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1007 Exhibit: Part 7 ¿¿¿ Pages 2401 2800 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH

Document IPR2019-00449, No. 1007-21 Exhibit - Part 7 ¿¿¿ Pages 2401 2800 File History for Non Provisional Patent Application Serial No 12413,439, filed March 27, 2009 ¿¿¿439 FH (P.T.A.B. Jan. 28, 2019...
Nonetheless, for ophthalmic uses, the previously described polymer concentration ranges are preferred.
Although many attempts have been madeto safely and efficiently administer insulin, heparin and other macromolecular drugs by non- injectable routes, none have proved successful, and it has become apparentthat the success of such ...
None of the six volunteers had local irritation of the nostrils 30 minutes after application, see table 2.
Visual inspection of the appearance of the spray plumeofthree solutions in the viscosity range from 5.8 to 41.7 revealed that a plume was formed and noneof them “squirted.” [00262] These results demonstrated that at 20-25°C all solvent ...
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1022 Exhibit: Liversidge et al, US Patent Application Publication No US 200601988...

Document IPR2019-00449, No. 1022 Exhibit - Liversidge et al, US Patent Application Publication No US 20060198896, Serial No 11354,249, published September 7, 2006 Liversidge (P.T.A.B. Jan. 28, 201...

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1011 Exhibit: Meezan et al, US Patent Application Publication No US 20060046962...

Document IPR2019-00449, No. 1011 Exhibit - Meezan et al, US Patent Application Publication No US 20060046962, Absorption Enhancers for Drug Administration, Serial No 11127,786, published March 2...

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1047 Exhibit: Gwozdz Assignment of Provisional in Non Provisional Case, dated Ap...

Document IPR2019-00449, No. 1047 Exhibit - Gwozdz Assignment of Provisional in Non Provisional Case, dated April 21, 2008, recorded September 23, 2010 Gwozdz Assignment (P.T.A.B. Jan. 28, 2019)

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1044 Exhibit: USP NF 2003, The United States Pharmacopeia, The National Formu...

Document IPR2019-00449, No. 1044 Exhibit - USP NF 2003, The United States Pharmacopeia, The National Formulary, United States Pharmacopeial Convention, Inc ¿¿¿USPNF¿¿¿ (P.T.A.B. Jan. 28, 2019)

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1034 Exhibit: Edman I et al, D Routes of Delivery Case Studies 1 Nasal delivery of p...

Document IPR2019-00449, No. 1034 Exhibit - Edman I et al, D Routes of Delivery Case Studies 1 Nasal delivery of peptide drugs, Advanced Drug Delivery Reviews, 8 1992 165 177 Edman I (P.T.A.B. Jan....

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1038 Exhibit: Bara, US Patent Application Publication No US20060178290, Serial N...

Document IPR2019-00449, No. 1038 Exhibit - Bara, US Patent Application Publication No US20060178290, Serial No 10563,967, published August 10, 2006 Bara (P.T.A.B. Jan. 28, 2019)

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1037 Exhibit: Colombo, Mucosal Drug Delivery, Nasal, pp 592 605, Vol 2, Encyclop...

Document IPR2019-00449, No. 1037 Exhibit - Colombo, Mucosal Drug Delivery, Nasal, pp 592 605, Vol 2, Encyclopedia of Controlled Drug Delivery Mathiowitz, editor, John Wiley Sons, 1999 Colombo (P.T...

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1045 Exhibit: Maitani, et al, Design of ocularlacrimal and nasal systems through an...

Document IPR2019-00449, No. 1045 Exhibit - Maitani, et al, Design of ocularlacrimal and nasal systems through analysis of drug administration and absorption, Journal of Controlled Release, Volume 49, I...

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1028 Exhibit: Ivaturi et al, Pharmacokinetics and tolerability of intranasal diazepam...

Document IPR2019-00449, No. 1028 Exhibit - Ivaturi et al, Pharmacokinetics and tolerability of intranasal diazepam and midazolam in healthy adult volunteers, Acta Neurol Scand 2009 Nov1205353 7 doi 1...

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1039 Exhibit: Behl et al, Effects of physicochemical properties and other factors on...

Document IPR2019-00449, No. 1039 Exhibit - Behl et al, Effects of physicochemical properties and other factors on systemic nasal drug delivery, Advanced Drug Delivery Reviews 29 1998 89¿¿¿116 Behl (P...

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1036 Exhibit: Deshmukh et al, Lorazepam in the Treatment of Refractory Neonatal ...

Document IPR2019-00449, No. 1036 Exhibit - Deshmukh et al, Lorazepam in the Treatment of Refractory Neonatal Seizures, Am J Dis Child 1986140101042 1044 Deshmukh (P.T.A.B. Jan. 28, 2019)

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1043 Exhibit: Knoester, et al, Pharmacokinetics and pharmacodynamics of midazo...

Document IPR2019-00449, No. 1043 Exhibit - Knoester, et al, Pharmacokinetics and pharmacodynamics of midazolam administered as a concentrated intranasal spray A study in healthy volunteers, Br J C...

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1016 Exhibit: Kee et al, US Patent No 5,369,095, Compositions And Method Compr...

Document IPR2019-00449, No. 1016 Exhibit - Kee et al, US Patent No 5,369,095, Compositions And Method Comprising Substituted Glycosides As Mucus Membrane Permeation Enhancers, issued Novem...

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1018 Exhibit: Tenta, US Patent No 3,949,072, Seborrheic Keratosis Treatment, iss...

Document IPR2019-00449, No. 1018 Exhibit - Tenta, US Patent No 3,949,072, Seborrheic Keratosis Treatment, issued April 6, 1976 Tenta (P.T.A.B. Jan. 28, 2019)

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