~.
`(12) INTERNATIONAL APPLICATION PUBLISHED UNDER THE PATENT COOPERATION TREATY (PCT)
`(19) World Intellectual Property
`>
`Organization
`en)
`International Bureau
`
`LNAI TAA
`
`(10) International Publication Number
`WO 2022/204725 Al
`
`==
`
`——
`WIPO( PCT
`
`(43) International Publication Date
`29 September 2022 (29.09.2022)
`
`(51) International Patent Classification:
`A6I1N 2/00 (2006.01)
`G16Y 40/20 (2020.01)
`A6IN 2/12 (2006.01)
`GI16Y 40/30 (2020.01)
`A6IB 5/374 (2021.01)
`G16Y 20/40 (2020.01)
`GI16Y 10/60 (2020.01)
`
`(21) International Application Number:
`PCT/U$2022/071355
`
`(22) International Filing Date:
`
`(25) Filing Language:
`
`(26) Publication Language:
`
`25 March 2022 (25.03.2022)
`
`English
`
`English
`
`(30) Priority Data:
`63/166,944
`
`26 March 2021 (26.03.2021)
`
`US
`
`(71) Applicant: WAVE NEUROSCIENCE,INC. [US/US];
`1601 Dove Street, Suite 205, Newport Beach, CA 92660
`(US).
`
`(72) Inventors: PHILLIPS, James, William; 1601 Dove
`Street. Suite 205, Newport Beach, CA 92660 (US). RING,
`Alexander; 1601 Dove Street, Suite 205, Newport Beach,
`CA 92660 (US).
`
`(74) Agent: DEMING,Benjaminct al.; Buchalter, IP Docket-
`ing, 18400 Von Karman Ave., Suite 800, Irvine, CA 92612
`(US).
`
`(81) Designated States (unless otherwise indicated, for every
`kind of national protection available): AE, AG, AL, AM,
`AO,AT. AU, AZ, BA, BB, BG, BH, BN, BR, BW, BY, BZ,
`CA, CH, CL, CN, CO, CR, CU, CZ, DE, DJ, DK, DM, DO,
`DZ, EC, EE, EG, ES, FI, GB, GD, GE, GH, GM, GT, HN,
`HR, HU,ID, IL,IN,IR,IS, IT, JM, JO, JP, KE, KG, KH,
`KN, KP. KR, KW, KZ, LA, LC, LK, LR, LS, LU, LY, MA,
`MD,ME. MG, MK, MN, MW, MX, MY, MZ, NA, NG,NI,
`NO, NZ, OM,PA. PE,PG, PH, PL, PT, QA, RO, RS, RU,
`RW,SA, SC, SD, SE, SG, SK, SL, ST, SV, SY, TH, TJ, TM,
`TN, TR, TT, TZ, UA, UG, US, UZ, VC, VN, WS, ZA, ZM,
`ZW.
`
`(84) Designated States (unless otherwise indicated, for every
`kind of regional proteciion available): ARIPO (BW, GH,
`GM, KE, LR, LS, MW, MZ, NA, RW,SD,SL, ST, SZ, TZ,
`UG, ZM, ZW), Eurasian (AM, AZ, BY, KG, KZ, RU, TJ,
`TM), European (AL, AT, BE, BG, CH, CY, CZ, DE, DK,
`EE,ES, FI, FR, GB, GR, HR, HU,IE,IS, IT, LT, LU, LV,
`MC, MK, MT, NL, NO, PL, PT, RO, RS, SE, SI, SK, SM,
`TR), OAPI (BF, BJ, CF, CG, CI, CM, GA, GN, GQ, GW,
`KM,ML, MR, NE, SN, TD, TG).
`
`(54) Title: ELECTROENCEPHALOGRAM (EEG) BASED TRANSCRANIAL MAGNETIC STIMULATION (TMS) DEVICES
`
`100°
`
`~ 900
`
`(57) Abstract: A system and method for providing transcra-
`nial magnetic stimulation (TMS) based on electroencephalogram
`(EEG) data. The system and method may include a porlable neu-
`ro-electroencephalogram synchronization therapy (NEST) sys-
`tem for capturing EEG data from a patient. The system and
`method may also include an electrophysiology database and cus-
`tomized TMS treatment system for receiving the EEG data from
`the portable NEST system. The electrophysiology database and
`customized TMStreatinent system may determine a TMStreat-
`ment based on the received EEG data. The portable NEST system
`may provide synchronized TMSbased onthe determined TMS
`treatment.
`
`
`
`FIG. 5A
`
`
`
`wo2022/204725AIIMINOMTAYATAA
`
`[Continued on nextpage]
`
`

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`WO 2022/204725 AA TIMITITNUINANA ITNTIN TTT TMCANAYANMTA
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`Declarations under Rule 4.17:
`as to applicant's entitlement to apply for and be granted a
`patent (Rule 4.17(ii))
`— as io the applicant's entitlement to claim the priority of the
`earlier application (Rule 4.17(iit)
`Published:
`
`— with international search report (Art. 21(3))
`— before the expiration of the time limit for amending the
`claims and to be republished in the event ofreceipt of
`amendments (Rule 48, 2(h)
`
`

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`WO 2022/204725
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`PCT/US2022/071355
`
`ELECTROENCEPHALOGRAM (EEG) BASED TRANSCRANIAL MAGNETIC
`STIMULATION(TMS) DEVICES
`
`CROSS-REFERENCE
`
`[0001] This application claims the benefit of U.S. Provisional Application No. 63/166,944, filed March
`
`26, 2021. entitled METHODS, SYSTEMS, KITS AND APPARATUSES FOR PROVIDING
`
`TRANSCRANIAL MAGNETIC STIMULATION (TMS) BASED ON ELECTROENCEPHALOGRAM
`
`(EEG) DATA,which application is incorporated herem in its cntircty by reference.
`
`[0002] This application is related to the following co-pending patent applications: application Serial No.
`
`PCT/2022/_ filed March 28, 2022 [Attorney Docket No W1352.2233]; and application Serial No.
`
`PCT/2022/_ filed March 28, 2022 [Attorney Docket No W1352.2234], which are incorporated
`
`herein in their entirely byreference.
`
`BACKGROUND
`
`[0003] Field
`
`[0004] The disclosure relates to devices for providing transcranial magnetic stimulation (TMS) therapy
`
`based on electroencephalogram (EEG)data.
`
`[0005] Background
`
`[0006] Mental disorders cause serious problemsfor affected people, their families, and society.
`
`Currently, psychiatrists and neurophysiologists treat these disorders with a variety of medications, many
`
`of which have significant negative side effects. Mental disorders can be painful, debilitating, and very
`
`costly for the affected individual and their family. Approximately onc in five adults in the US expericnces
`
`a mental disorder in a given ycar. 18.1% of adults in the US cxpericnce an anxictydisorder, such as
`
`posttraumatic stress disorder, obsessive-compulsive disorder (OCD) and specific phobias. 6.9% of adults
`
`in the US haveat least one major depressive episode each year. 1.1% of adults in the US live with
`
`schizophrenia. In fact, mental disorders are the third most common cause of hospitalization in the US for
`
`both youth and adults aged 18-44 and the consequencesof lack of treatmentare significant. Sadly, suicide
`
`is the 10th leading cause of death in the U.S. and the 2nd leading cause of death for those aged 15-24.
`
`Each day, approximately 18-22 veterans die by suicide.
`
`[0007] A keyfactor in treatment of mental disorders is proper diagnosis. The standard method of
`
`diagnosing mental disorders has been with either the Diagnostic and Statistical Manual of Mental
`
`Disorders (DSM)or the International Statistical Classification of Diseases and Related Health Problems
`
`(ICD), Chapter 5: Mental and behavioral disorders. Both standards primarily involve diagnosis using
`
`conversation with the patient regarding symptomsand behavior. This standard has the disadvantage of
`
`being subjectively based on the interviewer’s perception, which lessens the diagnostic reliability,
`
`sometimesresulting in two clinicians arriving at different diagnoses for the same patient. Additionally, a
`
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`patient’s responses to questions may vary based upontheir present situation orlife circumstance.
`
`Because the DSM and ICDare primarily concerned with the signs and symptomsof mental disorders,
`
`rather than the underlying causes, there is a general lack of pathophysiological understanding of mental
`
`disorders.
`
`[0008]
`
`It is apparent that a repeatable and reliable svstem for the diagnosis of mental disorders that is
`
`based on measurable data, independent of the biases and interpretation of an intervieweror a fluctuating
`
`situational condition of the patient, would provide significant benefit to patients and to the psychiatric
`
`community.
`
`[0009] Treatment of these disorders with magnetic fields, such as those generated by transcranial
`
`magnetic stimulation (TMS), may generate positive therapeutic responses.
`
`[0010] TMSis a generally known non-invasive procedure that uses magnetic pulses to stimulate nerve
`
`cells and neuronal circuitry in the brain to improve mental disorders such as depression. Magnetic pulses
`
`delivered at regular intervals, described as repetitive magnetic pulses, are referred to as rTMS.
`
`Traditionally, coils (e.g., a large electric coil) have been used to generate r™MS. Thelarge electric coil
`
`(e.g., electromagnetic coil) may be placed against a patient’s scalp when applying stimulation. Some
`
`studies have shown that r!MScan reduce the negative symptomsof schizophrenia, obsessive compulsive
`
`disorder (OCD), and depression undercertain circumstances.
`
`[0011] Magnetic fields, especially time and magnitude-varying magneticfields, can also be generated by
`
`movementof one or more magnets. For example, some devices provide TMSby using rotating permanent
`
`magnets where magnets are positioned around a patient’s head to provide TMStowards regionsofthe
`
`patient’s brain to stimulate nerve cells in those specific regions ofthe brain. In some of these examples,
`
`tTMSuses anelectromagnet placed onthe scalp that generates a series of magnetic field pulses roughly
`
`the strength of an MRI scan.
`
`[0012] There are also normative electroencephalogram (EEG)databases that have been in existence for
`
`several years at a few universities. The normative EEG databases are typically accompanied by clinical
`
`scores or evaluations of some kind for EEG data that was collected from paticnts. These normative EEG
`
`databases have been used to aid medical professionals in evaluating neurological statuses of patients prior
`
`to and after therapy to adjust therapy as needed based on EEG biofeedback. This deeper knowledge can
`
`benefit patients, medical professionals (e.g., clinicians), and the greater neurological or neurotherapy
`
`field. These databases are usually based on a wide age range from children up to adults. Examples of
`
`universities having these normative EEG databases include New York University (NYU) and the
`
`University of Maryland.
`
`[0013] What is needed are devices that customize application of TMSbased on normative EEG data.
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`SUMMARY
`
`[0014] The disclosure relates generally to devices for providing transcranial magnetic stimulation (TMS)
`
`based on normative electrophysiological measurement such as electroencephalogram (EEG) data. A
`
`normative database provides operational feedback to the devices that accounts for deviations from an
`
`expected normal parameters in a population.
`
`[0015] The devices includes: a portable neuro-electroencephalogram synchronization therapy (NEST)
`
`system for capturing the EEG data from a patient in communication with a normative EEG database
`
`whichis operable to customize the application of TMSbased on the EEG data compared to the normative
`
`EEGdata from the database. The electrophysiclogy database is used to customize TMStreatment
`
`delivered from the devices based on the received EEG data. The portable NEST devices mayprovide
`
`synchronized transcranial magnetic stimulation based on the determined TMStreatment.
`
`[0016] The portable NEST deviccs may also provide the synchronized transcranial magnetic stimulation
`
`relating to a defined treatment protocol.
`
`[0017] Additionally, the portable NEST devices may have a mobile design developed through
`
`miniaturization and compacting of components within the portable NEST devices allowing for use of the
`
`portable NEST devices at various locations and when the patient may be in-transit between locations.
`
`Additionally, the portable NEST devices maybe configured as a wearable headgear that provides the
`
`TMStreatment during mobility of the patient. A portable power source can also be provided. Safety
`
`features can also be provided to prevent misuse of the device.
`
`[0018] The portable NEST system may include a magnetic stimulation system having rotating magnets
`
`that may generate an alternating magnetic field that provides the synchronized transcranial magnetic
`
`stimulation based on the determined TMStreatment.
`
`[0019] The NEST systems may also provide the recommended synchronized transcranial magnetic
`
`stimulation to the patient. The systems mayinclude an electrophysiology database and customized TMS
`
`treatment system for accessing the EEG data for a patient. The electrophysiology database and
`
`customized TMStreatment system may also provide bursting analysis of the EEG data, and the
`
`electrophysiology database and customized TMS treatment system may determine a TMStreatment based
`
`on the bursting analysis and the EEG data. The electrophysiology database and customized TMS
`
`treatment system may recommend synchronized transcranial magnetic stimulation based on the
`
`determined TMStreatment. Additionally, the electrophysiology database and customized TMStreatment
`
`system may use the bursting analysis for diagnosing the patient. In some embodiments, the
`
`electrophvsiology database and customized TMS treatment system may use the bursting analysis for
`
`determining treatment parameters.
`
`3.
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`[0020] The devices can communication with secondary systems, such as an electrophysiology database
`
`and customized TMStreatment system for receiving the EEG data from the portable NEST system, and
`
`the electrophysiology database and customized TMStreatment system may determine the TMStreatment
`
`based on the received EEG data.
`
`[0021] A kit for providing TMS based on EEG data is disclosed. The kit may include a portable NEST
`
`system configured within a bounding box having a maximum volume with maximum dimensions of
`
`about X by about Y by about Z for providing one or more portability features for a patient. The portable
`
`NESTsystem may capture EEG data fromthe patient, and the portable NEST system may determine a
`
`TMStreatment recommendation based on the EEG data or mayreceive the TMStreatment
`
`recommendation from a second system based on the EEG data. The portable NEST system may provide
`
`synchronized transcranial magnetic stimulation based on the determmed TMStreatmentor the
`
`recommended TMStreatment. Portability featurcs may include at Icast one of compact, transportable,
`
`movable, mobile, easy to carry, or relatively lightweight. In some embodiments, the portability features
`
`may include at least one of positionable and removable, or modular.
`
`INCORPORATION BY REFERENCE
`
`[0022] All publications, patents, and patent applications mentioned in this specification are herein
`
`incorporated by reference to the same extent as if each individual publication, patent, or patent application
`
`was specifically and individually indicated to be incorporated byreference,
`
`[0023] US Patent 9,962,555 issued May 8, 2018 to Charleset al.; and
`
`[0024] US Patent 10,835,754 issued November 17, 2020 to Charlesetal.
`
`BRIEF DESCRIPTION OF THE DRAWINGS
`
`[0025] The novel features of the invention are set forth with particularity in the appended claims. A
`
`better understanding of the features and advantages ofthe present invention will be obtained by reference
`
`to the following detailed description that sets forth illustrative embodiments, in which the principles of
`
`the invention are utilized, and the accompanying drawings of which:
`
`[0026] FIG. 1 is a diagrammatic environment view that depicts an exemplary portable NEST system and
`
`an electrophysiology database and customized TMStreatment system communicating via a network, and
`
`communicating with various other systems, devices, processes, and information sources according to
`
`embodiments ofthe disclosure;
`
`[0027] FIG.2 is a diagrammatic view that depicts examples of the portable NEST system of FIG. 1
`
`according to embodiments of the disclosure;
`
`[0028] FIGS 3A-F are views ofa base station for the portable NEST headset;
`
`[0029] FIGS. 4A-P are views of a portable NEST headset;
`
`[0030] FIGS. SA-E are views of a portable NEST base station and headset device;
`
`4.
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`[0031] FIGS. 6A-B are bottom views that depict examples of a portable headset device of the portable
`
`NESTsystem without and with a magnet cover according to embodiments ofthe disclosure;
`
`[0032] FIG. 7 is an exploded view that depicts the portable headset device of the portable NEST system
`
`along with a base station of the potable NEST system according to embodiments of the disclosure;
`
`[0033] FIGS. 8A-C are side viewsthat depict examples of positioning of the portable headset device and
`
`positioning of magnets of the portable headset device with a user according to embodimentsof the
`
`disclosure;
`
`[0034] FIG. 9 is a diagrammatic view that depicts further examples of the portable headset device andits
`
`related systems and devices of an example portable NEST system according to embodiments of the
`
`disclosure;
`
`[0035] FIG. 10 a perspective view that provides further detail of the portable headset device of FIG. 9
`
`according to cmbodiments of the disclosure;
`
`[0036] FIG. 11 is an exploded assembly view that depicts the portable headset device of FIGS. 9 and 10
`
`according to embodiments ofthe disclosure;
`
`[0037| FIG. 12 is a close-up diagrammatic viewthat depicts details of a NEST controller of the example
`
`portable NEST system of FIG. 9 according to embodiments of the disclosure; and
`
`[0038] FIG. 13 is a diagrammatic view that depicts use of the NESTcontroller and the portable headset
`
`device of the example portable NEST system of FIGS. 9-12 according to embodimentsof the disclosure.
`
`DETAILED DESCRIPTION
`
`[0039] The disclosure relates to an electroencephalogram (EEG) and transcranial magnetic stimulation
`
`(TMS)process. In examples, the EEG and TMSprocess may be executed by any combination of a neuro-
`
`electroencephalogram synchronization therapy (NEST) system, an electrophysiology database and/or a
`
`TMStreatment system (optionally using an electrophysiology database and optionally providing for
`
`customized, patient-specific TMStreatment protocols, and/or optionally using a combined
`
`electrophysiology database and customized TMS treatment system), and/or any other computing device.
`
`[0040] The portable NEST system maybe casily carried or moved because the device or system may be
`
`lighter, compact, transportable, mobile, lightweight and/or smaller than typical or standard devices or
`
`systems. The portable NEST systems may include wearable NEST systems, NEST systems configured as
`
`headgear, positionable and removable NESTsystems (¢.g., may be conveniently positioned on or above a
`
`chair or seat and then easily removed from the chair or seat), modular NEST systems (e.g., capable of
`
`being integrated into another device or system), etc. The portable NEST system maybe sized to have a
`
`maximumvolume or a dimension range , such as about 285 mmlength by about 194 mmwidth by about
`
`188 mm height.
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`[0041] Tuming nowto FIG. 1 an example environment. The example environment includes a portable
`
`NEST system 100 with a NEST database 102 in communication with a network 300. The network 300 is
`
`also in communication with an electrophysiology database and customized TMStreatment system 200
`
`whichincludes a database integration system 202. One or more servers 101 can be provided in
`
`communication with the network 300 and/or components in communication with the network 300.
`
`Additional components in communication with the network 300 include, for example, external
`
`information source(s) 310, third party service(s) 306, clinician device(s) 304, and patient device(s) 302.
`
`An EEG and TMSprocess 400 may munacross any combination ofthe systems and devices. The EEG and
`
`TMSprocess 400 may be run across any combination of an EEG system (such as a portable NEST system
`
`100), an electrophysiology database, a customized TMStreatment system 200, and/or another computing
`
`device (e.g., server shown in FIG. 1). The EEG and TMSprocess 400 may be executed and run on the
`
`various systcms and computing deviccs via a nctwork 300. In FIG.1, the portablc NEST systcm 100 may
`
`communicate with the electrophysiology database and customized TMStreatment system 200 according
`
`to example embodiments ofthe disclosure. The portable NEST system 100 may use a NEST-database
`
`integration system 102 to communicate and interact with the electrophysiology database and customized
`
`TMStreatment system 200 via the network 300. Similarly, the electrophysiology database and
`
`customized TMStreatment system 200 may use a database integration system 202 to communicate and
`
`interact with the portable NEST system 100 via the network 300. Other devices (e.g., various computing
`
`devices or mobile devices) such as patient device(s) 302, clinician device(s) 304, and third-party
`
`service(s) may communicate with the electrophysiology database and customized TMStreatment system
`
`200 and the portable NEST system 100. The electrophysiology database and customized TMStreatment
`
`system 200 and the portable NEST system 100 may also communicate and interact with external
`
`information source(s) 310 via the network 300. As shown in FIG.1, the portable NEST system 100 may
`
`be positioned on the head of a patient 308.
`
`[0042] The portable NEST system 100 may capture EEG data from a patient. The electrophysiology
`
`databasc and customized TMStreatment system 200 mayreccive the EEG data from the portable NEST
`
`system 100. The electrophysiology database and customized TMStreatment system 200 may determine a
`
`TMStreatment based on the received EEG data. The portable NEST system 100 may provide sTMS
`
`based on the determined TMStreatment. The electrophysiology database and customized TMStreatment
`
`system 200 may also access the EEG data for a patient and mayclassify the patient as having a particular
`
`brain type based on the EEG data. The electrophysiology database and customized TMStreatment system
`
`200 may determine a TMStreatment based on the classified brain type and the EEG data. The
`
`electrophvsiology database and customized TMS treatment system 200 may recommend sTMSbased on
`
`the determined TMStreatment. In some examples, the portable NEST system 100 may capture the EEG
`
`he
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`data from the patient that mav be accessed bythe electrophysiology database and customized TMS
`
`treatment system 200. The portable NEST system 100 may provide the recommended synchronized
`
`transcranial magnetic stimulationto the patient. The electrophysiology database and customized TMS
`
`treatment system 200 mav access the EEG data for a patient and may analyze the EEG data. The analyzed
`
`EEGdata can be used indicate brain health of the patient. The electrophysiology database and customized
`
`TMStreatment system 200 may determine TMStreatment based on the brain health indication and the
`
`EEGdata. The electrophysiology database and customized TMStreatment system 200 may recommend
`
`sTMSbased onthe determined TMStreatment. In some examples, the electrophysiology database and
`
`customized TMStreatment system 200 may provide reporting ofthe brain health indication in the form of
`
`a brain health indicator for the patient. The electrophysiology database and customized TMS treatment
`
`system 200 may also use the brain health indication for diagnosing the patient. The electrophysiology
`
`database and customized TMStreatment system 200 mayaccess the EEG data for a paticnt and may
`
`provide bursting analysis of the EEG data. The electrophysiology database and customized TMS
`
`treatment system 200 may determine a TMStreatment based onthe bursting analysis and the EEG data.
`
`The electrophysiology database and customized TMStreatment system 200 may also recommend sTMS
`
`based on the determined TMS treatment. Bursting analysis may be used for diagnosing the patient. The
`
`bursting analysis may be used for determining treatment parameters. The portable NEST system 100 inay
`
`also capture EEG data froma patient and have one or more rotating magnets for generating an altemating
`
`magnetic field. The portable NEST system 100 may determine a TMS treatment recommendation based
`
`on the EEG data or may receive the TMStreatment recommendation from a second system based onthe
`
`EEG data. The portable NEST system 100 mayprovide sTMSby using the rotating magnets to generate
`
`the alternating magnetic field based on the determined TMStreatment or the recommended TMS
`
`treatment. The second system maybe the electrophysiology database and customized TMStreatment
`
`system 200 for receiving the EEG data from the portable NEST system. The electrophysiology database
`
`and customized TMStreatment system 200 maydetermine the TMStreatment based on the received EEG
`
`data.
`
`[0043] NEST System Components
`
`[0044] FIGS. 2A-B showa detailed view of the portable NEST system 100. The portable NEST system
`
`100 may include the NEST-Database integration system 102 (e.g., portable NEST system software that
`
`enables integration with software of the electrophysiology database and customized TMStreatment
`
`system 200), a magnetic stimulation system 104 (e.g., including one or more magnets that mayprovide
`
`synchronized magnetic stimulation or sTMS), an EEG capturing system 106 (e.g., detecting and capturing
`
`EEGdata from the patient 308 using sensors such as electrodes placed along scalp of the patient 308), a
`
`portable power source 108 (e.g., portable-type power source such as a battery), a safety feature system
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`110 (e.g., one or more safety mechanisms that may prevent or avoid misuse of the portable NEST system
`
`100 such as a locking mechanism), an Internet of Things (oT) system 112 (e.g., including various
`
`components that mayprovide IoT capabilities suchas relating to connecting the portable NEST system
`
`100 to the network 300), portable/mobile design feature(s) 114 (e.g., one or more features that enable for
`
`portability and mobility use of the portable NEST system 100 such as miniaturizing of some features or
`
`components), other neuromodulation system(s) 116 (e.g., systems that provide other therapies such as
`
`light stimulation therapies), a NEST controller 118 (¢.g., controller may be used for managing and
`
`directing one or more components of the portable NEST system 100), a TMStreatment determination
`
`system 120 (e.g., system for determining repetitive TMS (rTMS) and sTMSthat maybe based on the
`
`EEGdata obtained by the EEG capturing system 106) having treatment types and protocols 122 (e.g.,
`
`information and/or data related to treatment types and protocols as described in the disclosure that may be
`
`used by the TMStreatment determination system 120), a NESTdata store 124 (c.g., storing any and all
`
`data related to use of the portable NEST system 100 and possibly some data received from other systems
`
`and/or devices such as received fromthe electrophysiology database and customized TMStreatment
`
`svstem 200), and NEST mechanics 126 (e.g., various mechanical parts relevant to configuration ofthe
`
`portable NEST device, such as an example portable headset device, for use by the patient 308). The
`
`network 300 can be connected to one or more patient device(s) 302, one or more clinician device(s) 304,
`
`third party service(s) 306, and external information source(s) 310. The headset device provides a support
`
`framework with attached electronic devices that is worn on the head of the user. The form factor of the
`
`headset can be a cap, helmet, orhat.
`
`[0045] Portable NEST System Advantages
`
`[0046] There maybe several advantages to using the portable NEST system 100 over other traditional
`
`TMSdevices such as wire or coil TMS devices. For example, one advantage may be favorable results
`
`(e.g., positive results in terms of sham effect) from feasibility tests or studies conducted with some
`
`example embodiments of the portable NEST system 100.
`
`[0047] There may be other advantages to using the portable NEST system 100 comparcd to traditional
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`TMSdevices or systems. Traditionally, as described in the disclosure, TMShastypically used coils. A
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`coil-based system has several disadvantages in that the coil requires a relatively large capacitor to be
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`charged up and discharged through the coil. Frequently, there may be a thousand ampsat a thousand volts
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`passing through this coil that generate these pulsed currents in the brain. What has been foundis that if
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`treatment frequency (¢.g., pulse frequency) may be configured to match a brain’s intrinsic frequency, one
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`can lowerthese levels of current and voltage. The portable NEST system 100 mayuse a routine
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`permanent maintenance that may be a significant advantage over the coil devices in that 1) one can use
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`the portable NEST system 100 continuously, and 2) the portable NEST system 100 maybe less
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`expensive.
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`[0048] Another advantage relating to the portable NEST system 100 mayrelate to the idea of energy at a
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`resonant frequency. For example, a brain’s intrinsic frequency may be at about ten Hertz. In some
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`examples,if there is a pulsed signal (e.g., pulsed stimulus at about ten Hertz), it may be difficult to
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`measure a pulse (e.g., the pulse may be detected at one point then undetected at a next point and then
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`detected again, etc.). When looking at frequency distribution, the energy frequency domain may be quite
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`wide and distributed. Whereas viewing the frequencydistribution of a rotating permanent magnet(c.g.,
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`rotating magnets of the magnetic stimulation system 104 ofthe portable NEST system 100), it may be a
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`pure sinusoid. Thus, most (if not all) of the energyof the portable NEST system 100 maybeat the
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`patient’s intrinsic frequency.
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`[0049] Evcn though somecoil dcviccs may gencratc a powcr that may be significantly greatcr than the
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`portable NEST system 100 (e.g., 100 times greater than the portable NEST system 100). When
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`monitoring energy at a brain’s resonant frequency, the portable NEST system 100 may have a higher
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`energy. This may be due to most (if not all) of the energy from the portable NEST system 100 focusing
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`on one frequency.
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`[0050] For providing magnetic stimulation ofa brain of the patient 308 (shown in FIG.1), the magnetic
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`stimulation system 104 of the portable NEST system 100 may use a coil or a rotating magnet. Electrical
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`stimulation may use, Transcranial alternating current (AC) stimulation. For example, an example
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`magnetic stimulation system 104 may include electrodes that maybe placed onthe scalp or forehead of
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`the patient 308 for providing an electric current (e.g., very low-level current). A very small portion of that
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`current may be received in the brain. This maybea relatively small fraction of a total current that actually
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`passes through a scalp of the patient 308.
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`[0051] Portability Designs
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`[0052] The portable NEST system 100 may have portability features (e.g., portable/mobile design
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`features 114) in order to provide a portable NEST device. The portable NEST system 100 may be a NEST
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`system that may have a portable unit device that provides sTMS. The portable NEST system 100 may be
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`researched under sTMS. Suitable portable/mobile design features 114 include, but are not limited to, one
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`ot more of a specific range of dimensions and/or range of weights that allowfor the portable NEST
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`system 100 to have one or more of the example features, characteristics, and/or form factors relating to
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`the portable/nobile design features 114. Portable/mobile design features 114 (e.g., dimensions) may be
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`distinguishable from dimensions and/or other features of traditionally large TMS devices or systems that
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`have been typically used. Various materials and/or components (e.g., having portable/mobile design
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`features 114) may be included that enable a relatively small for integration into architecture of the
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`portable NEST system 100.
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`[0053] The portable NEST system 100 mayutilize portable in-home technology and mobile technology
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`(for example, patients may take portable NEST system 100 from place to place). The portable NEST
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`system 100 mayalso include portable/mobile design features 114 for enabling for portability and mobility
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`use of the portable NEST system 100 such as by miniaturizing of some features or components. The
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`portable/mobile design features 114 may make the portable NEST system 100 portable for use from
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`home, or added to (e.g., part of) a transportation or vehicle system suchas a car (e.g., using the portable
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`NESTsystem 100 while driving or while a passengerof a vehicle as delivered by the installed portable
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`NEST system 100), an airplane, a train, a boat, and/or other vehicle and other building establishments
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`suchas a hotel room, a restaurant, a retail store, and/or a user’s place of business, other systems and
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`cstablishments, and the like.
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`[0054] The portable NEST system 100 has a variety of applications including use in spacetravel to
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`combat cognitive decline/reinforce wellness. For example, portable NEST system 100 maybe designed
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`and configured to be integrated into and/or addedto (e.g., part of) a spacecraft, space station, and/or any
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`other vehicles used in space as well as intcgrated into and/or added to any medical facility where
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`astronauts may be treated after returning from space.
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`[0055] Portable/mobile design features 114 of the portable NEST system 100 enables the portable NEST
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`system 100 to be shifted from a clinic-based technology (requiring physician oversight) to a remotely
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`accessed used fromanylocation outside the clinic(e.g., non-clinic settings such as home,office, etc.).
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`The portable NEST system 100 maybe used by pat