`
`Title:
`
`Pub/Pat no:
`
`Pub/Issue Date:
`Inventor(s):
`
`Applicant(s):
`Classification:
`
`LENS INCORPORATING MYOPIA CONTROL OPTICS AND
`MUSCARINIC AGENTS
`
`JP2014032404A
`
`2014-02-20
`KHALED CHEHAB| ARTHUR H SHEDDENJR| SHU
`CHENG|KHALED CHEHAB |ARTHUR H SHEDDENJR |SHU
`CHENG
`
`JOHNSON & JOHNSON VISION CARE
`G02C7/04AI; A61K31/46AI; AG1K31/5513AI; AGIL27/00AI;
`AG61P27/02AI
`
`Application number:
`Priority number:
`
`—_JP20130157442 2013-07-30
`US201213563322 2012-07-31;
`
`Abstract of JP2014032404A
`
`PROBLEM TO BE SOLVED: To provide ophthalmic lenses. SOLUTION: Ophthalmic devices,
`
`such as contact lenses, may incorporate myopia control optics in combination with therapeutic
`agents also knownto control myopia to create a drug delivery mechanism to inhibit or arrest the
`
`progression of myopia in individuals. Any numberof contact lenses incorporating myopia control
`
`optics may be combined with a therapeutic agent such as atropine, atropine sulphate monohydrate,
`
`and/or pirenzepine.
`
`
`
`JP 2014-32404 A 2014.2. 20
`
`(19) ELAREN@S4FF (JP)
`
`(aa fd Fe FF 2 BRA)
`
`(11) $987 HS eS
`43682014-32404
`(P2014-32404A)
`(43) 439A S2RR264F2A 208 (2014.2. 20)
`
`Fl
`
`(51) Int.Cl.
`GO2C 7/04
`(2006. 01)
`7/04
`GO2C¢
`AG1L 27/00
`(2006. 01)
`AGIL 27/00
`ABILK 31/46
`(2006. 01)
`AG1K 31/4
`ABLK 31/5513
`(2006.01)
`AG1K 31/5513
`AGIP 27/02
`(2006. 01)
`AGIP 27/02
`
`BERR RK PROM 14 OL FBRWER
`(= 20 B)
`
`D
`
`FF—TI4I— (Bs)
`2HOOS6
`40081
`4CO086
`
`2)) HRB > 4339 2013-157442 (P2013-157442)|(71) HERA 510294139
`
`
`32 BR25487A308 (2013. 7. 30)
`(22) HERA
`VParvr- PUP - YPaervr: EPs
`(31) HERES 13/563, 322
`YP AYA-REG Fy K
`(32) 4t 48
`32 pe244F7A 318 (2012.7.3)
`Johnson & Johnson V
`33) BX#EBH 3*H (US)
`ision Care,
`Inc.
`FAUPASGRH, 32256 yaya
`, PeIV YEW, erPaty ne
`2uUxrft 7500
`7500 Centurion Park
`
`Jacksonville,
`way,
`FL 32256, United St
`ates of America
`
`(74) {REBA 100088605
`Ft MP BRE
`
`BRA litt <
`
`(64)
`
`[HRAOBA)] REE RTRULAD Y VERA SHS bYA
`
`Heo 6
`Ne
`
`nO
`"Cy
`
`OH
`
`(61) EW)
`[RE] HLeHENES S.
`
`(WRFE IVR bLY AR EOMATBIRE, HE
`HeHASSCECEMACH SARE LHARbDEN
`Je. VIEREAA TS LIChO, SHAT
`CTA OMEEAHATZ FeO, AAO
`REO CEMCES, VPARPBaa
`, ARMOIY RI bLYAR, PhO, WEE b
`ney, ROYMIE LYCEPOSE
`
`CHMAGDLST LACES,
`CER] Bll A
`
`
`
`(2)
`
`JP 2014-32404 A 2014. 2.20
`
`Cie at fa 2k © BE A
`Cai 3K IA 1]
`MAOCTOMM. Bik. RUS RGM ADABODEC LEILDOROORALY SA
`CHT,
`HLOMPANMSBREN. DODEMMMCPRSRPHMAA, AYREFREYAE,
`WitoVeF RL YVYASERT SHCA LOMB RMX N4ZADRIHMAWKENSZDO
`DE CLE -ACHSZBEAGMWPCMAUENERHRAAZAAUY ALE. RBA. WMMAAA
`UYRIM, BReEOMBMc dR > TROPIC BABT SZ EAC RENA. BALL RZ,
`Can ck TA 2 ]
`Wa BIL OMBAL NT POP e at, PRIA cMRO, HAO TOMA, Bok
`ROY RAHM OAZBEODPR CEE LOORMOORMALY A,
`(aa cK TA 3 ]
`WAAR IOMRD, VU AY ANT FOF Ve SE, PRB Lee KRO, ROC TO Hl
`fl. Bik, RO SRAM MODSBEODPECLELDORBOOMRALY &.
`Cad ok IA 4 ]
`
`Wah AADUYVAIAL FROCYRSaS., BRAL CERRO, CHO TOME, Bh
`IE, ROS RAMA ODEODECLRIOOROOMALY 2,
`(#8 RIA 5 ]
`Hama AAUY AD. WEP ho RE Ya So, FOR 1 aM, HO ETT OM Bl
`
`Rr, ROL RAM OABODPRCLELDOROORALY ZX,
`Cia 3k IA 6 )
`Wah hAAU YADA, ELV VEY eat, PRA CMRO. RAO TO Mil,
`Buk, ROA Mi HAO SBE ODR CER ILDOORMDORALY A,
`Can ck 1A 7 ]
`
`Wah AAU YAIR AWD. RHE BRIAR PICAMReNRP hoe Ye eo,
`RB 4AM OL ROB TOMM. Bik. ROY MAO D BE ODPRCEBELOIOR
`AOMALY ZA.
`{aa 3k A 8 ]
`Hach bh AAU YAIR AWSD., REFER RRB RP CAR SNR bare Yea
`. HRS aM OL AOC TOMM, Bt, ROY MAO SD EODECLERID
`OMBOMAL ’ z,
`(aa 3K A 9 ]
`Mah hAADU YAIR AWD. ROEM RR ARP ARM ENRELY PE Vea,
`
`MRA 6KCMRO. MMOUWTOMM. Bk, ROSRMAMAOSAEOPEC EB1DOD
`TOORAL YZ,
`(#3K IA 1 0]
`WAeIYVAPRhEYANKECMARAENS, HR EAS RSS, WRAL KMRO,
`
`MOU TOMM. Bb. ROMA OS BOD CLELOORMOORALY SZ,
`Cas 3K 1
`14)
`ic id
`MAI VY RI RLYAAKHMARBEN SHED 4 NV R-BR SBIR BOK IA 1
`RO. CROCE TOMM. MIL, MOY RAMMNDGEODPECLELOOROORAL
`YR.
`Cae °K JR 1 2)
`Mave? REY AM, PABAL YAR SS. PRL ICMRO, THOR TOM
`fl. Buk, ROS REMMOG BODE LERIVPORHOORALY A,
`Cagok JA 1 3)
`Manav aee REY AD, BAHL Y Ae SO, RI 1 aR O, ROTO
`Mil, Bue. ROU MAMMOSBEODE LEILDOROORALY 2,
`Cae ck JH 1 4)
`VRMOCTOMBM. BIE, ROS MRAMADSGEODPRCLERIDOROORALY SA
`
`
`
`(3)
`
`JP 2014-32404 A 2014. 2. 20
`
`
`
`CGHrT,
`BLOMADVSBREN. DOENRMMKARTRMASAG. OUYRAAREY AE,
`Wave bE YAReR RT SHA LOMAKRMENAD NIM AUVENZYO
`be kE-ACHSBAWHKCMAAENK FANS VPA BEL eA, BaF 78
`
`SUPRA BA, REOWMAK berks THORP ANT SEAR MENS, BRAY.
`C 38 AA @ FF AM Ze LA
`C$ fii > OF
`foo001)
`IRA VY Ril, KOM, RHMOUTe, BE. BW. Rakes
`AEA IS.
`SERRA NK,. WAL Y AAS S. KROME YAR.
`PF hoOeY, me
`KoeYy—KAM, ROE LY VUEVESaE, LADUY REAR EMAA DEH
`MM C4RERASOT EMC KD. LROEROMMEKESSZMRe HOM,
`(ERE iN)
`[0002]
`Mm MII, RP SCOTMAM RICE TSMR TNSOKRMD—WicRAT 4S,
`
`BMOKFWRMAL KARR ERM CHS. WA. HRN, BROMEBART XS
`
`DY. RUBE CAAMASZTHRMENDEUCS, WHI, FRAMDAAO 3 B78
`
`
`—e Yh FSEC. ERHAO-MOMMCH. AMOTSN-tYbICESEC.
`
`@eRlFL CWS. COMM#ARORAU. FACHS. LOLADS, CORAL,
`GHB ACR RN BEREOMAADHCKLAMHREMRE BY. VIF AZORRHAORM
`LY ARIAL. WRERMET STE MACES, TCOVAFADOBRAOLY RAE, A
`AHRMEHRMEPCSZTCELCLO, POLAK, MRRMLNE BBE CS, SAM Ble id
`
`MENSA. CHSEORWELY AU, UVMEMAT SM, CHAOBTSER LT SEO
`ClEW,
`(90003)
`RicFRhOBAK. FAOLDAEBEA LS EBM XH AZRADORSECOKEDERSE
`tL. FEE NTHOS. THEOHRELL CH. SRRALYAOFAAL LON ELOREMS
`AKENEELY AROMA, REHM ALY ZORA, HAM ALY ROA. ABO
`He. HBOMR. ROBMRAAL SCHAAR RTS,
`fooo4]
`SEALY ARUMBRAT SL YAOPAM. QRENKMSCOMRCRENSE
`535i, ENGOVLYAM, BHAOBMAMAZATIRNASO, POLMBAX MB ic
`WMOLTL. HSORK—RYR~SOR-vRYEO, HAMOPRRORHPOBRO, Ree
`DEBRAWHEERLBSZEWS AC. BOA CHSZTEMPAL TOS, EROMOD
`AREER. AMOBBCREAKAGERR, ROR REAL 6 BARI KS
`m. WMEWICSEL SWRA ePaBOKFA REE S, BAM, IRR LADY
`VEVEFAROP OEY. WROMBICAA CHS CEM, RSC OMRCRENTYH
`Bo
`[3$H OG)
`CHAD RRL KG ESSE)
`[0005]
`Litho. MEOMRR ERT SEH, REM A WER ARE OFA Ae ee) ile
`MASE OAO, LOKELOMARKORMRANMAR DHE, LHOLTOMP, Bik. &
`
`UY REMADABODPRL LE LDIORMHDOBREOREBRD EET SZ.
`(AReMeR ST SEDO FRY]
`(0006)
`BEHO.L HRM MCS RSTRURRW ALS AIF RA LAD UY REA REM BA
`geayvaey*epeurv Ald. (MRR ICMMT SMSC OFA AERTS.
`f[o007]
`feel knit, RHME. MROKTP OMB, MIL, ROS RAMA ODBODES
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(4)
`
`JP 2014-32404 A 2014. 2.20
`
`
`LBRLIOROOMALY Ae AM ECS, COMALY Al, BIOMA DSP Ren
`_ DDRGHMMAKSRPEMAAD, AVYRPRLYAEL, FEOUVRIPLVYAEERK
`SAA LOMRICMRINE NMEADRAMAAENSZDODESCLE-ACTHAZBRADHIC A
`AWEhRERRAAAUYVAIEL BBA. COPAAAUY AR. BEOMM KDR oTE
`OPicCBHT SRSA eBRENS.
`foo0os]
`
`
`HAPORRBOARSD, AS5OMORRRHReMET ZR Hic, RRM IY ah
`VRE POMEL YARRA S. MRR. APROBA, RU/SRARROKR ARE
`LRORRALOA-Mic ko tHeHTENS, MAW, KDADMOMM,. MAE
`
`RCRYRROMR MMe eM CL. ROPER, XBR O Rd ee Sl
`eMOUL. BHANIC. MI FOP VY RIC LE ARAM SSR CT. CHoOORT
`
`RECHT 4. HE OMBN RMB, UY RIFLE Y ARERR PORELY AOR
`A#eED. CNHSOMARMICHTS. KORMNEMBEL TH. LPO PO PTY
`
`Yee AT SM ROBR. RABKAARALY COMA SEV BAT HICEOL KB
`SHEA ASRBRACHBET SEA FROM BT SENS. LOLAMSH, THEAOEEB, Kit
`_ROYLSRCFRE,. CHOOMP#RHAAL SKA REOTERICHUTAZDACH DT
`. ROMA MORR. ROFCOBDUAOWBASMETZEOCHEY, TCHEOHKKR
`RPA KER. BAGAHEBRROV ATS EER SGCTHNEHSS, Bketk, CHE ORER
`G/L RIRHOSEOW PT NMA LEBEL HAL TE. BEARS L. RRS.
`MAR.
`aovye¥ sa RHRROUCFATF-Lh*eSOK, MEOBR AEH. WOK BNE
`MORMLIE, PMOKRRCWLTHSSZERSAeR FT RNMNHS, BMSTHNI, Wels
`, SEM EECRROY NUBILES,
`foo0o09)]
`AHI. MMO AOMM. MIE, RUS RXAAMODBEODSRC LEIDEAWNE
`TS. FRORY, MBP roe YyoRKA. ELV PEYVYSREORIRN AL < IER
`HES AEA A. ROSRURMRORROL AML HK. RRS RS. ZRAL
`-~HRAMSRT. PRAMS RT. ROY RGA MSRP SEM SAG, Lae
`AYARHYOAT FOF VAR. BSWVKET IP VAYAROL RAF O74 Va B
`FUP ANMAVAREVAT eMAYAREPOVV AY ANA FU W Csilicon hydrog
`el) GHEH S24, HAG DOUAYAAH LY YARBREAH ETS.
`
`foo010]
`
`KDOAAW ii, KBR. ER SNDABRBORBOMA, MOK AMAUBRR
`OMAZAAT SZeOM., LROCOX AOE, RSCOMRHAMAFBRHHRHLAD
`#. hODRS, EORSRERSEC. MAW. LOOBDY RARELY ASO. tOVY
`AOO. 002~0. 83HBN-vYheHB4YTS. O. OCO05~O. 5me,
`MHOC SRF EMAADETCHATSZCEBCHES, KREMOLYROREANEAAIA
`
`ih, HPAP LIRR EOMRARICKS, RAMEOMACHZERI. CHSO
`eS. PBA XH. 2Zomeg OBRMMiCHA4TS. BMHO. 5N—-veYb eB
`ASRSERTCHHENSEA, MILEROMRCHSSARNT -—FT7I"r 7 bie) ic Ml
`ABNOSDRURFELEWD, PAT ED OREN CHROME NS TECHS.
`Cl © fai H&B AA
`foo11]
`AAORMRORAROFR AL MOKRMORMRUAAK. LRFORAM Mic mReENS
`KAR. REM OME LORMRROLOARMEHA DO, AOD beetrHnas.
`[RLA]) @n€@nmerroeyvr—-KMMRUP FOR Y ORS ie.
`(1B) @€nFtnRer bute y—-KAMROF hoe YOR Ss BE,
`[h2) BRM ES. ACUVUE (88H) TrucEye (88S) Fore
`MAaveA7rELYR, ROIL-DAY ACUVUE (8888) MOIST (#888
`J PFIYFOAYAARYYROMRHAORAEBHOFIDIRR.
`[HSA] RHA KEA. PAHBEHEI-DAY ACUVUE (8&8) MOI
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(5)
`
`JP 2014-32404 A 2014. 2. 20
`
`
`
`ST (PRB) FovFOauyYRAPLYAKMATS, BBC RRECOMROFTD
`#8 AR o
`[M3 B) AHMCHA, MABMENEACUVUE (SRR) TrueEye (&
`RMI) FSIYFOUY AA REY AKAT 4S, BBKRERELOMROFIIER.
`[(M4A) RHACEA. PWHMEHRI-DAY ACUVUE (888) MOI
`ST (SBRMB) FIV FOIUY RIAL YAWNOUVYF-LEMOVFFIIRR.
`[H4B) AHMICKS, MAEM HNEACUVUE (SHS) TrueEye (@
`RM) Sov RFOaY RARELY AZAWNOUVYF-LRNOFTIIER.
`(h5)]) RHIC KS. MHBB*eNKEI-DAY ACUVUE (88H) MOIS
`T (ORME) FOV EOIUYRIRLYADSO, RWW RARKHOTDIRR.
`(H6] BHMICKS,. MMP BENHEI-DAY ACUVUE (@88&) MOIS
`T (PRM) FIOYFOauYRAIARPLY RY SORMAHRARHOTFTSTIER.
`(Ri7] BHAI KS. MARMENEACUVUE (88H) TrueEye (88
`MH) SIV RFOAVRIAPLYAPSORMARARMHOTFIDIRE.
`[M8] BHM KS, RAEASHEACUVUE (8R#MB) TrueEye (FR
`MM) FIV FOAUYV RIL YAY COMMA RARMHOFSD VR,
`[9] KRM KS. BRO SERENK. ACUVUE (SMR) Truebk
`ye (BRAB) FoIvFOaYRAREYRA, ROI-DAY ACUVUE (888%
`HM) MOIST (ORME) FOV FOUY AIREY RAORMAM SO, 247A OM
`eprEarraoevORRRHOVIIRA.
`[M1 OA) BHAI KS, ACUVUE (S9RMRM) TrucEye (ORR) Fo
`YEOUYRAAIRLYADPSOO, PREBE CO, RBT hLOEY-KAMORRRMO
`FUTBRM.
`[M1 OB] BMI KS. 1-DAY ACUVUE (@8 88) MOIST (88%
`HB) PRY POUYRITRLY AD SO. RAEBER COP LOKEYORARMOFS?
`#2 «
`(Al 1 A) RHR KS, MBP bhO EY KARA He. ACUVUE (8m
`MH) TrucEye (O9RMEM) FIV EFOANYRIRPVYAZORBKMOFTIIRE
`
`[H1l11B) BHMCES. ABV KORY —-—KAwKBBECR. 1-DAY ACU
`VUE (SRM) MOIST (Sm mR) FOOLY RFOUYAZ PLY RORARMHOF
`
`7 7 A o
`[M1 2) faa SRTFSZAORALY ZAOMKWAAR.
`C36 A ee Bio SR DO HE)
`foo12]
`AEH. HAT. HAM OWC Te AMBRE RAR ILEVPZE HO, MMH IY ae?
`LLY AADBRER, MARY bFOEYROYRUEELYUEYO, PRE~ RR, Bl
`AlUEDYRAUREYAOO. 25mg/4UYARHCOMAUAIMTS, FPkKORE MI
`
`
`_ KRM ObFORY Sy VAGUE CHO, BORMAN AK SA, POMILOUY TAR
`ULYAOKBKOHNMKCHS TS, LAAUYRARAT Oy 7TAZTHEM KDA
`4. FFHRARMAAADUYAIELTRMENS, FROEVK, Ai kot. HAO
`Ric CHACHKSTCEM, MACHAMENTHOSZ, FPROYYOREW, APRA
`
`
`
`MA OBIE. WoC. KIRLA. RUBBER ECOMMT ZARB MRE. BRELTSE
`ZO, LeRAOC. PEL RBORKREAL AY AYRE Y Re LEEOHTATEL
`
`MPCe4S, KNAKRHCM, RR OUC Te BEM ILEPEZE HO, FROREVYEED
`
`BRN < SIERO. ME MRORR O(LAWERc, RHPA AR TEA
`AJDT. REDIF NMIYVAREONA FOP VHB, BS4UKEF 9777 VAIVARMATS
`FPanwaovBp, FHVUPVeANMIVARAGI PA NIYARHOYV YU ay na Fue (si
`licon hydrogel) CHEMEHNSZGMARDHAYRIARPLYANMCHS., ABW,
`
`ABP RP LR. UM RAS RAB CM AAD PATHE, FONFRT ME
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(6)
`
`JP 2014-32404 A 2014. 2. 20
`
`
`RAOWUSTODDSORWENSEIFAD McC RRME NK, KOBAKRABADERRR
`ELTHBH SDV, BELWMREEL ER SZ EFA ONG, Bill. BH. CORBO
`
`SEFRP RO Ro CHHENS, PHORM RED ORR SSRN 44RD, FROAEY EEO
`RSA AROMA FER LC. RBBB Te Re TAC EMCES.
`[0013]
`AORN SHB ROMA BIS, ARR SCE MBE CHS, PAI,
`Jom 1 Bees er YR EL CARMAN SMAAK, COCKER. COWMRMPORETE
`HO. RIMES NSRBROO. Sm gtHAl.,. HM3SOmgORROTRI4VIVA
`
`LY AicH LT, AVE FREY AWOL.
`66H BN-—tYE ORAL, MUO. 5meg
`“AvVYACHSTS. LeNot,. BREA. SHBA-—teYhRELCHMRENSZHE
`ilk. TOTCKM. FZOBMPORBCHO. WMICMeENZHRROO. 25me ic thY
`L. AYRIRVYAANOO. 83BRN-LYEORMA, MIO. 25meg/%bY Rie
`BML. EA OO. OBB N-—eY REL CTMRE NEARS. TOTEM. EO
`WRMPORBECHO. MCMENSZARMOO. OO5mghKHYL, AYA bEYR
`AOO. O16 HMN-VYhOMA REO. O0OS5Smeg/4EYAKHSTS.
`foo014]
`AEA kn. FRR EVR EDR. 2OORR CHAAR CHOL TRG
`~FROEYRORBT AREY —Kime,
`FTF hePERPAUVSY CTHE) ROK C1
`43. VAD. BRS-N CELOH) ROK CIYI1. vA). pH< 28 8974
`
`MeR. FUeaO-W, HAWKE CARMEN RRARKEZ EO, POC ARRULA
`MAIC AMECSTCEBCES., RWC, COMA/BHOBRAMWE. AVYAIAbLY
`AAIMAUBTCEA CES, TVYSEAREYAAK,. COMA ARs H AUB EAE
`
`tk, MPM O. OOILREBN-tY~HO. SORBA-tYLOMRAOBREB CT
`
`LKOEYRUY/ REBT bOEY-KAME AD, PREM BARAT ZAR. Bl
`AW FU ARON OYA. a VPRO TT OR PY RSeEeBTSZTCLAC ES.
`LCOTFVASR- Kye -VAOMRMPtC. AY ATE YAS HEBLEB.
`tTOPFUABZ
`
`“Awe — VRB ILC. RTS. PU ARH Ky TH VAOLY AK, A1 aH]
`48h A OMMOMAKbDEoTHRAIER OURS, BHOMO LE AY RARELY AME
`
`Benak. FRO YROYS RMB Poe YK ld, EOWA bk oe
`YVAPDSBMYS. VYREBRMI SHA. MOKMLY ALK RBENSEROBMHAA
`—74eA VIM, MAIER OACHHORBROX TS YF RRETS.
`(0015)
`
`WAOW TEM ILM ABE SE HOICMAT STE MCES., RBECOIYAAPY
`YADPRHETS. HAM. KBRRPRA7., 637, 6125 (Menezes) Clk.
`
`
`
`
`MOT. EORMMNARHRAT S2be 6 LE1LDORMMe ED TROMENS,
`HK
`eV YORI. BARARHRAOKRAAT 4S. SRALY ARR SZC HERMES
`
`C. ZFRWEMEFSTCEMNCEZRAMRENS, TOPRECEBRIDIOLY ARM
`. COPRMO, PY AOKZF POC RE MVR R DS, FOMMORENAMNORARA LB
`
`HIZMONT. BRAD OMBN ICMAT SEORMAMMEEHERST 3,
`(0016)
`AIR RIEU. PRP RRORKSZ RANK TSZERGIRHENKRAYAPRELEYA
`OROVUOFZRCH4, ARPRBROMBA, LoPHkTAzcreke Kot. COR
`
`OXLSHRRADRE SS. TCOTLA. POURRA S4HREATS. Hallie
`are neheoOoOavyse RLY Re, WMH, HMR LL, Wich oAT, CORE
`LYAR KT. BRCM LUTCMASHSZRAD, —RM KAR PRBS PUES 4S.
`FZ
`OPM RO, RAOMMMEE SENS, COME. LA~SAK DRT TRA
`
`CHRGS, VYAW.L IA~3ATEKRRAT NS. ABRBELVY ABA SRB
`
`MAPA SOCK. CROP TRRM RMT SOCEM, PRC EOREN
`TW4S, KEN WMMBCABE20104032860486 (Collins&S5) tk, fA
`CELA OMOKSHNRHADS, ARB EMAROBOROXFSMRMRHAeBLAC ce
`
`
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(7)
`
`JP 2014-32404 A 2014. 2. 20
`
`mko CHEM ENS, BRB RFASI + -RABORHM CMSA LE TCRAHEN,
`NOAM AMOURERES PSHE OICAATSZCEMCES. VYALEMRLTWS, &
`Ly At, ABVY-YVicho CTHCROMENSZAMY-vYe ko th omen, PR
`
`
`OHV Ye, RPHOBOLKEBON4ZMBLeEE, HEV--YAORBOBM tO
`LY ARRAR. ARM EXBOMON SH RHHD 5S, ARR EWR OBOROKSH
`MAZEL CTC. COV-YAORRMCOMFRAARBERT CLM KOT,
`eH eEMS,
`foo017]
`
`KEG HRRAA 2010701950445 (Collins 5) &, WHOL
`EGE MIU SIS HtSHAO, HARMARORAAA WMCOKMILEC MT SHE Ric fit
`
`5. BME ATS. PY AORREM RUTH S., CORA CH. BLY Ai,
`ABVYo-ve ko CTHKEMROAENSZAAVY-Yie ko CRORENK, PROMBY-
`YVRATSOR¢. BAOAOLERBENSZMBLFSER. HB4V-YAOERORM
`COLVYARMHAM. ARMPR CHILE NER OSOBMeEN SHAK. RAM CO
`HEBER D SMHS HEAP A CRY eR SBME Ne BAe OB,
`
`
`ROA OUPRR RMP SB HSHKAPA ECAR OM ER RM SBM eNKaMAS
`
`OeO. HAR. AR. BLS EERY GBH SENSE, HELE MAR AHR EO THA S
`
`NS, CORROBGAZKEBI, BILECROXB4, WER A VicCMT 4B Re
`
`AL#tk. HM icik, HRM LAV IMT SRR E ED EDEWD, EHMA, H
`Dae Cl b> CR OCMSRA CMU CK, RRB OW CRORES flips 4
`ROCRBEENSHKSNRPAOB EA, WER RA OMe e ARE T SS. KD
`INA WFC HIF SHE VY YORI MRT STEMCES, CONRMAPRER MOH
`
`MClk, HARA. BARAK MMT SZEOKARTCHEMGES,
`[0018]
`KERB, 045, 5784 (Collins S) tt. EORONFBeZRBeT 4c
`“Lik, PAR OWRROMLOHKREH RU CWS, RHO Bic, PY ARCA
`OMY oSHNSAM CHAT SHIRA CE MENS, AMRMeATSLEY AME tt
`$HUMS,. VYAOWDORRCASTI MCR, HRYOMA ERE EO WS Mi bic &
`BMAAptSNS, MRMORMMBRTKAS ABM, AR OMRL ORM OC MANIC
`
`Pebton, MBLC, FCOKOEORAMMEMFOMENS, TOIEMO RMU eld
`
` FROKREMHN ST SH MNHS, Blower SERS HM ReromT oki kO,L WD
`KORCMET 4AM ERAT S.
`foo019]
`
`tt. £HRUE
`KXERPEREA 2009701412358 (Collins 45)
`MOC TIM S. WIC Ko CHICA ST ORE ON R, PEC LEMBDHCHRT
`StH KOT. RROKEREHATAZERODOFREM ML TO4S. BRON Ris,
`EARRE RO PARR Oe Ck E-AH Ka CHIMASHN4AZAO, RBRUOMAMARO
`MAZARTS. BPRONODMIA, MRCHEnS LIRBRO FRMODR kbB-Alk
`ko CMicMAzASN4ZAe, HCH. COHARRMMTSZIAYRARPEY RUE HREU
`Sc bteegt, RBOA ODMR. Hm CHnit ELREBROTRBODe SC Le
`tckoCHKMASN4ZAR. BCKEVW RAK, ERUAIBBeRFEEWROK
`Mic, BRAT AZCL LAD, SC OMBRAESRAL TC. RROAe TREC STEM
`
`CX. CHSOMBREE LTH. BS. PER, TAA. BREE. RU KS
`NHeE MAP oONSA, CHR ANEW, LRBRO FRB ko CRicmae on
`SHR AREUSZT LU, SMH YAeESBCTSATCHEHH EDT. RMKILONEORFE
`MRACH YASSER SC TST LM hot, BRT STEMCES, VYARECTSTE
`CMT SKBRE. ACS ARMHAAL SC HeAWK. RA IOUNELORERRAAC. LY
`
`ROA OMEBREBRT ZTE CHS, COLYAMHOMEBRU, KOM AL, RUE
`DECREE NS.
`foo020]
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(8)
`
`JP 2014-32404 A 2014. 2. 20
`
`KE AH 5H. 448, 38128 (RoffmansSd) tt, HRRK EDTA RICHS
`CHEPBMENS, BAHRARURARACATSADOEORMRAY-YDok4. @
`
`fA IYVATPEYRORUPEARETWS., WR Y YORE EO, PRR OWMR
`MicCHOR Mea bDPAZT EATER T4ZROO, BPA BSOMMHAM, ZSBHK Rmx
`
`41
`foo021]
`
`KERB 7. 625, 08 6B (Wooley 5S) da, ABRAKKDCARKE AZT
`LRBMXNS. BARARUITARAICMT ZA OHEORMRKY-YPons, EB
`BIVAZ7RLEYAORAMOCMAKSZ HA RUTHS. RV - YORE EOL EE
`HOWRWCMOR MEA DHATL RAHI TZEOO, BRHFOMMHAD. £AN
`Me ES.
`[0022]
`
`EMOKRDU. RMOETPEMLRGBESHSZEOD, PRBRBRLMASDETCHAT
`ZBOCLPCHES. REC OIYRVUPVLYARLORUHMHETSA, UFCAMRE HS BBs
`~_FREOEYRUYSRGRBEP POE YHKMMRE OMA. OY RFRVLY AAA
`AWUCCLORMARRe RT tLOCHS., Ball, BR, RMS RT ee OILY
`RIRLYANKRBEN SD, LP CHHAENSGRRid, HABIORALENDA-*R
`MOUGRREEAT SH MIC. 2DORRSZSZTPSOLYARHA ATS. MAENSZ 200
`R4fFOvY AU. ACUVUE (ARMM) TrueEye (mmm) Fovron
`YRIRLYARCATED,. BOI-DAY ACUVUE (8888) MOIST (&
`RM) SovePoauyvyaeaeyreyA CIDAM) CHS. ATELY AM, YUI-Y
`NATPFOUOFNMRVUVY-OF SV ¢VOYRRe#eBA, 1-DAY YAK. BakATAVE
`NT FOUFWRUYUVT-ODRRPHMIAYVA, RORVEAWEODU FY CPV P) @ at
`o FRCHAT 4. HBP KORE Y-KEMROPF FOE YORADLS RB, TNE
`NMHRILARUMIBCRI.,. 257 nmCORAGPHHRBKREAMAL TL. @TOUY SY
`Ze fe AT L Fe o
`[0023]
`FJRUEYROUYRGRBP hOREY-KA Me DY eV PLY ARR RAT ZR OO
`BRARR RET Se MI. PFROREYROYS RABAT PORE YK EARS
`HEZTEMRMCHSRLEARACOMMBeEART LR. KP RPBEBR CHAAR
`
`SSTCLMPRECHS, LMLEANS, KREORBRACEBRL, DDU/SMEIRBOBKRSE
`
`AATF SZCEMABABEBGAMES, VYAM, RPHAPCORBORREL CHETS,
`
`
`HSOSBARATSZEMiC. KHCBIAR, KES HRMBALTHBLE, RUC. tH
`BOVYAeS. STECOA-PYAC4S SHH MMBRA HE. MPBLK. BUY ALKALT
`3B ORBRHT Lic. LROLOBREOK, RARAM EPC, PY ReEBMER.L Cc
`
`OW’BHWHAOBM YAOWPBRBBeHETSAZtCeEM LOT, BHROMODOAASHELE
`» MP PCRRANSZERCRDWC, BHAA RE HELE.
`C% 1]
`
`AE Se — BR
`WRSHE= CX 100%
`AAPLEtie
`
`foo024]
`22O8Al FbuUeY CAT) ROMBRPFOEY—KA Mw CATSM) OMBROW’
`Ree. RA RAR CRM Le. BRN, ME ORBR SRA OBO BARA ICR
`MUC. MPA OBREe Ale Li.
`[0025]
`Vv
`COMMRMAROUAMMRRRBRiI BOW et, DRk/-WYK, ROTHPF Ao C1: 3B
`AV) BMAULT. Hh, ATSMROUAT@# LY ANK BALA. BAKA L TE
`~ BARA COLA. PY REKPCHMBL. BRE. BRLELY RARER ELT
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`10
`
`20
`
`30
`
`40
`
`(9)
`
`JP 2014-32404 A 2014. 2. 20
`
`
`_RPFORleCRtTBRBRPREBLE, 4B CC. 4S RAM OR, by Re RRP le
`MEGi U7. MIMO T. PY ARE REUC, BOR BTS4ZTER ED. ROKENKE
`MIOBZHELR, BX OPRBAMICMT 4. PY ANKROKAENKERAIOBe. 1D
`AML YAKRMT SUP RMMRORZ. RUATEVY AKRATSZUFRMKROR3 CH
`MP4. 1IDAMLYAANK, SLC BYERS CHEB eS HRMBT LOE Y— KADER
`&, BRAC H DOORS, 2DOLYAORSASTAK,. ARORDHMEHETEKA
`Bene, LALEAS, S4HBK,. BDRM RAE NZ EG. RBA
`ALT. PYAAOUMAORRHMATAZTEACES,
`[#1]
`
`#1: SACSHe
`
`
`
`K:
`THE“K(13, vv) H20me-“mLOPROEY
`SARS:
`EtOH71-71, v-7v) $20me.“mLO FREY
`
`
`i B
`
`
`
`
`SR:
`se
`
`BRtEIK (pH<2) H10mg-“mLOPFORY
`| IYBORLAOA, SEBEL
`
`[#2]
`
`#2: DAME Y 25.Ree
`BwABA(meLYS)
`
`1DAM—3
`574
`
`1DAM—4
`|
`0. 48
`
`
`(#3]
`
`#3: ATELY ANA~OALER
`7H
`
`
`
`
`ATE-1
`
`ATE-—2
`
`ATE—3
`
`ATE—4
`
`3. 26
`
`0. 46
`
`[0026]
`MAH ene YAM, BHO, PY ARRROLY AMAA OB ED
`
`FET SZDPRDEHET ZERO, BRABROUVF-LRAKCMLUCHAHOR., B
`FAC RAUL THE. 85 O~ TOON MARNHNMEEC. RHBSHELE. 125-18
`
`mUVYF—-Lew@AlC. RY NDP RRBMERAT LE, FYARIPRRMAM, BAH
`OoMMB. 2RMB. RUOSHHBRCNEL EK, BiH RSM RAR. TeDETEM
`Mere. VbUy FAADBADReE MET SEO RTLE.
`(0027)
`Im LOUYVEREEMBK CPBS) Hi#
`5S DOMAPBWL Y RES CRMC.
`M@L. S4EC CRM KA HK EARLE. —~HPOMMCUY SV ERRL. PLY PBS
`CRoOBAR. MHP YT LESH BR CML. BES He LE. MRIC, EK FO
`MAL ER MRL TL. WHKOUY ST CREW RREAR PRLS ANS He BAI) Eh
`LUM SEDOBLDHEF SZYRDEHELE, MMI RAAB MHA EBIELE RS
`ZeK KDC. BRRIONKHHBRERAT ZTE AME CH AZDEDEWMHETZEHMI, B
`AOZMRUMHERL OBR BRERA UCM LK. RA ERA ARLE. OA
`
`
`
`(10)
`
`JP 2014-32404 A 2014. 2. 20
`
`TEVY AOR IU, KRACMMRENSRACRALEBESCOKPAT SMe MRM Id
`AAD U7.
`IDAMOBGCi, ReRRECOL, TAR/—-WVROK C121) HATS
`ARIMA CR. ATELY ADSOATSMOMMBCML TH, BHA RYSLY SA
`Z#RoOomeCTHFTOCCeER EO, BS WHRALEMALSRALH.
`IDAMLEY ALE
`
`LUM. bY ARERR. SOO6ZGKRALCR/-VeERAL. MARA Ai lc HK
`eth
`[#4]
`
`
`R4 : RHO OMREH ET SOILIE
`Lurae
`Al
`RE
`(mg/mL)
`
`
`
`
`
`
`ATE
`ATSM
`250
`
`ATE
`ATSM
`100
`
`ATE
`ATSM
`50
`
`ATE
`[ATSM
`10
`
`
`1DAM
`AT
`20
`
`
`1DAM
`AT
`10
`
`1DAM
`VAT
`5
`
`f[o028]
`Hick, BAOMHIC MLC, RRKERBALE LOL YARRA TSTCEMBELWH
`G@MBS,. LEMoT. ATELY AR BAEHEML CMB SH, RVC. RREBAL
`LUCHR#EBL. BH-OMMO BIC. RHOMRAAAROLOL RADARPELE.
`H2OHMi, 4ECC HM. 250mg /4/mMmLOATSMKBRAPCHRMLi. BIBS
`Nee yvy AR. PBSHIKBALT. BORA LEHBSMSHRAERAL.L RUC. 37
`BCCGPBSHPicMmhe tee,
`fo029]
`
`IDAMULUY XE,
`AMAR RRAOMRE, M2tmt, COMMRLEBEZESK.
`
`De/J-NVPROKPOMA TC. BHKBMBPT4-ACL. YUA-YVYRA BEBO,
`
`MWC CkCGUEWA, ATELY AUEKPCOMBOWMBLHIC. THRPROTASYA
`VHOMNA CRY RBH RT,
`(90030)
`UW PFORSKMRT4S, TO2ZDOBROT LORY OWME tc tk,
`WHE OM BRA.
`HIE HRA RELL RMA ORAS ARME PSHM EME RT AR EE LEY. BEB
`
`AOU. ABR R—KA WOR RORAK,. SRO GBM HC. RickeEBeh ce, BD
`icmMOGMREe RT AC. REMEPROMAME, THFROLTSA/—-WHG, OW
`
`1CHhS, FVUeU-Wd, BERBAARMRRRLEM, COMMA, VY AMSOR
`
`RA SRAD ARCH SCEDR OM CHO, CNMA PALE DDE CLM A BENE
`
`, BABB MUCK. BOR BOBBEL, MEORABARBELORDGYARRDE
`Hic, THR EK, ROTKES—-WERK (1:23. v/v) ORAWEAALE.
`
`10
`
`20
`
`30
`
`40
`
`
`
`(11)
`
`JP 2014-32404 A 2014. 2.20
`
`[#5]
`
`
`
`AE ORRAE
`
`BRATS
`
`FROL ViSae
`mg/mL
`
`ATSMAAREE
`memL
`
`
`THF
`~150
`HES CIEL
`
`EtOH
`
`FijeoO—Ie
`
`~250
`
`~10
`
`~200
`
`~ 400
`
`
`
`
`
`
`
`
`H,0
`~2.0
`~ 2500
`PBS
`~2.5
`~s00
`
`~12.5
`
`mee s
`
`BSEZK {pH 1. 9)
`[0031]
`
`
`
`
`BSARUR SBKEBNECNSBHEOMRA, WHEILRL CT. Be ORABR OM
`AA DECERBEHEEGAOL OPRHOLYAPAOBABROA(LERMRT4EO Cie
`WwW, nok, FRAY RERMBT KORY KH KAMOUTNOREL, DY RAO
`BW ec MR BeERFFTELOCKEOTCEMAS HY CHS, LALEMNS, BEARS EE
`ALL TATELY ARBALERAK. AFOBAROMDRRELKRAKRABRT4ATE
`DHweACHS.
`[0032]
`RYRGRB (CUYF—-L) MBORRE, MA ARUNMABKERT, BK TCE CHEW
`
`MB. 1IDAMUY Rid, PHM. ATEVPY ALOE SCORVATRRROAAE,
`AR SDE RBARICIS CC. BAIOG EK AY, FBV AFT ARS IC -RMOARAFORIEM
`fiEL He. MAM.
`IDAMEY Al, DH /-VBRLEBKBRHOMWT HOY CHEE
`
`EHERBAL, UVF -LRBORMDEMMCRLEAM, FOLYARMEBT4AZUVF—-L
`
`OMe. BRAOMHEHICMALE. PTORHMERM GC. POUSTORBAEC. WR
`PiEMLT, ATELY AK BMT AZSYRIRBOBEMBATAZMMMEELE, TO
`
`RA Cl. TNSOWAAD. BIARANORBORRCHOEOD. RiMA ORRICK
`SbOCHDMOMIEFMA CHS, FRROEYROWMBT OEY -KAMOFEK HW
`~_ LDAMLY ACH, AFOHZRMFAETSA, FTNSOBBAILRNA LE <. Wale
`
`RET SEOEBDNA, LALEAS, ATELY ACI. SRB, BARES
`
`Beatctk, MOWENSZUYF-LOWMAKMAGEL. COMA. STORK CAS
`
`eB,
`(0033)
`BCOVYINO, BHU BPM MRR. FSeEDETEMMAA, VRFUYy ZTAAMC
`OMAMFOW-EORMEBRAL ER ARKARPSZCE MBE CHS.
`0034]
`lim LOUYERGERB
`AIM IRR eH TSR Hi, SOOMAIRBALY Ae.
`Hk (PBS) BRHCHEBL. 34 C CRB KA PREBLE. TCOLMLARe-E
`OM CRRUL,. MUM PBSBRCMOHAK, BROUVY SVE DPHHK BE CML
`_ Rhee ne RA OME ELE.
`[0035]
`Moth. 1DAMUYADPSO, ATRUATSMOBBEAL (AIRE N ERM
`AL. M6.
`IDAMLYAPEO, ATKROATSMOBZHNWMMORMERT.
`1
`DAML YADSORHAKALT. Mot menNSMRRA, KORMKHROATSMAER
`
`. ROM, KOKRICMHENSZATLERUETS., WET RCM HK,
`6 ORM ei
`ASWMC DED CHELE. PTOBROMMI, BREBHROB HS. ROBE
`
`
`
`7M AAR Hic ko CT, HI ICRENSEODOCH DE,
`(0036)
`
`
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(12)
`
`JP 2014-32404 A 2014. 2.20
`
`
`
`B7Mm., ATELY APSO, ATROATSMOBBSAL SKIER HEN ERB ER
`L. M8. ATELY ANSO, ATRUATSMOBRNHHWMORKMERT, A7 le
`MENZAKDKE.
`IDAMEYRAEHRL TT. BTR ATSMORMMRED, ATEL
`VARA CHE MRENK. HST, BARA ETAL CH SZ LEV IARBRE EAD
`BFL, ATELY AMSH, EOPRVEORAMRHENKECES, MOLD 5 BB
`
`SZTEMCEHES, Bild, MMONEWFZHOB, ATELY ADS O, &€TOnRFoOtt
`RBN-EOMHAIHRXNtTBO, ATELY ARBBERMUCBOATROATSM#RO
`WAT EWDHHCLMDST., Rd, MARAOMMR DEA. EKURBEZLOTSE
`
`2 ie.
`[0037]
`MAB OWMK SEY ADSORHOHMBMOFREL CT. RBH AREMRLI. HC
`LH25me/4mLOBRACHERENEATOMMUCMLT, PRERT. MW,
`
`OMMic kot. CRABB NAZTEMES. nme. COTEM, KHOR
`EHS ARMRAR CHAAR ARY CERRY SZTCEMCES, TCOBAOMMI,
`
`BS. PY AORAMLOMAOM ALC KS, MATHLYORBRK KD THAMES
`tik, 2ZDOVYARASPAKK, ZANE RBMGE LADO,
`[0038]
`BL1OAM., 250mg/mL~1lOmg/mLOBMARMBE TO, ATELY AD
`SFBOATSMORBEBeRL. -ACHIOBM., 20meg/4%mL~5Bmeg/’mLOR
`
`
`HARMIBE CO.
`IDAMLYZDSOATORHNEABe ART, BARRE S SMA
`BREA LC. FR OUYROMBT FORE Y -KAYORMME eH TSC ER
`WR CHSOAR., MBILOAROMILOBDSLRHSZTEMCES, Moi, HMERe
`
`tkot. IRM ABE RAN COL SNK BOE BE OBB ERTSZTCLEATES.
`[0039]
`
`ka @HBic mre kG, LAK LAREN! OO. SNH EYP OP LOE i
`Mik, MMO TA ERE AUCZAMER RT. SOR LOMMARB. ROSRATCT 1AM
`WMReENSLEMHPT4E,. HAO, SFROPKMPENSZYbFUEYOWMHT 4a. A
`
`O. 5mg CHS, LALAPS,. TCOMODISK-LYbLECEM, TORO
`Feam@i kone, Bilt, 8SOKR-vYbLEORAID, AVY RAPLY ADS RES
`
`HeaRMcCKRDODNARLER,. METEZTENMCES, FTHMA, THEOMEKBAOCLE
`. waro. 0O0O05~0. 50mg ORAM, AYRARL YAMS RBENSINTS
`Bmw,
`€NOWAL, TCOVYADSOMHE NS Bl. FROE VERMA T4Z4MBIMLT
`MY CHSZTEMREH CHS,
`[0040]
`
`ATEV-YARUIDAMLYADNSEOD, ATSMARHDCOMBAHS. RAMO
`MicpbeenYvYaeF hPL YAMS OMMA, THEN, BI IARCH 1
`1 Biamt, W
`
`
`Bpic, MAOBAC. UY Att, FRUEYOBRPCHIAL, BAIeMHBT ATED,
`CHS, TCOTLUA, RACKETS. BEN MORAKETATEMTES,
`[0041]
`TCHOMDBBMORR CHOC EE. RAB AY RARELY AMSO, FROEY ROG:
`
`Mr boOEY-KAMORAOKHMM. BAP RBTZARRAEPRT ERA GHNS,
`MRCNERABRAL YS ZLOMAORH DOO, HARM OMMSA MMT STEREO
`
` KRHRAPORAO. PRN MOSBR ELE STTCEMARECHS. UVC EK
`2TMENSZEAR,. MOKBARORMHK HD MAIO SRM OBR id. FEL BPO
`
`o LAaLEZAS, BS 4. REMRRORRA, COBOKBMAPCOMMBT. LY A
`tkoTMOAEN, ACHR CRHENSRAOMR ACH oe, TOTHMEYD, B
`fEFRPT HEL VY AD SOMHE ERA CH ORSZTCEMREE HS. MEBTNE,. BA
` JARROBRMeFAONSZcCHICKO, MEOMM IY SA hE YAS RBE RL KY
`CC. FOL Y AS RHAT STEDCES,
`[0042]
`
`
`
`10
`
`20
`
`30
`
`50
`
`
`
`(13)
`
`JP 2014-32404 A 2014. 2. 20
`
`EMORSDM. KHRABT. 637. 61285 (Menezes) tH, HHABKS
`HBRreAT SAL YVYARHMAL TKS, M1 2k. Menezes OPMRMRLYARRT
`
`[0043]
`Bl 2th. WBV OY 1 20O2ROHR MEN EYARY- VY 1204 ATS. EY
`1200@mRd, H¥VY-Y1202M%, PRVY-Y1I1206R0RMY—-Y1208%
`ee, PRY-Y1206H%, DY AZOXVMK POMBE NCBEO, PY AOHF POD
`
`
`
`
`PoMewENS. HO. 5~2mmO, FEE K. HMI~1. SmmO*BEGTS,
`
`
`PRY-YIL.20O6AMOMRAK,. ZAHN -EORBARAMHACHO., H-O.
`5
`OYATR-~M-12. 0O0OYATR-CHS4. AWBVY-Y1208A0, EORHA
`OieMic ko, BHRORBRARMACRBETAZRE OM HBR AKBMENSZRHHAEER
`Re S. RARARRAKAS SWABS, PRVY-Y 1 2O6ANKRRETATED,
`
`
`SPELORBADSS., TCOMBMEORM. FRY-Y1206DRR,. RURKENS
`
`EORMRBEOAKESKEGBUCCHEETS,. LPLEMS, BHWWiclk, © OUR Is,
`WO. 25~H 1. OOYVATA-TtCHS,
`foo044]
`AwMVv-Y1208ik, BENMOBR 1210, THe#HppaLPYAOHZ ROR REI
`
`WRG. AMWY-Y1208OREtNAM ORR 1 212NEBRAT ZION T,. ke
`HDR EMI HATS. EORMMIME ARR 4. HY-Y120 SAORI
`ZHOWAKU. Pv RONSHPOMSH2. SmmO#EC, HO. 25~H 27°F 7 R-
`LPFSTEDBCEHE. REL K. WO. 5~HW1. SOYA YR-CHS, AWY-vY 1
`208, WO. 5~H3. SmmO, FEL UM, WI~H2mmMOBeALES,
`[0045]
`Bl 2tcmoek St, PRY-Y1L206RUAMY—-—Y1208&. EHS OMI
`MemRAReZATSY—-YCHhS. KEM KRMBR CH. BANC -HORAMHAMHA
`LIEORMRNBE LOMA. FPHRBRARDEERST. ZAK -EORAAABIADA
`_ ROEORMRMEOMAD 1 DOV-YVYeEBRRTS,
`(0046)
`
`RAH OLY AR Ra SR. EORMANMA IM, BHAORKOMA OWE HAT
`
`MAST IS., CNMAL PHORM EL, PEL CAL PY ABA SORMMEA RH ic
`REST. RWC, FCONFOWMEKABEGRAWNEMREHENS, BSWlE, 0. 1D
`A/mm"? SLO, RMP. ROMER LTCHPAT SZC EACHES., RAMBIS.
`FROMM CHER ARc kao THM BET SZTCEMCHX, CORRE L TEA. HROMAH
`
`OPAC ESZRLOPBPENSD, THEME NAY,
`(0047)
`Be ORMFRROD BOW NDA AL TC. RH OLY AOE VYVee
`ZTLMCE, FEHSEOMFMRMEL TI, RH, HRB. ZAP SAY, Ae he. 2H
`RE PARSONS. TCHECRBECNAY, BELWHHBR Ci. PAV vid,
`
`REC URE CH OL, PRY VY EAM VE ONMKMUMAR EBD EET SZ. EO
`
`KOGAM GET, AEEMOK-KRERBRROLKSR RAB CHS. MR
`
`PATS THR EDT. MHC TFAZTCEMCES.
`[0048]
`FRoOUeY, TEP KORY KAM. ROUL YP EV RAMS OMENS! DD,
`MRA AAVYHMOFFAOMOBMASA AT SOR ECES, BAR, Fe AVR RY
`~Ye7ORAYREOh, AVY RORY, ADRS SY, FEYVRREY, RAY HRY ER
`COUARYVEYESOR, HOMLADAUYALE, ARM CRO TA AT ATER CE
`%. Biclk, HOV TADOMARNGABB. HAR. PREVEA FOEVPVUTFY,
`YER, BROVHREFNeRHOE, FOS VPA BOER, RHR CHO CHAS
`SZTLEMCES,
`fo049)]
`
`
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(14)
`
`JP 2014-32404 A 2014. 2.20
`
`
`
`
`
`
`
`PF broOeEYR
`LRORWAU. HRD ETOM MS BRT SROOHRMAREOWT.
`OmMT7 FORE Y-KAMeEAOR. LAW UYV EER REM AR D*THE, MH ETH
`SRPFRkAG. BAP Y A, ARB eI Y aA hE YL RAEBH ETS, LOELEBSE,
`MAP Y A. ARM oY ee Pp EY ARIA LC. SRE RES RET AZTLAN
`BFSOAAICHBTFAZCEMNBHCHS, MRI, COAYAIAPLYAW, RSC ORME
`UR ROUMB. MH, MOKMIELOZBOILDUELOR MO, RAMS, HR. ROC
`RIERA RST SRAMMBRTSZTEMCES, TOAVAYPLEYASHALT
`mr hoeY, AVRFOEY, AGDHRPSYHBr, YFOUAYERE-PFHCI,
`+
`OPASKR., ROVAAILIUVHC 1 ® SOE, RERUOCOKL ERAT RE RE RET
`HSLTCEMCGES, TOAYVRAARLYAKM, PEP F-OMB, MH, ROMEOS EO
`1LODMEDRMO, TUPAFYHC1], 2VV Be RA RAF YY, CREF AFYHC 1
`_ ACN BT RF 7 ev, LRARAFYHC1, FOANARYYHCL, YL vBI
`SSSY. ROUYVRBY YVSEVY UY ae REBT SZ EG. MRT ATE MCES, TOMY
`A@UPLYARGA LT. Mime e ical, MAR. FOEVUYFRUUAL OPE
`SPFROASR SY, AFFOSENIFRUGDA, RORNMAZUFPAPAVUDLE RET AZT
`LEMBES, TOAYRAREYASHRBL TT. UY RFE AZ eV YP RUD BR, FE
`PAAVY, VuAOAReOY, MBIVAORROY, TARY MIUFTL-FSJHW,
`BRBTLERPa2YVaOY., UVB LE FSEVaYtbhUG AR, APU YY, UA VOY.
`ER
`UPvAY/AYPRbRARPKSHK, ANFAAF UA FR RRSTAZTEMCES,
`MOAveaPEYARHAL CTC. PUP eryosae Yer PUR, APA ey, Ys
`FPorzvyrerurvhsh, FrFuUs7RUALRRY, VFAOAKRU YY, FPAVAYYARRLE
`BPO hL PVP FAP UY, ROFUEFAUSFVYReSbR, EAT UT FEMKEMe
`RET SZC EMCES, CONDYVRYbVLYARHPALT. RPS, EY IO
`BYeYyy, Avast Y, AF Vay Y, vFaVaAstyY, FPvVaATAYY.,
`ANMATVYEDVOYVADEY. AWA P RET FREUG AL RY AVY YY, KY
`S-UVYvB. YSAYY, SUF YY, PROS yy, ANP AV EHO
`i
`VAPIY. AWA P RAT FPRVUGAFhRSVAPU YY, FPEYVVAAUY, Yau
`BUY UY. ear bee Y, PERV YU YIP OB. RT UP eV ORD
`4b, TVARYHA YY, APOE YY, PYAR AY YY, PYRTAY YA
`VIPVPYY, RUYUARSYREOK, HRPM EKETAZTCLEACHES, TO
`IUYRIRLYARHAUL CT. VERDUYRSOR, LEAP UY PFs Y
`BROUTUELYVYERHME.L a-2PF RFLP UY SRA, AREY SI, ANS AR
`Ww UR / AAW, AF PST /AN—-W, ROFERD-WHKAOK, PUA: AMAIA
`-VBROKFOANWVEVH SRO, BHRMMAl: Dee VAF FRY ROLAF AIT TOs
`Bb. DUYLAF ST -VBA SS PveAaEVYOR FL PUY YSZ FL FIV OSR,
`ROAXVAIR FRAO RBM KBARASA PRY FOAAL, UEVEPFAALL US
`RFBIARL VAPFPMAR- YY Fe PW, ROP RPOAbeRB HE, PAAR
`SYUYROR SOARS FRAO, RMAROMB, MH, ROMIEOABOLOUE
`OhROORMASRETSZTCERCES, TONVHREAbLEYAREGALT. REP VEY
`PRUGA, RAAMVRY REKRUODR, AYY FORM RUD RAYE ae
`WVMHCO1, KUPWMUYY. TYF7OeREN, ROVrPhVvF7oOeNe Sok. HUTA
`MARES STE MCES, CONVRIYSULYRERPALT. FR SPATYHCI1,
`GASATYHCL. FUORSATYHCIBRUV IAP ET YT RUUD AL ASE
`—hKBROVUATLUAYIFRUOAL, HOUMA EY A- PROV MATL IV YY PU
`UA# SH. REAR ASRE SF STE MDCES, TOAYVYAAPVLYARSEPALT,
`FhRatV—-M, Fey bY YY, PYRE B, the ast VOW, ROT bh AAT
`VoNVPeSOE. PABA eR TAC EMCES, CHOIUYAVTRPLY ASPHALT.
`FuRPS/FevyROaFAY. Feeyst/YF7errYROULPROIRFY, Fes
`
`
`
`Fur. FRHDBA. AFPFAInrY, MOM RIV -VESHK, BMAlSe KT 4
`CeHEMCGES, COAYRAEARELYARPA LC, BRC FUY, Beto ev
`
`
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(15)
`
`JP 2014-32404 A 2014. 2. 20
`
`
`
`BRP et Ab ITU YY, BBS RPE FOV UY, ROSS YV ARV UVES OR, WE
`WAM ERT STLEACHS, TCOINYVADVPLYARGALT. ERAYAL DLR
`GeEXSEYVEL MTT Y, BOUY, FUVBFAY, UP FUY SY, RSE RAH
`
`fe, ERSY, Bie ILA, MOR RRBAHHAMERKBETACEMRCES,
`[90050]
`CMOmuyvyaPpEYV AM. BAM SCH SN SBRBOWT NMI MBLEAS. HS
`OSBENE. HAZVHORRMSeT MMT SZEDICRHETS. BMA SHA NM RAS
`
`MARARBTEMCHESZAK. ARTF 4Z4CLMBE CHS, MAU, HRAAMELEY AA
`MAROC eEICKO, HS4WVHORRMBSRRATSTE ACES. HOMRNERSH
`ZMH Cia. PED VA -RPREL YAAK MAAGSCLEICKO, ASZOHORRE
`BeKRMeSZCEPBCES,
`[o051]
`mLAAMPOPELVHKMBRPRCHSZLEHEAZSCHSEZLOM, MEROHRMENH SAM,
`
`MAROMAR EN SHH ORA MOK ARKDOCOMRA, SRRKRUAASMAHENSZEO
`
`CHO, RHE OBEROUMHD SMURF STEER C HAT AZCLEA CHK AZRMW SEY
`HO, BHM, HARON RENSHEOMMICHMMENSEOCHLE<S. RAO
`MROMAMKAENBAZSTOMBE-NTZKACHMKENSZNECHS.
`[0052]
`(2 Hi OD FE RE)
`C1)
`JRROUTOMM. BEL, ROS RAMAN SA BODE LELVOKHOMRA
`b-YACH OT.
`ALOMAR SBMREAN,. PDA MCFRTSHMSAG, AYR PEYAE,
`Mal Ivy RIPLEY ARE RI SMMBIOMBCRMXNAZDNIHMAKENS DO
`Dm CER -ACHSZBAMHPICHAAENKGHAAAUYEALE, RRA, HM AAD
`UVa, BE OHMMc bea TRO IBHMT ZED CMR ENS. BAY,
`(2) WetRIOMAD. vn FOP VSD, RAR 1 RRO. UA OM TOM
`fl, Book, ROYREHMMOSBEODR CLEIDORMYOMRALY A,
`(3) Wadi OBA. YUaY AT Fu dW Csilicon hydrogel) ®@0. # iit
`REL tcaRO. UH OMTOMM, Buk. RO/SRAHMMOABEODEC LELVIORS
`OWA LY A,
`
`(4) WHRLADUYAID, PRUE YESS, SRR 1 MRO, MMOD O
`HHl, BRIE, RUS RGMAMODBODRCERIVIOROOMBALY AZ.
`(5) WHRLAAUYAID, MBF FOEVASG, SRR LCR O,L RAO
`TOMB. Bik, ROS REMADOSAEODVRCLEILOOKOORALY &,
`(0053)
`
`(6) WHA ADUYRID, PLY PEV eet, SRR 1 CRO, MOB
`Offi, BiEL. ROLSKAMMODSEODECEBEIDOROOMALYS,
`
`(7) WaehAAAUYALRADS,. REEL BRARPRBRENET LOEVRE
`
`%. ZR 4 CaM O, MAROC OMM, MIL, ROY/ RAHM MOAEOPEC ES
`LDORAOMALY ZA,
`
`
`(8) WHA AAU YAIR AMY, RGLMBRARP RARE NeRBET hokY
`eet, ZRH SAMO, RR OU TOM, Mik, ROS MAMA OSAG BODES
`
`LCEILIOROOMALY ZA.
`
`(9) Wea AAU YARRA, RHE RRARPICRRENEELYCEYVs
`Seid, BMPR 6 CeO. PHM OCTOMMBM. MIL, ROS RAMA ODBEODECE
`&1DOkAOMALY A,
`C10) WHMIYASARLYYANCMAAENS, HHA SH Rt. RRR 1 Ic
`aeRO. MAO LTOMM. Bik, ROSRAMMAODIA BODE LELVDOROORA
`LY,
`[0054]
`
`
`
`10
`
`20
`
`30
`
`40
`
`50
`
`
`
`(16)
`
`JP 2014-32404 A 2014. 2. 20
`
`C11) Wave? hRLEYANKRMAUENSZART + VX-PRABSO, Sih
`REAR 1 caeROL MMOETOMM,. Bik, ROY RSH ADIAGEODRC LELOOR
`wHORALY Zz,
`C12) WalbOvyeybhELYAD, RABALY ARSE, BRM 1 icacdeo. ra
`
`OTOMAM. Bik, ROS RAMMODAGBEODECLEIDOROORALY &.
`(13) WHaIyRk7hLYAM, BAUR Y Ae et, SER LR OL
`
`POUT OMM. BEL, ROY REM MODBODR £CELIDIORHOOMALY SA,
`(14)
`FROMWTOMHA, MIE, ROL RAMMODEODEC LE 1LOIORDORB
`ALY ACH OT.
`HLOMPADSBRE Nn. PDE HAMMAR eMAAG. AYAAhREY RE,
`Ma Ive hE YAR RR AMAA I OMAR RMENAZADRUAMAWUENRE DO
`DRC kLE-A CHE 4ZHEAWHKHAAENE FONSI YU RBELL £AAYL Had FS
`
`
`SVFABM. REOMMK bea CHOP CBT ZED IHREN S. BAL YS,
`
`10
`
`(M1 Aj
`
`HacLefoun 9
`
`[H3A]
`
`
`
`.
`
`Te
`
`s
`H
`—_—+— THB
`60
`Pn
`venGreeAE
`&
`[1B
`+ BH
`40
`aaED
`CHg
`Ho
`20
`--w-- #4
`
`
`
`7 O—C—CHCH2OH}+Ha$04 400 500 600. 700.—~—BOO
`
`
`N
`WW_ ff
`0 Trrrre T Trrreypererrryreerreye
`
`a*H,0 #E(nm)
`[43 B]
`ene
`400
`|
`
`80 ae
`os
`= 60
`#
`yy
`
`
`
`
`—o— sf
`sungSENHA
`40
`—v— SRA?
`aa EES
`20
`w-e-- EMOTES
`
`0 TIT]
`400
`-500s«0s—ts«700
`800
`32(nm)
`
`
`
`[ei 2)
`90
`80
`= 70
`s 60
`B 50
`S 49
`30
`z 20
`= 40
`
`=f
`
`o
`
`OO 1DM
`ATE
`
`
`
`(17)
`
`JP 2014-32404 A 2014. 2. 20
`
`CH 5]
`
`nage (ORR)
`—o— sd ---e-- SRS
`sion EMA
`--— BARA
`[EI 6 ]
`
`Bee)
`
`+ Mae
`secon BARD
`
`---e--RS
`—-— BM
`
`C
`
`—— 1DAMLYX
`a ow ATELYX
`
`2
`
`4
`
`6
`Bey (Bee)
`
`8
`
`0
`
`2
`
`[FM 10A]
`
`SAAR(me)
`MEH(me)
`SA(me) 0
`--e— 10 mg/mL
`
`Byte] (fel)
`
`oR Deana
`@ cee
`CHl4B]
`~ O06
`iv
`2 04
`
`03
`
`>a
`
`ATE{
`
`ATE2 ATES
`
`ATE4
`
`SA
`
`ATE
`SHB
`
`2;p
`
`r Of
`2=
`oo
`
`EQ one C1 255Rl
`mm Seah
`
`{H7]
`
`—e— #61
`were SEMIHED
`.
`fe gp emnnen nennn ERD
`Le
`ae SEAR
`
`a £
`
`z
`z
`ae
`
`o
`
`0
`
`35
`2
`FIL CER)
`
`4
`
`50
`
`[Hi 8]
`
`
`weBMI
`
`Bate) Cle)
`
`2?
`me
`—o— sisi
`3
`BotpdAreeOve SEMAED
`£
`—e— 250 mgimL
`=
`wate SEABED
`Bo104
`LOOo---- 100 mg/mL
`=
`---e-- 50 mg/mL
`
`(H#i4A]
`300
`
`2504
`2004
`|
`150
`H
`1004
`
`YFLR(webz) 8
`
`OP
`
`é4
`
`WNHl 4
`
`Hl
`‘
`Hn
`HN
`cIDAM 1DAM1 1DAM2 1DAMa 1DAM
`paBabes
`
`| 4i
`
`
`
`(18)
`
`JP 2014-32404 A 2014. 2. 20
`
`[H10B]
`3.