti sufficiency ni‘ wiiieh are hereby acknnwiedged, WRGECAL Biflifii’iicsi LLC (hereinafter referred in as “ASSiGNC§R”i, having its principai piece (ii hneiness at 60 Chastain Center Snuieveri‘i, Suite iii), Kennesew, GA 33144, is; the owner (if the entire right, titie and interest of any inventiens that reiete :0 er enuid he derived from:
ASSiGNQR HEREBY AGREES {a} to communicate te ASSEGNEE, its successors and assigns, or their representative or agents, eii facts and informetien known or evaiienie ta ASSEGNQR teseecting said inventien Oi“ inventiens, improvements, and modifications inciutiing evidence for interference, reexamination, reissue, enpositien, revecation, extensien, or infringement purpeses er ether iegal, judiciai, er administrative proceedings, whenever requested by ASSiGNi—Ei—Z; (is; to execute anti deiiver, upen request by ASSEEGNEE, aii iawiui papers inciuding, but not iimited m, nriginai, divisionai, centinuatien, and reissue appiicetiens, reneweis, assignments: powers of atterney, oaths, affidavits, and deciarations, depositions; ant;i id} to previde eii reasonetiie assistanee tn ASSEGNEE, its successors and assigns, in ebteining and enfercing primer titie in and preteetien fer said inventien or inventions, improvements, and madificatiens under the inteiiectuai property Haws at the United States and muntries fereign theteto.
This paper is timely filed atong with or before the payment of the issue fee Applicants note, with approval, that the Title of the invention was amended to read “Improved Placenta} Tissue Grafts” in the Notice ofAlIowance.
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1009 Exhibit: Shenaq

Document IPR2015-00669, No. 1009 Exhibit - Shenaq (P.T.A.B. Feb. 2, 2015)

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1025 Exhibit: Ishino

Document IPR2015-00669, No. 1025 Exhibit - Ishino (P.T.A.B. Feb. 2, 2015)

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1011 Exhibit: CN Language Wei He

Document IPR2015-00669, No. 1011 Exhibit - CN Language Wei He (P.T.A.B. Feb. 2, 2015)

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1027 Exhibit: Shimazaki

Document IPR2015-00669, No. 1027 Exhibit - Shimazaki (P.T.A.B. Feb. 2, 2015)

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1038 Exhibit: 665 Provisional Application

Document IPR2015-00669, No. 1038 Exhibit - 665 Provisional Application (P.T.A.B. Feb. 2, 2015)

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1029 Exhibit: Taguchi

Document IPR2015-00669, No. 1029 Exhibit - Taguchi (P.T.A.B. Feb. 2, 2015)

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1036 Exhibit: 780 Provisional Application

Document IPR2015-00669, No. 1036 Exhibit - 780 Provisional Application (P.T.A.B. Feb. 2, 2015)

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1020 Exhibit: Robson

Document IPR2015-00669, No. 1020 Exhibit - Robson (P.T.A.B. Feb. 2, 2015)

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1021 Exhibit: Rinastiti

Document IPR2015-00669, No. 1021 Exhibit - Rinastiti (P.T.A.B. Feb. 2, 2015)

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1019 Exhibit: Hanada

Document IPR2015-00669, No. 1019 Exhibit - Hanada (P.T.A.B. Feb. 2, 2015)

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1013 Exhibit: Sulner

Document IPR2015-00669, No. 1013 Exhibit - Sulner (P.T.A.B. Feb. 2, 2015)

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