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1043 Exhibit: Knoester, et al, Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray A study in healthy volunteers, Br J Clin Pharmacol 2002 May535501 7

Document IPR2019-00450, No. 1043-61 Exhibit - Knoester, et al, Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray A study in healthy volunteers, Br...
None had a history of cardiac or neurological disease.
The symptoms disappeared within 10 min in all but one subject, in whom intranasal irritation lasted for 25 min All subjects tolerated intranasal administration well and none found it to be painful.
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1004 Exhibit: Part 5 ¿¿¿ Pages 1401 1750 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH

Document IPR2019-00450, No. 1004-9 Exhibit - Part 5 ¿¿¿ Pages 1401 1750 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)
None of these references describe nanoparticulate active agent compositions comprising a peptide surface stabilizer.
For compounds ofthe formula NRRoR3Ru™: (i) none of R ...
It is preferable thatlittle or none of component c contains halogen substituted hydrocarbons since these tend to have ’ lower biocompatibility.
From Figure 4 (n=8) it appears that none of the investigated formulations has a severe burst effect.
... al Application No PCT/GB2005/002217 INTERNATIONAL SEARCH REPORT Patent document cited in search report WO 2005046642 US 5807573 A A 15-09-1998 date Patent family member(s) Publication date 26-05-2005 NONE ...
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1042 Exhibit: PDR 54th Edition 2000, DIASTAT¿¿ diazepam rectal gel MIACALCIN¿¿ Calcitonin Nasal Spray VALIUM¿¿ diazepam injection, Physicians¿¿¿ Desk Reference

Document IPR2019-00450, No. 1042-60 Exhibit - PDR 54th Edition 2000, DIASTAT¿¿ diazepam rectal gel MIACALCIN¿¿ Calcitonin Nasal Spray VALIUM¿¿ diazepam injection, Physicians¿¿¿ Desk Reference (P...
None of the content of this publication may be reproduced, stored in a retrieval system, resold, redistributed, or transmitted in any form or by any means (electronic, mechanical, photocopying, recording, or otherwise) without the prior ...
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1044 Exhibit: USP NF 2003, The United States Pharmacopeia, The National Formu...

Document IPR2019-00450, No. 1044-62 Exhibit - USP NF 2003, The United States Pharmacopeia, The National Formulary, United States Pharmacopeial Convention, Inc ¿¿¿USPNF¿¿¿ (P.T.A.B. Jan. 29, 201...

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1047 Exhibit: Gwozdz Assignment of Provisional in Non Provisional Case, dated Ap...

Document IPR2019-00450, No. 1047-65 Exhibit - Gwozdz Assignment of Provisional in Non Provisional Case, dated April 21, 2008, recorded September 23, 2010 Gwozdz Assignment (P.T.A.B. Jan. 29, 20...

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1012 Exhibit: Jamieson et al, US Patent Application Publication No US 2008007090...

Document IPR2019-00450, No. 1012-28 Exhibit - Jamieson et al, US Patent Application Publication No US 20080070904, Pharmaceutical Compositions of Benzodiazepines and Method of Use Thereof, Se...

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1003 Exhibit: US Patent No 8,895,546, Administration Of Benzodiazepine Compos...

Document IPR2019-00450, No. 1003-4 Exhibit - US Patent No 8,895,546, Administration Of Benzodiazepine Compositions, filed June 13, 2012 ¿¿¿546 Patent (P.T.A.B. Jan. 29, 2019)

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1040 Exhibit: Part 2 Pages 251 500 File History for EP 128 013729, based on WO 2...

Document IPR2019-00450, No. 1040-57 Exhibit - Part 2 Pages 251 500 File History for EP 128 013729, based on WO 2012174158 and PCTUS2012042311 (P.T.A.B. Jan. 29, 2019)

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1004 Exhibit: Part 7 ¿¿¿ Pages 2101 2450 File History for ¿¿¿546 Patent, Ser No 1349...

Document IPR2019-00450, No. 1004-11 Exhibit - Part 7 ¿¿¿ Pages 2101 2450 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)

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1004 Exhibit: Part 6 ¿¿¿ Pages 1751 2100 File History for ¿¿¿546 Patent, Ser No 1349...

Document IPR2019-00450, No. 1004-10 Exhibit - Part 6 ¿¿¿ Pages 1751 2100 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)

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1007 Exhibit: Part 7 ¿¿¿ Pages 2401 2800 File History for Non Provisional Patent App...

Document IPR2019-00450, No. 1007-21 Exhibit - Part 7 ¿¿¿ Pages 2401 2800 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019...

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1026 Exhibit: Kibbe, editor, Handbook of Pharmaceutical Excipients, Third Edition 2...

Document IPR2019-00450, No. 1026-42 Exhibit - Kibbe, editor, Handbook of Pharmaceutical Excipients, Third Edition 2000, American Pharmaceutical Association, Washington DC Kibbe (P.T.A.B. Jan. 29,...

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1030 Exhibit: Gizurarson et al, Intranasal Administration of Diazepam Aiming at the...

Document IPR2019-00450, No. 1030-46 Exhibit - Gizurarson et al, Intranasal Administration of Diazepam Aiming at the Treatment of Acute Seizures Clinical Trials in Healthy Volunteers, Biological and Pha...

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1041 Exhibit: Declaration of Dr Nicholas A Peppas

Document IPR2019-00450, No. 1041-59 Exhibit - Declaration of Dr Nicholas A Peppas (P.T.A.B. Jan. 29, 2019)

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1004 Exhibit: Part 8 ¿¿¿ Pages 2451 2681 File History for ¿¿¿546 Patent, Ser No 1349...

Document IPR2019-00450, No. 1004-12 Exhibit - Part 8 ¿¿¿ Pages 2451 2681 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)

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