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Displaying 129-143 of 145 results

1004 Exhibit: Part 4 ¿¿¿ Pages 1051 1400 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH

Document IPR2019-00450, No. 1004-3 Exhibit - Part 4 ¿¿¿ Pages 1051 1400 File History for ¿¿¿546 Patent, Ser No 13495,942 ¿¿¿546 FH (P.T.A.B. Jan. 29, 2019)
The term "heteroaryl", as used herein, unless otherwise indicated, includes an organic radical derived from an aromatic heterocyclic compound by removal of one hydrogen, such as pyridyl, furyl, pyroy!, thienyl, isothiazoly!, imidazolyl, benzimidazolyl, tetrazolyl, pyrazinyl, pyrimidyl, quinolyl, isoquinoly:, benzofuryl, isobenzofury!, benzothieny!, pyrazolyl, indoiyl, isoindolyl, purinyl, carbazolyl, isoxazolyl, thiazoly!, oxazolyl, benzthiazoly!
The presentinvention also relates to a pharmaceutical composition for (a) the treatment of a condition selected from the group consisting ofarthritis, osteoporosis, cancer, synergy with cytotoxic anticancer agents, tissue ulceration, macular degeneration, restenosis, periodontal disease, epidermolysis bullosa, scleritis, in combination with standard NSAID'S and analgesics and other diseases characterized by matrix metalloproteinase activity, AIDS, sepsis, septic AQUESTIVE EXHIBIT 1004=page 1056 AQUESTIVE EXHIBIT 1004 page 1056
Solid compositions of a similar type may also be employedasfillers in gelatin capsules; preferred materials in this connection also include lactose or milk sugar as well as high molecular weight polyethylene glycols.
intravenous use) a sterile injectable solution of the active ingredient Salutions of a therapeutic compoundof the present invention in either sesame or peanutoil orin aqueous propylene glycol may be employed.
)propionicacid A solution of (2S)-2-hydroxy-3-(4-methoxybenzenesulfonyl)propionic acid benzyl ester (1.0 grams, 2.8 mmole) in methanol (70 mL) wastreated with 10% palladium on activated carbon (100 mg) and hydrogenated at 3 atmospheres pressure for 3 hours in a Parr shaker.
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1024 Exhibit: Osborne et al, Skin Penetration Enhancers Cited in the Technical Literature, Pharmaceutical Technology, November 1997 Osborne

Document IPR2019-00450, No. 1024 Exhibit - Osborne et al, Skin Penetration Enhancers Cited in the Technical Literature, Pharmaceutical Technology, November 1997 Osborne (P.T.A.B. Jan. 29, 2019)
Al- though recent efforts in using chemical enhancers have fo- cused on substances categorized as generally recognized as safe (GRAS), early work included a wide range of materi- als.
Additives that en- hance skin delivery by altering solubility of the active ingredi- ent in the formulation (including supersaturation) or by opti- AQUESTIVE EXHIBIT 1024 page 0002
Penetration of Guinea Pig Skin by Acyclovir in Different Vehicles and Correlation with the Efficacy of Topical Therapy of Experimental Cutaneous Herpes Simplex Virus Infection.
Effect of Azone and Propylene Glycol on Penetration of Trifluorothymidine Through Skin and Efficacy of Different Topical Follnulations Against Cutaneous Herpes Simplex Virus Infections in Guinea Pigs.
Effect of Penetration Enhancers on the in vitro Transport of Ephedrine Through Rat Skin and Human Epidermis from Matrix Based Trans dermal Foi inulations .
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1029 Exhibit: O¿¿¿Dell et al, School nurses¿¿¿ experience with administration of recta...

Document IPR2019-00450, No. 1029 Exhibit - O¿¿¿Dell et al, School nurses¿¿¿ experience with administration of rectal diazepam gel for seizures, J Sch Nurs, June 2007, 233166 9 O¿¿¿Dell (P.T.A.B. Jan. 29, ...

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1003 Exhibit: US Patent No 8,895,546, Administration Of Benzodiazepine Compos...

Document IPR2019-00450, No. 1003 Exhibit - US Patent No 8,895,546, Administration Of Benzodiazepine Compositions, filed June 13, 2012 ¿¿¿546 Patent (P.T.A.B. Jan. 29, 2019)

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1007 Exhibit: Part 2 ¿¿¿ Pages 401 800 File History for Non Provisional Patent Applic...

Document IPR2019-00450, No. 1007 Exhibit - Part 2 ¿¿¿ Pages 401 800 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)

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1010 Exhibit: US Patent Application Publication No US 20090258865, Administratio...

Document IPR2019-00450, No. 1010 Exhibit - US Patent Application Publication No US 20090258865, Administration of Benzodiazepine Compositions, Serial No 12413,439 Cartt¿¿¿865 (P.T.A.B. Jan. 29, 2...

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1017 Exhibit: Cartt et al, WO 2008137960, Nasal Administration Of Benzodiazepine...

Document IPR2019-00450, No. 1017 Exhibit - Cartt et al, WO 2008137960, Nasal Administration Of Benzodiazepines, published November 13, 2008, International filing date May 7, 2008 PCTUS200806296...

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1022 Exhibit: Liversidge et al, US Patent Application Publication No US 200601988...

Document IPR2019-00450, No. 1022 Exhibit - Liversidge et al, US Patent Application Publication No US 20060198896, Serial No 11354,249, published September 7, 2006 Liversidge (P.T.A.B. Jan. 29, 201...

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1028 Exhibit: Ivaturi et al, Pharmacokinetics and tolerability of intranasal diazepam...

Document IPR2019-00450, No. 1028 Exhibit - Ivaturi et al, Pharmacokinetics and tolerability of intranasal diazepam and midazolam in healthy adult volunteers, Acta Neurol Scand 2009 Nov1205353 7 doi 1...

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1007 Exhibit: Part 5 ¿¿¿ Pages 1601 2000 File History for Non Provisional Patent App...

Document IPR2019-00450, No. 1007-5 Exhibit - Part 5 ¿¿¿ Pages 1601 2000 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 29, 2019)

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1035 Exhibit: Davis, Delivery of peptide and non peptide drugs through the respirat...

Document IPR2019-00450, No. 1035 Exhibit - Davis, Delivery of peptide and non peptide drugs through the respiratory tract, Pharmaceutical Science Technology Today, Vol 2, No 11 November 1999, pag...

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1014 Exhibit: Gwozdz et al, WO 2009120933, Pharmaceutical Solutions And Metho...

Document IPR2019-00450, No. 1014 Exhibit - Gwozdz et al, WO 2009120933, Pharmaceutical Solutions And Method For Solubilizing Therapeutic Agents, published October 1, 2009, International Filing Da...

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1038 Exhibit: Bara, US Patent Application Publication No US20060178290, Serial N...

Document IPR2019-00450, No. 1038 Exhibit - Bara, US Patent Application Publication No US20060178290, Serial No 10563,967, published August 10, 2006 Bara (P.T.A.B. Jan. 29, 2019)

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1015 Exhibit: Cartt et al, US Patent Application Publication No US 20080279784, N...

Document IPR2019-00450, No. 1015 Exhibit - Cartt et al, US Patent Application Publication No US 20080279784, Nasal Administration Of Benzodiazepines, Serial No 12116,842, published November 13, 2...

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1040 Exhibit: Part 2 Pages 251 500 File History for EP 128 013729, based on WO 2...

Document IPR2019-00450, No. 1040-2 Exhibit - Part 2 Pages 251 500 File History for EP 128 013729, based on WO 2012174158 and PCTUS2012042311 (P.T.A.B. Jan. 29, 2019)

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