PTO/SB/16 (12-08)
`Approved for use through 06/30/2010. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1995, no persons are required to respondto a collection of information unlessit displays a valid OMB control number.
`PROVISIONAL APPLICATION FOR PATENT COVER SHEET — Page1 of 2
`This is a requestfor filing a PROVISIONAL APPLICATION FOR PATENTunder 37 CFR 1.53(c).
`Electronically Filed
`April 15, 2011
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`Given Name (first and middle [if any])
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`Family Name or Surname
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`Residence
`City and either State or Foreign Count
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`Additional inventors are being named on the
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`separately numbered sheets attached hereto
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`TITLE OF THE INVENTION (500 characters max):
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`METHODS AND COMPOSITIONS FOR DETERMINING NUCLEIC ACID FRAGMENTATION
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`The address corresponding to Customer Number:
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`021971
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`OR
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`CORRESPONDENCE ADDRESS
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`Telephone
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`Email
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` Direct all correspondenceto:
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`Firm or
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`Individual Name
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`Address
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`Country
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`ENCLOSED APPLICATION PARTS(checkall that apply)
` BX] Application Data Sheet. See 37 CFR 1.76
`[_] cp(s), Numberof CDs
`Xx] Drawing(s) Numberof Sheets
`1
`[| Other(specify)
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`Specification (e.g. description of theinvention) Number of Pages
`18
`also due, which is $270 ($135 for small entity) for each additional 50 sheets or fraction thereof. See 35 U.S.C. 41(a)(1)(G) and 37 CFR 1.16(s).
` Fees Due: Filing Fee of $220 ($110 for small entity). if the specification and drawings exceed 100 sheets of paper, an application sizefee is
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`METHOD OF PAYMENTOF THE FILING FEE AND APPLICATION SIZE FEE FOR THIS PROVISIONAL APPLICATION FOR PATENT
` [| Applicant claims small entity status. See 37 CFR 1.27.
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`["] A check or moneyorderis enclosed to coverthe filing fee and application size fee (if applicable).
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`| Paymentbycredit card. Form PTO-2038is attached
`TOTAL FEE AMOUNT($)
`Account Number: 23-2415
` XxX The Director is hereby authorized to chargethefiling fee and application size fee (if applicable) or credit any overpaymentto Deposit
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`220.00
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`USE ONLY FORFILING A PROVISIONAL APPLICATION FOR PATENT
`This collection of information is required by 37 CFR 1.51 . The information is required to obtain or retain a benefit by the public whichis tofile (and by the USPTO
`to process) an application. Confidentiality is governed by 365 U.S.C. 122 and 37 CFR 1.11 and 1.14. This collection is estimated to take 8 hours to complete,
`including gathering, preparing, and submitting the completed application form to the USPTO. Timewill vary depending upon the individual case. Any comments
`on the amountof time you require to complete this form and/or suggestions for reducing this burden, should be sent to the Chief Information Officer, U.S. Patent
`and Trademark Office, U.S. Department of Commerce, P.O. Box 1450, Alexandria, VA 22313-1450. DO NOT SEND FEES OR COMPLETED FORMSTO THIS
`ADDRESS. SEND TO: Commissioner for Patents, P.O. Box 1450, Alexandria, VA 22313-1450.
`if you need assistance in completing the form, call 1-800-PTO-9199 and selectoption 2.
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`4329080 1.DO0C
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`

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`PROVISIONAL APPLICATION COVER SHEET
`Page 2 of 2
`
`PTO/SB/16 (12-08)
`Approved for use through 06/30/2010. OMB 0651-0032
`U.S. Patent and Trademark Office; U.S. DEPARTMENT OF COMMERCE
`Under the Paperwork Reduction Act of 1 995, no persons are required to respondto a collection of information unless it displays a valid OMB control number.
`
`The invention was made by an agencyof the United States Governmentor under a contract with an agencyof the United States Government.
`Xx]
`No
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`[| Yes. the nameof the U.S. Government agency and the Governmentcontract numberare:
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`WARNING:
`Petitioner/applicant is cautioned to avoid submitting personal information in documents filed in a patent application that may
`contribute to identity theft. Personal information such as social security numbers, bank account numbers, or credit card
`numbers(other than a checkor credit card authorization form PTO-2038 submitted for payment purposes)is never required by
`the USPTO to support a petition or an application.
`If this type of personal information is included in documents submitted to
`the USPTO, petitioners/applicants should consider redacting such personalinformation from the documents before submitting
`them to the USPTO. Petitioner/applicant is advised that the record of a patent application is available to the public after
`publication of the application (unless a non-publication request in compliance with 37 CFR 1.213(a) is madein the application)
`or issuance of a patent. Furthermore, the record from an abandoned application may also be available to the public if the
`application is referenced in a published application or an issued patent (see 37 CFR 1.14). Checks and credit card
`authorization forms PTO-2038 submitted for payment purposes are not retained in the application file and therefore are not
`publicly available.
`SIGNATURE
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`Date April 15, 2011
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`,
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`TYPED or PRINTED NA
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`effrey J. Seidel, Ph.D., Patent Agent
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`REGISTRATION NO. 61,063
`(if appropriate)
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`TELEPHONE 650.493.9300
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`Docket Number: 38938-718.101
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`4329080_1.DOC
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