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IPR2019-00450, No. 1032-48 Exhibit - Edman II et al, Microspheres as a nasal delivery system for peptide drugs, Journal of Controlled Release, Vol 21 1992 165 l72 Edman II (P.T.A.B. Jan. 29, 2...
Journal of Controlled Release, 2 0 1992 Elsevier Science Publishers B.V. All rights reserved 01%3659/92/$05.00 165 COREL 00753 Microspheres as a nasal delivery system for peptide drugs P. EdmanaTb, E. Bjiirka>b and L. RydCnb “Kabi Pharmacia Therapeutics, Uppsala, Sweden bCrppsala University, Department of Pharma~~t~cs, BMC, Uppsa~a, Sweden (Received 7 July 199 1; accepted in revised form 9 March 1992 ) Microspheres of starch and dextran, cross-linked with epichlorohydrine, function as an enhancer system for the absorption of insulin in rats.
A conceivable hypothesis with regard to the mech- anism of action of DSM can be that the epithelial mucosa is dehydrated, with a reversible “shrinkage” of the cells, thus giving a physical separation of the intercellular junctions.
Variations of pH [ 61, ionic strength f 71, and inhibition of proteolytic enzymes in the nose [ 8 ] are some ex- amples of parameters which can be varied in or- der to promote the nasal absorption of peptides.
This finding indicates that the mode of action of DSM on the epitheiial cell barrier, giving in- creased permeability of hydrophiIic compounds, is a temporary widening of the tight junctions, AQUESTIVE EXHIBIT 1032 page 0006
K. Morimoto, H. Yamaguchi, Y. Iwakura, K. Morisaka, Y. Ohashi and Y. Nakai, Effects of viscous hyaluronate- sodium solution on the nasal absorption of vasopressin and an analogue, Pharm. Res.
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IPR2019-00450, No. 1032-48 Exhibit - Edman II et al, Microspheres as a nasal delivery system for peptide drugs, Journal of Controlled Release, Vol 21 1992 165 l72 Edman II (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1029-45 Exhibit - O¿¿¿Dell et al, School nurses¿¿¿ experience with administration of rectal diazepam gel for seizures, J Sch Nurs, June 2007, 233166 9 O¿¿¿Dell (P.T.A.B. Jan. 2...
Perceived Barriers to Diazepam Rectal Gel Administration in the School Perceived Barrier Number Privacy/setting Access/availability of nurse Legal/delegation issues Staff anxiety/fear Lack of training None Consent of ...
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IPR2019-00450, No. 1029-45 Exhibit - O¿¿¿Dell et al, School nurses¿¿¿ experience with administration of rectal diazepam gel for seizures, J Sch Nurs, June 2007, 233166 9 O¿¿¿Dell (P.T.A.B. Jan. 29, 20
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IPR2019-00450, No. 1006-14 Exhibit - Provisional Patent Application No 61570,110, filed December 13, 2011 ¿¿¿110 Provisional (P.T.A.B. Jan. 29, 2019)
... If Required, Foreign Filing License Granted: 12/27/2011 The country code and number of your priority application, to be used for filing abroad under the Paris Convention, is US 61/570,110 Projected Publication Date: None ...
... If Required, Foreign Filing License Granted: 12/27/2011 The country code and number of your priority application, to be used for filing abroad under the Paris Convention, is US 61/570,110 Projected Publication Date: None ...
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IPR2019-00450, No. 1006-14 Exhibit - Provisional Patent Application No 61570,110, filed December 13, 2011 ¿¿¿110 Provisional (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1004-7 Exhibit - Part 3 ¿¿¿ Pages 701 1050 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)
The reaction was worked up by partitioning between citric acid and ethyl acetate, drying the organic layer and solvent removal to give the crude product (1g).
Biochem., 99, procedure of Cawston and Barrett, 340-345, 1979), hereby incorporated by reference, 11. whereby a ImM solution of the inhibitor being tested or 12 dilutions thereof was incubated at 37° for 16 hours 13 with collagen and collagenase (buffered with 25mM 14 Hepes, pH 7.5 containing 5mM CaCly5, 0.05% Brij 35 and 0.02% NaN3).
J., 195, 159-165 1981), hereby incorporated by reference, whereby a 1mM solution of the inhibitor being tested or dilutions thereof was incubated at 37°C for 16 hours with stromelysin and 14, acetylate casein (buffered with 25mM Hepes, pH 7.5 containing 5mM CaCl5, 0.05% Brij 35 and 0.02% NaN3.
Armenia Austria Australia Barbados Belgium Burkina Faso Bulgaria Benin Brazil Belarus Canada Central African Republic Congo Switzerland Cite d'Ivoire Cameroon China Czechoslovakia Czech Republic Germany Denmark Estonia Spain Finland France Gabon Malawi Mexico Niger Netherlands Norway New Zealand Poland Portugal Romania Russian Federation Sudan Sweden Singapore Slovenia Slovakia Senegal Swaziland Chad Togo Tajikistan Trinidad and Tobago Ukraine Uganda United States of America Uzbekistan
The term "alkyl", as used herein, unless otherwise indicated, includes saturated monovalent hydrocarbon radicals having straight, branched or cyclic moieties or combinations thereof.
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IPR2019-00450, No. 1004-7 Exhibit - Part 3 ¿¿¿ Pages 701 1050 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1007-15 Exhibit - Part 1 ¿¿¿ Pages 1 400 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)
... Assignment For Published Patent Application HALE BIOPHARMA VENTURES, LLC, Encinitas, CA Powerof Attorney: None Domestic Priority data as claimed by applicant This appin claims benefit of 61/040,558 03/28/2008 Foreign ...
... PA; Andrew Loxley, Philadelphia, PA; Mark Mitchnick, East Hampton, NY; David F. Hale, San Diego, CA; Assignment For Published Patent Application HALE BIOPHARMA VENTURES, LLC, Encinitas, CA Powerof Attorney: None ...
It is preferable thatlittle or none of component c contains halogen substituted hydrocarbons since these tend to have ’ lower biocompatibility.
From Figure 4 (n=8) it appears that none of the investigated formulations has a severe burst effect.
... al Application No PCT/GB2005/002217 INTERNATIONAL SEARCH REPORT Patent document cited in search report WO 2005046642 US 5807573 A A 15-09-1998 date Patent family member(s) Publication date 26-05-2005 NONE ...
It is preferable thatlittle or none of component c contains halogen substituted hydrocarbons since these tend to have lower biocompatibility.
... SEARCH REPORT Information on patent family members Inter 1al application No PCT/GB2005/004746 Publication date Patent document cited in search report Publication date Patent family member(s) A 26-05-2005 NONE ...
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IPR2019-00450, No. 1007-15 Exhibit - Part 1 ¿¿¿ Pages 1 400 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1021-37 Exhibit - Merkus, US Patent Application Publication No US 20050153956, Serial No 11034,474, published July 14, 2005 Merkus (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1021-37 Exhibit - Merkus, US Patent Application Publication No US 20050153956, Serial No 11034,474, published July 14, 2005 Merkus (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1007-18 Exhibit - Part 4 ¿¿¿ Pages 1201 1600 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019...
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IPR2019-00450, No. 1007-18 Exhibit - Part 4 ¿¿¿ Pages 1201 1600 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1050-68 Exhibit - Table of Various Diazepam Solutions Described in or Modified From Sonne¿¿¿s Example 11 ¿¿¿DS11¿¿¿ (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1050-68 Exhibit - Table of Various Diazepam Solutions Described in or Modified From Sonne¿¿¿s Example 11 ¿¿¿DS11¿¿¿ (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1004-5 Exhibit - Part 1 ¿¿¿ Pages 1 350 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1004-5 Exhibit - Part 1 ¿¿¿ Pages 1 350 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1007-17 Exhibit - Part 3 ¿¿¿ Pages 801 1200 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1007-17 Exhibit - Part 3 ¿¿¿ Pages 801 1200 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1028-44 Exhibit - Ivaturi et al, Pharmacokinetics and tolerability of intranasal diazepam and midazolam in healthy adult volunteers, Acta Neurol Scand 2009 Nov1205353 7 d...
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IPR2019-00450, No. 1028-44 Exhibit - Ivaturi et al, Pharmacokinetics and tolerability of intranasal diazepam and midazolam in healthy adult volunteers, Acta Neurol Scand 2009 Nov1205353 7 doi 101111j1
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IPR2019-00450, No. 1019-35 Exhibit - Ueda et al, US Patent No 4,657,901, Pharmaceutical Composition, issued April 14, 1987 Ueda (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1019-35 Exhibit - Ueda et al, US Patent No 4,657,901, Pharmaceutical Composition, issued April 14, 1987 Ueda (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1015-31 Exhibit - Cartt et al, US Patent Application Publication No US 20080279784, Nasal Administration Of Benzodiazepines, Serial No 12116,842, published November 1...
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IPR2019-00450, No. 1015-31 Exhibit - Cartt et al, US Patent Application Publication No US 20080279784, Nasal Administration Of Benzodiazepines, Serial No 12116,842, published November 13, 2008 Cartt ¿
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IPR2019-00450, No. 1014-30 Exhibit - Gwozdz et al, WO 2009120933, Pharmaceutical Solutions And Method For Solubilizing Therapeutic Agents, published October 1, 2009, International Filing...
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IPR2019-00450, No. 1014-30 Exhibit - Gwozdz et al, WO 2009120933, Pharmaceutical Solutions And Method For Solubilizing Therapeutic Agents, published October 1, 2009, International Filing Date March 27
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IPR2019-00450, No. 1008-24 Exhibit - Provisional Patent Application No 61040,558, filed March 28, 2008 ¿¿¿558 Provisional (P.T.A.B. Jan. 29, 2019)
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IPR2019-00450, No. 1008-24 Exhibit - Provisional Patent Application No 61040,558, filed March 28, 2008 ¿¿¿558 Provisional (P.T.A.B. Jan. 29, 2019)
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