MODIFIED ANTIBODIES, 62/511,771, No. J3OXO8X5RXEAPX3 (U.S. Pat. App. Jun. 8, 2017)

`
`Sequence Listing was accepted.
`
`See attached Validation Report.
` If you need help call the Patent
`
`
`
` Electronic Business Center at
`
`(866)
`
`
`
`
`
`
`
`217-9197 (toll free).
`
`Reviewer: Douglas, Keisha (ASRC)
`
`day=8; hr=17; min=26;
`[year=2017; month=6;
`Timestamp:
`sec=46;
`
`
`ms=664;
`
`]
`
`

`Validated By CRFValidator v 1.0.5
`
`Application No:
`
`62511771
`
`Version No:
`
`1.0
`
`Input Set:
`
`Output Set:
`
`Started:
`
`2017-05-26 17:05:13.696
`
`Finished:
`
`2017-05-26 17:05:27.675
`
`Elapsed:
`
`O hr(s)
`
`0 min(s)
`
`13 sec(s)
`
`979 ms
`
`Total Warnings:
`
`Total Errors:
`
`No. of SeqIDs Defined:
`
`55
`
`2
`
`28
`
`Actual SeqID Count:
`
`28
`
`Error code
`
`Error Description
`
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`
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`BE
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`BE
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`Ww
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`W
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`W
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`Ww
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`W
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`W
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`Ww
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`W
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`W
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`Ww
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`W
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`W
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`Ww
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`W
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`W
`
`Ww
`
`W
`
`W
`
`201
`
`201
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`213
`
`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`213
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`
`
`
`
`
`Mandatory field data missing
`in <140>
`
`Mandatory field data missing in <141>
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`or Unknown found in <213>
`in SEQ
`
`Artificial
`
`Artificial
`
`or Unknown found in <213>
`
`in SEQ
`
`or Unknown found in <213>
`
`in SEQ
`
`
`
`
`
`

`Input Set:
`
`Output Set:
`
`Started:
`
`2017-05-26 17:05:13.696
`
`Finished:
`
`2017-05-26 17:05:27.675
`
`Elapsed:
`
`O hr(s)
`
`0 min(s)
`
`13 sec(s)
`
`97
`
`9 ms
`
`Total Warnings:
`
`Total Errors:
`
`of SeqIDs Defined:
`
`Actual SeqID Count:
`
`55
`
`2
`
`28
`
`28
`
`Error code
`
`Error Description
`
`
`Artificial
`
`Artificial
`
`
`
`
`
`W
`
`W
`
`w
`
`w
`
`213
`
`213
`
`447
`
`447
`
`This error has occured more than 20 times,
`
`tne num
`
`nm or Xaa used,
`
`for:
`
`SEQID(24)
`
`o
`
`for:
`
`SEQID(24)
`
`o
`
`
`tne num
`
`ber
`
`1235
`
`
`or Unknown found in <213>
`in SE
`
`or Unknown found in <213>
`
`
`
`
`
`in SE
`
`Q ID
`
`(19)
`
`Q ID
`will
`
`(20)
`l not be displayed
`
`ber
`
`1231
`
`nm or Xaa used,
`
`nm or Xaa used,
`
`for:
`
`SEQID(24)
`
`nm or Xaa used,
`
`for:
`
`SEQID(25)
`
`nm or Xaa used,
`
`for
`
`SEQID(25)
`
`nm or Xaa used,
`
`for
`
`SEQID(25)
`
`nm or Xaa used,
`
`for
`
`SEQID(26)
`
`nm or Xaa used,
`
`for
`
`SEQID(26)
`
`
`tne num
`
`tne num
`
`
`tne num
`
`
`tne num
`
`tne num
`
`
`tne num
`
`ber
`
`1239
`
`ber
`
`1325
`
`ber
`
`1329
`
`ber
`
`1333
`
`ber
`
`1404
`
`ber
`
`1408
`
`o
`
`o
`
`o
`
`o
`
`o
`
`o
`
`w
`
`w
`
`w
`
`w
`
`w
`
`w
`
`w
`
`447
`
`447
`
`447
`
`447
`
`447
`
`447
`
`447
`
`
`
`447
`
`447
`
`447
`
`447
`
`447
`
`w
`
`w
`
`w
`
`w
`
`w
`
`
`
`
`
`nm or Xaa used,
`
`nm or Xaa used,
`
`nm or Xaa used,
`
`nm or Xaa used,
`
`nm or Xaa used,
`
`nm or Xaa used,
`
`
`
`for
`
`for
`
`for
`
`for
`
`for
`
`for
`
` 1708
`
`1696
`
`1704
`
`1688
`
`1692
`
`ber
`
`ber
`
`ber
`
`ber
`
`ber
`
`
`tne num
`
`tne num
`
`
`tne num
`
`
`tne num
`
`tne num
`
`tne num
`
`o
`
`o
`
`o
`
`o
`
`o
`
`
`
`SEQID(28)
`
`SEQID(28)
`
`SEQID(28)
`
`
`
`
`
`
`
`
`
`
`SEQID(28)
`
`SEQID(28)
`
`SEQID(28)
`
`w
`
`w
`
`w
`
`w
`
`w
`
`w
`
`447
`
`447
`
`447
`
`447
`
`447
`
`447
`
`nm or Xaa used,
`
`for
`
`SEQID(26)
`
`nm or Xaa used,
`
`for
`
`SEQID(27)
`
`nm or Xaa used,
`
`for
`
`SEQID(27)
`
`nm or Xaa used,
`
`for
`
`SEQID(27)
`
`nm or Xaa used,
`
`for
`
`SEQID(28)
`
`nm or Xaa used,
`
`for
`
`SEQID(28)
`
`
`tne num
`
`tne num
`
`
`tne num
`
`
`tne num
`
`tne num
`
`
`tne num
`
`ber
`
`1412
`
`ber
`
`1473
`
`ber
`
`1477
`
`ber
`
`1481
`
`ber
`
`1672
`
`ber
`
`1676
`
`ber
`
`1680
`
`o
`
`o
`
`o
`
`o
`
`o
`
`o
`
`o
`
`

`Input Set:
`
`Output Set:
`
`Started:
`
`2017-05-26 17:05:13.696
`
`Finished:
`
`2017-05-26 17:05:27.675
`
`Elapsed:
`
`0 hr(s)
`
`0 min(s)
`
`13 sec(s) 979 ms
`
`Total Warnings:
`
`Total Errors:
`
`No. of SeqIDs Defined:
`
`Actual SeqID Count:
`
`55
`
`2
`
`28
`
`28
`
`Error code
`
`Error Description
`
`

`
`
` Y ENCE LISTING
`
`EOU
`
`T,
`CAMPBE
`L, DAVID
`
`
`
`MODIFI
`
`ED ANTIBODIES
`
`52426-
`
`701.102
`
`US 62
`2017-
`
`/511, 771
`05-26
`
`28
`
`Patent
`
`In version 3.5
`
`A 110>
`
` <170>
`
`A 140>
`
`A 160>
`
`cial Sequence
`
`1 4
`
`0
`PRT
`Artifi
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
` EATURE
`MISC_F
`(1).. ¢
`40)
`
`This sequence may encompass 6-20 'GS' repeating units
`wherein some positions may be absent
`
`<400>
`
`1
`
`Gly Ser Gly
`1
`
`Ser Gly Ser Gly
`i)
`
`Ser Gly
`
`Ser Gly Ser Gly Ser Gly Ser
`10
`15
`
`Gly Ser Gly
`
`Ser Gly Ser Gly
`20
`
`Ser Gly
`25
`
`Ser Gly Ser Gly Ser Gly Ser
`30
`
`Gly Ser Gly
`35
`
`Ser Gly Ser Gly
`
`ser
`
`A0
`
`2 3
`
`9
`PRT
`
`Artifi
`
`cial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`
`
`
` ERATURE
`MISC_F
`
`(1)... (
`
`39)
`
`

`<223> This sequence
`units wherein
`
`may encompass 4-13 'GGS' repeating
`some positions may be absent
`
`<400>
`
`2
`
`Gly Gly Ser
`1
`
`Gly Gly
`
`Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
`10
`15
`
`Gly Ser Gly
`
`Gly Ser
`20
`
`Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
`25
`30
`
`Ser Gly Gly
`35
`
`Ser Gly
`
`Gly Ser
`
`3 4
`
`0
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FERATURE
`(1)... (40)
`
`This sequence
`units wherein
`
`may encompass 3-10 'GGGS' repeating
`some positions may be absent
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<400>
`
`3
`
`Gly Gly Gly
`
`Ser Gly
`5
`
`Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
`10
`15
`
`Gly Gly Gly
`
`Ser Gly
`20
`
`Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser
`25
`30
`
`Gly Gly Gly
`35
`
`Ser Gly
`
`Gly Gly Ser
`40
`
`4 4
`
`0
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`
`
`MISC_F HATURE
`
`

`<222> (1)... (40)
`
`<223> This sequence may encompass 2-8 'GGGGS'
`repeating units wherein some positions may be absent
`
`<400> 4
`
`Gly Gly
`1
`
`Gly
`
`Gly Ser
`5
`
`Gly Gly
`
`Gly Gly Ser Gly Gly Gly Gly Ser Gly
`10
`15
`
`Gly Gly
`
`Gly
`
`Ser Gly
`20
`
`Gly Gly
`
`Gly Ser Gly Gly Gly Gly Ser Gly Gly
`25
`30
`
`Gly Gly
`
`ser
`
`35
`
`Gly Gly
`
`Gly Gly
`
`Ser
`
`A0
`
`<210> 5
`<211> 40
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`
`
`
`<221> MISC_FEATURE
`<222> (1).. (40)
`<223> This sequence
`units wherein
`
`<400> 5
`
`may encompass 12-40 'G' repeating
`some positions may be absent
`
`Gly Gly
`
`Gly
`
`Gly Gly
`
`Gly Gly
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly
`10
`15
`
`Gly Gly
`
`Gly
`
`Gly Gly
`20
`
`Gly Gly
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly
`25
`30
`
`Gly Gly
`
`Gly
`35
`
`Gly Gly
`
`Gly Gly
`
`Gly
`40
`
`<210> 6
`<211> 33
`<212> PRT
`
`<213> Artificial Sequence
`
`<220>
`
`<223> Description of Artificial Sequence: Synthetic
`polypeptide
`
`<220>
`
`

`<221>
`<222>
`<223>
`
`
`
`
`MISC_FERATURE
`(1)... (33)
`
`This sequence may encompass 1-3 'GGGSGSGGGGS' repeating
`units wherein some positions may be absent
`
`<400>
`
`6
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly
`1
`5
`10
`15
`
`Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly
`20
`25
`30
`
`7 3
`
`3
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FEATURE
`(1)... (33)
`
`This sequence may encompass 1-3 'GGGGGPGGGGP' repeating
`units wherein some positions may be absent
`
`Ser
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<400>
`
`7
`
`Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly
`1
`5
`10
`15
`
`Pro Gly Gly Gly Gly Pro Gly Gly Gly Gly Gly Pro Gly Gly Gly Gly
`20
`25
`30
`
`8 3
`
`6
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`Pro
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`

`<220>
`<221>
`<222>
`<223>
`
`
`
`
`MISC_FEATURE
`(1)... (36)
`
`This sequence
`units wherein
`
`may encompass 2-6 'GGSGGD' repeating
`some positions may be absent
`
`<400>
`
`8
`
`Gly Gly Ser
`
`Gly Gly
`5
`
`Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`10
`15
`
`Gly Asp Gly
`
`Gly Ser
`20
`
`Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`25
`30
`
`Ser Gly Gly
`35
`
`Asp
`
`9 3
`
`6
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`
`
`
`
`<221> MISC_FEATURE
`<222> (1).. (36)
`
`<223> This sequence
`units wherein
`
`<400> 9
`
`
`may encompass 2-6 'GGSGGE' repeating
`some positions may be absent
`
`Gly Gly Ser Gly Gly
`1
`5
`
`Glu Gly Gly Ser Gly Gly Glu Gly Gly Ser Gly
`10
`15
`
`Gly Glu Gly Gly Ser
`20
`
`Gly Gly Glu Gly Gly Ser Gly Gly Glu Gly Gly
`25
`30
`
`Ser Gly Gly Glu
`35
`
`<210> 10
`<211> 116
`<212> PRT
`<213>
`
`Artificial Sequence
`
`<220>
`<223>
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`

`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`
`
`
`MISC_FEATURE
`(1)... (40)
`
`This region may encompass 0-20 'GS' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(41).. (76)
`
`This region may encompass 2-6 'GGSGGD' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(77).. (116)
`
`This region may encompass 0-20 'GS' repeating
`units wherein some positions may be absent
`
`<400>
`
`10
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`1
`
`Gly
`15
`
`Ser
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`
`Gly
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Gly Ser Gly Gly Asp
`35
`40
`45
`
`Gly
`
`Gly
`
`Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`50
`55
`60
`
`Gly
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Ser
`65
`70
`75
`
`Gly
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`85
`90
`
`Gly
`95
`
`Ser
`80
`
`ser
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`100
`105
`110
`
`Ser
`
`Gly
`
`Gly Ser Gly Ser
`115
`
`<210>
`<211>
`<212>
`<213>
`
`11
`114
`PRT
`
`Artificial Sequence
`
`

`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FEATURE
`(1) -. (39)
`
`This region may encompass 0-13 'GGS' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(40) ..(75)
`
`This region may encompass 2-6 'GGSGGD' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(76) .. (114)
`
`This region may encompass 0-13 'GGS' repeating
`units wherein some positions may be absent
`
`<400>
`
`11
`
`Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
`1
`
`Gly
`
`Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser
`20
`25
`30
`
`Gly
`
`Gly
`
`Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Asp Gly
`35
`40
`45
`
`Ser
`
`Gly
`
`Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly
`50
`55
`60
`
`Asp
`
`Gly
`
`Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser
`65
`70
`75
`
`Gly
`
`Gly
`80
`
`Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly
`
`Gly
`
`Ser
`
`Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly Ser Gly Gly
`100
`105
`110
`
`Ser
`
`Gly
`
`Gly Ser
`
`<210> 12
`
`

`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FEATURE
`
`(1)... (40)
`This region may encompass 0-10 ‘'GGGS' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`
`(41)... (76)
`This region may encompass 2-6 'GGSGGD' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`
`(77) .. (116)
`This region may encompass 0-10 'GGGS' repeating
`units wherein some positions may be absent
`
`<400>
`
`12
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`1
`
`Gly
`15
`
`ser
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`20
`25
`30
`
`Ser
`
`Gly
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Ser Gly Gly Asp
`35
`40
`45
`
`Gly
`
`Gly
`
`Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`50
`55
`60
`
`Gly
`
`Asp
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`
`Gly
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`85
`90
`
`Gly
`95
`
`Ser
`80
`
`Ser
`
`Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly Gly Ser Gly Gly
`100
`105
`110
`
`ser
`
`Gly
`
`Gly Gly Gly Ser
`
`

`115
`
`13
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FEATURE
`(1)... (40)
`
`This region may encompass 0-8 'GGGGS' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(41).. (76)
`
`This region may encompass 2-6 'GGSGGD' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(77) .. (116)
`
`This region may encompass 0-8 'GGGGS' repeating
`units wherein some positions may be absent
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<400>
`
`13
`
`Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
`1
`
`Ser
`15
`
`Gly
`
`Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser
`20
`25
`30
`
`Gly
`
`Gly
`
`Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Ser Gly Gly Asp
`35
`40
`45
`
`Gly
`
`Gly
`
`Ser Gly Gly Asp Gly Gly
`
`u oO K
`uo uo
`
`Gly Gly Asp Gly Gly Ser Gly
`60
`
`Gly
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`65
`70
`75
`
`Gly
`
`Gly
`80
`
`Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly
`85
`90
`
`Gly
`95
`
`ser
`
`Gly Gly Gly Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Gly
`
`ser
`
`Gly
`
`

`100
`
`105
`
`110
`
`Gly Gly Gly Ser
`115
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`14
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FEATURE
`(1) -. (40)
`
`This region may encompass 0-40 'G' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FERATURE
`(41)... (76)
`
`This region may encompass 2-6 'GGSGGD' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`(77) .. (116)
`
`This region may encompass 0-40 'G' repeating
`units wherein some positions may be absent
`
`<400>
`
`14
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`1
`
`Gly
`15
`
`Gly
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`20
`25
`30
`
`Gly
`
`Gly
`
`Gly Gly
`
`a a K Gly Gly Gly Gly Gly Gly Gly Ser Gly Gly Asp
`Ww a
`40
`45
`
`Gly
`
`Gly
`
`Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly
`50
`55
`60
`
`Gly
`
`Asp
`
`Gly Gly Ser Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly Gly
`65
`70
`75
`
`Gly
`
`Gly
`80
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`
`Gly
`
`Gly
`
`

`85
`
`90
`
`95
`
`Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly Gly
`100
`105
`110
`
`Gly Gly Gly Gly
`115
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`15
`102
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence:
`polypeptide
`
`Synthetic
`
`
`
`
`MISC_FEATURE
`
`(1)... (33)
`This region may encompass 0-3 'GGGSGSGGGGS"
`units wherein some positions may be absent
`
`repeating
`
`
`
`
`MISC_FEATURE
`
`(34)... (69)
`This region may encompass 2-6 'GGSGGD'
`repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`
`(70) .. (102)
`This region may encompass 0-3 'GGGSGSGGGGS’
`units wherein some positions may be absent
`
`repeating
`
`<400>
`
`15
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly
`1
`
`ser
`
`Gly
`
`Gly
`
`Gly
`
`ser
`
`15
`
`Gly
`
`Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser
`20
`25
`
`Gly
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`
`30
`
`Ser Gly Gly Ser Gly Gly Asp Gly Gly Ser
`35
`40
`
`Gly
`
`Gly
`
`Asp
`45
`
`Gly
`
`Gly
`
`Ser
`
`Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly
`50
`55
`
`Gly
`
`ser
`
`60
`
`Gly
`
`Gly
`
`Asp
`
`Gly
`
`Gly Ser Gly Gly Asp Gly Gly Gly Ser Gly
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`
`Gly
`
`Ser
`
`

`65
`
`70
`
`75
`
`80
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Ser Gly Gly Gly Ser Gly
`85
`90
`95
`
`Ser Gly Gly Gly Gly Ser
`100
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`16
`102
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence:
`polypeptide
`
`Synthetic
`
`
`
`
`MISC_FEATURE
`
`(1)... (33)
`This region may encompass 0-3 'GGGSGSGGGGP’”
`units wherein some positions may be absent
`
`repeating
`
`
`
`
`MISC_FEATURE
`
`(34)... (69)
`This region may encompass 2-6 'GGSGGD'
`repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`
`(70) .. (102)
`This region may encompass 0-3 'GGGSGSGGGGP’
`units wherein some positions may be absent
`
`repeating
`
`<400>
`
`16
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly
`1
`
`Pro
`
`Gly
`
`Gly
`
`Gly
`
`ser
`
`15
`
`Gly
`
`Ser Gly Gly Gly Gly Pro Gly Gly Gly Ser
`20
`25
`
`Gly
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`
`30
`
`Pro Gly Gly Ser Gly Gly Asp Gly Gly Ser
`35
`40
`
`Gly
`
`Gly
`
`Asp
`45
`
`Gly
`
`Gly
`
`Ser
`
`Gly Gly Asp Gly Gly Ser Gly Gly Asp Gly
`50
`55
`
`Gly
`
`ser
`
`60
`
`Gly
`
`Gly
`
`Asp
`
`Gly
`
`Gly Ser Gly Gly Asp Gly Gly Gly Ser Gly
`
`Ser
`
`Gly
`
`Gly
`
`Gly
`
`Gly
`
`Pro
`
`

`65
`
`70
`
`75
`
`80
`
`Gly Gly Gly Ser Gly Ser Gly Gly Gly Gly Pro Gly Gly Gly Ser Gly
`85
`90
`95
`
`Ser Gly Gly Gly Gly Pro
`100
`
`<210>
`<211>
`<212>
`<213>
`
`<220>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`<220>
`<221>
`<222>
`<223>
`
`17
`116
`PRT
`
`Artificial Sequence
`
`Description of Artificial Sequence: Synthetic
`polypeptide
`
`
`
`
`MISC_FEATURE
`
`(1)... (40)
`This region may encompass 0-20 'GS' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`
`(41)... (76)
`This region may encompass 2-6 'GGSGGE' repeating
`units wherein some positions may be absent
`
`
`
`
`MISC_FEATURE
`
`(77) .. (116)
`This region may encompass 0-20 'GS' repeating
`units wherein some positions may be absent
`
`<400>
`
`17
`
`Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser Gly Ser
`1
`5
`
`

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