`Application No. 18/250,921
`
`Amendments to the Claims
`
`This listing of claims will replace all prior versions, and listings, of claims in the application.
`
`1.-48.
`
`(Canceled)
`
`49.
`
`(Original)
`
`Impurity A, having the structure:
`
`O
`
`son
`
`NH,
`
`>
`
`or a tautomer, salt or solvate thereof.
`
`50.-146.
`
`(Canceled)
`
`147.
`
`(New) A composition comprising the compound of claim 49, or a tautomer,salt, or
`
`solvate thereof, and carbachol, or a pharmaceutically acceptable salt thereof.
`
`148.
`
`(New) A composition comprising the compound of claim 49, or a tautomer,salt, or
`
`solvate thereof, and brimonidine, or a pharmaceutically acceptable salt thereof.
`
`149.
`
`(New) A composition comprising the compound of claim 49, or a tautomer,salt, or
`
`solvate thereof, carbachol, or a pharmaceutically acceptable salt thereof, and brimonidine, or a
`
`pharmaceutically acceptable salt thereof.
`
`150.
`
`(New) The composition of claim 149, wherein the composition comprises less than
`
`5 wt % impurity A after storage at 25 °C and 40% relative humidity for at least 5 months.
`
`Atty. Dkt. No. 4902.0110003
`
`
`
`Rhett M. SCHIFFMAN
`Application No. 18/250,921
`
`151.
`
`(New) The composition of claim 149, wherein the composition comprises less than
`
`1 wt % impurity A after storage at 25 °C and 40% relative humidity for at least 5 months.
`
`152.
`
`(New) The composition of claim 147, further comprising Impurity B, having the
`
`structure:
`
`Br
`
`0
`
`SN
`
`ZA
`
`N
`
`TT Sy NH>
`
`O
`
`>
`
`or a tautomer, salt, or solvate thereof.
`
`153.
`
`(New) The composition of claim 148, further comprising Impurity B.
`
`154.
`
`(New) The composition of claim 149, further comprising Impurity B.
`
`155.
`
`(New) The composition of claim 154, wherein the composition comprises less than
`
`2 wt % impurity B after storage at 25 °C and 40% relative humidity for at least 5 months.
`
`156.
`
`(New) The composition of claim 154, wherein the composition comprises less than
`
`0.25 wt % impurity B after storage at 25 °C and 40% relative humidity for at least 5 months.
`
`157.
`
`(New) A methodfor ameliorating or reducing presbyopia in a subject comprising
`
`administering the composition of claim 149 to at least one eye of the subject.
`
`158.
`
`(New) The method of claim 157, wherein the amelioration or reduction of
`
`presbyopiais effective for at least 6 hours.
`
`159.
`
`(New) The method of claim 157, wherein the amelioration or reduction of
`
`presbyopiais effective for at least 8 hours.
`
`Atty. Dkt. No. 4902.0110003
`
`
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