Title:
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`Pub/Pat no:
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`Pub/Issue Date:
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`Inventor(s):
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`Applicant(s):
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`Classification:
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`Bibliographic data
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`Atropine sulfate insitu forming cye gel
`
`CNIO132 72164
`
`XIAO ZHENGLIAN
`
`ZHENGLIAN XTAO[CN]
`
`AGIB3 1/46AL, ASTRO/OOAT, AGIKATBA4AAT, ASTP27/02AT
`
`Application number:
`
`Priority number:
`
`CN200711 11597: 2007-06-22
`
`CN20071111597 2007-06-22,
`
`Abstract of CN101327216A
`
`The invention discloses.an instant atropine sulphate eye gel and a preparation methed thereof.
`According to the invention, 10Q0m] of the instant atropine sulphate eye gel contains le to 20g of
`atropine sulphate, 0.05g to 1g of preservative, 1.0g to 75g of osmotic pressure adjusting agent,
`and 30g to 150g of gel stroma, and the rest includes acid-alkali buffer and water for injection. The
`invention, throughthe optimization of accessories and the improvement of the technique, enriches
`the pharmaceutical dosage form of the atropine sulphate, greatly prolongs the time for which the
`medicine stays in the eyes, and not only improves the curative effect and shortens the time for
`reaching the function peak, but also reduces the amount of the medicine flowing into-and absorbed
`by dacryocysts-and relieves the side effect: and toxic reaction of the atropinesulphate.
`
`

`

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`

`200710111597. 7
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`28S 5 Ft|AY 1.0 5 PEG-1000 20 Fi
`
`
`
`PEG-400
`
`5 Se
`
`YESNA 2K 1
`
`fli: RACER ALKa,ONZE 80°C, MATRIC, ROBART Ce,
`
`PAA DL EAKA,
`
`SHONATZRK, BEE 30 4PSPLL LE, BAB
`
`PEE,LYE(0. 22 um) PE. WE NAAR 40°C, #2 2d A PEG-400. PEG-1500
`
`All FA SEFSe, SP AGL C18-25°C), FRUUYES FAK theeee = 1000 Tt, tik
`
`PEELERIS RB, FOBPBN 4G
`
`SETAE16
`
`ADFT: GRARBTFE 2 bo|ARR CO. 05mol/L) 400 Ft
`
`
`
`CARR=4 PRR8.0 As CF 0.5 5
`
`ZW
`
`5 Ft
`
`BULAN
`
`1.05%
`
`PEG-1000
`
`20 FE
`
`PEG-400
`
`536
`
`YEWAZK
`
`toe
`
`BY: REIN FA zkDUA,ANZ 80°C, ATID, ACER FOE,
`
`WPA EAA, FFA ZO, HERE 330 EPWL, BAA eat
`
`FE, WA SLURHR C0. 22 um) VEL, VEE INGA 40°C, HeRVDIA PEG-400. PEG-1000
`
`AU FA SLAP ER, POPES (18-25°C), FROIVERTALK+}Ee 1000 BH. Tit
`
`FEE EE RS Sy REIS, FCBeorBe BI 7S
`
`Sk je Bil 17
`
`AbT: GRBRBTFEA 3 ef
`
`APR CO.05mol/L) 400 Ft
`
`0.5 5%
`«RESTORE 5.0 5E Ze
`ATR 8.55%
`
`
`Z.RE SET|BULAN 1.03% PEG-1000 20 +
`
`
`PEG-400
`
`5 ot
`
`YE ST FAK
`
`as
`
`I:SEA zk oo eH, AA 80C, MARMBMI, KAR ART AES,
`
`WPA DW LAA, FPO ARRRA, PEPE 30 PLL, BAB
`
`10
`
`

`

`200710111597. 7
`
`vi
`
`OW OB9/14
`
`POPE, WW TLVERR (0.22um) jet, VERMA 40°C, BAMAaM. PSE
`
`£F4. PEG-1000 #il PEG-400, Padea C18-25°C), AINEAKER EaS
`
`1000 SEFt, PRPFEMEHTE RIDA EE, FOR SR BN TG.
`
`Sc Hifil 18
`
`Shy: WiMBBTFEGL 105
`
`WiMB CO.05mol/L) 200 BH
`
`
`
`ITRRIRA 8.5 50|=ASREPHERR 5.0 FE ARR 0.5 58
`
`
`
`Z. RE
`
`5 ZeFt
`
`BUG
`
`5.0 5%
`
`PEG-1000
`
`70 5
`
`VENAZK8i&
`
`HU: ORAEEIN AkOA ob, AANA 80°C, ATI, FRAT CEH,
`
`PFEAD EAA. FROLARTREA, BEFE 30 SEHD, PRIA Ra
`
`THF, WLR €0.22um) gE, VERA 40C, BAMARLA, FE
`
`2 ERA PEG-1000, PPE 2S Sh (18-25°C), FINEAKA SEBES 1000 SH,
`
`PPE RIE ROSS RB, FORE BNTG
`
`eB 19
`
`AQT: TiRRBTFEih 10 52=ALEVE AA CO. lmol/L) 200 Ar
`
`A 5.65)
`
`tHReZTHE Se 5.050
`
`ARF AREY
`
`ZR
`
`5 Ft
`
`RUG
`
`5.0 5e
`
`PEG-4000
`
`0.5 5
`
`100
`
`JEnAK =i
`
`ily: RAEI 7kDuda, Ye ANZE 80°C, DOATERBRDFE, FEOAAR.
`
`SAS FN, PPE 30 PEP, BDURPE,TLE IR (0. 22 um)
`
`YEW, VERAINIAZ 40°C, AIA PEG-4000 AFA SEZPOER, PPE SU (18-25
`
`°C), FRUIVESN RAK+hBE 1000 EFL, BEERISER. FORE
`
`48
`
`ATG: PRERBAFE AA 10 be ASL CO. Imol/L) 200 Ft
`
`kids fi] 20
`
`AAS FRSEZEHER 5.0 5|RAR ABR5.6 55 0.5 58
`
`
`
`
`
`
`
`ZR
`
`5 2&Ft RA
`
`5.03% PEG-6000
`
`100 5%
`
`YENAZK
`
`81h
`
`A: KHERAKA, AEN 80°C, MAMARTTEG, FES BRAT Ce
`
`, PRA DEA, SFARL, BR 30 oP, at
`
`11
`
`

`

`200710111597. 7
`
`Be
`
`WAR
`
`Oh
`
`3810/1401
`
`PUTLUE ARCO. 22m) peist, PEREDOTA 40°C, eADNA PEG-6000 Fl HILAFHER,
`
`RPE AY (C18-25°C), BONEN AA7KAh}ERE 1000 BH, MPRERY
`
`ESVREASS, FCB aBN 7G
`
`Sei Pl 21
`
`AbTy: PBBPTFE a 105=BLS EH CO. 1mol/L) 200 Ft
`
`
`
`
`
`ATR 14.05|FRESHER 5.0E|FARE 0.5 55
`
`ZF
`
`5 BEFt aL 5.0 5—
`
`PEG-6000
`
`50 St
`
`PEG-20000
`
`5 3%
`
`YESSAA7K =
`
`WA: OREN FAKAA,ONZE 80°C, DART, PRC AAT ie
`
`1, TAAD ERA, POAERRPIAA, BEPE 30 SPRL,
`
`WHAFLYERR (0. 22nm) UES, TERS One 40°C, ANA PEG-20000, PEG-6000
`
`A FRR P ER, PFE SS (18-25°C), ADEN KALB as 1000 BH, Hi
`
`FEE ATEIS AEBS, FCB 7B BN G
`
`SK iti Pil 22
`
`ADFT: HMBFEA 10 be
`
`ERM® (0. 05mol/L) 250 &Ft
`
`=CBRIZ 305¢
`
`LATER 5. O58
`
`Ax CBE
`
`ARICA
`
`5 BeFt
`
`BULA
`
`1.03%
`
` PEG-1500
`
`0.552
`
`35 Fe
`
`PEG~400 5 TEN Fk i
`
`HA: KEMAK, AANZ 80°C, DAMIR, RCRA,
`
`WPAD ERA, FFAS ZR, PEPE 30 APPLE, AEB
`
`TAPE.TLEAR CO. 22 u m) EI. VER GAR 40°C, HMA PEG-400, PEG-1500
`
`All FA ZF ER, PR PRS SEV (18-25°C), BUENA Kt} eRe 1000 BA, Hi
`
`FREE TEESE, FOR BEBE.
`
`SE Tae Pil 23
`
`AkFy: WiBRBTFE A 10 5E ERB CO. 05mol/L) 400 BH
`
`=ZCRK 3850
`
`FARATHER 5.0 Fe
`
`ACE
`
`ZS
`
`SH =A 1.0%
`
`PEG-1000
`
`0.5 5
`
`20 Fe
`
`PEG-400
`
`53%
`
`ESNFA 7K
`
`ie
`
`HVE: IETERAKI Aa, ASAE 80°C, MARBLE. ACEART AES,
`
`aEAD EYSRA, FEUD ASS ZRS, BPE 30 4HLLE, BAB
`
`12
`
`

`

`200710111597. 7
`
`vis
`
`WE HCL 14H
`
`SHEE. SEWTLURHR CO. 22 u m) Yt, PER DIAZ 40°C, HAIMAPEG-400. PEG-1500
`
`AN FR SEAT ESE, PPR SY (18-25°C), FOIEZ7Kth CHS 1000 St, Rt
`
`PEE TE MIDS ER, FORA CRE BI.
`
`SE Ti Fil 24
`
`AFT: GARRY FEA 10bo|RAB CO. 05mol/L) 400 BH
`
`
`
`CO 841 5c|FARES HER 5.0 HE Ae CBF 0.5 5
`
`
`
`ZRF
`
`5 SeFt aL 1.0 5@
`
`PEG-10000
`
`10 3@
`
`
`
`PEG-400 YEWAK=ih53h)
`
`
`
`A: RESAKDAA, SNE 80, DARREL, ACRT C+,
`
`WPA AA. FFODA Ze, PEPE 30 2EPUL, BA
`
`FF, WASLUBHE C0. 22 nm) HBL, VERDNA40°C, RNA PEG-400. PEG-10000
`
`AN ASE EER, PAPER SE (C18-25°C), BOWEN AIK+# CHS 1000 Bt, Hi
`
`PEELBAI EBS, FCB ORE BNE.
`
`SLOGBill 17S Ag BA BEBE pH (EM ce
`
`1 FRE
`
`AS Ty1H VAAREFS AS Ha, CAPA AR VESSEL, LA pH4. 7 aK 9
`
`PER TP FE 17, WUE ERBEL pH1H.
`
`2 (at
`
`2.1 MBRFit: WUE O~14pH; WEAF SO. 02pH.
`
`2.2 pH BERRA, SALAD ACE pH7 AA.
`
`2.3 AAS HER.
`
`2.4 Wait: weve RW O~100°C.
`
`2.5 MAR: 50 BT.
`
`2.6 Hert BAAFEB AT ASS
`
`3 wil
`
`3.1 pH4 tvEBerey
`
`MERAAKEX 10.21 SEAR AE— FASBY (KHC8H204),, WFiRHIAKH EAA IL.
`
`F ARS, PATA. UALAAR, MAD YK
`
`YevE Paha (hoLD) Hes Be A YBPRA
`
`13
`
`

`

`200710111597. 7
`
`3.2 pH? tree
`
`Bi WAH12/ 14
`
`ot FEAR EX 3. 5GEE120+ 10°C-F KR 2hFFAANA Sd IA ATC7K BEB AL
`
`=A(Na2HPO4),Ze 3. 40 ELAR AEBERR—SLAF (KH2P04), — tPA TIAHIKI ERE
`
`IL. ACEARRRATAAS. 6 AIS.
`
`3.3 pH9 Rye ZePH
`
`HETAPREL 3.81 FEAR ALHWS (Na2B407 + 10H20), WFAA IAF
`
`Fe AZ IL. AARRRA SAR PHAKe. DAE
`
`fill 4 0
`
`LIBPMEETS Ti EREPYpH(ELE 1 AT AN
`
`42 1 BRERAET AE PY pHfh
`
`4 AHR
`
`4.1 FRAMES
`
`4.1.1 HPRTSOMMARTTHBSA BR, MIE ph4 EARPRie
`
`Bio TEASE, DSVELARP RI, REITPK. EA
`
`# KNVA MM RS e, RREFRACE 0. 1mol/L #4, 0. lmol/L AMAL, 0. Imol/L the
`
`BPRS 5 opt. FAK a. FRE pH4 PR Pie.
`
`4.1.2 (ROAEe AB AES aBeEE 10 RA
`
`ARIEEEA eR, EU TP PRE IMIE AEABU
`
`ALAM AE — TE WAAL o
`
`4.2 (X481E
`
`WS TTAB) INR. FDSDLPAS AYE. EAT URS UE ebEA BE BIE
`
`ERE DR
`
`4.3 pH Sef
`
`ARTEL, TRERo POA fir.
`
`4.3.1 FAH
`
`FY —AH pH (ES BON SECA eH HYEB. EER AG FTAUKPG HR
`
`BBB 2 KUL. Sa PAFSeOe ARACEI(ERR,
`
`VA he, FEL ABRJER Pals THF Ba Fd STA NAB E)0 ARTE LEPAPA,AFR, FA
`EOEPROMb. HUEOSUBOLBEEER5 se CSBRUE BD. PELREF
`
`TEER HAAY pH A, RMX ELK pH fh. BSWE. REREI~2h,
`
`14
`
`

`

`200710111597. 7
`
`BARGE A ik.
`
`4.3.2 PRK ei
`
`Bi WH H13/ 14
`
`FAX pH? Pere eh wRkK EEFEOT 6 FAREFFA —EER ET BR
`
`
`WU BEBC ARR PE, Te pH4 PR, APAWLE, ii pHO SEPP MR) LA BRAR A, FAR J
`
`OBAAAR A, FERRARA, FREE, de PERI. A
`
`aR28 Tie 4 (HIE BTS AS BAe 7SMAEFSBEAA pH (AL. HE 1 ~2 KR
`
`RAGE DLER TEABE Aik.
`
`4.3.3 = xAlFIVAsEfiz
`WETS=TEBE, oP a BA pH4. 7. 9 breBe RK. BH PSK 4.81 OE
`
`i Jes» FW 5 5 PS PRER AY pH {8=EREEBE
`
`
`
`GAA DLA pH (AE RUE Hh aSLETA. a =AHB
`
`PRU (EAR Ea AK F OO. 02pH SAAT, ATAA188 ARIE AS PEAT REE) pH WW az.
`
`4.4 HeeIRE wU ZE
`
`ERAP RAATSS, FERREBPE 2 KEK. RR, BA
`
`FEAR FFMET pH (WE. WhFie.
`
`5. WAC HARRY pH AE WLR 1
`
`
`#1 ARAM ERY pH
`
`SiG)pHEGRSEH)PHOSEM
`
`Siw 1
`
`SkBi 2
`
`SKB 3
`
`Sk He Bil 4
`
`SEED5
`
`SE HatAl 6
`
`SE iil 7
`
`SETH Bl 8
`
`5.63
`
`5. 83
`
`5.03
`
`8.13
`
`4, 68
`
`6.77
`
`8. 89
`
`5. 67
`
`Sk itiBl 9
`
`SEi Hi] 10
`
`SeiPl 11
`
`SE Ti il 12
`
`SET13
`
`Ski Bil 14
`
`SKhifal 15
`
`SEiti fil 16
`
`4,35
`
`5. 30
`
`5. 24
`
`8. 44
`
`4. 85
`
`6. 54
`
`8. 83
`
`5. 43
`
`SE HE17
`
`SEE 18
`
`Sk Hi] 19
`
`SE aa] 20
`
`SE iti Bi] 21
`
`Sk ia) 22
`
`SETH 23
`
`SEEBi] 24
`
`4, 63
`
`5. 81
`
`5.21
`
`8. 08
`
`4. 06
`
`6. 72
`
`8. 70
`
`5. 61
`
`HUES SeA, AR ACB ATER pH (Ab4. 35-8. 89 ZA.
`
`SEG Bi 2—AS Be FS RBS BD A Pe 1YhBE
`
`HEHEiidBE SW ETASS ARFl SCR CN1377706A PHA3 WA MX
`
`15
`
`

`

`200710111597. 7
`
`Be
`
`WR
`
`Oh 314/141
`
`AE, PBS AGE Kila], FLFR 2
`
`Be 2 ANAC AAS YY FASOe PE
`
`Sk reBil
`RASS (hdFE
`SE Tiil
`FASS (Yet PE
`SE He Hl]
`RABE (OYPE
`
`Sell31-35sCHHD~S~*«C8s=<“<«é<ALTOC*“‘i_
`
`
`
`SiG]229-31SeHAB)IOSehiblis282928-32
`
`
`SETA 3
`
`30-34
`
`SE Ite A) 11
`
`SETt4
`
`39-36 Sw 12
`
`SEW5
`
`29-34
`
`SE HEPA 13
`
`28-31
`
`30-34
`
`31-32
`
`SEitiWl 19
`
`Sk He Al 20
`
`SET21
`
`27-29
`
`27-29
`
`27-30
`
`SETPl 6
`29-32
`Seite Bt 14
`29-32
`STiPil 22
`28-31
`SHGG)7«30-31.~~15~——(80-33~=*é<“‘«‘NHYQB~*~*«~
`MEGS=«381-32—~S—é«CALHP16~=~S*«C8Dsst=<“<«é‘éUHSC=<“i«*“C
`FESESEOOBEB,252THOEETADSSEEYF27-36°C,MEWREAR
`
`ES) BLN AY Pe Be ekYinA PAS WRAI A Jere 1 TL RIBS, TAB MER 25OB EA
`
`HI BEC FR o
`
`BS AY BDeBo) A= URRY. pH (RAY A FURR, Ep
`
`ekFE AR AY HbFB PAAESF, AS A Htaa2
`
`BESET, (AAAS ACH AB SEHR ACH, UAE BURR REBe 9 Fk oe PE BB BE
`
`APRBRAY abu EP BDAA REBORN pH EG REKAE UW. K
`
`BE AHFS BEA FEBe9EP i TRAFDEY DH La, ALTO RUE TE
`
`Be FLAS BUR ATEee A AeOE
`
`‘SEASfal] 3—AS Be BA ESFE] BA 20se YTa al KT ik
`
`40 A= Aaa10 4, APRESSRE AA2 2c 8 BOSFBa
`
`PS CSEMRBI 1S 4. 7. 9, 12. 16, 18, 20. 22 F124), RUSCAO DA PYLACHER,
`
`#$ 45pe — ik, UK TR, FEIAE hk SRAR, ERE 4K. FOR
`
`EN MASAAR. SRRRAR, SARE. AKA. SRE RZ
`
`Wo TAABR AS ACHAER FR BUERE, AR ZAZATCRIB
`
`16
`
`

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