(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`(19) World Intellectual Property
`Organization
`International Bureau
`
`MOANA AAMT AT TARTARA
`
`(43) International Publication Date
`21 January 2016 (21.01.2016)
`
`WIPOIPCT
`
`Zz
`
`(10) International Publication Number
`WO 2016/009451 A2
`
`G1
`
`@)
`
`International Patent Classification: Not classified
`
`International Application Number:
`
`PCT/IN2015/050066
`
`(22)
`
`InternationalFiling Date:
`
`(25)
`
`(26)
`
`(30)
`
`(71)
`
`(72)
`
`Filing Language:
`
`Publication Language:
`
`13 July 2015 (13.07.2015)
`
`English
`
`English
`
`Priority Data:
`2289/MUM/2014
`
`14 July 2014 (14.07.2014)
`
`IN
`
`Applicant: GENNOVA BIOPHARMACEUTICALS
`LIMITED [IN/IN]; P-1, IT-BT Park, Phase-IL, M.LD.C.,
`Ilinjwadi, Pune 411057 (IN).
`
`Inventors: RAGHUWANSHI, Arjun; Gennova Vaccine
`Formulation Centre and Research Laboratory, BTS-2
`Building, Chrysalis Enclave, Block-2, Plot-2, International
`Biotech Park, Phase I, MIDC, Hinjwadi, Pune 411057
`(IN). SINGH, Shrawan Kumar; Gennova Vaccine For-
`mulation Centre and Research Laboratory, BTS-2 Build-
`ing, Chrysalis Enclave, Block-2, Plot-2, International Bi-
`otech Park, Phase LL, MIDC, Hinjwadi, Pune 411057 (IN).
`THAKER, Nidhiben; Gennova Vaccine Formulation
`Centre and Research Laboratory, BTS-2 Building, Chrysal-
`is Fnclave, Block-2, Plot-2, International Biotech Park,
`Phase II, MIDC, Hinjwadi, Punc 411057 (IN). SHANK-
`AR, Shagun; Gennova Vaccine Formulation Centre and
`Research Laboratory, BTS-2 Building, Chrysalis Enclave,
`Block-2, Plot-2,
`International Biotech Park, Phase II,
`MIDC, Hinjwadi, Pune 411057 (IN). KARDILE, Pavan;
`Gennova Vaccine Formulation Centre and Research Labor-
`atory, BTS-2 Building, Chrysalis Enclave, Block-2, Plot-2,
`International Biotech Park, Phase I, MIDC, Hinjwadi,
`
`(74)
`
`(81)
`
`Pune 411057 (IN). SINGH, Sanjay; Gennova Vaccine
`Formulation Centre and Research Laboratory, BTS-2
`Building, Chrysalis Enclave, Block-2, Plot-2, International
`Biotech Park, Phase II, MIDC, Hinjwadi, Pune 411057
`(IN).
`
`Agent: ARVIND, Chitra; Rajeshwari & Associates, Am-
`soft Business Centre, Unitech Trade Centre, Sector-43,
`Gurgaon 122002 (IN).
`
`Designated States (unless otherwise indicated, for every
`kind of national protection available): AE, AG, AL, AM,
`AO, AT, AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY,
`BZ, CA, CH, CL, CN, CO, CR, CU, CZ, DE, DK, DM,
`DO, DZ, EC, EE, EG, ES, FL, GB, GD, GE, GH, GM, GT,
`HN, HR, HU,ID,IL,IN,IR,IS, JP, KE, KG, KN, KP, KR,
`KZ, LA, LC, LK, LR, LS, LU, LY, MA, MD, ME, MG,
`MK, MN, MW, Mx, MY, MZ, NA, NG, NI, NO, NZ, OM,
`PA, PE, PG, PH, PL, PT, QA, RO, RS, RU, RW, SA, SC,
`SD, SE, SG, SK, SL, SM, ST, SV, SY, TH, TJ, TM, TN,
`TR, TT, TZ, UA, UG, US, UZ, VC, VN, ZA, ZM, ZW.
`
`(84)
`
`Designated States (unless otherwise indicated, for every
`kind of regional protection available): ARIPO (BW, GH,
`GM, KE, LR, LS, MW, MZ, NA, RW, SD, SL, ST, SZ,
`TZ, UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU,
`TJ, TM), European (AL, AT, BE, BG, CII, CY, CZ, DE,
`DK, EE, ES, FI, FR, GB, GR, HR, HU,IE,IS, IT, LT, LU,
`LV, MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SL SK,
`SM, TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ,
`GW, KM, ML, MR,NE, SN, TD, TG).
`Published:
`
`without international search report and to be republished
`upon receipt ofthal report (Rule 48. 2(g))
`
`(54) Title: A NOVEL PROCESS FOR PURIFICATION OF RHU-GCSF
`
`(57) Abstract: The present invention provides a novel, scalable and industrially viable downstream process for purification of re-
`combinant human G-CSF.
`
`
`
`
`
`wo2016/009451A2INITMINIINIINIATIENITAITTAINANTAMUIA
`
`

`

`SP 2017 526649 A 2017914
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`20
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`

`4
`
`SP 2017 526649 A 2017914
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`PO-AHP, FSEVEFISO3, RUFFIFFIVSE HiCap, LNHELKS
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`

`5
`
`SP 2017 526649 A 2017914
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`SP 2017 526649 A 2017914
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`SP 2017 526649 A 2017914
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`12
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`SP 2017 526649 A 2017914
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`13
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