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2004 Exhibit: Shire Exhibit 2004 Part 14 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-13 Exhibit - Shire Exhibit 2004 Part 14 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 10 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-7 Exhibit - Shire Exhibit 2004 Part 10 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 23 of 37 Certified File History of US Patent No...

Document IPR2019-00459, No. 2004-19 Exhibit - Shire Exhibit 2004 Part 23 of 37 Certified File History of US Patent No10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 24 of 37 Certified File History of US Patent No...

Document IPR2019-00459, No. 2004-24 Exhibit - Shire Exhibit 2004 Part 24 of 37 Certified File History of US Patent No10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 20 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-17 Exhibit - Shire Exhibit 2004 Part 20 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 8 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-10 Exhibit - Shire Exhibit 2004 Part 8 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 22 of 37 Certified File History of USPatent No1...

Document IPR2019-00459, No. 2004-23 Exhibit - Shire Exhibit 2004 Part 22 of 37 Certified File History of USPatent No10,080,788 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 3 of 14

Document IPR2019-00459, No. 2001-2 Exhibit - Certified file history for 14855,168 Part 3 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 13 of 14

Document IPR2019-00459, No. 2001-13 Exhibit - Certified file history for 14855,168 Part 13 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 5 of 14

Document IPR2019-00459, No. 2001-4 Exhibit - Certified file history for 14855,168 Part 5 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 6 of 14

Document IPR2019-00459, No. 2001-6 Exhibit - Certified file history for 14855,168 Part 6 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 11 of 14

Document IPR2019-00459, No. 2001-11 Exhibit - Certified file history for 14855,168 Part 11 of 14 (P.T.A.B. Apr. 9, 2019)

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2001 Exhibit: Certified file history for 14855,168 Part 4 of 14

Document IPR2019-00459, No. 2001-3 Exhibit - Certified file history for 14855,168 Part 4 of 14 (P.T.A.B. Apr. 9, 2019)

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2004 Exhibit: Shire Exhibit 2004 Part 2 of 37 Certified File History of US Patent No 10,080,788

Document IPR2019-00459, No. 2004-2 Exhibit - Shire Exhibit 2004 Part 2 of 37 Certified File History of US Patent No 10,080,788 (P.T.A.B. Apr. 9, 2019)

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1001 Exhibit: CSL Exhibit 1001

Document IPR2019-00459, No. 1001 Exhibit - CSL Exhibit 1001 (P.T.A.B. Dec. 21, 2018)

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