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2001 Exhibit: Certified file history for 14855,168 Part 12 of 14

Document IPR2019-00459, No. 2001-12 Exhibit - Certified file history for 14855,168 Part 12 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 9 of 14

Document IPR2019-00459, No. 2001-9 Exhibit - Certified file history for 14855,168 Part 9 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 7 of 14

Document IPR2019-00459, No. 2001-7 Exhibit - Certified file history for 14855,168 Part 7 of 14 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 7 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-5 Exhibit - Shire Exhibit 2004 Part 7 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 3 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-3 Exhibit - Shire Exhibit 2004 Part 3 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2002 Exhibit: Shire Exhibit 2002 US Patent 9,616,111

Document IPR2019-00459, No. 2002 Exhibit - Shire Exhibit 2002 US Patent 9,616,111 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 8 of 15

Document IPR2019-00459, No. 2001-8 Exhibit - Certified file history for 14855,168 Part 8 of 15 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 1 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004 Exhibit - Shire Exhibit 2004 Part 1 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 10 of 14

Document IPR2019-00459, No. 2001-10 Exhibit - Certified file history for 14855,168 Part 10 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 2 of 14

Document IPR2019-00459, No. 2001-5 Exhibit - Certified file history for 14855,168 Part 2 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 1 of 14

Document IPR2019-00459, No. 2001 Exhibit - Certified file history for 14855,168 Part 1 of 14 (P.T.A.B. Apr. 9, 2019)

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