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`SAOT SHSRSASTE
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`Claims
`Drawings
`Original document
`Citations
`Legal evenis
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`
`
`The present invention relates to a pharmaceutical composition for treating fundus diseases,
`and more particularly to a oharmaceulical composition for treating glaucoma prepared fram
`plant Chinese herbal medicine.
`
`Glaucoma ts an eye disease with elevated pathological pressure associated with visual
`field, vision, and optic nerve damage. The disease is mainly caused by continuous increase
`in intraocular pressure, which gradually shrinks with the optic nerve, shrinks the visualfield,
`and reduces vision. lt often leads to blindness and is one of the most harmful and mainly
`blinded eve diseasss. The green wind cataract and the blue wind cataract mentioned by
`Chinese medicine are similar to glaucoma. The motherland medicine believes that the
`pathogenesis of the Qingfeng cataract is caused by depression and anger, causing liver ai
`stagnation, unfavorable meridians, liver stagnation and fire, and the wind and fire disturbing
`the eyes and causing qi and bload disharmony. The water stagnates and is the disease.
`When the blue wind cataract is anset, the patient is unconscicus or stunned slightly, and
`looks too long. It can be heavy, tired, and
`
`painful. H looks like a rainbowaround the lights. The initial visual acuityts infact, ihe white
`eyes, the black eyes, and the sacred gods are the same; those who are seriously il, the
`sacred gods are medium and large, and the sacredness is weak. The temperament of the
`gadis is slightly cyan, the eyes are slightly hard, and the eyes are fainting. Il can also be
`seen that the wheel is reddish and the surface of the black eye is covered wilh mist. The
`fundus can be changed in the early stage of the fundus, and then the central vascular af the
`niople is slightly displaced to the nasal side. The nippie depression is deepened and
`enlarged, and the nipple vessels are moved to the edge of the optic papilla, which is a knee-
`climbing shape, and the nipple becomes pale and visible. The gray dots of the board. The
`green wind cataract is suddenly onset, and if can also be a "cure wind and severe disease"
`(Criminal Rule, Seven Doors"). The disease is extremelyfierce, the head is severely
`
`

`

`painful, the bead is splitting, and the vision is rapidly falling. The cause is mainly due to
`sorrow and sorrow, violent anger, gas in the liver, ai occlusion, venting dereliction of duty,
`yin and yin, from the liver to the gallblacicer, the liver and gallbladder are blazing, the fire is
`full of wind, the fire is scattered, The hurricane is blazing, the wind and fire are disturbing,
`and itis an the eye. The green wind calaraci often attacks aller anger or tredness. From
`the beginning, the eyeball is slightly swollen, the frontal angie is partial pain, the head is
`dizzy, and the nose is painful. In severe cases, the eyes are painful and cracked, and the
`headache is like soutum, The swelling is implicated in the eyes and the forehead and
`cheeks. The vision is rapidly decreasing. Although il is different from the symptoms af
`Qingfeng cataract, its incidence is related to the adverse effects of the slagnation. In the
`treatment of glaucoma, Western medicine is mainly based on surgical treatment. For
`patienis who are not suilable for surgery for other reasons, eye drops 1%-2%pilocarpine
`eye crops are used to reduce iniraocular pressure and relieve symptoms. Surgery is mare
`fearful, so itis not necessaryto do sa. itis generally unwilling to undergo surgery.
`Ghemicals such as pilocarpine cannot fundamentally sliminate the pathogenic factors of
`glaucoma. Therefore, itis not the best drug choice. in clinical treatment, traditional Chinese
`medicine uses Danshen, scorpion, licarice, angelica, mecdiar, white peony, Atractylodes,
`and Bupleurum, which are made by Dan Xiaoyao (see "Medical Abstract"), or by gentian,
`habitat, angelica, Longdan Xiegan Decoction composed of Bupleurum, Mutong, Alisma,
`Psyllium, Radix Scutellariae, Radix Astragall, and Licarice (see “Ui Zong Jin Jian") for
`treatment, but the effect is not very satisfactory.
`
`itis an object of the present invention to provide a pharmaceutical composition whichis
`effective and which substantially eliminates its causative factors.
`
`The object of the present invention is achieved in this way, based on the pathogenesis and
`treatment principles of glaucoma {ie, green wind dysfunction, bleu cataract) in the
`motherland medicine, and the use of clearing heat and purging fire, soothing liver and wind,
`and reducing fire, Overcast and fire. According to the weight, 10-30 paris of Dendrobium,
`10-30 paris of white peany, 10-30 parts of Ophiopogon, 10-30 parts of mediar, 15-45 parts
`of Cassia, 10-30 parts of psyilum 10-30 parts of Scraphulariaceae, 10-30 parts of
`OQingxiangz!, 10-30 parts of Mi Menghua, 10-30 paris of night sand, 5-25 paris of licorice,
`15-45 paris of Uncaria, and Cassia 15-45 Paris, magnets 15-45 parts, chrysanthemum 10-
`30 parts.
`
`Preferred weight ratios of the invention are:
`
`15-20 parts of Dendrobium, 15-20 parts of while peony, 20-30 paris of Ophiopagon
`japonicus, 20-30 parts of mecdiar, 25-30 parts of Cassia, 15-20 parts of Uncaria, 15-20 parts
`of riagnel, 20-30 parts of chrysanthemum, 30-45 paris of Cassia, 10-20 parts of psyillum,
`20-3) parts of Scrophularia, 15-20 paris of Gingxiangzi, 20-30 parts of dense flawer, 20-30
`Of night sand Serve, 20-25 parts of Hcorice.
`
`

`

`The medicament of the present invention can be prepared into various oral preparations
`such as tablets, capsules, oral liquids, and granules.
`
`The method for preparing the medicament of the present invention into a capsule is:
`
`1. According io the ralic of the compasilion af the present invention, the components are
`
`weighed, soaked in water for 2-4 hours, bolled for 1-2 hours, filtered, and the two filtrates
`are cambined, and the filtrate is concentrated under vacuum to a thick paste, dried, and
`pulverized. The fine powder is passed through a mesh of 80 mesh - 100 mesh, and then
`divided into capsules, each coniaining 0.3 g of pawder.
`
`The dosage of the capsule prepared by the medicament of the invention in the treatment of
`glaucoma is: four capsules each time, three times a day, for three consecutive weeks as a
`course of treaiment.
`
`An important innovation of the present invention is the screening of the combined
`pharmaceutical components with good synergistic effects. The medicine of the invention
`adopts the hook vine, ihe grass cassia, the chrysanthemum, the Pinggan breeze, and at the
`same time, the stone cassia, ihe psylium, the night sand, the licorice are ail laken into the
`ohiegm anc bioad for the bload, accompanied by the scrophularia, the green Phases,
`densely scented flowers, mediar, Ophiopogon japonicus, magnets fo nourish yin and
`maisten the lungs, and the choice of Dangwuwu, Baiqi, so thal its drugs nave the effect of
`regulating bload, liver and liver. Various medicines cooperate with clearing heat, calming
`the liver, and venting the wind, so that the blue wind dysfunction has the effect of bottoming
`
`Out.
`
`The dosage ratio of each carmponent of the drug of the present invention is determined by
`long-term repeated experimental screening. Hf ensures that the drug of the present invention
`has the characteristics of high efficacy and long-lasting effect.
`
`The preferred ratio of the components of the present invention allows for better synergyof
`the components.
`
`The beneficial effects of the pharmaceutical compositions of the invention were verified by
`systematic clinical observation of 132 patients.
`
`The method for verifying the efficacy of the drug of the present invention is:
`
`

`

`132 patients with clinical glaucoma diagnoslic criteria were selected (dlagnostlic crileria are
`published in the Peaple’s Miltary Medical Publishing House, and the General Lagistics
`Department of the Peapie’s Liberation Army compiled the "Clinical Disease Diagnosis
`Based on Cure improvement Standards")
`
`Efficacy criteria:
`
`Gure: anterior chamber recovery, symptoms cisappear, and intraocular pressure drops to
`normal.
`
`Better: The intraocular pressure is iower than before.
`
`irivalid: Clinical symptoms have not improved.
`
`The experimental results are shown in the following table:
`
`The following are specific embodirnenis of the invention.
`
`Exampie 1:
`
`Weighing 30kg of Dendrobium, 1Okg of white peony, 20kg of oyster, 2Okg of mediar, 45kg
`of cassia, 15kg of Uncaria, 20kg of magnet, 2O0kg of chrysanthemum, 15kq of cassia, 20kg
`of osyllium, G0kg of scrophularia, and blue phase 15kg, 2Omm of dense Hower, 15kq of
`mght sand, 20kq of licarice, mix various medicines, soak for 2 hours with water, boil for 1
`hour, filer, medicinal solution, add water and decoct for 1 hour, combine two filtrates.
`
`Concentrate to a thick paste, dry, pulverize into a fine sowder, pass through a SO mesh
`sieve, and dispense 0.3 g of extract powder per capsule.
`
`The following Examples 2-6 were prepared in the same manner as in Example 1, except
`that the proportions of the cornpanents were different, but the objects and effects of the
`present invention were achieved.
`
`Example 2-8:
`
`

`

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