`
`MANTYLA EINAR [IS]; ORVAR BJORN LARUS [IS]; BJIARNASON
`JON BRAGI [IS]; BALMER YVES [CH] =(MANTYLA EINAR
`- BALMER
`,; BJARNASON JON BRAGI
`ORVAR BJORN LARUS
`YVES)
`
`Applicant(s)
`
`ORF LIFTAEKNI HF [IS] = (ORF LIFTAEKNI HF)
`
`AGIK31/728; AGIK38/18; AGIK8/G4; COFK14/485
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`Classification
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`=In
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`- cooperative
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`Application
`number
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`1orl
`ity
`Pri
`number(s)
`
`KR20127020435 20110106
`
`Global Dossier
`
`is 20700008877 201007106
`
`Also
`published as
`
`ALUPCOT 204391 (Al) BREI2O12016575 (A2) CA2Z7 85637 (Al)
`CN102811704 (Al EP2521532 (A2). more
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`8 (12) SASS ERA)
`(51) Sas 424 (Int. Cl.)
`AGIK 38/18 (2006.01) AGIK 31/728 (2006.01)
`AGIK 8/64 (2006.01)
`CO7K 14/485 (2006.01)
`(21) 29Hns
`10-2012-7020435
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`2011.4014062
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`ALY 9
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`S}CTNF(Tumor Necrosis Factor)-a), @°F BAF e14--SECINF-b),
`912) 4] 2-2 e}Cinterferon-gamma,
`INF-g),
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`
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`
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`BSIFSG 10-2012-0115535
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`glo) 2E (paste), AZ, HHsalve), #E, 4A HE WHA (semiliquid) AA, AWBserum), W4l, AYNS
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`
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`
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`apa 21 He 22] SoA, ASPHAAS VU] SSH Ael BA Bel/Bpss 2ge.
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`APY 24
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`AlZzR el z}(PDGF), FGF-a, @ FGF-b, FGF-4 @ FGF-62 %@3 AfRBAE AA
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`PE}-2, TGF WJE}-3S Vee GAs Bsels-ver(iGr-b), Saas Bells
`ety} (TGF-a), Wz] ESSME (Epo), eee-sae 34 SlLALKICIGF-1), cle e--4} 49%} ol AF IICIGF-II),
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`oka] SA] APS SEZ] SS, H-AS +414] 7] Ql(mon-plant genetic origin)2| AS-aAz oo] AS el zb(Cplant-
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`SIS 10-2012-0115535
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`E] = 71-8(1L-8), QE} ZI-10(1L-10), ele FZ1-13C1L-13), gle) ZI-15C1L-15), 21e)FZ1-18(1L-18), daz
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`4 4) FGF-6- S36) 41-f-A]3 494) Ol44(FGF), TGF AE}-1, TGF HI eh TGF WJE}-3S 4ES FAAS as
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`@& Aas Aysbelz}-2S(1GF-a), oe] =#Fo} Epo), Meat ast MAI ICIGF-1),
`leee]—-f-A} AP4}
`OL X}-IICIGF-II),
`IL-1 Gs} @ IL-1 WES 2S AMS SZ1-1CL-1), MH 71-2C1L-2),
`SE) FzZ1-4(1L-4), SE) ZI-5CIL-5), 1 E] 21-6(1L-6),
`Sl E-#ZI-7C1L-7),
`Sl E)#2I-8(1L-8), ele) zZI-
`10CIL-10), Qle+41-18C1L-13), Qe 441-15C1L-15), gle 2-18CIL-18), Qle}=41-20(1L-20), @ek HAF 9h
`AL-QESECTNF-a), SC SAL OLAvuERCTINE-b), GLE) SIS-ZeECINF-g), =H Bet 2S elAKG-CSF), 24°
`HANS 4S 2S SIAECGM-CSF), CHAISESP AES RL *EGMECSF), BRE 7dQIAECPLGF), 41-3 do) 4}
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`24 8 zAS|Ala} 2 2484 22S] Bs] 2S TSAA + Vt. BS Y Are S OB zee BZ, B
`He He ASWAs Ge SH AAs ae; So] GAA, att 2 FF 24] +relsto], BAS] HBS #2
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`ae Eye] WEAR, BE BH$e] @ Solty. 29 FA(eczema)\ = OSM 24] WY ASM(persistent skin
`condition] S4Hs-7] ASecp.Set B24, WP PS), 7a 2 as, 7 AA (crusting), '
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`W @Al(flaking), @#¥% GJ (blistering), eh(cracking) ee 87) areozing) He 2a Gs =
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`lamina)2) aPae] Bosc}, o Se Ales] FAS Aa Feaa, Bey, was] fe SUS F244 +
`al, FAAS23}, ASEAN42442 A4sya, AZ @ ANS 4RSe] wa] B@ AASFES = Ve.
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`Ito S(2009)2 7JZ WSS(AsM) AeA, MMP(Matrix metalloproteinase) @ TIMP(tissue inhibitor of
`metalloproteinase)2] Wee] #epal ata] Bo] AMES] OS BAS, ep FIZ ByVal 7AS +
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`ans AS BLAS}. PDGF= mRNA EB Et Al <=<20] 4] MMP-1(Matrix Metalloprotease-1)2] BAS wa-A) zt
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`LAS}, TGF-HES} APSh= A, PDGME MMP-39] 24 AS SAS HY Sc}. TIMP-12 TGr-HNe} B
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`SIFSA 10-2012-0115535
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`PDGFSe PPA OS PYRAS| Yr}.
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`Nakatani $(2009)2 8|¢h# (hyaluronan)3]/4¢ ey aje1-q MMP-12) Wa BY wed So] Vee vy
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